Article
Nanoscience & Nanotechnology
Junfeng Wu, Shuang Ma, Mengyue Li, Xingyue Hu, Niandong Jiao, Steve Tung, Lianqing Liu
Summary: This study developed enzymatic/magnetic micromotors for synergistic cancer treatment, achieving self-propulsion and enhanced kinetic power through chemical and magnetic engines, as well as drug release. The micromotors showed great anticancer efficacy in cancer cell treatment and have potential clinical applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Ting Zhao, Ce Liang, Yanrong Zhao, Xiangdong Xue, Zhao Ma, Jinlong Qi, Haitao Shen, Shaokun Yang, Jia Zhang, Qingzhong Jia, Qing Du, Deying Cao, Bai Xiang, Hailin Zhang, Xianrong Qi
Summary: A dual pH-responsive peptide (DPRP) was designed and synthesized for co-delivering PLK-1 specific siRNA and anticancer agent DTX. Results showed that under mildly acidic conditions, the system could enhance drug penetration, improve cellular uptake, and ultimately exhibit significant anti-tumor effects.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Won Hur, Yeongwon Park, Eunbi Seo, Seong Eun Son, Seongnyeon Kim, Hyemyung Seo, Gi Hun Seong
Summary: Targeted tumor therapy using TME-responsive nanoplatforms is a promising strategy for selectively killing cancer cells. In this study, a multi-component metal-organic framework nanocomposite, ZIF@GOx@PBNPs, was developed, which exhibited cascade catalytic activity within the TME. The nanocomposites released glucose oxidase (GOx) and Prussian blue nanoparticles (PBNPs) in the acidic TME, enabling starvation therapy and sequential Fenton reaction for chemodynamic therapy. The cascade catalytic reactions enhanced reactive oxygen species production and caused oxidative damage to DNA, leading to remarkable tumor growth inhibition.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Gaole Dai, Jacky C. H. Chu, Cecilia Ka Wing Chan, Chung Hang Jonathan Choi, Dennis K. P. Ng
Summary: A polymer nanoparticle was prepared using thioketal condensation, incorporating various functional molecules to achieve targeted tumor therapy through light irradiation, effectively promoting cell death.
Article
Pharmacology & Pharmacy
Miao Pan, Chao Lu, Wancong Zhang, Huan Huang, Xingyu Shi, Shijie Tang, Daojun Liu
Summary: Anticancer peptides and polymers can interact with tumor cells to overcome multidrug resistance. In this study, PLO-b-PLF block copolypeptides were prepared and self-assembled into polymeric micelles. The cationic micelles interacted with cancer cells via electrostatic interactions and killed them via membrane lysis. To reduce cytotoxicity, anionic PLO(DCA)-b-PLF was designed to recover anticancer activity in the acidic tumor microenvironment. These PLO-based polypeptides have potential applications in drug-free tumor treatment.
Article
Oncology
Yun Haeng Lee, Minkyeong Kim, Hyon Jin Park, Ji Yun Park, Eun Seon Song, Haneur Lee, Gahyun Ko, Soonkil Ahn, Hyung Wook Kwon, Youngjoo Byun, Changmu Kim, Jaehyuk Choi, Joon Tae Park
Summary: A study identified that the mycelium culture extract of Polyporus mushrooms has potential anticancer properties by inducing apoptosis and S-phase arrest. The active ingredient 3,4-dihydroxybenzaldehyde was found to inhibit cancer cell proliferation similar to the mycelium extract, but without increasing the proportion of chemoresistant side population. These findings have clinical applications for treating chemo-resistant cancer.
Article
Biochemistry & Molecular Biology
Jun Liu, Shuang Si, Jinyi Xu, Peng Xue, Kaipeng Li
Summary: The developed doxifluridine-conjugate prodrug (LYX) has shown effective stability and stimulus responsive properties, leading to improved drug release efficiency and reduced side effects, offering a unique opportunity for diagnosis and imaging additional analytes or enzymatic activities.
BIOORGANIC CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Shanshan Zheng, Yue Cai, Yulu Hong, Yubei Gong, Licheng Gao, Qingyong Li, Le Li, Xuanrong Sun
Summary: The lytic peptide PTP7-drug paclitaxel conjugate assembling nanoparticles (PPP) is a targeted anti-tumor drug that can respond to dual stimuli in the tumor microenvironment, providing passive tumor-targeted delivery and on-demand release of a tumor lytic peptide (PTP-7) as well as a chemotherapeutic agent of paclitaxel (PTX).
