Review
Cell Biology
Luiz F. Piochi, Ivo F. Machado, Carlos M. Palmeira, Anabela P. Rolo
Summary: Mitochondria play a crucial role in myogenesis and their interaction with myogenic differentiation needs further exploration. SESN2 may act as a regulator of mitochondrial quality control under stress conditions induced by ROS, suggesting its potential involvement in myogenic differentiation.
AGEING RESEARCH REVIEWS
(2021)
Article
Cell Biology
Joe Ibarra, Tyler Hershenhouse, Luay Almassalha, David Walterhouse, Vadim Backman, Kyle L. Macquarrie
Summary: The study found chromosome-specific differences in the organizational characteristics of chromosomes during normal myogenesis, with chromosome 2 showing increased area occupation and a shift in peripheral localization. Additionally, it was discovered that the positioning of chromosome 2 changes during differentiation, with a preference for positioning along the major nuclear axis only in myotubes, whereas RMS cells do not display such preference.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xuan Jiang, Siyu Ji, Siyuan Cui, Rong Wang, Wei Wang, Yongquan Chen, Shenglong Zhu
Summary: This study found that Apol9a regulates myogenic differentiation via the ERK1/2 pathway, providing a promising therapeutic target for intervention in obesity and obesity-induced muscle atrophy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Mai Thi Nguyen, Wan Lee
Summary: Kank1 is a critical regulator of actin dynamics and cell proliferation in muscle progenitor cells, with its depletion impairing myogenic differentiation by promoting myoblast proliferation through F-actin-induced YAP1 nuclear translocation.
Review
Biochemistry & Molecular Biology
T. G. Sahana, Ke Zhang
Summary: Amyotrophic lateral sclerosis is a fatal motor neuron degenerative disease with multiple genetic and non-genetic risk factors. Cellular stress plays a significant role in ALS conditions, with the MAPK pathway being implicated in the disease pathogenesis and potential drug targeting.
Article
Developmental Biology
Olga G. Jaime, Jessica Arias, Shreya Pavani, April D. Pyle, Michael R. Hicks
Summary: The co-expression of SIX1 and PAX3 is the most indicative factor for skeletal muscle differentiation in human pluripotent stem cells (hPSCs). Manipulating seeding density, monitoring metabolic secretion, and altering the concentration of CHIR99021 can enhance the emergence of SIX1+PAX3+ precursors in hPSC differentiation. Inhibition of non-myogenic lineages can modulate PAX3 expression independently of SIX1.
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Wan Lee
Summary: This study showed that miR-302a affects proliferation and myogenic differentiation of myoblasts by inhibiting TWF1 expression. Palmitic acid, the most prevalent saturated fatty acid in the diet, decreased TWF1 expression and increased miR-302a levels in myoblasts. MiR-302a directly targeted the 3' UTR of TWF1 to suppress its expression. Furthermore, ectopic expression of miR-302a promoted cell cycle progression and proliferation by increasing F-actin accumulation and facilitating YAP1 nuclear translocation. This study demonstrated that miR-302a suppresses myoblast differentiation by inhibiting myogenic factor expression through TWF1 and promoting myoblast proliferation via F-actin-mediated YAP1 activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Trang Thi Huyen Dang, Jong Won Yun
Summary: BMP10 plays crucial roles in muscle physiology by promoting myogenic differentiation, glucose uptake, and lipid catabolism, mainly via the Smad 1/5/8 signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mengxun Li, Quan Liu, Su Xie, Chong Fu, Jiaxuan Li, Cheng Tian, Xin Li, Changchun Li
Summary: In this study, it was found that the lncRNA TCONS_00323213 is upregulated during porcine skeletal muscle satellite cell (PSC) differentiation and plays a role in the proliferation and differentiation of PSC. The interaction between TCONS_00323213 and PKNOX2 promotes the expression of MyoG and enhances PSC differentiation. This finding provides insights into the molecular mechanisms by which lncRNAs regulate porcine myogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, You Han Won, Tae Won Kwon, Wan Lee
Summary: This study reveals the significant role of TWF1 in the proliferation and differentiation of C2C12 myoblasts, affecting cell fate by regulating the expression of F-actin and YAP. Knockdown of TWF1 hinders myoblast differentiation and myotube formation.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Shufang Cai, Bin Hu, Qi Zhu, Tianqi Duo, Xiaoyu Wang, Xian Tong, Xiaorong Luo, Renqiang Yuan, Yaosheng Chen, Jing Wang, Chenglong Luo, Baosong Xing, Delin Mo
