Article
Immunology
Siri Tahtinen, Ann-Jay Tong, Patricia Himmels, Jaehak Oh, Andres Paler-Martinez, Leesun Kim, Sara Wichner, Yoko Oei, Mark J. McCarron, Emily C. Freund, Zhainib Adel Amir, Cecile C. de la Cruz, Benjamin Haley, Craig Blanchette, Jill M. Schartner, Weilan Ye, Mahesh Yadav, Ugur Sahin, Lelia Delamarre, Ira Mellman
Summary: Lipid-formulated RNA vaccines can cause systemic inflammatory responses in humans, which were not predicted in preclinical studies. The IL-1 pathway plays a key role in triggering vaccine-induced inflammation, but this effect is dampened in mice.
Article
Immunology
Ewa Oleszycka, Eoin C. OBrien, Michael Freeley, Ed C. Lavelle, Aideen Long
Summary: Bile acids, synthesized from cholesterol, play a role in promoting intestinal absorption and have been associated with inflammatory diseases. This study demonstrates that bile acids can induce the secretion of pro-inflammatory cytokines and the recruitment of innate immune cells, suggesting their mechanistic role in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Juan F. Hernandez-Franco, Shaojun Xie, Jyothi Thimmapuram, Darryl Ragland, Harm HogenEsch
Summary: Recent studies have demonstrated that corn-derived cationic alpha-D-glucan nanoparticles, called Nano-11, can significantly enhance the immune response as a vaccine adjuvant in mice and pigs. These nanoparticles can also be combined with other immunostimulators like poly(I:C) to further boost the immune response. The aim of the current experiments was to investigate the mechanism of action of Nano-11 alone and in combination with poly(I:C). The results showed that Nano-11 and Nano-11/poly(I:C) induced differential gene expression in porcine monocyte-derived dendritic cells (Mo-DCs) and increased the expression of maturation markers. The p38 MAPK signaling pathway was found to play a crucial role in the activation of Mo-DCs by these adjuvants.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Mohamed Ahmed Attia, Ebtessam Ahmed Essa, Toka Tarek Elebyary, Ahmed Mostafa Faheem, Amal Ali Elkordy
Summary: Vaccination is the most effective means of preventing infectious diseases, and advancements in biotechnology and nanoparticles have enabled successful vaccine development. Liposomes, as a versatile carrier for vaccines, have shown great potential in delivering antigens and eliciting desired immune responses during the ongoing pandemic of COVID-19.
Article
Oncology
Mark Aleynick, Judit Svensson-Arvelund, Gvantsa Pantsulaia, Kristy Kim, Samuel A. Rose, Ranjan Upadhyay, Michael Yellin, Henry Marsh, Daniel Oreper, Suchit Jhunjhunwala, Christine Carine Moussion, Miriam Merad, Brian D. Brown, Joshua D. Brody
Summary: This study found that viral or bacterial components in pathogen vaccines can effectively activate and recruit tumor antigen-reactive dendritic cells, promoting cross-priming of antigen-specific T cells. Combining multiple pathogen vaccine components can further enhance T cell cross-priming and improve anti-tumor effects.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Pharmacology & Pharmacy
Xuemei Zhong, Guoqing Wang, Fu Li, Sixian Fang, Siai Zhou, Akihiro Ishiwata, Alexander G. Tonevitsky, Maxim Shkurnikov, Hui Cai, Feiqing Ding
Summary: Beta-glucan, a homopolysaccharide composed of D-glucose, is widely found in cereals and microorganisms and possesses various biological activities including anti-inflammatory, antioxidant, and anti-tumor properties. Recent research has shown that beta-glucan acts as a physiologically active biological response modulator, promoting dendritic cell maturation, cytokine secretion, and regulating adaptive immune responses, all of which are directly connected to beta-glucan-regulated glucan receptors.
Review
Pharmacology & Pharmacy
Beata Biri-Kovacs, Zoltan Banoczi, Anitha Tummalapally, Ildiko Szabo
Summary: Skin cancer is the most common type of cancer, with melanoma being a leading cause of skin cancer deaths. Recent advancements in understanding melanoma tumorigenesis and its interaction with the immune system have led to the development of new therapeutic strategies. Peptide-based vaccines, which target tumor antigens and activate immune responses, have shown promise in treating advanced melanoma. However, the immunogenicity of peptide antigens can be enhanced through synthetic modifications, adjuvants, and delivery systems. This review summarizes the various chemical approaches for developing effective peptide-based vaccines for immunotherapy in advanced melanoma.
Review
Medicine, Research & Experimental
Despo Chatzikleanthous, Derek T. O'Hagan, Roberto Adamo
Summary: Despite the progress in vaccine adjuvants, there are still unmet needs for vaccines against challenging pathogens like HIV, tuberculosis, and cancer. Liposomes have shown to be effective as adjuvant/delivery systems and have potential for further use in vaccine development, as seen in recent COVID-19 vaccines. This review outlines different approaches for lipid-based vaccine adjuvant/delivery systems and how they can be combined to develop multicomponent vaccines.
