Review
Materials Science, Biomaterials
Avha R. Mohanty, Akhila Ravikumar, Nicholas A. Peppas
Summary: There have been significant advancements in glucose sensing and insulin delivery for treating type I diabetes mellitus in the past few decades. The introduction of closed-loop insulin delivery systems has shifted the research focus in this field. In this contribution, recent advancements over the last 5 years are discussed, along with persisting issues in these technologies.
REGENERATIVE BIOMATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Mengyun He, Pei Yu, Yanlei Hu, Juan Zhang, Manman He, Cunpeng Nie, Xia Chu
Summary: The study presents a novel glucose-responsive nanoplatform that mimics insulin secretion and enables intravenous smart delivery, effectively stabilizing blood glucose levels and prolonging time in normoglycemia.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Qingqing Huo, Jun Zhou, Hui Tang, Wenbo Wu, Shuai Hu, Enpeng Dong, Yang Huang, Yunyi Zhou, Yue Gao, Yuancheng Bai, Dongfei Liu
Summary: Researchers developed a surface decoration strategy to achieve efficient drug encapsulation and precise ratiometric control in a smart self-regulated drug delivery system. By surface decoration with cationic carrier materials, the surface properties of protein and peptide nanoparticles were uniformed to those of the adsorbed carrier materials, leading to good dispersity in the oil phase and inhibition of drug transfer from oil to water. This approach enables co-encapsulation of multiple types of proteins and peptides with precise control of ratios.
Article
Multidisciplinary Sciences
Jie Tang, Xiaojing Tong, Yongjun Chen, Yue Wu, Zhiyuan Zheng, A. Basak Kayitmazer, Ayyaz Ahmad, Naveed Ramzan, Jintao Yang, Qingchun Huang, Yisheng Xu
Summary: This study presents the development of a nanopesticide formulation that enhances adhesion and deposition of pesticides, improving their utilization efficiency. The nanopesticides, prepared using temperature-responsive copolymers as carriers, show increased anti-washing efficiency and reduced toxicity to zebrafish compared to commercial formulations. This work addresses an important challenge in pesticide applications and has potential to maximize pesticide usage.
NATURE COMMUNICATIONS
(2023)
Article
Polymer Science
Jit Sarkar, Kai Bin Jonathan Chan, Atsushi Goto
Summary: A double hydrophilic block copolymer vesicle was synthesized using organocatalyzed living radical polymerization, capable of encapsulating external guest molecules and releasing them under reducing conditions.
Article
Chemistry, Multidisciplinary
Karin Mannerstedt, Narendra Kumar Mishra, Ebbe Engholm, Morten Lundh, Charlotte S. Madsen, Philip J. Pedersen, Priska Le-Huu, Soren L. Pedersen, Nina Buch-Manson, Bjorn Borgstrom, Thomas Brimert, Lisbeth N. Fink, Keld Fosgerau, Niels Vrang, Knud J. Jensen
Summary: A glucose responsive insulin (GRI) has been developed using glucose cleavable linkers based on hydrazone and thiazolidine structures, demonstrating glucose responsiveness in vitro, particularly for thiazolidines. Clamp studies confirmed increased glucose infusion at hyperglycemic conditions for one GRI, indicating a true glucose response. The glucose responsive cleavable linker in these GRIs drives the release of active insulin from a circulating depot in response to changes in glucose levels.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Materials Science, Biomaterials
Zhaoyang Guo, Haiyang Liu, Zhekun Shi, Lulu Lin, Yinping Li, Miao Wang, Guoqing Pan, Yifeng Lei, Longjian Xue
Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Polymer Science
Jaeman J. Shin
Summary: The effect of inorganic nanoparticles on the structure of hybrid block copolymer particles and the local distribution of nanoparticles is studied. The study focuses on comparing the nanoparticles made of Au and Fe3O4. The distribution of nanoparticles inside the particles was found to affect the overall particle morphology. Au nanoparticles were selectively localized inside certain domains regardless of the particle morphology, while Fe3O4 nanoparticles clustered and segregated to the interfaces of the particles.