Summary: Delving into porcine embryonic myogenesis is crucial for understanding the complex regulation of breed-specific differences in growth performance and meat production. This study reveals that pigs with less meat production exhibit earlier embryonic myogenesis, and the Notch signaling pathway plays a crucial role in regulating myogenic progenitor maintenance and differentiation. Inhibition of Notch signaling promotes myogenic differentiation and accelerates the process of myogenic progenitors differentiating into myoblasts. These findings provide valuable insights into the underlying mechanisms of breed-specific differences in meat production.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Agriculture, Dairy & Animal Science
Qiang An, Rui-Men Zhang, Yao Wei, Yong-Wang Zhang, Le-Yi Wang, Shi-Nan Ma, Er-Kang Zhang, Chao-Xia Zou, Su-Fang Yang, De-Shun Shi, Ying-Ming Wei, Yan-Fei Deng
Summary: In this study, a newly identified circular RNA, circRRAS2, was found to be significantly upregulated during the differentiation phase of bovine muscle stem cells (MuSCs). CircRRAS2 was shown to inhibit MuSCs proliferation and promote myoblast differentiation. Furthermore, chromatin isolation with RNA purification and mass spectrometry identified 52 RNA-binding proteins that could potentially interact with circRRAS2 to regulate muscle cell differentiation. These findings suggest that circRRAS2 may serve as a specific regulator of myogenesis in bovine muscle.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Cell Biology
Aleksandra Ulman, Marta Kot, Klaudia Skrzypek, Barbara Szewczyk, Marcin Majka
Summary: Induced pluripotent stem cells are a useful tool for studying human embryo development processes such as myogenesis due to their ability to differentiate into three germ layers. Different protocols for obtaining myogenic cells have been described, with Protocol III found to be the most efficient. CD56 was also found to not be a specific marker for evaluating myogenic differentiation.
Article
Cell & Tissue Engineering
Tali Kiperman, Weini Li, Xuekai Xiong, Hongzhi Li, David Horne, Ke Ma
Summary: This study reports a screening platform to discover circadian clock modulators that promote myogenesis. Chlorhexidine was identified as a clock-activating molecule with pro-myogenic activities, enhancing myoblast proliferation and migration.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Mai Thi Nguyen, Wan Lee
Summary: This study investigates the functional significance and mechanism of miR-141-3p in myogenic differentiation. The results reveal that miR-141-3p directly targets and suppresses CFL2 expression, leading to altered F-actin dynamics and enhanced YAP activity in mechanotransduction. Additionally, miR-141-3p promotes myoblast proliferation and cell cycle progression, but inhibits the expression of myogenic factors and impedes myogenic differentiation.
Article
Biochemistry & Molecular Biology
Sun-Il Choi, Jong Seok Lee, Sarah Lee, Wan-Sup Sim, Young-Cheul Kim, Ok-Hwan Lee
Article
Biochemistry & Molecular Biology
Wan-Sup Sim, Sun-Il Choi, Tae-Dong Jung, Bong-Yeon Cho, Seung-Hyun Choi, Sung-Min Park, Ok-Hwan Lee
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Biotechnology & Applied Microbiology
Dinesh K. Patel, Yu-Ri Seo, Sayan Deb Dutta, Ok Hwan Lee, Ki-Taek Lim
BIOMED RESEARCH INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Min Woo Baek, Han Ryul Choi, Tifsehit Solomon, Cheon Soon Jeong, Ok-Hwan Lee, Shimeles Tilahun
Summary: The research findings demonstrate that preharvest MeJA treatment can significantly enhance the phytochemical composition and antioxidant activities of hydroponically grown pak choi. Hydroponically grown MeJA-treated pak choi shows higher levels of chlorophylls, total phenolics, GSLs, total flavonoids, and stronger antioxidant capacities compared to soil-grown counterparts.
Article
Biochemistry & Molecular Biology
Hee-Yeon Kwon, Sun-Il Choi, Xionggao Han, Xiao Men, Gill-Woong Jang, Ye-Eun Choi, Ok-Hwan Lee
Summary: This study established an extraction method to optimize the sinigrin content in Brassica juncea and confirmed the antiobesity mechanism of the extract. In the study, lipid accumulation and ROS production were significantly suppressed in both the BJJ extract and sinigrin-treated groups. It was also found that the expression of proteins regulating lipid accumulation, fatty acid oxidation, heat generation, and energy metabolism was effectively controlled by the BJJ extract and sinigrin, indicating their potential as a health functional food material for obesity.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Hee-Do Hong, Sun-Il Choi, Ok-Hwan Lee, Young-Cheul Kim
Summary: The study demonstrates that ginsenosides Rb1 and Rg3 found in red ginseng have positive effects on adipocyte differentiation and the insulin signaling pathway, with the combination of Rb1 and Rg3 showing superior results.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Analytical
Sun-Il Choi, Hee-Yeon Kwon, Im-Joung La, Yeon-Hui Jo, Xionggao Han, Xiao Men, Se-Jeong Lee, Yong-Deok Kim, Geum-Su Seong, Ok-Hwan Lee
Summary: The study demonstrated changes in bioactive compounds in Morinda citrifolia L. through fermentation, while also developing an HPLC analysis method for measuring these compounds, with validation in terms of precision and accuracy.
