Review
Immunology
Kasidis Phongkhun, Thananop Pothikamjorn, Karan Srisurapanont, Kasama Manothummetha, Anawin Sanguankeo, Achitpol Thongkam, Nipat Chuleerarux, Surachai Leksuwankun, Tanaporn Meejun, Jaedvara Thanakitcharu, Morgan Walker, Shilpa Gopinath, Pattama Torvorapanit, Nattapong Langsiri, Navaporn Worasilchai, Chatphatai Moonla, Rongpong Plongla, Olivia S. Kates, Saman Nematollahi, Nitipong Permpalung
Summary: This study aimed to summarize the disagreement between infectious diseases and ophthalmology professional societies regarding ocular screening in patients with candidemia. The prevalence of ocular complications was found to be high, suggesting the need for joint recommendations by the Infectious Diseases Society of America and American Academy of Ophthalmology.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Matthew O'Donnell, Andrew W. Eller, Evan L. Waxman, Cornelius J. Clancy, M. Hong Nguyen
Summary: This article discusses the controversy surrounding the screening of candidemic patients for ocular candidiasis, highlighting the accuracy and safety of indirect funduscopy in diagnosis and the potential impact of positive findings on treatment recommendations. However, the lack of conclusive evidence on the effectiveness of treatment changes in improving outcomes is acknowledged. The authors endorse routine screening and suggest exploring digital fundus photography and teleophthalmology as alternatives to inpatient ophthalmologic consultations in asymptomatic patients.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Medicine, General & Internal
Soo-Min Ok, Donald Ho, Tyler Lynd, Yong-Woo Ahn, Hye-Min Ju, Sung-Hee Jeong, Kyounga Cheon
Summary: Candida species are common opportunistic pathogens that can cause chronic oral mucosa infections and damage salivary gland function. Clinicians should actively manage Candida infections by educating patients on oral hygiene, conducting timely diagnosis, and providing effective treatment plans.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Divyesh H. Shastri, Ana Catarina Silva, Hugo Almeida
Summary: Therapeutic proteins, including monoclonal antibodies, have played a significant role in ocular therapies for various diseases. However, their formulation faces challenges due to their complex structure and instability. Efforts have been made to overcome these barriers, such as altering protein structure or using new delivery systems, which have shown promising results. Further research is needed to develop more effective and stable formulations for ocular delivery of therapeutic proteins.
Review
Dentistry, Oral Surgery & Medicine
Romeo Patini, Gioele Gioco, Cosimo Rupe, Maria Contaldo, Rosario Serpico, Michele Giuliani, Carlo Lajolo
Summary: This study assessed the prevalence of oral colonization by Candida spp. in patients with psoriasis and the prevalence of oral lesions associated with Candida spp. It also identified the risk factors for oral lesions. The results showed that psoriatic patients had a higher risk of oral Candida colonization, especially those who received immunosuppressive therapies.