MOLECULAR PHARMACEUTICS
(2021)
Review
Immunology
Arianna Raponi, James M. Brewer, Paul Garside, Donatello Laera
Summary: Purified vaccine antigens offer safety advantages compared to live vaccines, but adjuvants like aluminum salts are needed to induce the required immune response. By reducing aluminum particle size from micro to nanometers, a more effective adjuvant can be obtained, with the ability to sterile filter the vaccine product.
SEMINARS IN IMMUNOLOGY
(2021)
Review
Chemistry, Physical
Aihua Qu, Maozhong Sun, Liguang Xu, Liqiang Liu, Lingling Guo, Panpan Chen, Qing Wang, Zhiyong Du, Zhimeng Wu, Chuanlai Xu, Hua Kuang
Summary: Chiral nanomaterials play a crucial role in the field of vaccines by promoting antigen presentation and activating the immune system for tumor immunotherapy. However, there are still challenges in this research, such as finding better synthesis methods and addressing the issue of immune system regulation.
Article
Oncology
Bram Van den Eeckhout, Leander Huyghe, Sandra Van Lint, Elianne Burg, Stephane Plaisance, Frank Peelman, Anje Cauwels, Gilles Uze, Niko Kley, Sarah Gerlo, Jan Tavernier
Summary: The study demonstrates that an IL-1 beta-based AcTakine can effectively promote anticancer cellular immunity, enhancing proliferation and effector functionality of CD8(+) T cells without inducing significant toxicity. Combination treatment with a tumor necrosis factor AcTakine can lead to complete tumor eradication and establishment of immunological memory. Interferon-gamma enhances the synergistic effects of AcTakine.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Javier Castrodeza-Sanz, Ivan Sanz-Munoz, Jose M. Eiros
Summary: In recent decades, improvements in traditional vaccines have led to the development of more processed vaccines with better tolerability profiles but lower immunogenicity. Adjuvants provide a good solution to enhance the immunogenicity of these vaccines with improved tolerability and fewer side effects. The approval of protein-based vaccines in 2022 and 2023 further expanded the options. Adjuvanted vaccines can induce potent immune responses in populations with weak or insufficient immune systems, such as the elderly, and could play a crucial role in completing global COVID-19 vaccination efforts in the present and future.
Review
Biochemistry & Molecular Biology
Vincent Pretre, Dimitrios Papadopoulos, Jean Regard, Marc Pelletier, Janghee Woo
Summary: Inflammation plays a significant role in the development and progression of cancer. Inflammation in the tumor microenvironment alters the adaptability of tumor cells, promoting their survival and progression. Recent studies have shown that inhibiting interleukin-1 beta (IL-1 beta) can significantly decrease the risk of lung cancer. This article reviews the role of IL-1 beta and its upstream regulator NLRP3 in solid tumor and hematologic malignancies, and discusses the pharmacologic tools used to evaluate the effects of blocking tumor-promoting inflammation.
Article
Biochemistry & Molecular Biology
Salvatore Calogero Gaglio, Marta Donini, Piyachat Evelyn Denbaes, Stefano Dusi, Massimiliano Perduca
Summary: Oxyresveratrol suppresses cytokine production by activated dendritic cells and when loaded into poly(lactic-co-glycolic acid) nanoparticles, it mitigates the pro-inflammatory effects. This suggests that oxyresveratrol could serve as a promising anti-inflammatory and immune-suppressive agent.
Article
Immunology
Giuditta Guerrini, Antonio Vivi, Sabrina Gioria, Jessica Ponti, Davide Magri, Arnd Hoeveler, Donata Medaglini, Luigi Calzolai
Summary: Physicochemical properties of adjuvant-protein antigen complexes impact vaccine efficacy and safety, and a multi-staged characterization strategy has been developed for accurate assessment of nanoaluminum-ovalbumin complex, which can be adapted for various adjuvant-protein antigen combinations to control quality and improve immunological outcomes of vaccines.