Article
Agronomy
Min Woo Baek, Han Ryul Choi, Lee Yun Jae, Ho-Min Kang, Ok-Hwan Lee, Cheon Soon Jeong, Shimeles Tilahun
Summary: The preharvest treatment of 0.25 mM methyl jasmonate (MeJA) and 0.5 mM salicylic acid (SA) had significant positive effects on the yield and quality parameters of 'Kumato' tomatoes, including increasing important secondary metabolites, amino acids, and antioxidant activities. MeJA treatment was found to be more effective than SA in improving the yield and nutritional quality of 'Kumato' tomatoes.
Article
Chemistry, Multidisciplinary
Xionggao Han, Sun-Il Choi, Xiao Men, Se-Jeong Lee, Heegu Jin, Hyun-Ji Oh, Eunjin Kim, Jongwook Kim, Boo-Yong Lee, Ok-Hwan Lee
Summary: The study evaluated the anti-obesity effect of ESETM extract and found that it can inhibit adipogenesis and lipid accumulation, reducing weight change. The results suggest that ESETM may regulate weight through adipogenesis, lipogenesis, lipolysis, and thermogenesis pathways.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Sun-Il Choi, Xionggao Han, Se-Jeong Lee, Xiao Men, Geon Oh, Doo-Sik Lee, Ok-Hwan Lee
Summary: In this study, a simple analytical method using HPLC-PDA was developed to detect thiabendazole in frequently consumed foods in South Korea. The method showed good sensitivity and precision, and was applicable for both solid and liquid food samples.
Article
Nutrition & Dietetics
Xiao Men, Xionggao Han, Se-Jeong Lee, Geon Oh, Keun-Tae Park, Jong-Kwon Han, Sun-Il Choi, Ok-Hwan Lee
Summary: It was found that broccoli sprout powder, mustard seed powder, and sulforaphane-rich mixture powder have anti-obesogenic effects by inhibiting adipocyte differentiation and adipogenesis, and by increasing the expression of proteins related to lipid metabolism and lipolysis.
Article
Cell Biology
Hyun-Ji Oh, Heegu Jin, Byung-Yong Kim, Ok-Hwan Lee, Boo-Yong Lee
Summary: A natural compound CHDT, made from Angelica gigas and Artemisia dracunculus, has been found to potentially prevent muscle atrophy by regulating the Akt/mTOR signaling pathway and reducing the production of inflammatory cytokines.
Article
Chemistry, Multidisciplinary
Sun-Il Choi, Xionggao Han, Xiao Men, Se-Jeong Lee, Geon Oh, Ye-Eun Choi, Jung-Mo Yang, Ju-Hyun Cho, Ok-Hwan Lee
Summary: This study aimed to determine the anti-osteoporosis effect of Benincasa hispida extract and 2-furoic acid in ovariectomy-induced osteoporosis in mice. The results showed that bone density and bone formation markers were significantly recovered in the supplementation groups of 2-furoic acid and high-dose Benincasa hispida extract. Furthermore, bone resorption markers were significantly decreased in these supplementation groups. These findings suggest that Benincasa hispida extract could be used to prevent ovariectomy-induced osteoporosis and bone metabolic diseases.
APPLIED SCIENCES-BASEL
(2023)
Review
Food Science & Technology
Xiao Men, Xionggao Han, Geon Oh, Ji-Hyun Im, June Seok Lim, Geun Hee Cho, Sun-Il Choi, Ok-Hwan Lee
Summary: Sulforaphane (SFN) is a commonly found isothiocyanate in cruciferous vegetables. It has various biological effects and is widely used in functional foods and clinical medicine. However, its unstable structure and degradability limit its application. Therefore, studying its properties, stability, and finding methods to increase its content are of great importance.
FOOD SCIENCE AND BIOTECHNOLOGY
(2023)
Review
Food Science & Technology
Xiao Men, Sun-Il Choi, Xionggao Han, Hee-Yeon Kwon, Gill-Woong Jang, Ye-Eun Choi, Sung-Min Park, Ok-Hwan Lee
Summary: Pumpkin is widely planted and rich in nutrients, with potential anti-obesity, anti-diabetic, antibacterial, and anticancer effects, attracting attention in the medical field. Further research is needed to understand its mechanisms and potential benefits.
FOOD SCIENCE AND BIOTECHNOLOGY
(2021)