Article
Biochemistry & Molecular Biology
Fayaz Ahmad Mir, Ehsan Ullah, Raghvendra Mall, Ahmad Iskandarani, Tareq A. Samra, Farhan Cyprian, Aijaz Parray, Meis Alkasem, Ibrahem Abdalhakam, Faisal Farooq, Abdul-Badi Abou-Samra
Summary: This study found differential expression of serum metabolites and pathways between Arabic subjects with obesity and metabolic syndrome compared to subjects with obesity only. Lipids, including sphingomyelin, were significantly decreased in the group with metabolic syndrome. Non-lipid metabolites, such as quinolinate, kynurenine, and tryptophan, were also decreased in the group with metabolic syndrome. Metabolites and pathways associated with chronic inflammation were found to be dysregulated in subjects with metabolic syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Pier Paolo Bassareo, Michele D'Alto
Summary: Pulmonary hypertension (PH) is a complex disease that can lead to irreversible pulmonary arterial hypertension (PAH) and death. Metabolomics is a laboratory technique that can provide insights into the metabolic pathways related to PH/PAH. This systematic review identified specific metabolic fingerprints and highlighted the potential for new therapeutic agents targeting the disarranged metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Zhiwei Kong, Bin Li, Chuanshe Zhou, Qinghua He, Yuzhong Zheng, Zhiliang Tan
Summary: In high-altitude areas, hypoxia poses a serious stress on dairy cows, leading to metabolic changes primarily in amino acid metabolism and sphingolipid metabolism, with a negative correlation observed between sphingolipid metabolism and increasing altitude. The findings of this study contribute to understanding the hypoxia-adaptive mechanism of dairy cows in high-altitude areas.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Lars Lind, Samira Salihovic, Johan Sundstrom, Solve Elmstahl, Ulf Hammar, Koen Dekkers, Johan Arnlov, J. Gustav Smith, Gunnar Engstrom, Tove Fall
Summary: This study compared the plasma metabolome in obese subjects with and without metabolic syndrome (MetS) to normal-weight subjects without MetS. The results showed significant differences in metabolite profiles between obese and normal-weight individuals without MetS, with a gradual deterioration in metabolite profile from lean to obese to MetS. The pathways highlighted in this study, such as amino acid synthesis/metabolism and sphingolipid metabolism, may play a role in this metabolic deterioration, with insulin resistance as a potential mediator.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Fangfang Di, Danfeng Gao, Lihua Yao, Runjie Zhang, Jin Qiu, Liwen Song
Summary: Polycystic ovary syndrome (PCOS) often coexists with a metabolic disorder, and dysfunction of adipose tissue, especially abdominal adipose tissue, can worsen reproductive and metabolic problems in PCOS patients. The study used LC-MS/MS to analyze adipose samples from PCOS patients, and identified PCOS biomarkers engaged in inflammatory diseases and mitochondrial beta-oxidation. In vitro experiments showed that isoleucine could ameliorate the effects of hyperandrogenism on granulosa cells and related metabolic disorders. GC-MS/MS analysis revealed significantly decreased levels of isoleucine in PCOS patients. The findings suggest that metabolome alterations could be a novel therapeutic target for PCOS treatment.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Rita Araujo, Victoria Fabris, Caroline A. Lamb, Claudia Lanari, Luisa A. Helguero, Ana M. Gil
Summary: This study characterized the metabolic adaptations accompanying the progression of breast cancer from hormone-dependent to hormone-independent and eventually to resistant tumors. The analysis of metabolites revealed specific metabolic signatures that could potentially serve as markers for the development and acquisition of resistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ting-Wei Kao, Chin-Chou Huang
