期刊
BRITISH JOURNAL OF NUTRITION
卷 111, 期 6, 页码 1069-1076出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114513003346
关键词
Breast-feeding; Metabolic syndrome; CVD; Blood pressure
资金
- Foundation for Pediatric Research in Helsinki, Finland
- Academy of Finland in Helsinki, Finland
- Folkhalsan Research Foundation in Helsinki, Finland
- Helsinki University Central Hospital Research Funds in Helsinki, Finland
- Sigrid Juselius Foundation in Helsinki, Finland
- Ida Montin Foundation in Helsinki, Finland
- Yrjo Jahnsson Foundation in Helsinki, Finland
The aim of the present study was to evaluate the impact of infant breast-feeding on cardiovascular risk in young adults. This unique study group involved 158 subjects (eighty-two females) originally collected prospectively at birth in 1975 and followed up to the age of 32 years. Frequent visits during the first year guaranteed the knowledge of the precise duration of breast-feeding. All infants received at least some breast milk. Participants were assessed for both individual cardiovascular risk factors (blood pressure, plasma lipids, homeostatic model assessment of insulin resistance and waist circumference) and the general clinical risk of cardiovascular events by calculating the Framingham risk score (FRS) and the metabolic syndrome criteria score (NCEP-ATPIII; National Cholesterol Education Program's Adult Treatment Panel III). Data on lifestyle factors were carefully collected. Linear regression analyses revealed that the effect of the duration of breast-feeding was not relevant (0 center dot 02 decrease in the FRS per one additional breast-feeding month; 95% CI -0 center dot 19, 0 center dot 09). Similarly, the effect of breast-feeding was minor on all of the individual cardiovascular risk factors. We used sex, physical activity, dietary fat and vitamin C, smoking and alcohol consumption as covariates. Again, logistic regression analyses detected no significant impact of the duration of breast-feeding on the risk of the metabolic syndrome according to the NCEP-ATPIII (OR 0 center dot 95, 95% CI 0 center dot 8, 1 center dot 1). The strongest independent predictor for later CVD risk was male sex. In conclusion, in this prospectively followed cohort of young adults born at term and at weight appropriate for gestational age, the duration of breast-feeding did not have an impact on the accumulation of cardiovascular risk factors.
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