Article
Virology
Ashley F. George, Matthew McGregor, David Gingrich, Jason Neidleman, Rebecca S. Marquez, Kyrlia C. Young, Kaavya L. Thanigaivelan, Warner C. Greene, Phyllis C. Tien, Amelia N. Deitchman, Trimble L. Spitzer, Nadia R. Roan
Summary: HIV pre-exposure prophylaxis (PrEP) is more effective in men who have sex with men than in women, potentially due to low adherence and biological factors. Research suggests that endometrial stromal fibroblasts (eSF) in the female reproductive tract may enhance HIV infection, leading to reduced antiviral efficacy of PrEP drugs. This highlights the potential for drug combinations targeting both the virus and infection-promoting factors in the female reproductive tract to be more effective in preventing sexual transmission of HIV to women.
Review
Genetics & Heredity
Nomusa M. Zondo, Parveen Sobia, Aida Sivro, Sinaye Ngcapu, Veron Ramsuran, Derseree Archary
Summary: The use of antiretrovirals as pre-exposure prophylaxis for HIV prevention has shown mixed results in African women, with drug transporters and biological factors playing a critical role in determining the efficacy of oral and topical PrEP.
FRONTIERS IN GENETICS
(2022)
Review
Immunology
Andrew Plesniarski, Abu Bakar Siddik, Ruey-Chyi Su
Summary: The microbiome plays a crucial role in regulating the function of the female genital tract mucosa as a barrier, involving microbial diversity, soluble factors from both host and microbe, and the host immune system.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Infectious Diseases
Lauren Orser, Patrick O'Byrne, Dave Holmes
Summary: The nurse-led PrEP-RN program in Canada offers a new solution for HIV prevention through pre-exposure prophylaxis (PrEP). Qualitative interviews revealed differences between participants' motivations and beliefs about the benefits of PrEP compared to healthcare providers' views of risk. Incorporating individual motivations and beliefs into patient education and counseling could improve targeted HIV prevention care for those at elevated risk.
BMC INFECTIOUS DISEASES
(2022)
Article
Economics
Eamon O. Murchu, Conor Teljeur, Catherine Hayes, Patricia Harrington, Patrick Moran, Mairin Ryan
Summary: The study found that introducing a publicly funded PrEP program in Ireland is cost-saving and provides significant health benefits to the population. PrEP efficacy and HIV incidence have the greatest impact on cost-effectiveness, while an increase in sexually transmitted infections has a negligible effect on the results.
Article
Public, Environmental & Occupational Health
Erin Chase, Leandro Mena, Kendra L. Johnson, Mariah Prather, Christine M. Khosropour
Summary: Pre-exposure prophylaxis (PrEP) persistence is suboptimal in the United States, especially in the Deep South region. Patterns of PrEP discontinuation have not been explored extensively. A study on a clinic-based PrEP program in Jackson, Mississippi revealed that a majority of patients did not continue using PrEP and only a small number restarted after discontinuation. Patients assigned female at birth and those living farther from the clinic were more likely to stop PrEP early.
Article
Psychology, Clinical
Devon M. Price, Devin English, Sarit A. Golub
Summary: This study compared the changes in anxiety symptoms and HIV-related worry between a group of preexposure prophylaxis (PrEP) users and a comparison cohort who were not taking PrEP. The results showed that PrEP users experienced significant decreases in both HIV worry and anxiety symptoms over time compared to non-PrEP users. These findings provide quantitative evidence for the potential of PrEP to reduce HIV worry and anxiety symptoms.
Article
Multidisciplinary Sciences
Steven A. John, Juan P. Zapata, Madeline Dang, Benedikt Pleuhs, Andrew O'Neil, Sabina Hirshfield, Jennifer L. Walsh, Andrew E. Petroll, Katherine G. Quinn
Summary: In 2021, intramuscular cabotegravir for long-acting injectable HIV pre-exposure prophylaxis (LAI-PrEP) was approved by the U.S. FDA. A study was conducted to explore LAI-PrEP decision-making among young sexual minority men (YSMM) aged 17-24. The findings revealed that YSMM had varying preferences and considerations regarding LAI-PrEP, including concerns about adherence, awareness of safety and efficacy data, comfort with injections, minimizing stigma, and the option of self-administration. YSMM recognized the benefits of having more PrEP options for supporting uptake and persistence.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Hil R. O'Connell, Shannon M. Criniti
Summary: This study tested the feasibility of integrating routine PrEP counseling in a high-volume FP clinic and found significant improvements in PrEP knowledge and acceptability after counseling. The WPCC tool helps standardize counseling sessions, enhancing its impact on patients.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Multidisciplinary Sciences
Nicholas Fonseca M. Nogueira, Nicole Luisi, Ana S. R. Salazar, Emily M. L. Cherenack, Patricia L. Raccamarich, Nichole R. Klatt, Deborah L. Jones, Maria L. Alcaide
Summary: This study evaluates PrEP awareness and use among sexually active women in Miami, Florida. The results show low PrEP awareness, particularly among Black and Hispanic women, as well as women with inconsistent condom use during vaginal sex with male partners.
