Article
Immunology
Yanyan Zhang, Xiaorong Tian, Yi Dong, Rui Li, Meng Shen, Dan Yi, Tao Wu, Lei Wang, Di Zhao, Yongqing Hou
Summary: The study found that supplementation with BC can alleviate the decrease in average daily feed intake caused by ETEC infection in piglets by regulating the gut microbiota, reducing intestinal epithelial apoptosis, and oxidative stress.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Weichun Xie, Liying Song, Xueying Wang, Yigang Xu, Zengsu Liu, Dongfang Zhao, Shubo Wang, Xiaolong Fan, Zhaorui Wang, Chong Gao, Xiaona Wang, Li Wang, Xinyuan Qiao, Han Zhou, Wen Cui, Yanping Jiang, Yijing Li, Lijie Tang
Summary: LR-LFCA can colonize the intestines of piglets, improve growth performance, enhance immune response, and benefit intestinal health by improving intestinal barrier function and modulating gut microbiota composition. LR-LFCA attenuated weight loss and diarrhea incidence in piglets infected with ETEC, by decreasing inflammation and oxidative stress, increasing tight junction proteins expression, and enhancing antioxidant capacity. LR-LFCA may activate MLCK and inhibit NF-kappa B pathways, providing a promising alternative therapeutic method for intestinal inflammation.
Article
Agriculture, Dairy & Animal Science
Yitong Zeng, Rui Li, Yi Dong, Dan Yi, Tao Wu, Lei Wang, Di Zhao, Yanyan Zhang, Yongqing Hou
Summary: The aim of this study was to investigate the effect of puerarin supplementation on the growth performance and intestinal function of piglets challenged with enterotoxigenic Escherichia coli (ETEC) K88. Dietary supplementation with 5 mg/kg puerarin alleviated intestinal injury and improved the intestinal function of piglets challenged with ETEC K88 by increasing the number of beneficial intestinal bacteria and reducing the number of harmful bacteria, as well as reducing oxidative stress and inflammation in the intestines.
Article
Biochemistry & Molecular Biology
Haixiu Wang, Eric Cox, Bert Devriendt
Summary: Enterotoxigenic Escherichia coli (ETEC) strains recognize and respond to factors secreted by gut epithelial cells, leading to transcriptional modulation of key ETEC virulence genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Applied
Jin Wan, Jiao Zhang, Qingsong Xu, Heng Yin, Daiwen Chen, Bing Yu, Jun He
Summary: The study demonstrates that alginate oligosaccharide can protect the intestinal mucosa from inflammatory injury induced by Escherichia coli and achieve this effect by inhibiting the activation of NF-kappa B.
CARBOHYDRATE POLYMERS
(2021)
Article
Veterinary Sciences
Haihua Li, Xuejiao Liu, Zhiyuan Shang, Jiayun Qiao
Summary: This study demonstrated that probiotic Clostridium butyricum attenuates inflammation induced by enterotoxigenic Escherichia coli by regulating intestinal villi injury and the activation of the toll-like receptor signaling pathway.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Guojun Hou, Minyang Zhang, Jing Wang, Weiyun Zhu
Summary: The study found that chitosan-chelated zinc can help regulate the composition of ileal microbiota, alleviate inflammatory response, and maintain intestinal function in weaned piglets.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Environmental Sciences
Andong Zha, Ruiqi Tu, Ming Qi, Jing Wang, Bie Tan, Peng Liao, Chenchen Wu, Yulong Yin
Summary: The study showed that dietary supplementation of MOSS had beneficial effects on ETEC-induced diarrhea in weaned piglets, increasing growth performance, reducing diarrhea incidence, and regulating intestinal microbiota composition. MOSS also decreased inflammation and oxidative stress, and improved intestinal barrier function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Biochemistry & Molecular Biology
Xin Luo, Shizhe Wu, Hai Jia, Xuemeng Si, Zhuan Song, Zhian Zhai, Jun Bai, Jun Li, Ying Yang, Zhenlong Wu
Summary: This study found that resveratrol pretreatment could protect porcine intestinal epithelial cells against damage caused by ETEC K88 infection by activating the SIRT-1 signaling pathway.
Article
Veterinary Sciences
Kun Zhang, Xiaoyang Shen, Lu Han, Mengyun Wang, Shaoqiang Lian, Kejun Wang, Chunli Li
Summary: In this study, orally administering piglets with ETEC K88 resulted in decreased villus length to crypt depth ratio in the duodenum and ileum, down-regulated expression of tight junction proteins, and up-regulated expression of certain cytokines and pBDs. Furthermore, the expression of TLR4, p38 MAPK, and NF-kappa B p65 increased in all intestinal segments. The abundance of Acidobacteria and Proteobacteria phyla in the gut microbiota was also found to change after infection.