Article
Polymer Science
Harpal S. Dhiraj, Fumi Ishizuka, Maria Saeed, Amr Elshaer, Per B. Zetterlund, Fawaz Aldabbagh
Summary: Higher order morphologies, such as rods and worms, can be formed by combining core-shell nanoparticles with boronic acid moieties under basic conditions. For the first time, it is observed that lactate, an anaerobic metabolite, can bind to the BA moiety of amphiphilic block copolymers at a lower physiological pH of 7.4. Self-assembly experiments show that the resulting nanoparticles have similar structures to those formed by reacting with glucose.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Physical
Xiaomin Xu, Yani Xu, Yuai Li, Min Li, Leilei Wang, Qiang Zhang, Bingjie Zhou, Qing Lin, Tao Gong, Xun Sun, Zhirong Zhang, Ling Zhang
Summary: In this study, a glucose-responsive system mimicking erythrocytes was designed by coupling glucose-responsive nanoparticles to red blood cells, allowing for long-term response to hyperglycemia and potential application in diabetes treatment.
Article
Polymer Science
Kuo Zhang, Zhong-Yuan Lu, Li Zhao
Summary: This study investigates the dissipative self-assembly of azobenzene-contained block copolymers under time-dependent light irradiations through non-equilibrium dissipative particle dynamics simulations. It demonstrates that dissipative steady structures can be formed when the oscillation period is much smaller than the diffusional timescale of the block copolymer, and as the oscillation period increases, periodic dissipative structures with structural variation are formed. Additionally, the dissipative steady structures can be finely tuned by adjusting the volume fraction of photo-responsive chains in the block copolymer melt.
Article
Engineering, Chemical
Xiangyue Ye, Jiemei Zhou, Chenxu Zhang, Yong Wang
Summary: Intelligent responsive membranes have attracted much attention due to their ability to reversibly change separation performances under environmental stimulation. This study develops responsive membranes from block copolymers using CO2 gas as a stimulus. The membranes exhibit nano-porous structures and CO2-responsive chains, enabling controllable regulation of water permeance and protein separation.
JOURNAL OF MEMBRANE SCIENCE
(2022)
Article
Chemistry, Physical
Kai Wang, Yali Xue, Jianjian Lin, Jun Yu, Qimeng Wang, Zhiying Xie, Haizhou Yu, Xiaoyan Qiu
Summary: A biocompatible porous material, ZMDPCs, based on ZIF-8 is designed with ordered topology and dual responsive surfaces to address the challenges of dosage limitation, toxicity, and intelligent responsiveness. The high loading capacity is achieved through the large specific surface area and hierarchical pores. Polydopamine decoration enhances biocompatibility, and it can trigger the phase transition of PCM (a thermal response valve) through NIR irradiation. Drug release can be controlled by NIR or pH stimulation. With its biocompatibility, degradability, and responsive surfaces, ZMDPCs show promising potential as a drug delivery vehicle.
SURFACES AND INTERFACES
(2023)
Review
Polymer Science
Kang Hee Ku
Summary: This review provides an overview of recent approaches for developing responsive polymer particles, focusing on the physical principles affecting particle shape and inner structure, as well as the latest advances and future directions in this field.
Article
Polymer Science
Shuqi Dong, Li Liu, Hanying Zhao
Summary: In this study, oxidation-responsive amphiphilic block copolymers were synthesized and self-assemblies with different morphologies were achieved by adjusting the hydrophobic block length. Hybrid polymersomes with Cu2+-cross-linked membrane were fabricated, featuring a responsive property to competitive ligands, thanks to the metal-ligand interaction.
Article
Energy & Fuels
Robert Underwood, Moonyong Kim, Storm Drury, Yuchao Zhang, Li Wang, Catherine Chan, Brett Hallam
Summary: The global cumulative PV installed capacity has exceeded 1 TW, but more PV is needed to achieve complete decarbonization. To sustainably mitigate climate change, all factors, including reducing the demand for abundant materials, must be considered.