Article
Biotechnology & Applied Microbiology
Shaochen Wang, Qiaoqiao Zhou, Shuling Yu, Shuang Zhao, Jiahua Shi, Jintao Yuan
Summary: This study reports a nanotherapeutic system with excellent photothermal performance, stable drug loading, tumor targeting, and strong membrane penetration. The system showed outstanding photothermal performance and therapeutic efficacy in vivo.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Polymer Science
Arjaree Jobdeedamrong, Man Theerasilp, Nutthanit Thumrongsiri, Paweena Dana, Nattika Saengkrit, Daniel Crespy
Summary: In this study, GSH-responsive and self-immolative polyprodrug nanoparticles were prepared for cancer treatment. These nanoparticles showed high drug loading and efficient redox-responsive release, displaying high cytotoxicity against cancer cells and low cytotoxicity against cancer cells treated with GSH scavenger or normal cells.
Article
Biotechnology & Applied Microbiology
Fan Li, Yan Liang, Miaochen Wang, Xing Xu, Fen Zhao, Xu Wang, Yong Sun, Wantao Chen
Summary: The pH cascade-responsive micellar nanoplatform with nucleus-targeted ability effectively combines synergistic chemo-photodynamic therapy for cancer treatment. The novel multifunctional nanoplatform demonstrates high anticancer efficacy both in vitro and in vivo, making it a promising candidate for synergistic anticancer therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biophysics
Xiaowei Wang, Yaxuan Gu, Qi Li, Yapeng Xu, Yifan Shi, Zheran Wang, Mingyu Xia, Ji Li, Dongkai Wang
Summary: The study introduces an intelligent polymer drug carrier based on pH-responsive charge-reversal, which delivers drugs for chemo-photothermal combination therapy, leading to enhanced efficacy in tumor treatment.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Multidisciplinary
Shun Xing, Dong-Hui Wang, Hai-Feng Zhang, Li-Dan Liu, Cheng-Ce Li, Chao Wei, Jun-Yu Liu, Nai-Jian Ge, Xuan-Yong Liu
Summary: To improve patient survival time and avoid side effects, a layered double hydroxides (LDHs) film was constructed on a nitinol stent, and arsenic drugs were used for local intervention. This design provides a new approach for the treatment of gallbladder cancer.
Article
Biophysics
Xizhe Li, Bingyu Li, Ruirui Liu, Yanhua Dong, Yongxi Zhao, Yayan Wu
Summary: pH-responsive nanocomposites (PDA@Kana-AgNPs) were developed to penetrate bacterial biofilms, achieve biofilm-triggered on-demand drug release, exhibit excellent antimicrobial activity, and demonstrate biocompatibility with mammalian cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biophysics
Ning Zhang, Daquan Wang, Tingting Yang, Xunan Jing, Lingjie Meng
Summary: To enhance the efficacy of chemotherapy and minimize the toxicity of small molecule anti-cancer drugs, researchers have developed a novel polymer-based nanocarrier that can rapidly degrade and release drugs in the tumor microenvironment. This carrier efficiently delivers doxorubicin, exhibiting a high kill efficiency against tumor cells.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Engineering, Biomedical
Tongtong Zhu, Mengyang Jiang, Mingran Zhang, Liguo Cui, Xiaoyu Yang, Xukai Wang, Guangyao Liu, Jianxun Ding, Xuesi Chen
Summary: This study developed a bio-functionalized composite scaffold for osteonecrosis therapy, which showed excellent performances in enhancing osteoconduction, angiogenesis, and a favorable metabolic microenvironment.
BIOACTIVE MATERIALS
(2022)
Review
Nanoscience & Nanotechnology
Mingran Zhang, Jiaxue Liu, Tongtong Zhu, Hanxiang Le, Xukai Wang, Jinshan Guo, Guangyao Liu, Jianxun Ding
Summary: Bone adhesives are expected to have significant advantages in treating bone injuries compared to traditional internal fixation devices. Different research directions of bone adhesives, such as liquid scaffold and liquid plate, are summarized. Recent advances in mechanical strength, osseointegration, osteoconductivity, and osteoinductivity of bone adhesives are discussed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Chemistry, Multidisciplinary
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.