RESEARCH IN VETERINARY SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Lingfei Du, Bingnan Liu, Ziyi Han, Yaoyao Xia, Miaomiao Wu, Shaojuan Liu
Summary: This study investigated the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage functions. The results showed that ETEC infection blocked melatonin production in porcine macrophages and melatonin altered porcine macrophage functions, including bacteriostatic and bactericidal activities, as well as reducing macrophage death caused by ETEC infection.
Article
Agriculture, Dairy & Animal Science
Lingfei Du, Bingnan Liu, Ziyi Han, Yaoyao Xia, Miaomiao Wu, Shaojuan Liu
Summary: This study investigated the changes in the serotonin pathway of porcine macrophages during ETEC infection and the effect of melatonin on porcine macrophage functions. The results showed that ETEC infection blocked melatonin production in porcine macrophages and melatonin altered macrophage functions, enhancing bacterial clearance and reducing macrophage death. Melatonin may play a crucial role in shaping porcine macrophage function during ETEC infection.
Article
Pharmacology & Pharmacy
Matthias Dierick, Ruben Ongena, Daisy Vanrompay, Bert Devriendt, Eric Cox
Summary: Lactoferrin, as an alternative for antimicrobials, shows potential in preventing ETEC infections in pigs by reducing fluid secretion and colonization ability of ETEC.
Article
Biotechnology & Applied Microbiology
J. Yang, Y. Qiu, S. Hu, C. Zhu, L. Wang, X. Wen, X. Yang, Z. Jiang
Summary: Pre-treatment with Lactobacillus plantarum can inhibit the inflammatory response induced by ETEC K88 in IPEC-1 cells and the activation of related signaling pathways.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Article
Immunology
Jingchun Gao, Shuting Cao, Hao Xiao, Shenglan Hu, Kang Yao, Kaiyong Huang, Zongyong Jiang, Li Wang
Summary: This study demonstrated that LR1 can reduce inflammatory response and improve intestinal epithelial barrier function by suppressing the MLCK signaling pathway in ETEC K88-challenged IPEC-J2.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Agriculture, Dairy & Animal Science
Laia Blavi, David Sola-Oriol, Pol Llonch, Sergi Lopez-Verge, Susana Maria Martin-Orue, Jose Francisco Perez
Summary: The weaning period in swine industry is crucial, and a range of dietary and management strategies are needed to optimize health, maturity, and weight at weaning. Various strategies have been explored to enhance fetal growth, reduce oxidative and inflammatory status of sows, modulate sow microbiota, improve colostrum and milk production, and ensure care of neonatal piglets.
Article
Physiology
Nedra Abdelli, Alison Ramser, Elizabeth S. Greene, Lesleigh Beer, Travis W. Tabler, Sara K. Orlowski, Jose Francisco Perez, David Sola-Oriol, Nicholas B. Anthony, Sami Dridi
Summary: The study revealed that heat stress affects body weight and the gene expression of nutrient transporters in the jejunum of different broiler populations, showing diverse impacts among populations.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Nedra Abdelli, David Sola-Oriol, Jose Francisco Perez
Summary: Plant phytogenic feed additives have been widely tested in poultry production to improve feed efficiency, digestion, and reduce pathogenic load, but their mechanisms of action still need further research. More efforts are needed to determine the proper inclusion levels and fully elucidate their mode of actions.