Summary: Metabolic syndrome is a challenging disease with increasing incidence and diverse affected populations, requiring thorough investigation. Recent studies have shown differential expression of substances in MetS, as well as the influence of diet and exercise on energy metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Arturo Vega-Beyhart, Marta Iruarrizaga, Adriana Pane, Guillermo Garcia-Eguren, Oriol Giro, Laura Boswell, Gloria Aranda, Vanesa Flores, Gregori Casals, Cristina Alonso, Mireia Mora, Irene Halperin, Francesc Carmona, Joaquim Ensenat, Oscar Vidal, Ting Hu, Gemma Rojo, Ramon Gomis, Felicia A. Hanzu
Summary: Chronic cortisol excess leads to metabolic alterations that go beyond conventional biomarkers, particularly in patients with Cushing syndrome (CS). The extent of hypercortisolism determines lipid and amino acid concentrations, resulting in a unique metabolic signature of 20 metabolites. Cortisol excess profoundly affects the Kennedy and Lands cycle pathways.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Pharmacology & Pharmacy
Yang Lin, Zi-Yuan Wang, Ma-Jie Wang, Zheng-Meng Jiang, Ya-Qiu Qin, Tian-Qing Huang, Yu Song, Hui-Ting Liang, E-Hu Liu
Summary: This study examined the effects of baicalin (BC) on high-fat diet-induced metabolic syndrome (MetS) in mice and its impact on gut microbiota composition. The results showed that BC could reduce body weight gain, hepatic fat accumulation, and abnormal blood lipids, and increase insulin sensitivity. BC also reversed the alteration of metabolites induced by high-fat diet and affected metabolic pathways. The analysis of gut microbiota demonstrated that BC altered the composition and function of gut microbiota in MetS mice. The study suggests that BC may be a potential therapeutic drug for improving MetS and the gut microbiome could be a novel mechanistic target for BC treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Lin-Lin Cao, Yi Han, Yuanxiao Wang, Lin Pei, Zhihong Yue, Li Qin, Boyu Liu, Jingwen Cui, Mei Jia, Hui Wang
Summary: Metabolic syndrome (MetS) is an independent risk factor for hepatocellular cancer (HCC). Currently, there is a lack of highly sensitive and specific biomarkers for HCC surveillance in MetS population. In this study, metabolomic analysis identified L-glu, PA, and 7-mG as novel biomarkers for MetS(+) HCC. A biomarker panel consisting of L-glu, PA, and AFP showed high diagnostic performance for discriminating MetS(+) HCC from other cancers associated with MetS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Plant Sciences
Qi Chen, Huansong Xie, Guanyun Wei, Xiaorui Guo, Jian Zhang, Xueyan Lu, Zhonghua Tang
Summary: The metabolic differences between S. salsa and P. tenuiflora under saline-alkali stress were explored. It was found that S. salsa resists the toxicity of saline-alkali stress using aboveground organs, while P. tenuiflora eliminates this toxicity via roots. S. salsa has a stronger habitat transformation ability and can provide better habitat for other plants.
Article
Medicine, General & Internal
Qiong Wu, Jiankang Li, Xiaohui Sun, Di He, Zongxue Cheng, Jun Li, Xuhui Zhang, Yongming Xie, Yimin Zhu, Maode Lai
Summary: The study identified novel biomarkers of Metabolic syndrome (MetS), including LysoPC(15:0). Three SNPs were found to be associated with LysoPC(15:0). The research suggested that abnormal metabolism of LysoPC(15:0) may be causally linked to metabolic risk.
Article
Biochemistry & Molecular Biology
Qianru Rao, Ting Zhang, Manyun Dai, Bin Li, Qianlun Pu, Min Zhao, Yan Cheng, Dongmei Yan, Qi Zhao, Zhanxuan E. Wu, Fei Li
Summary: This study compared the metabolic pathways of delta 9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in human and mouse liver microsomes using a metabolomic approach. The study identified 32 metabolites of THC, including nine undescribed metabolites. It was found that THC forms glutathione (GSH) and cysteine (Cys) adducts in its metabolism. The study also demonstrated that CYP3A4 and CYP1B1 are the primary enzymes responsible for the formation of THC-GSH and THC-Cys. Overall, this study highlights the role of metabolomics in identifying novel drug metabolites and expanding knowledge of drug metabolism and safety.