Review
Chemistry, Multidisciplinary
Jin Zhang, Yandai Lin, Zhe Lin, Qi Wei, Jiaqi Qian, Renjie Ruan, Xiancai Jiang, Linxi Hou, Jibin Song, Jianxun Ding, Huanghao Yang
Summary: This review discusses the use of stimuli-responsive nanoparticles (srNPs) in cancer immunotherapy, highlighting their potential to enhance anti-tumor immune responses by combining with tumor microenvironment and external stimuli. The goal is to achieve synergistic immunotherapy and long-term immune memory to prevent tumor recurrence.
Review
Chemistry, Multidisciplinary
Ruotao Li, Kai Liu, Xu Huang, Di Li, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Skin wound repair is a complex process involving multiple cellular and molecular interactions. Bioactive materials can promote wound healing by modulating the wound microenvironment and cell behaviors.
Article
Chemistry, Multidisciplinary
Yang Liu, Zhongyu Jiang, Shizheng Tong, Yifu Sun, Yu Zhang, Jiayuan Zhang, Duoyi Zhao, Yuanzhen Su, Jianxun Ding, Xuesi Chen
Summary: Biomineralization is a normal physiological process involving nucleation, crystal growth, phase transformation, and orientation evolution. Inducing biomineralization in tumor tissue has shown promise as a therapy for malignancy. However, the limited ion-chelating capabilities of carboxyl-containing biomineralization initiators have hindered their efficacy. In this study, a biomineralization-inducing nanoparticle (BINP) was developed for blockade therapy of osteosarcoma. BINP exhibited tumor inhibition rates of 59.3% and 52.1% for subcutaneous and orthotopic osteosarcomas, respectively. The BINP-mediated blockade therapy also inhibited bone dissolution and pulmonary metastases. This selective biomineralization approach holds promise for clinical osteosarcoma therapy.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Qihui Wang, Jiayi Luan, Zhilong Zhao, Weihui Kong, Congxiao Zhang, Jianxun Ding
Summary: Dentin hypersensitivity (DH) is a common cause of toothache with rapid onset and short duration. Current clinical treatment strategies have limitations, leading to long-term administration, poor dentinal tubule closure, and the development of secondary caries. Various biomaterials have been developed to improve the treatment efficiency of DH by participating in dental remineralization. This review discusses the application of biomaterials for DH therapy based on different desensitization mechanisms and presents a perspective on the future of dentin regeneration medicine for DH therapy.
CHINESE CHEMICAL LETTERS
(2023)
Review
Chemistry, Multidisciplinary
Xukai Wang, Mingran Zhang, Tongtong Zhu, Qiuhua Wei, Guangyao Liu, Jianxun Ding
Summary: Osteomyelitis is a refractory disease in orthopedics caused by infection with pathogenic microorganisms. Antibacterial therapy, in addition to surgical debridement, is currently the main approach for treating osteomyelitis. However, traditional antibiotics are facing bacterial resistance, prompting the development of advanced antibacterial agents. This review discusses the main targets and mechanisms of antibacterial agents for osteomyelitis treatment, as well as their potential clinical applications.
Editorial Material
Pharmacology & Pharmacy
Zongtai Liu, Jin Zhang, Changfeng Fu, Jianxun Ding
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Jiazhen Yang, Hongjie Li, Haoyang Zou, Jianxun Ding
Summary: Intoxication is a common cause of accidental death worldwide. Although some antidotes have been developed, clinicians mainly rely on nonspecific extracorporeal techniques for removing toxins. Nano-intervention strategies using nanoantidotes to neutralize toxicity in situ have shown clinical potential. However, most nanoantidotes are still in the proof-of-concept stage, and challenges such as constructing clinical relevance models and understanding their pharmacokinetics hinder their translation to the clinic. This Concept reviews the detoxification mechanisms of polymer nanoantidotes and discusses the opportunities and challenges of their clinical application.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Review
Chemistry, Physical
Di Li, Siqi Liu, Yang Ma, Shixian Liu, Yahui Liu, Jianxun Ding
Summary: The immune system plays a vital role in the occurrence and development of cancer. Immunotherapy offers a promising approach to treat and cure cancer. During immunotherapy, the immunogenic cell death (ICD) of tumor cells activates innate and adaptive immune responses by releasing tumor-associated antigens and damage-associated molecular patterns. This review summarizes the progress in using biomaterials to induce ICD and discusses their potential application in cancer immunotherapy.