Article
Medicine, Research & Experimental
Fangjia Lu, Qingyang Liu
MEDICAL HYPOTHESES
(2018)
Article
Multidisciplinary Sciences
Jackeline Franco, Christina Ferreira, Tiago J. Paschoal Sobreira, John P. Sundberg, Harm HogenEsch
Article
Immunology
Santosh Dhakal, Sankar Renu, Shristi Ghimire, Yashavanth Shaan Lakshmanappa, Bradley T. Hogshead, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Harm HogenEsch, Steven Krakowka, Chang Won Lee, Gourapura J. Renukaradhya
FRONTIERS IN IMMUNOLOGY
(2018)
Review
Immunology
Harm HogenEsch, Derek T. O'Hagan, Christopher B. Fox
Article
Immunology
Fangjia Lu, Yung-Yi C. Mosley, Brooke Carmichael, Devonte D. Brown, Harm HogenEsch
Article
Immunology
Sankar Renu, Ninoshkaly Feliciano-Ruiz, Fangjia Lu, Shristi Ghimire, Yi Han, Jennifer Schrock, Santosh Dhakal, Veerupaxagouda Patil, Steven Krakowka, Harm HogenEsch, Gourapura J. Renukaradhya
Article
Biochemistry & Molecular Biology
Jackeline Franco, Bartek Rajwa, Christina R. Ferreira, John P. Sundberg, Harm HogenEsch
Article
Immunology
Juan F. Hernandez-Franco, Yung-Yi C. Mosley, Jackeline Franco, Darryl Ragland, Yuan Yao, Harm HogenEsch
Summary: The combination adjuvant of cdAMP and Nano-11 significantly enhanced the immune response to intradermal vaccines in mice and pigs, with minimal local reaction at the injection site. This adjuvant showed a strong synergistic interaction in activating APCs and inducing immune responses, supporting a balanced immune response.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jackeline Franco, Bartek Rajwa, Paulo Gomes, Harm HogenEsch
Summary: The study found significant differences in the lipid composition of skin and blood between dogs with atopic dermatitis and controls, with treatments impacting both skin and blood lipids. A set of skin lipid features accurately classified samples as control or atopic dermatitis with 95% accuracy. Blood lipids discriminated between control and atopic dogs with 90% accuracy, supporting the use of rapid lipid profiling as a tool for identifying novel biomarkers.
Article
Microbiology
Shankar Thangamani, Ross Monasky, Jung Keun Lee, Vijay Antharam, Harm HogenEsch, Tony R. Hazbun, Yan Jin, Haiwei Gu, Grace L. Guo
Summary: The study found that taurocholic acid (TCA) promotes fungal colonization and dissemination of Candida albicans (CA) from the gastrointestinal tract through regulating the gut microbiota and host defense system.
Article
Agriculture, Dairy & Animal Science
Rebecca N. Klopp, Juan F. Hernandez Franco, Harm Hogenesch, Tana S. Dennis, Kate E. Cowles, Jacquelyn P. Boerman
Summary: Reducing reliance on antibiotics and evaluating the effects of medium-chain fatty acids on calf growth and health as well as the adaptive immune response to vaccination is crucial for the dairy industry.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Microbiology
Abhishek Datta, Juan F. Hernandez-Franco, Sungtae Park, Matthew R. Olson, Harm HogenEsch, Shankar Thangamani
Summary: This study found that taurocholic acid promotes colonization and dissemination of Candida albicans in the intestine, while reducing the number of immune cells responsible for controlling the infection.
Review
Pharmacology & Pharmacy
Donatello Laera, Harm HogenEsch, Derek T. O'Hagan
Summary: Aluminum-based adjuvants, with their excellent safety profile and flexible platform, are widely used in vaccines, including approved ones and those under development. Although considered relatively 'weak', their performance can be improved through co-delivery of immune potentiators like Toll-like receptor agonists. This review summarizes different aluminum salts used in vaccines, discusses the analytical challenges in creating well-characterized formulations, and highlights the use of aluminum in developing improved adjuvants through the adsorption and delivery of various TLR agonists.
Article
Immunology
Juan F. Hernandez-Franco, Ganesh Yadagiri, Veerupaxagouda Patil, Dina Bugybayeva, Sara Dolatyabi, Ekachai Dumkliang, Mithilesh Singh, Raksha Suresh, Fatema Akter, Jennifer Schrock, Gourapura J. Renukaradhya, Harm Hogenesch
Summary: This study evaluated the effectiveness of commercially available cross-protective swIAV vaccines and monovalent whole inactivated H1N2 swine influenza vaccine when administered through different routes. The results showed that intradermal vaccination generated a stronger cross-reactive antibody response and higher avidity, and induced the production of both IgG and IgA virus-specific antibody-secreting cells.
Article
Immunology
Veerupaxagouda Patil, Juan F. Hernandez-Franco, Ganesh Yadagiri, Dina Bugybayeva, Sara Dolatyabi, Ninoshkaly Feliciano-Ruiz, Jennifer Schrock, Raksha Suresh, Juliette Hanson, Hadi Yassine, Harm Hogenesch, Gourapura J. Renukaradhya
Summary: The study investigated the efficacy of split SwIAV H1N2 antigens adsorbed with a plant origin nanoparticle adjuvant or in combination with a STING agonist in pigs. The results showed that both vaccines induced strong immune responses, characterized by increased activated monocytes, cytotoxic lymphocytes, and the production of specific antibodies. Despite the genetic differences between the vaccine and challenge viruses, the vaccines were able to induce moderate levels of cross-protective immune responses.
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)