Article
Endocrinology & Metabolism
Xiaoxuan Zhao, Xiaoling Feng, Xinjie Zhao, Yuepeng Jiang, Xianna Li, Jingyun Niu, Xiaoyu Meng, Jing Wu, Guowang Xu, Lihui Hou, Ying Wang
Summary: The study revealed significant differences in general characteristics, reproductive hormones, and metabolic parameters between the PCOS-MS group, PCOS group, and healthy controls. 40 differential metabolites were identified, involving 23 pathways. 11 of these metabolites showed a correlation coefficient greater than 0.4 with clinical parameters, potentially serving as biomarkers for clinical diagnosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Claudia Ottka, Katariina Vapalahti, Sebastian P. P. Arlt, Alexander Bartel, Hannes Lohi
Summary: Using a H-1 NMR metabolomics platform, this study investigated the metabolic effects of canine reproductive status. The results showed that lactation, pregnancy, and heat all caused distinct metabolic changes, while pseudopregnancy metabolically resembled anestrus. Albumin and glycoprotein acetyls were identified as potential metabolites for detecting pregnancy. These findings contribute to improving maternal health and reproductive success in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Nutrition & Dietetics
Janine Wirth, Elaine Hillesheim, Lorraine Brennan
Summary: This systematic review and meta-analysis found no clear relationship between increased protein intake and sleep outcomes, although the evidence strength was low. More randomized controlled trials focusing on this specific research question are needed.
Article
Nutrition & Dietetics
Elaine Hillesheim, Lorraine Brennan
Summary: Personalised nutrition advice is found to be more effective than population-level advice in improving dietary intake and health outcomes. Metabotyping, which groups individuals based on metabolic profiles, has been successfully used to identify subgroups with different responses to dietary challenges and interventions. However, more studies are needed to examine the efficacy of this approach in improving health parameters.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
Article
Nutrition & Dietetics
Diana Maria Munoz-Perez, Clara Helena Gonzalez-Correa, Elcy Yaned Astudillo Munoz, Maite Sanchez-Giraldo, Juan Carlos Carmona-Hernandez, Jose Lopez-Miranda, Antonio Camargo, Oriol Alberto Rangel-Zuniga
Summary: Overweight and obesity are major global health issues. Healthy diets can induce molecular level changes. A study was conducted to evaluate the effect of a diet based on fruit, avocado, whole grains, and trout on obesity-related gene expression.
Editorial Material
Nutrition & Dietetics
Jessica Rigutto-Farebrother, Sanne Ahles, Janet Cade, Karen J. Murphy, Jogchum Plat, Lukas Schwingshackl, Helen M. Roche, Sangeetha Shyam, Carl Lachat, Anne-Marie Minihane, Connie Weaver
Summary: This article describes an initiative led by the Federation of European Nutrition Societies to develop an extension to the CONSORT statement specifically for nutrition trials. An international working group was formed to provide recommendations for the reporting of nutrition trials. The article emphasizes the need for additional guidance to improve the quality and consistency of reporting in this field.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Croi E. Buckley, Xiaofei Yin, Sebastian Meltzer, Anne Hansen Ree, Kathrine Roe Redalen, Lorraine Brennan, Jacintha O'Sullivan, Niamh Lynam-Lennon
Summary: Resistance to neoadjuvant chemoradiation therapy in rectal cancer is a challenge, and there is a need to identify its underlying mechanisms and develop predictive biomarkers and novel treatment strategies. This study identified an in vitro model of radioresistant rectal cancer and found significant alterations in multiple molecular pathways, including cell cycle, DNA repair, and oxidative phosphorylation-related genes. Metabolomic profiling of pre-treatment serum samples from rectal cancer patients identified metabolites significantly associated with treatment response and overall survival. This study highlights metabolic reprogramming as a role in radioresistance of rectal cancer and suggests altered metabolites as potential circulating predictive markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Julie Turbitt, Lorraine Brennan, R. Charlotte Moffett, Peter R. Flatt, Paul R. V. Johnson, Andrei I. Tarasov, Neville H. McClenaghan
Summary: The study found that taurine, alanine, and proline can promote insulin secretion through the regulation of ion transport and inhibition of the sodium-potassium-chloride cotransporter. This action of taurine may have potential value in the treatment of diabetes.