Article
Agriculture, Dairy & Animal Science
Sandra Villagomez-Estrada, Jose F. Perez, Diego Melo-Duran, Francesc Gonzalez-Sole, Matilde D'Angelo, Francisco J. Perez-Cano, David Sola-Oriol
Summary: During birth and lactation, piglets born from hyperprolific sows with light body weight exhibit higher expression of stress and pro-inflammatory genes. The present study aimed to evaluate the physiological weaknesses of light piglets compared to their middle-weight littermates through gene expression analysis. Light piglets showed downregulation of genes related to immune response, antioxidant enzymes, digestive enzymes, and nutrient transporters at birth. However, at the end of the suckling period, these gene expression differences disappeared and genes involved in barrier function, inflammation, and stress responses were over-expressed in light piglets compared to their heavier littermates. This suggests that light piglets have compromised gene expression for nutrient absorption, immune and stress responses from birth to the end of lactation.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Mireia Saladrigas-Garcia, David Sola-Oriol, Sergi Lopez-Verge, Matilde D'Angelo, Maria Carmen Collado, Bea Nielsen, Martin Faldyna, Jose Francisco Perez, Susana M. Martin-Orue
Summary: The aim of this study was to determine the effects of probiotic supplementation during gestation and lactation on the performance of sows and piglets, as well as the intestinal health of piglets after separation from the mother. Results showed that probiotic supplementation improved the reproductive performance of sows and had an impact on the fecal microbiota composition of both mothers and piglets.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Microbiology
Agustina Rodriguez-Sorrento, Lorena Castillejos, Paola Lopez-Colom, Gloria Cifuentes-Orjuela, Jose A. Moreno-Munoz, Susana M. Martin-Orue
Summary: The study investigated the effects of synbiotics on challenging enteric pathogens, finding that synbiotics did not significantly impact pathogen load, but did affect fermentative activity and immune regulation.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Asal Forouzandeh, Laia Blavi, Jose Francisco Perez, Matilde D'Angelo, Francesc Gonzalez-Sole, Alessandra Monteiro, Hans H. Stein, David Sola-Oriol
Summary: The study investigates the effects of adding copper sulfate or monovalent copper oxide to the diet of growing pigs on oxidative stress, inflammation, gene abundance, and microbial modulation. The results show that these additions can regulate gene abundance related to the immune system and growth, and promote changes in the intestinal microbiota. However, monovalent copper oxide induces less systemic oxidation and inflammation compared to copper sulfate.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Multidisciplinary Sciences
Francesc Gonzalez-Sole, David Sola-Oriol, Yuliaxis Ramayo-Caldas, Maria Rodriguez-Prado, Gemma Gonzalez Ortiz, Michael R. Bedford, Jose Francisco Perez
Summary: Supplementing XOS to lactating piglets promotes fiber-degrading bacterial populations in their hindgut. The effects of XOS supplementation on the microbiota have long-term implications during the nursery period.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Francesc Gonzalez-Sole, David Sola-Oriol, Sandra Villagomez-Estrada, Diego Melo-Duran, Laura Victoria Lopez, Nathaly Villarroel Roman, Marina Lopez-Arjona, Jose Francisco Perez
Summary: This study aimed to investigate whether the growth differences during the lactation and nursery periods in pigs are associated with fecal microbiota composition and fermentation capacity. The study found that fast-growing pigs during the nursery period had higher cortisone concentrations in their hair and a tendency to have a lower cortisol-to-cortisone ratio. Both lactation and nursery growth influenced the fecal microbiota structure. Additionally, the fecal butyrate concentration was higher in pigs with fast growth during lactation and/or nursery. The study highlights the importance of early colonization on the establishment of the adult microbiota and suggests the potential implications of cortisol conversion to cortisone in animals with fast growth.
Article
Agriculture, Dairy & Animal Science
Laia Ferreres-Serafini, Lorena Castillejos, Marga Martin, Cindy Le Bourgot, Susana M. Martin-Orue
Summary: Although the use of antimicrobials in livestock has reduced in recent years, it is still widely used in swine production. However, due to increased antimicrobial resistance, it is urgent to avoid using these drugs. Different probiotics and prebiotics are effective alternatives, but there is limited information on the potential benefits of combining both strategies through a synbiotic approach.
Article
Agriculture, Dairy & Animal Science
Paola Lopez-Colom, Lorena Castillejos, Agustina Rodriguez-Sorrento, Eva Mainau, Monica Puyalto, Juan Jose Mallo, Susana M. Martin-Orue
Summary: Improving intestinal health in weaned piglets is important for their performance and welfare. This study investigates the behavioral changes in piglets challenged with enterotoxigenic Escherichia coli F4 and fed different additives. The results suggest that behavioral indicators can be a useful tool for assessing piglet health and responses to feed additives, but caution is needed before applying them to farm conditions.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Montserrat Paniagua, Sandra Villagomez-Estrada, Francisco Javier Crespo, Jose Francisco Perez, Anna Aris, Maria Devant, David Sola-Oriol
Summary: Weaning is a challenging period for pigs, resulting in digestive disturbances and hindered growth. The traditional use of zinc oxide and antibiotics to prevent gastrointestinal problems during this phase has been restricted due to concerns about the environment and bacterial resistance. This study explores the potential alternative of supplementing citrus flavonoids and a single antibiotic (amoxicillin) to minimize the use of multiple antibiotics and zinc oxide in weaned pigs. The results show that citrus flavonoids plus amoxicillin significantly improve growth performance, gut health, and gastrointestinal barrier function without detrimental effects on performance.
Article
Microbiology
Mireia Saladrigas-Garcia, Mario Duran, Matilde D'Angelo, Jaume Coma, Jose Francisco Perez, Susana Maria Martin-Orue
Summary: This study investigated the development of piglet gut microbiota from birth to weaning in commercial conditions, highlighting the impact of age on microbial diversity and the influence of farm environment on microbiota composition. Results showed a succession of microbial groups towards a more homogeneous ecosystem with increasing age, and differences in microbial colonization patterns and specific taxa between farms.