Review
Chemistry, Multidisciplinary
Ke Yi, Huimin Kong, Yeh-Hsing Lao, Di Li, Rachel L. Mintz, Tianxu Fang, Guojun Chen, Yu Tao, Mingqiang Li, Jianxun Ding
Summary: CRISPR/Cas9 gene-editing technology has great potential in cancer treatment, but limitations of viral delivery have led to the development of non-viral nanomaterials. Optimizing the packaging capacity, pharmacokinetics, and targetability of non-viral CRISPR/Cas9 nanoformulations can enhance the safety and efficacy of cancer therapy.
ADVANCED MATERIALS
(2023)
Article
Engineering, Biomedical
Qiang Luo, Wei Sun, Zhibo Li, Jinfeng Sun, Yu Xiao, Jichang Zhang, Cuilin Zhu, Bin Liu, Jianxun Ding
Summary: Although reperfusion therapy is commonly used for the treatment of acute myocardial infarction, its efficacy is limited by the occurrence of myocardial ischemia-reperfusion injury (MIRI). Systemic drug administration to reduce MIRI is often ineffective. Therefore, the development of functional biomaterials to improve drug targetability and bioavailability, and reduce side effects, is of great importance.
Article
Chemistry, Multidisciplinary
Guanqing Yang, Yang Liu, Jinjin Chen, Jianxun Ding, Xuesi Chen
Summary: Cancer is a disease characterized by uncontrolled growth and division of abnormal cells. However, the clinical application of therapeutic agents is hindered by low tumor specificity and high toxicity to healthy tissues. Self-adaptive nanomaterials, which undergo transformation in response to specific stimuli, have the potential to overcome these limitations and improve the efficacy of cancer therapy.
ACCOUNTS OF MATERIALS RESEARCH
(2022)
Review
Materials Science, Biomaterials
Jinjin Chen, Jiazhen Yang, Jianxun Ding
Summary: This review summarizes the development of Cys(2)-based polypeptide nanoparticles and their unique properties and multifunctional applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Zhiyuan Shi, Yong Hu, Xin Li
Summary: Controlled drug delivery systems that can respond to mechanical force offer a unique solution for on-demand drug activation and release. Among various mechanical stimuli, ultrasound (US) has advantages in achieving spatiotemporally controlled drug release. Traditional US-triggered drug release relies on heat-induced phase transitions or chemical transformations, while the cutting-edge approach of Sonopharmacology leverages polymer mechanochemistry. The remaining challenges and potential future directions in this field are also discussed.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Lijie Zheng, Yuanzheng Chen, Xun Gu, Yingying Li, Hanqing Zhao, Wenjun Shao, Tao Ma, Chuanbin Wu, Qingqing Wang
Summary: In this study, a novel dosage form consisting of dissolving microneedles and an adhesive transdermal patch was developed for the treatment of rheumatoid arthritis. In vitro and in vivo experiments demonstrated that the combination of drugs delivered by this dosage form effectively reduced joint inflammation and damage.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Kyungjik Yang, Hwa Seung Han, Seung Hwan An, Kyung Hoon Park, Keonwook Nam, Shinha Hwang, Yuyeon Lee, Sung Yeon Cho, Taehyung Kim, Deokyeong Choe, Sang Won Kim, Wonkyu Yu, Hyunah Lee, Jiyong Park, Sangguan You, Dong- Gyu Jo, Ki Young Choi, Young Hoon Roh, Jae Hyung Park
Summary: This study developed CP-loaded CS microcapsules to enhance the oral bioavailability of CP through controlled gastrointestinal delivery. The optimized microcapsules exhibited desirable physicochemical properties, showed anti-photoaging effects via antioxidant activity, and achieved controlled release in the gastrointestinal tract. This research provides a simple and economical approach for enhancing the oral bioavailability of CP for customized bioactive compound administration.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Huiyang Li, Shuo Liu, Wenjin Dai, Bingmei Yao, Yong Zhou, Sujia Si, Hairong Yu, Riguang Zhao, Fang Jin, Liqun Jiang