Article
Food Science & Technology
Elaine Hillesheim, Xiaofei Yin, Geetha Priya Sundaramoorthy, Lorraine Brennan
Summary: This study investigated the effectiveness of personalized nutrition advice compared to population-level advice in improving dietary quality and metabolic health biomarkers. A 12-week parallel randomized controlled trial was conducted with 107 healthy adults. The personalized group received dietary advice based on their metabotype characteristics and individual traits, while the control group received generic dietary advice. The personalized approach resulted in higher dietary quality and significant improvements in various metabolic health biomarkers.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Nutrition & Dietetics
Jose D. Torres-Pena, Antonio P. Arenas-de Larriva, Juan F. Alcala-Diaz, Jose Lopez-Miranda, Javier Delgado-Lista
Summary: Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, and it is associated with obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a global public health concern, affecting individuals of all ages, and its prevalence is expected to increase due to its connection with obesity. Genetic and lifestyle factors may modulate NAFLD and partly explain its relationship with cardiovascular disease (CVD). Currently, there is no specific drug for the treatment of NAFLD, and management relies on lifestyle modifications and a healthy diet.
Article
Oncology
Fiona O'Connell, Eimear Mylod, Noel E. Donlon, Aisling B. Heeran, Christine Butler, Anshul Bhardwaj, Sinead Ramjit, Michael Durand, Gerard Lambe, Paul Tansey, Ivan Welartne, Kevin P. Sheahan, Xiaofei Yin, Claire L. Donohoe, Narayanasamy Ravi, Margaret R. Dunne, Lorraine Brennan, John V. Reynolds, Helen M. Roche, Jacintha O'Sullivan
Summary: This study conducted a detailed assessment of adipose tissue metabolism and secreted pro-inflammatory, metabolite, and lipid profiles in OAC patients. The study found that OAC patients with obesity and metabolic dysfunction had increased metabolic profiles linked to tumorigenesis and inflammation. These findings suggest that targeting these altered signaling mechanisms could potentially aid current treatment strategies.
Article
Biochemistry & Molecular Biology
Claire Connolly, Xiaofei Yin, Lorraine Brennan
Summary: This study examines the impact of lactation stage on bovine milk metabolite levels using metabolomics analysis. The results show significant differences in metabolites across lactation stages, with early-lactation milk having a distinct metabolomic profile.
Article
Biochemistry & Molecular Biology
Clement Agoni, Ilias Stavropoulos, Anna Kirwan, Margharitha M. Mysior, Therese Holton, Tilen Kranjc, Jeremy C. Simpson, Helen M. Roche, Denis C. Shields
Summary: This study identified and synthesized peptides from milk protein Alpha-S1-casein that were predicted to be cell-penetrating. The peptides showed cell penetrating behavior without affecting cell homeostatic mechanisms. Further investigation is warranted to explore their potential bioactivities.
Article
Endocrinology & Metabolism
Christopher E. E. Shannon, Meabh B. Ni Chathail, Sinead M. Mullin, Andrew Meehan, Fiona C. C. McGillicuddy, Helen M. M. Roche
Summary: Obesity is a complex disease with diverse cardiometabolic risk profiles. Traditional dietary weight management approaches have failed to address the biological heterogeneity among individuals. This review explores the tissue-level pathophysiological processes that contribute to distinct cardiometabolic phenotypes in obesity, including abnormalities in adipose tissue, liver, skeletal muscle, gut microbiome, and the innate immune system. The potential of precision nutritional approaches to target these pathways and optimize cardiometabolic benefits is discussed.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Aoife E. Mcnamara, Xiaofei Yin, Cassandra Collins, Lorraine Brennan
Summary: It has been well-established that consuming cruciferous and brassica vegetables is correlated with reduced rates of negative health outcomes. This study aimed to identify biomarkers of broccoli intake and examine the dose-response relationship using metabolomic approaches. The results showed that urinary S-methyl cysteine sulfoxide (SMCSO) and several LC-MS features appeared as potentially promising biomarkers of broccoli consumption.
Article
Geriatrics & Gerontology
Caoileann H. Murphy, Sinead N. McCarthy, Aoibheann M. McMorrow, Brendan Egan, Maureen J. McGowan, Sheena Rafferty, Clare A. Corish, Helen M. Roche
Summary: This study assessed the prevalence and determinants of sarcopenia among community-dwelling older adults in Ireland. The study found a relatively high prevalence of sarcopenia, which was independently associated with polypharmacy, lower height, and lower instrumental activities of daily living score. Energy-adjusted macronutrient intake, as determined by 24-hour recall, was not independently associated with sarcopenia.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)