Article
Medicine, General & Internal
Francesco Luzza, Rosalba De Sarro, Roberto Licordari, Pasquale Crea, Pietro Pugliatti, Giuseppe Certo, Lorenzo Pistelli, Francesca Campanella, Maria Claudia Lo Nigro, Matteo Casale, Michele Correale, Giuseppe Dattilo
Summary: QT interval varies with heart rate and needs to be corrected. Atrial fibrillation (AF) is associated with elevated heart rate and beat-to-beat variation. The study aims to find the best correlation between QTc in AF and restored sinus rhythm (SR) and determine the best correction formula and method for determining QTc in AF. The results show that Bazzett's formula is the least accurate in estimating QTc during AF.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
Arwa Younis, Nofrat Nehoray, Michael Glikson, Christopher Bodurian, Eyal Nof, Nicola Luigi Bragazzi, Michael Berger, Wojciech Zareba, Ilan Goldenberg, Roy Beinart
Summary: This study evaluated the changes in QTc over time following electrical cardioversion (ECV) in patients with persistent atrial fibrillation (AF), and compared the effectiveness of continuous Holter monitoring and conventional ECG follow-up. The results showed that ECV was associated with an increased transient risk of QTc prolongation in nearly half of the patients, and Holter monitoring was superior to conventional monitoring in detecting clinically significant QTc prolongation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medicine, General & Internal
Christine M. Albert, Nancy R. Cook, Julie Pester, M. Vinayaga Moorthy, Claire Ridge, Jacqueline S. Danik, Baris Gencer, Hasan K. Siddiqi, Chee Ng, Heike Gibson, Samia Mora, Julie E. Buring, JoAnn E. Manson
Summary: The study showed that marine omega-3 fatty acids and vitamin D-3 supplementation did not have a significant effect on preventing atrial fibrillation. The findings do not support the use of these supplements for primary prevention of incident AF.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Nutrition & Dietetics
Eric T. Guardino, Yanping Li, Xuan-Mai Nguyen, Peter W. F. Wilson, J. Michael Gaziano, Kelly Cho, Emelia J. Benjamin, Luc Djousse
Summary: Contrary to the hypothesis, dietary intake of EPA/DHA/DPA was not associated with an increased risk of atrial fibrillation (AF), but instead showed a nonlinear inverse relationship with AF risk.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Chen Fang, Kun Zuo, Yuan Fu, Xiaoming Zhu, Jing Li, Jiuchang Zhong, Li Xu, Xinchun Yang
Summary: This study explored the altered gut microbiota community and metabolic patterns in hypertensive patients with atrial fibrillation (HTN-AF), compared to hypertensive patients without AF. The study found significant differences in microbial diversity and dominant species between the two groups, as well as changes in metabolite levels, particularly saturated and unsaturated fatty acids. These findings suggest that the dysbiosis of gut microbiota and imbalances in metabolites are associated with increased susceptibility to AF in hypertensive patients. This provides potential targets for AF prediction and prevention in hypertensive patients.
Article
Nutrition & Dietetics
Parveen K. Garg, Weihua Guan, Sarah Nomura, Natalie L. Weir, Nathan Tintle, Jyrki K. Virtanen, Yoichiro Hirakawa, Frank Qian, Qi Sun, Eric Rimm, Rozenn N. Lemaitre, Paul N. Jensen, Susan R. Heckbert, Fumiaki Imamura, Marinka Steur, Karin Leander, Federica Laguzzi, Trudy Voortman, Toshiharu Ninomiya, Dariush Mozaffarian, William S. Harris, David S. Siscovick, Michael Y. Tsai
Summary: This study aimed to evaluate the association between circulating levels of linoleic acid and arachidonic acid with incident atrial fibrillation (AF). The results showed that biomarkers of n-6 fatty acids including linoleic acid and arachidonic acid are not associated with incident AF.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Medicine, General & Internal
Thomas Andersen Rix, Pia Dinesen, Soren Lundbye-Christensen, Albert Marni Joensen, Sam Riahi, Kim Overvad, Erik Berg Schmidt
Summary: The study showed a monotonous inverse association between the content of EPA in adipose tissue and the risk of AF in both men and women. The content of DHA was inversely associated with the risk of AF in women, whereas no clear association was found for men.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Nutrition & Dietetics
Martin E. Reiner, Philipp Baumgartner, Andrea Wiencierz, Michael Coslovsky, Nicole R. Bonetti, Mark G. Filipovic, Giulia Montrasio, Stefanie Aeschbacher, Nicolas Rodondi, Oliver Baretella, Michael Kuehne, Giorgio Moschovitis, Pascal Meyre, Leo H. Bonati, Thomas F. Luescher, Giovanni G. Camici, Stefan Osswald, David Conen, Juerg H. Beer
Summary: The study showed that EPA and DPA were associated with large noncortical or cortical infarcts (LNCCIs) in patients with atrial fibrillation, with EPA negatively correlated and DPA positively correlated with LNCCIs. However, there was no significant correlation between EPA and DPA with markers of small vessel disease in atrial fibrillation patients.