Summary: Changes in bodily fluid pressures are crucial in diseases like high-altitude pulmonary edema (HAPE). Researchers have developed hydrostatic pressure-sensitive multivesicular liposomes (PSMVLs) that can release drugs in response to pressure changes, with potential applications in HAPE treatment. Animal experiments showed that this system provides better protection for lung tissues and respiratory function, reducing the occurrence of pulmonary edema.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Qian Hu, Hongbing Lan, Yinmei Tian, Xiaonan Li, Mengmeng Wang, Jiao Zhang, Yulin Yu, Wei Chen, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Coacervate droplets formed through liquid-liquid phase separation have potential as delivery vesicles for therapeutics. However, their lack of physiological stability and membranes are challenges. In this study, polylysine-polynucleotide complex coacervate droplets with favorable stability were formulated to concentrate molecules and nanoparticles. Phospholipid membranes were further coated on the droplets to create coacervate-based artificial protocells (ArtPC) with membrane-like structures. These biofunctional ArtPC effectively reduced blood uric acid levels and prevented renal injuries.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Xiaowei Wang, Hongwei Lu, Fang Luo, Dan Wang, Apeng Wang, Xuelei Wang, Wenkai Feng, Xiaobo Wang, Jiayi Su, Mingliang Liu, Guimin Xia
Summary: Four novel lipid-like GEM diesters were synthesized and encapsulated into liposomes to improve the antitumor efficacy of Gemcitabine. The liposomes loaded with dimyristoyl GEM (LipodmGEM) showed enhanced cellular uptake, improved inhibition of cell migration, and a greatly extended half-life compared to free Gemcitabine. LipodmGEM successfully enriched the drug in the tumor and exhibited excellent anticancer efficacy in vivo with negligible systemic toxicity.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu, Haiyan Hu
Summary: Chronic pulmonary infection caused by Pseudomonas aeruginosa is a serious public health problem with high mortality rates. In this study, infection-microenvironment responsive nanoparticles were developed to eradicate biofilms and inhibit virulence. These nanoparticles showed promising results in treating chronic pulmonary infections.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Yajing Sun, Ze Lu, John A. Taylor, Jessie L. S. Au
Summary: A recent development in cancer chemotherapy is the use of cytotoxics to induce tumor-specific immune response through immunogenic cell death (ICD). This study describes a method that utilizes immunostaining and machine-learning to identify cells with ecto-CRT in intact 3-dimensional tissues. The method was successfully applied to study drug-induced ICD in human bladder cancer.
JOURNAL OF CONTROLLED RELEASE
(2024)
Review
Chemistry, Multidisciplinary
Rafat Ali, Shantanu Sen, Rohil Hameed, Aamir Nazir, Sandeep Verma
Summary: This review provides a focused overview of emerging strategies for delivering gasotransmitters in a controlled and sustained manner to reestablish neurophysiological homeostasis.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Jing Chen, Xinyi Zhang, Jinshen Zhang, Zhaoxia Wang, Guilan Zhu, Ming Geng, Jinmiao Zhu, Yajun Chen, Wei Wang, Youcui Xu
Summary: In this study, a multifunctional responsive hydrogel system was developed for synergistic reoxygenation and chemo/photothermal therapy. The hydrogel system showed both therapeutic effects against metastatic breast cancer and wound infection, making it a promising strategy for treating and preventing tumor recurrence and associated wound infection.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Baoshan Huang, Na Zhang, Xinying Qiu, Rui Zeng, Shuimiao Wang, Mengxia Hua, Qing Li, Kaihui Nan, Sen Lin
Summary: This study revealed that robust ROS can oxidize mitochondrial DNA (ox-mtDNA) and cause its release into the cytosol, resulting in the activation of NLRP3 inflammasome. By using the mitochondria-targeted antioxidant SkQ1 and a novel mitochondria-targeted nanoparticle (SkQ1 NP), it was found that mitochondrial ROS scavenging could in situ inhibit DED-induced mtDNA oxidation and suppress NLRP3-mediated inflammation.
JOURNAL OF CONTROLLED RELEASE
(2024)
Article
Chemistry, Multidisciplinary
Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang, Yunbing Wang
Summary: Myocardial infarction is the leading cause of cardiovascular mortality, and current treatment methods have limitations. This study developed a smart carrier that can release different therapeutic substances for different pathological processes, effectively improving cardiac function, promoting cardiac repair, and preventing ventricular remodeling.
JOURNAL OF CONTROLLED RELEASE
(2024)
