期刊
JOURNAL OF CONTROLLED RELEASE
卷 211, 期 -, 页码 144-162出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jconrel.2015.06.006
关键词
Albumin; Half-life; FcRn; Cubilin; Megalin; Therapeutics; Engineering
资金
- Research Council of Norway through its Centres of Excellence funding scheme [179573]
- Research Council of Norway [230526/F20, 179573/V40]
- Research Council of Norway through its programme for Global Health and Vaccination Research (GLOBVAC) [143822]
- University of Oslo
Albumin is the most abundant protein in blood and acts as a molecular taxi for a plethora of small insoluble substances such as nutrients, hormones, metals and toxins. In addition, it binds a range of medical drugs. It has an unusually long serum half-life of almost 3 weeks, and although the structure and function of albumin has been studied for decades, a biological explanation for the long half-life has been lacking. Now, recent research has unravelled that albumin-binding cellular receptors play key roles in the homeostatic regulation of albumin. Here, we review our current understanding of albumin homeostasis with a particular focus on the impact of the cellular receptors, namely the neonatal Fc receptor (FcRn) and the cubilin-megalin complex, and we discuss their importance on uses of albumin in drug delivery. (C) 2015 Elsevier B.V. All rights reserved.
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