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Parag Ravindra Gajendragadkar, Adam Von Ende, Maysson Ibrahim, Elsa Valdes-Marquez, Christian Fielder Camm, Federico Murgia, Alexander Stiby, Barbara Casadei, Jemma C. Hopewell
Summary: Using a mendelian randomisation approach, this study found evidence supporting a causal association between lifelong differences in ECG parameters representing longer atrial conduction times within the normal range and a lower risk of AF. These findings suggest the need for more individualised treatment strategies for AF.
Article
Food Science & Technology
Ligang Yang, Chao Yang, Zhixiu Song, Min Wan, Hui Xia, Xian Yang, Dengfeng Xu, Da Pan, Hechun Liu, Shaokang Wang, Guiju Sun
Summary: Postprandial metabolism plays significant roles in various pathological conditions, and the n-6/n-3 polyunsaturated fatty acid ratio is closely associated with physiological disorders. This study investigated the effects of high fat meals with different n-6/n-3 PUFA ratios on postprandial metabolism in normal control and hypertriglyceridemia rats. The results showed that the n-6/n-3 PUFA ratio influenced the postprandial response of triglyceride, total cholesterol, tumor necrosis factor alpha, malondialdehyde, and reactive oxygen species in both normal control and hypertriglyceridemia rats.
FOOD SCIENCE AND HUMAN WELLNESS
(2023)
Review
Medicine, General & Internal
Ji Hye Huh, Sang -Ho Jo
Summary: Some clinical trials have shown that omega-3 fatty acids can reduce the incidence of cardiovascular disease, while others have found an increased risk of atrial fibrillation. Atrial fibrillation is the most common sustained cardiac arrhythmia worldwide, associated with high morbidity and mortality rates and significant public health burden. Previous studies on the effect of omega-3 fatty acids on atrial fibrillation have reported contradictory results.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Parveen K. Garg, Weihua Guan, Sarah Nomura, Natalie Weir, Amy B. Karger, Daniel Duprez, Susan R. Heckbert, Michael Y. Tsai
Summary: This study found that higher plasma concentrations of n-6 PUFAs, particularly arachidonic acid (AA), were associated with a reduced risk of incident AF in a multiethnic cohort of individuals free of baseline cardiovascular disease. Important differences in AF risk were also noted across race/ethnicity for the n-3 PUFAs DHA and EPA.
JOURNAL OF NUTRITION
(2021)
Review
Cardiac & Cardiovascular Systems
Dasheng Lu, Xinyue Zou, Hongxiang Zhang
Summary: Atrial fibrillation (AF) is a highly prevalent and disabling condition. The incidence of AF has increased rapidly due to aging population, imposing a significant burden on society and patients. Therefore, it is important to identify prevention and treatment strategies for AF. Several studies have explored the occurrence, development mechanism, and intervention measures of AF. The human gut microbiota, which consists of non-pathogenic microorganisms, plays a crucial role in the construction and function of the metabolic and immune systems. Recent clinical studies and basic experiments have demonstrated the involvement of gut microbiota and its metabolites in metabolic disorders and chronic inflammatory diseases. Additionally, the gut microbiota has been implicated in cardiovascular diseases such as hypertension and heart failure. However, the relationship between AF and gut microbiota remains unclear. This review summarizes relevant literature on the association between AF and intestinal flora and its metabolites, including Trimethylamine N-Oxide, short-chain fatty acids, lipopolysaccharide, and bile acids. Therefore, this review may contribute to further advancements in related research.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Alejandro Gonzalez-Benjumea, Dolores Linde, Juan Carro, Rene Ullrich, Martin Hofrichter, Angel T. Martinez, Ana Gutierrez
Summary: Research on epoxide metabolites from n-3 and n-6 polyunsaturated fatty acids has shown that fungal unspecific peroxygenases can convert these fatty acids into mono-epoxides with high regio- and enantioselectivity. Specifically, Agrocybe aegerita and Collariella virescens enzymes demonstrated 91% conversion rates with strict regioselectivity. This study highlights the potential synthetic utility of fungal peroxygenases in fatty acid epoxidation.
