Article
Oncology
Michelle M. Moring, Hetty Mast, Eppo B. Wolvius, Gerda M. Verduijn, Steven F. Petit, Nienke D. Sijtsema, Brend P. Jonker, Remi A. Nout, Wilma D. Heemsbergen
Summary: This study investigated the incidence and risk factors of osteoradionecrosis (ORN) in oral cavity cancer patients receiving postoperative radiotherapy, revealing a high risk of mandibular ORN among these patients. Smoking and mandibular volume receiving >= 60 Gy were identified as major predictive factors.
Article
Health Care Sciences & Services
Haye H. Glas, Joep Kraeima, Silke Tribius, Frank K. J. Leusink, Carsten Rendenbach, Max Heiland, Carmen Stromberger, Ashkan Rashad, Clifton D. Fuller, Abdallah S. R. Mohamed, Stephen Y. Lai, Max J. H. Witjes
Summary: This study aimed to identify a possible relation between the received radiation therapy (RT) dose, exposed bone volume, and the progression of mandibular osteoradionecrosis (ORN) after segmental resection. The results showed that all recurrent ORN cases were resected within an isodose volume of >= 56 Gy, and the absolute and proportional mandibular volume radiated with 56 Gy were significantly smaller in the recurrent group. This suggests that the 56 Gy isodose volume could serve as a starting point for pre-operative planning to reduce the risk of ORN recurrence.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Chung-Ta Chang, Shih-Ping Liu, Chih-Hsin Muo, Yu-Fang Liao, Kuan-Ming Chiu, Chun-Hao Tsai, Yi-Fang Huang
Summary: This study aimed to investigate how different timelines of various dental therapies were related to the development of osteoradionecrosis in oral cancer patients under consideration of radiotherapy dosage. The results showed that performing periodontal therapy combined with irradiation significantly increased the risk of osteoradionecrosis in patients receiving low irradiation dosages. Starting radiotherapy within three months after dental surgery greatly increased the risk of developing osteoradionecrosis. Patients treated with high radiation doses had a significantly higher occurrence of osteoradionecrosis if they received dental surgery within one month prior to radiotherapy. Performing dental surgery during the course of radiotherapy greatly increased the risk of osteoradionecrosis.
Article
Oncology
Raissa Soares dos Anjos, Giovana Nobrega de Padua Walfrido, Romulo Oliveira de Hollanda Valente, Luiz Alcino Gueiros, Alessandra Albuquerque Tavares Carvalho, Preeyan Patel, Stephen Porter, Jair Carneiro Leao, Igor Henrique Morais Silva
Summary: Pentoxifylline and tocopherol showed good efficacy in managing osteoradionecrosis of the jaws, promoting complete mucosal healing and potentially avoiding sequestrectomy for some patients. However, the treatment was less effective for advanced cases compared to early stage cases.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Otorhinolaryngology
Pei-Hsun Liao, Chi-Hsiang Chu, Yao-Min Hung, Pei-Ling Tang, Tsu-Jen Kuo
Summary: The study found that the subsites of oral cavity tumors are independent risk factors for osteoradionecrosis of the jaw after radiotherapy. Pre-RT mandible surgery, tooth extraction either before or after RT, and tumor sites were associated with the risk of ORNJ. There was no significantly higher risk of ORNJ in the post-RT extraction group (less than 6 months) compared to the pre-RT extraction group or during-RT extraction group.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Article
Oncology
Betina Borresen, Maja L. Arendt, Elise Konradsson, Kristine Bastholm Jensen, Sven A. J. Back, Per Munck af Rosenschold, Crister Ceberg, Kristoffer Petersson