Review
Energy & Fuels
Mbega Ramadhani Ngata, Baolin Yang, Warda Khalid, Elbek Ochilov, Grant Charles Mwakipunda, Mohammed Dahiru Aminu
Summary: Carbon capture and storage is an important technology for mitigating climate change, but it can lead to formation damage that affects storage capacity. This study reviews the experimental studies on the interaction between CO2, formation water, and rock minerals, which often result in mineral dissolution and precipitation, and the precipitation of scales and minerals can cause formation damage.
Article
Physics, Multidisciplinary
Quanyong Xu, Hu Ren, Hanfeng Gu, Jie Wu, Jingyuan Wang, Zhifeng Xie, Guangwen Yang
Summary: This paper presents the development of an efficient implicit solver, "sprayDyMFoam," based on the Sunway TaihuLight supercomputer for the whole-engine numerical simulation of aeroengines. The solver improves the PIMPLE algorithm in the solution of aerodynamic force and adjusts the droplet atomization model for the combustion process to ensure the matching between components and the combustion chamber. The parallel communication mechanism for AMI boundary processing is also optimized. The sprayDyMFoam solver shows good computational capacity and efficiency in simulating a typical double-rotor turbofan engine.
Article
Engineering, Environmental
Zhiyang Liao, Jinrong Lu, Kunting Xie, Yi Wang, Yong Yuan
Summary: Machine learning models were developed to predict the values of three photochemical reactive intermediates (PPRIs) apparent quantum yields (phi) based on dissolved organic matter (DOM) spectral parameters, experimental conditions, and calculation parameters. The CatBoost model showed the best predictive performance, outperforming traditional linear regression models. The significance of wavelength range and spectral parameters on phi PPRIs predictions was revealed, indicating that DOM with lower molecular weight, lower aromatic content, and a more autochthonous portion possessed higher phi PPRIs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Clinical Neurology
Zheng Wang, Xinli Hu, Peng Cui, Xu Liu, Weiguo Zhu, Chao Kong, Wei Wang, Shibao Lu
Summary: The purpose of this study was to investigate the PI- and age-related cervical alignment changes of Chinese healthy population. The results showed that there was no obvious difference observed between PI and cervical sagittal parameters, except for caudal arch. However, C2-7, cranial arch, caudal arch, T1S, and C2-7 SVA increased remarkably with age. Based on the classification in the study, high or low PI apparently did not correlate with the occurrence of cervical degenerative disease.
EUROPEAN SPINE JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yuting Zhuang, Tingting Li, Xiaoxi Hu, Yilin Xie, Xinyu Pei, Chaoqun Wang, Yuyang Li, Junwu Liu, Zhongrui Tian, Xiaowen Zhang, Lili Peng, Bo Meng, Hao Wu, Wei Yuan, Zhenwei Pan, Yanjie Lu
Summary: The long noncoding RNA (lncRNA) MetBil plays a significant role in cardiac fibrosis by interacting with METTL3 and regulating the expression of methylated fibrosis-associated genes. Overexpression of MetBil enhances collagen deposition, cardiac fibroblast proliferation, and activation, while silencing MetBil has the opposite effects. This study provides a new potential target for interventions in fibrosis-related cardiac diseases.
Article
Energy & Fuels
Hui Luo, Shilin Zhao, Anjun Ma, Kang Sun, Yanqun Zhu, Zhiqiang Sun
Summary: This study investigated the effects of flue gas components (O2, CO2, SO2, and NO) on the Hg-0 removal of mechanochemical S2Cl2-modified BC (S2Cl2-MC). It was found that O2 and CO2 promoted the escape of Hg2+ but inhibited the adsorption of Hg-0, while SO2 and NO had a certain promoting effect on the removal of Hg-0.
Article
Genetics & Heredity
Zhiqiang Xia, Lixia Xie, Dongyuan Li, Xinyi Hong, Chenhu Qin
Summary: The three members of TRPML subfamily, TRPML1, TRPML2, and TRPML3, are highly expressed in the lung tissue, as well as spleen and kidney tissues of mice. TRPML1 and TRPML3 showed decreased expression in response to LPS stimulation, while TRPML2 showed increased expression. This suggests that TRPML1 and TRPML3 play important roles in immune and inflammatory regulation.