Article
Health Care Sciences & Services
Shimrit Keddem, Aneeza Agha, Sabrina Morawej, Amy Buck, Peter Cronholm, Sarita Sonalkar, Matthew Kearney
Summary: This study examined historical trends in Twitter hashtags related to women and HIV PrEP and explored the content shared through Twitter. The findings showed that most relevant tweets were posted by organizations, with individual users including activists and personal users. The tweets predominantly targeted people of color and the LGBTQ community, but lacked cues to action. Future tweets should incorporate more theoretical constructs and broaden their audience to achieve greater impact, while also drawing on strategies used by the LGBTQ community.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Oncology
Ru Wang, Hao Yu, Ming Liu, Ting Hao, Xiangyu Wang, Lianbao Cao
Summary: Multiple morphological changes in the female genital tract, involving two or more sites of concurrent multifocal mucinous lesions, are indicative of SMMN-FGT which is not related to high-risk HPV infection. Positive characteristic immunohistochemistry was observed for MUC6 and HIK-1083. The condition is rarely described. We present a case of an SMMN-FGT patient with lung metastases and STK11/KRAS gene mutations. Based on current research, we hypothesize that SMMN-FGT is closely associated with the development of cervical gastric adenocarcinoma.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Seth Zissette, Elizabeth E. Tolley, Andres Martinez, Homaira Hanif, Katherine Gill, Nelly Mugo, Laura Myers, Ednar Casmir, Menna Duyver, Kenneth Ngure, Gustavo F. Doncel
Summary: This study validated the structure of the adherence screening tool and the construct of the oral PrEP monitoring tool, demonstrating their utility in diverse populations and adapting to the monitoring needs of different HIV prevention products.
Article
Virology
Veronica O. Martin, Novatus A. Tesha, Bruno F. Sunguya
Summary: This study examined the uptake of oral PrEP and its associated factors among female sex workers in the Tanga region of Tanzania. The findings showed that about 55% of the participants used oral PrEP, and those with three or more children and a positive attitude were more likely to take oral PrEP. The study also identified poor belief and drug side effects as barriers to PrEP use.
Review
Immunology
Christine Tzelios, Werner M. Neuhausser, David Ryley, Nhi Vo, Rocio M. Hurtado, Ruvandhi R. Nathavitharana
Summary: Female genital tuberculosis is a significant cause of infertility worldwide. Early treatment is crucial to prevent irreversible organ damage.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Sravan Kumar Patel, Wissam Beaino, Carolyn J. Anderson, Jelena M. Janjic
CLINICAL IMMUNOLOGY
(2015)
Review
Medicine, Research & Experimental
Sravan Kumar Patel, Jelena M. Janjic
Review
Instruments & Instrumentation
Sravan Kumar Patel, Lisa Cencia Rohan
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2017)
Article
Immunology
Jelena M. Janjic, Kiran Vasudeva, Muzamil Saleem, Andrea Stevens, Lu Liu, Sravan Patel, John A. Pollock
JOURNAL OF NEUROIMMUNOLOGY
(2018)
Meeting Abstract
Clinical Neurology
K. Vasudeva, S. Patel, M. Saleem, A. Balducci, T. Hitchens, J. Janjic, J. Pollock
Meeting Abstract
Clinical Neurology
J. Janjic, C. Bagia, S. Patel
Article
Pharmacology & Pharmacy
Haitao Yang, Jing Li, Sravan Kumar Patel, Kenneth E. Palmer, Brid Devlin, Lisa C. Rohan
Article
Pharmacology & Pharmacy
Galit Regev, Sravan Kumar Patel, Bernard J. Moncla, John Twist, Brid Devlin, Lisa C. Rohan
Article
Pharmacology & Pharmacy
Tiantian Gong, Sravan Kumar Patel, Michael A. Parniak, Byron Ballou, Lisa C. Rohan
Article
Pharmacology & Pharmacy
Jing Li, Galit Regev, Sravan Kumar Patel, Dorothy Patton, Yvonne Sweeney, Philip Graebing, Sheila Grab, Lin Wang, Vinayak Sant, Lisa C. Rohan
Article
Pharmacology & Pharmacy
Kunal Jhunjhunwala, Charles W. Dobard, Sunita Sharma, Natalia Makarova, Angela Holder, Chuong Dinh, James Mitchell, Lin Wang, Junmei Zhang, Sravan Kumar Patel, Walid Heneine, Lisa C. Rohan
Summary: Receptive anal intercourse (RAI) significantly increases the risk of HIV transmission, highlighting the need to develop HIV prevention options for individuals engaging in RAI practices. Research has shown that rectal suppositories can serve as a promising on-demand strategy for HIV PrEP and supports their clinical development.
Article
Polymer Science
Xin Tong, Sravan Kumar Patel, Jing Li, Dorothy Patton, Elaine Xu, Peter L. Anderson, Urvi Parikh, Yvonne Sweeney, Julie Strizki, Sharon L. Hillier, Lisa C. Rohan
Summary: In this study, a nanoparticle-in-film technology was developed for sustained delivery of MK-2048 against HIV. The engineered film loaded with MK-2048 nanoparticles showed comparable efficacy to free MK-2048 in vitro, had no impact on Lactobacillus, and exhibited increased permeability in cell lines and macaque models. The nanoparticle films sustained drug levels in vaginal fluid for at least 3 weeks. This study highlights the synergy of nanomedicine and polymeric film technology for sustained vaginal drug delivery.
Meeting Abstract
Immunology
Sravan Kumar Patel, Katherine Bunge, Julie Downs, Sharon Hillier, Lisa Rohan
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2018)
Meeting Abstract
Immunology
Lisa Rohan, Sheila Grab, Dorothy Patton, Peter Anderson, Yvonne Cosgrove Sweeney, Lane Bushman, Lin Wang, Sravan Kumar Patel, Julie Strizki, Sharon Hillier
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2018)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