Summary: This study demonstrates that single-fraction high dose FLASH RT is generally effective in a mixed group of malignant oral tumors, but the risk of osteoradionecrosis is a serious clinical concern.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Thyago Morais Vicente da Silva, Thayanara Silva Melo, Romulo Cesar de Alencar, Jose Ricardo Dias Pereira, Jair Carneiro Leao, Igor Henrique Morais Silva, Luiz Alcino Gueiros
Summary: Photobiomodulation therapy (PBMT) has a significant positive impact on promoting surgical alveolar mucosal lining in patients who have undergone head and neck radiation therapy, leading to faster healing and reduced postoperative pain.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Medicine, General & Internal
Erkan Topkan, Ahmet Kucuk, Efsun Somay, Busra Yilmaz, Berrin Pehlivan, Ugur Selek
Summary: Radiotherapy or concurrent chemoradiotherapy is crucial for head and neck cancer treatment, but it can lead to severe late toxicities, such as osteoradionecrosis of the jaws. The incidence of ORNJ has decreased to less than 5-6% due to advancements in dental preventive care programs, RT planning systems, and techniques. RT modality, technique, and dose-volume-related factors play significant roles in ORNJ risk.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Vinod Patel, Jerry Kwok, Mary Burke, Teresa Guerrero Urbano, Michael Fenlon
Summary: Patients receiving head and neck radiation treatment are required to undergo dental assessment to ensure dental fitness. However, challenges exist in the dental assessment for HPV-related oropharyngeal cancer patients. This perspective piece proposes a potential adaptation to the dental assessment for HPV OPC patients.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Sagar Patel, Nisma Patel, Isabel Sassoon, Vinod Patel
Summary: Medical management of ORN using pentoxifylline, tocopherol, and dodronate has shown promise in healing the condition, especially in patients at Notani I stage and non-infected ORN. Infection status plays a critical role in the final outcome, with successful treatment correlating with the severity of ORN.
RADIOTHERAPY AND ONCOLOGY
(2021)
Review
Oncology
Jianfei Zhang, Liyan Dai, Ahmed Abdelrehem, Jinyang Wu, Xiaobo Li, Steve Guofang Shen
Summary: The report describes a rare case of temporomandibular joint ankylosis in a 12-year-old boy following radiotherapy for rhabdomyosarcoma. The use of modified gap arthroplasty technique combined with pterygo-masseteric muscle flap successfully lowered the risk of osteoradionecrosis caused by surgical trauma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Kristin Lang, Thomas Held, Eva Meixner, Eric Tonndorf-Martini, Oliver Ristow, Julius Moratin, Nina Bougatf, Christian Freudlsperger, Juergen Debus, Sebastian Adeberg
Summary: This study retrospectively evaluated and compared patient- and treatment-related factors associated with the development of osteoradionecrosis (ORN) in oral cavity cancer patients undergoing postoperative radiotherapy. The study found that pre-radiotherapy dental status and dosimetric parameters were significantly associated with ORN.
HEAD & FACE MEDICINE
(2022)
Article
Oncology
Szu Ching Khoo, Syed Nabil, Azizah Ahmad Fauzi, Siti Salmiah Mohd Yunus, Wei Cheong Ngeow, Roszalina Ramli
Summary: Results of a retrospective analysis suggest that dental extraction more than 5 years after radiotherapy, surgical removal procedure, and invisible upper cortical line of mandibular canal on the DPT are predictors of osteoradionecrosis (ORN).