Review
Immunology
Gillian Taormina, Ramya Gopinath, Jason Moore, Yuliya Yasinskaya, Philip Colangelo, Kellie Reynolds, Sumati Nambiar
Summary: The pathogenesis of neonatal candidiasis differs from systemic candidiasis in adults, with a higher incidence of central nervous system involvement. While clinical trials for neonatal candidiasis are challenging, it is important to address the unmet need for effective treatment in this population. A regulatory review approach has been described to guide the use of micafungin in pediatric patients younger than 4 months, while acknowledging areas of uncertainty in labeling.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Ophthalmology
Aaron M. Yeung, Jill R. Wells, Hans E. Grossniklaus
Summary: Secondary ocular malignancies mostly spread to the choroid. Prognosis has improved with newer treatments including immunotherapy. Timely diagnosis and treatment by ophthalmologists, along with referral to oncology colleagues, are crucial to optimizing systemic treatment for primary cancer and maximizing visual potential.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Immunology
Paul Nyirjesy, Carolyn Brookhart, Gweneth Lazenby, Jane Schwebke, Jack D. Sobel
Summary: This article discusses the latest CDC STI Treatment Guidelines for vulvovaginal candidiasis (VVC). Yeast culture remains the gold standard for diagnosis, but newer molecular assays have also shown good performance. Azole antifungals are still the treatment of choice for uncomplicated VVC. There are promising new drugs for recurrent VVC and non-albicans yeast infections.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Hei-Nga Chan, Xiu-Juan Zhang, Xiang-Tian Ling, Christine Huyen-Trang Bui, Yu-Meng Wang, Patrick Ip, Wai-Kit Chu, Li-Jia Chen, Clement C. Tham, Jason C. Yam, Chi-Pui Pang
Summary: This paper provides a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others. Evidence suggests a relationship between vitamin D deficiency and myopia, AMD, DR, and DES, but limited evidence is available for the association with other ocular diseases such as glaucoma, TED, and RB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Inorganic & Nuclear
Qiuxiang Wang, Aiwen Zhang, Lu Zhu, Xuewen Yang, Guihua Fang, Bo Tang
Summary: Cyclodextrin (CD), a cyclic oligosaccharide, is a promising pharmaceutical excipient due to its ability to form complexes with small molecules and polymers. Over the past two decades, CD-based ocular drug delivery systems have rapidly developed, offering excellent biocompatibility, safety, and stability. This review discusses recent progress in CD-based ocular drug delivery systems, including drug/CD complexes, CD-based nanocarriers and microcarriers, CD-based hydrogels, and CD-based inserts. Additionally, the methods for ocular safety evaluation and patents and clinical trials for CD-based ocular drug delivery systems are systematically summarized.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Public, Environmental & Occupational Health
Ying Cheng, Tianmin Ren, Ningli Wang
Summary: Diabetes-induced hyperglycemia can lead to various ocular diseases due to disturbances in biomechanical homeostasis. This review aims to provide an overview of the mechano-environment of the eyeball and its influencing factors, emphasizing the relationship between ocular biomechanical dyshomeostasis and common eye diseases. The study also discusses the potential role of biomechanical homeostasis in ophthalmic pathology and explores new strategies for investigating biomechanical properties to develop diagnostic and treatment approaches targeting mechanobiology.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Multidisciplinary Sciences
Roni Kraut, Fabiola Diaz Carvallo, Richard Golonka, Sandra M. Campbell, Anoush Rehmani, Oksana Babenko, Mao-Cheng Lee, Pedro Vieira-Baptista
Summary: Cytolytic vaginosis (CV) is a little-known and controversial condition that is often overlooked in women with vulvovaginitis symptoms. This scoping review identified 64 studies on CV from around the world, with most studies published since 2007. There are knowledge gaps in various aspects of CV research, and further studies are needed to validate CV and ensure effective diagnosis and treatment for women.
Review
Biochemistry & Molecular Biology
Monica Zuzarte, Ligia Salgueiro
Summary: This review gathers and systematizes relevant information on the antifungal effects of several essential oils and volatile compounds against respiratory mycosis. It focuses on pathogens such as Aspergillus fumigatus, Candida auris, and Cryptococcus neoformans. The main mechanisms of action of essential oils' antifungal effects and current limitations in clinical translation are presented.
Review
Infectious Diseases
Hameid Alenazy, Amenah Alghamdi, Ruxandra Pinto, Nick Daneman
Summary: Candida colonization is strongly associated with the likelihood of developing invasive candidiasis in critically ill patients with sepsis. The presence of Candida colonization has a high negative predictive value, but a low positive predictive value.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Chemistry, Analytical
Gabriel Davi Marena, Matheus Aparecido dos Santos Ramos, Tais Maria Bauab, Marlus Chorilli
Summary: Micafungin is considered one of the most active drugs for treating candidemia and is widely used in prophylaxis for invasive fungal infections. This review gathers important research results on the biological potential of the drug and presents analytical methods for determining antifungal potential and monitoring dosages. The provided data allows the scientific community to choose analytical methods for clinical and scientific research to ensure greater safety and reliability of results.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)