Article
Astronomy & Astrophysics
Zixu Zhao, Jian Chen, Zongcheng Ling, Xuejin Lu, Zexi Li
Summary: The timeline of volcanic activity on the Moon is crucial for understanding its thermal evolution. This study focuses on the basaltic volcanism in the Procellarum region and analyzes its chronology, composition, and mineralogy. The results reveal three major episodes of volcanic events occurring approximately 3.5 Ga, 2.5 Ga, and 1.8 Ga.
Article
Engineering, Electrical & Electronic
Yukan Zheng, Yuan-Xin Li, Choon Ki Ahn
Summary: This article focuses on the synchronization control of networked uncertain parabolic partial differential equations (PDEs) with uncertain nonlinear actuator dynamics. A novel passive identifier is designed to estimate the states and unknown parameters, and a synchronization controller is presented based on the passive identifier and Lyapunov function method to ensure synchronization control and boundedness of closed-loop signals for cascaded parabolic PDE systems. The effectiveness of the obtained results is illustrated using simulation.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS
(2023)
Article
Physics, Fluids & Plasmas
Nanya Zhong, Xiao Wei, Yu Zhong, Yijun Wang, Wenqi Chen, Kama Huang
Summary: This paper proposes a novel self-excited atmospheric pressure microwave plasma jet (APMPJ) based on a coaxial line for medical treatment. The optimal size of the APMPJ is determined using finite-element method (FEM). The plasma parameters, including electron density and electron temperature, are calculated within 0.1 ms. Experimental results show that the argon plasma jet can be self-excited at an incident power of 20 W, and the gas temperature of the plasma jet is approximately 318 K at an incident power of 15 W. Moreover, the air plasma jet can be self-excited at an incident power of 110 W. The analysis of the density ratio of hydroxyl (OH) radical to other particles when water vapor is added to the APMPJ at different flow rates reveals that a small amount of water vapor can significantly increase the relative content of OH, as tested by a spectrometer.
IEEE TRANSACTIONS ON PLASMA SCIENCE
(2023)
Article
Agricultural Engineering
Xiaolong Li, Xiaohan Shang, Jinyan Lyu, Yubao Tong, Wei Situ, Liusong Yu, Ting Wu, Heng Xie, Jinping Qu
Summary: A synergistic strategy involving weak shear and melt quenching process was used to fabricate high-performance PLA/PHB composites, which minimized the damage to PLA molecular chains and promoted interfacial bonding. The resulting composites exhibited high molecular weight, favorable thermal stability, and optimal mechanical properties.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Mengyang Li, Xilin Luo, Yaoxiao Zhao, Wenxin Zhang, Kun Yuan, Xiang Zhao
Summary: With density functional theory calculations, crown-shaped pyrrole-based hosts doped with metal atoms (Li, Na, and K) were designed for effective recognition of C60. Enhanced interaction of the concave-convex host-guest system with doped metal atoms enabled selective recognition of C60. The electrostatic interaction between host and guest was studied through natural bond order charge analysis, reduced density gradient, and electrostatic potential. Simulated UV-vis-NIR spectra of host-guest structures provided guidance on the release of the fullerene guest. This work offers a new strategy for designing hosts with modest interaction to effectively recognize fullerene molecules, and is useful for fullerene assembly.
INORGANIC CHEMISTRY
(2023)
Article
Engineering, Electrical & Electronic
Yu Zhong, Francesco Zardi, Marco Salucci, Giacomo Oliveri, Andrea Massa
Summary: In this article, a novel inversion strategy is proposed to solve inverse scattering problems with inhomogeneous backgrounds. The strategy combines the multiscaling regularization scheme and the difference contraction integral equation formulation, which mitigates nonlinearity and ill-posedness to obtain reliable high-resolution reconstructions.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2023)
Article
Computer Science, Information Systems
Jinchao Liang, Zijing Feng, Riqing Chen, Xiaolong Liu
Summary: A novel scheme based on basin-hopping improvement (BHI) is proposed to generate adversarial examples with invisible watermarks, achieving a high success rate of 93.5%.
INFORMATION SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