RADIATION ONCOLOGY
(2021)
Article
Oncology
Atsushi Musha, Hirofumi Shimada, Nobuteru Kubo, Hidemasa Kawamura, Naoko Okano, Hiro Sato, Takuya Kaminuma, Kohei Okada, Mai Anakura, Akiko Adachi, Katsuyuki Shirai, Jun-ichi Saitoh, Satoshi Yokoo, Kazuaki Chikamatsu, Tatsuya Ohno
Summary: This retrospective study analyzed the occurrence of osteoradionecrosis (ORN) of the mandible in patients with head and neck tumors treated with carbon ion radiotherapy (C-ion RT). The findings indicate that doses of 30 Gy to the mandible and teeth had the most significant effects on causing ORN, with cut-off values identified. This study provides important insights for establishing clinical strategies for patients receiving C-ion RT near the mandible.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Zhengrui Li, Rao Fu, Xufeng Huang, Xutao Wen, Ling Zhang
Summary: This study aimed to assess the correlation between oral microbiota and the extent of bone resorption in ORN patients. The results showed that the ORN group had higher microbial abundance and species diversity, and specific microbial communities were potentially associated with ORN. In addition, an imbalance in the oral microbiota may disrupt bone regeneration by regulating specific metabolic pathways that increase osteoclastic activity. Therefore, radiation-induced ORN is associated with significant changes in the oral microbiota.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Niall M. H. McLeod, Nadeem R. Saeed
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2016)
Article
Dentistry, Oral Surgery & Medicine
N. M. H. McLeod, D. C. Bowe
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2016)
Article
Dentistry, Oral Surgery & Medicine
N. M. H. McLeod, D. C. Bowe
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2016)
Article
Dentistry, Oral Surgery & Medicine
D. C. Bowe, E. A. Gruber, N. M. H. McLeod
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2016)
Review
Dentistry, Oral Surgery & Medicine
Soudeh Chegini, Niamh Gallighan, Niall Mcleod, Rufus Corkill, Stana Bojanic, Stewart Griffiths, Daljit Dhariwal
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2016)
Editorial Material
Pediatrics
Mary E. Coleman, Niall M. H. McLeod, Nadeem Saeed
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2017)
Article
Dentistry, Oral Surgery & Medicine
N. M. H. McLeod, D. Van Gijn
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2018)
Review
Dentistry, Oral Surgery & Medicine
R. Ologunde, N. M. H. McLeod
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2018)
Article
Dentistry, Oral Surgery & Medicine
H. Leonhardt, A. Franke, A. Nowak, N. M. H. McLeod, G. Lauer
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2019)
Review
Dentistry, Oral Surgery & Medicine
Niall M. H. McLeod, Matthew Keenan
Summary: The debate between surgical and non-surgical management of mandibular condyle fractures remains contentious due to the lack of directly comparable outcomes in the literature, driven in part by the disparate range of classification systems used. The existence of a wide diversity of classification systems for condyle fractures makes it challenging to compare surgical access, fixation and outcomes, highlighting the need for a standardized classification system to facilitate future research and comparisons.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2021)
Article
Dentistry, Oral Surgery & Medicine
N. R. Saeed, N. M. H. McLeod
Summary: The study aimed to determine the prevalence of temporary and permanent facial nerve injury in total TMJ replacement surgery, identifying factors such as bilateral surgery, revision replacement, and number of previous surgeries that increase the risk of temporary injury, while factors leading to permanent injury are less predictable.
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2021)
Article
Medicine, General & Internal
Andreas Neff, Niall McLeod, Frederik Spijkervet, Merle Riechmann, Ulla Vieth, Andreas Kolk, Andrew J. Sidebottom, Bernard Bonte, Bernard Speculand, Carrol Saridin, Christian T. Wilms, Constantinus Politis, David Faustino angelo, Dusan Hirjak, Esben Aagaard, Fabrizio Spallaccia, Florencio Monje, Gerhard Undt, Giovanni Gerbino, Hadas Lehman, Jacinto F. Sanroman, Louis G. Mercuri, Luke Cascarini, Mattias Ulmner, Maurice Mommaerts, Nadeem R. Saeed, Orhan Gueven, Salvatore Sembronio, Vladimir Machon, Linda Skroch
Summary: Although there was initially significant heterogeneity in the preliminary voting on terminology, diagnostics, and treatment for condylar dislocation, a strong consensus was ultimately achieved in the final voting. Multiple alterations led to the development of 24 final recommendations for the assessment and management of TMJ dislocation. These recommendations, based on both evidence and consensus, represent the first international guidelines in the field of TMJ surgery and should serve as the basis for clinical practice guidelines.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Niall MH. Mcleod, Nadeem R. Saeed, Barbara Gerber
Summary: This study retrospectively reviewed the use of poly-lactic acid pins for condylar head fracture fixation and found that the resorption process did not adversely affect remodelling of the condylar head. The position, shape, and bone changes of the condyle compared favorably with conservative management or fixation with titanium screws.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. Leonhardt, A. Franke, N. M. H. McLeod, G. Lauer, A. Nowak
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2017)
Article
Dentistry, Oral Surgery & Medicine
R. J. McGalliard, J. Kimpton, N. M. H. McLeod
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2017)