Consequence of therapy discontinuation in bisphosphonate-associated osteonecrosis of the jaws

We report a patient with bisphosphonate-associated osteonecrosis of the jaws who developed pathological fractures of the upper and lower extremities after the suspension of treatment with bisphosphonates. Temporary discontinuation of the drugs does not alter the clinical course of the disease. and Could result in the recurrence of bone pain and the progression of metastases or osteolytic lesions. (C) 2008 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.