Article
Transplantation
Ivar A. Eide, Trond Jenssen, Anders Hartmann, Lien M. Diep, Dag O. Dahle, Anna V. Reisaeter, Kristian S. Bjerve, Jeppe H. Christensen, Erik B. Schmidt, My Svensson
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2016)
Article
Nutrition & Dietetics
Christian S. Bork, Marianne U. Jakobsen, Soren Lundbye-Christensen, Anne Tjonneland, Erik B. Schmidt, Kim Overvad
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Nutrition & Dietetics
Anne M. L. Wurtz, Mette D. Hansen, Anne Tjonneland, Eric B. Rimm, Erik B. Schmidt, Kim Overvad, Marianne U. Jakobsen
BRITISH JOURNAL OF NUTRITION
(2016)
Article
Anesthesiology
Jiwei Gu, Jan J. Andreasen, Jacob Melgaard, Soren Lundbye-Christensen, John Hansen, Erik B. Schmidt, Kristinn Thorsteinsson, Claus Graff
JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA
(2017)
Article
Nutrition & Dietetics
Mette Damborg Hansen, Anne Mette Lund Wurtz, Camilla Plambeck Hansen, Anne Tjonneland, Eric Bruce Rimm, Soren Paaske Johnsen, Erik Berg Schmidt, Kim Overvad, Marianne Uhre Jakobsen
Summary: In the Danish Diet, Cancer and Health cohort study, replacing potatoes with different types of vegetables was associated with a lower risk of ischemic stroke.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Anupam Chandra, Magnus Nakrem Lyngbakken, Ivar Anders Eide, Helge Rosjo, Thea Vigen, Hakon Ihle-Hansen, Eivind Bjorkan Orstad, Ole Morten Ronning, Trygve Berge, Erik Berg Schmidt, Arnljot Tveit, Torbjorn Omland, My Svensson
Article
Nutrition & Dietetics
Randi Tobberup, Andreas Carus, Henrik H. Rasmussen, Ursula G. Falkmer, Martin G. Jorgensen, Erik B. Schmidt, Nikolaj A. Jensen, Esben B. Mark, Agnieszka M. Delekta, Christian S. Antoniussen, Martin Bogsted, Mette Holst
Summary: This study aimed to evaluate a multimodal intervention targeting nutritional status in patients with non-small cell lung cancer, and found that a larger proportion of patients in the intervention group gained skeletal muscle. Dietary counselling and fish oil use were effective strategies, while motivation for unsupervised physical intervention was low.
CLINICAL NUTRITION
(2021)
Article
Nutrition & Dietetics
Anne Mette L. Wurtz, Marianne U. Jakobsen, Monica L. Bertoia, Tao Hou, Erik B. Schmidt, Walter C. Willett, Kim Overvad, Qi Sun, JoAnn E. Manson, Frank B. Hu, Eric B. Rimm
Summary: Replacing red meat consumption with other protein sources such as poultry, seafood, low-fat dairy, high-fat dairy, eggs, legumes, and nuts was associated with a lower risk of type 2 diabetes mellitus.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Erik Berg Schmidt, Berit Storgaard Hedegaard, Kjetil Retterstol
Article
Rheumatology
Signe Holm Nielsen, Samra Sardar, Anne Sofie Siebuhr, Annette Schlemmer, Erik Berg Schmidt, Anne-Christine Bay-Jensen, Morten A. Karsdal, Jeppe Hagstrup Christensen, Salome Kristensen
Summary: PsA patients show elevated levels of ECM metabolites PRO-C3, PRO-C4, and C4M compared to healthy individuals, while no differences were found for OC, CTX-I, PRO-C1, and C3M. Patients receiving n-3 PUFA treatment had a 7% increase in PRO-C3 after 24 weeks. Tissue turnover is increased in PsA patients compared to healthy individuals, but n-3 PUFA treatment for 24 weeks did not have a significant effect on tissue turnover.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Rheumatology
Salome Kristensen, Signe Holm Nielsen, Erik Berg Schmidt, Anne Christine Bay-Jensen, Morten A. Karsdal, Jeppe Hagstrup Christensen
Summary: The study found that there was no significant correlation between the content of fatty acids in granulocytes and disease activity in patients with psoriatic arthritis (PsA). However, marine n-3 PUFA was positively correlated with collagen degradation, while n-6 PUFA was positively correlated with collagen formation. Further investigation is needed to explore the relationship between fatty acids and biomarkers of bone and soft tissue turnover.
RHEUMATOLOGY INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Hanne Skou Jorgensen, Ivar Anders Eide, Trond Jenssen, Anders Asberg, Jens Bollerslev, Kristin Godang, Anders Hartmann, Erik Berg Schmidt, My Svensson
Summary: The study did not find a significant effect of 44 weeks of supplementation with 2.6 g of marine n-3 PUFA on bone mineral density (BMD) in kidney transplant recipients.
Article
Endocrinology & Metabolism
Berit Storgaard Hedegaard, Borge Gronne Nordestgaard, Helle Lynge Kanstrup, Kristian Korsgaard Thomsen, Jan Bech, Lia Evi Bang, Finn Lund Henriksen, Lars Juel Andersen, Thomas Gohr, Linnea Hornbech Larsen, Anne Merete Boas Soja, Frank-Peter Elpert, Tomas Joen Jakobsen, Anette Sjol, Albert Marni Joensen, Ib Christian Klausen, Erik Berg Schmidt, Christian Sorensen Bork
Summary: This study investigated the presence of lipoprotein(a) in individuals referred to Danish lipid clinics and found that elevated lipoprotein(a) played a role in a quarter of individuals who met the diagnosis criteria for clinical familial hypercholesterolemia (FH).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
A. Gammelmark, M. S. Nielsen, S. Lundbye-Christensen, A. Tjoenneland, E. B. Schmidt, K. Overvad
EUROPEAN HEART JOURNAL
(2016)
Article
Biochemistry & Molecular Biology
Kristian Laake, Ingebjorg Seljeflot, Erik B. Schmidt, Peder Myhre, Arnljot Tveit, Harald Arnesen, Svein Solheim