Article
Environmental Studies
Manuela Ortega-Gil, Antonio Mata Garcia, Chaima ElHichou-Ahmed
Summary: This study analyzes data from 33 European countries and finds that factors such as arrears of people aged 65 and over are positively correlated with life satisfaction, while income of people aged 65 and over is negatively correlated. Environmental issues and inequality show different relationships with life satisfaction at different levels of satisfaction.
Review
Psychology, Multidisciplinary
Qing Zhong, Cheng Chen, Shulin Chen
Summary: Life review and reminiscence therapy have a positive impact on improving the quality of life and life satisfaction among older adults. Individual sessions of life review and reminiscence therapy are more effective in improving quality of life, while six to eight intervention sessions can enhance life satisfaction more effectively.
BEHAVIORAL SCIENCES
(2023)
Article
Fisheries
Jiayu Liu, Rui Shao, Yawen Lan, Xinmeng Liao, Jinjin Zhang, Kangsen Mai, Qinghui Ai, Min Wan
Summary: The study demonstrates that vitamin D-3 enhances immune responses in fish, leading to lower mortality and reduced bacterial load in infected fish. Additionally, VD3 supplementation promotes bactericidal activity and modulates immune cell responses, highlighting its potential as a defense mechanism against pathogen infection in fish.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Ecology
Michael Briga, Simon Verhulst
Summary: The study found that basal metabolic rate decreases linearly with age while standard metabolic rate increases linearly with age. The absolute standardized change with age was faster for basal metabolic rate compared to standard metabolic rate, and the within-individual correlation of age related change was negligible. Sex did not show specific differences in metabolic rate or metabolic ageing rate.
FUNCTIONAL ECOLOGY
(2021)
Article
Social Sciences, Interdisciplinary
Ioana Ramia, Malina Voicu
Summary: The older population is increasing globally, and active ageing has been a key focus in Europe for enhancing the quality of life of older people. This study examines the impact of active ageing on subjective quality of life using data from a European survey. The findings suggest that remaining active in later life does not always lead to improvements in subjective quality of life, and different strategies are at work to maintain life satisfaction and happiness.
SOCIAL INDICATORS RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay A. Orekhov, Andrey V. Grechko, Alexander N. Orekhov
Summary: This review focuses on the roles of mitochondrial metabolism, ROS production, mitochondrial dynamics, and mitophagy in normal aging and pathological conditions. It also discusses the impact of inflammaging on neurodegenerative diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Ezgi Dogan-Sander, Roland Mergl, Anja Willenberg, Ronny Baber, Kerstin Wirkner, Steffi G. Riedel-Heller, Susanne Roehr, Frank M. Schmidt, Georg Schomerus, Christian Sander
Summary: The study revealed a significant negative correlation between depressive symptoms and vitamin D levels, as well as positive associations between depressive symptoms and inflammatory markers. WBC was found to partially mediate the association between vitamin D levels and depressive symptoms. Future research is needed to explore the impact of vitamin D supplementation on inflammation and depressive symptomatology for causal assessment.
Review
Biochemistry & Molecular Biology
Yu-Jih Su, Pei-Wen Wang, Shao-Wen Weng
Summary: The role of mitochondria in the immune system is crucial, providing energy, activating cells, and playing a key role in tissue regeneration and aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
J. Talevski, K. M. Sanders, A. Lal, J. J. Watts, A. Beauchamp, G. Duque, F. Borgstrom, J. A. Kanis, A. Svedbom, S. L. Brennan-Olsen
Summary: This study identified the costs and health-related quality of life impacts of post-fracture multidisciplinary care pathways specific to individual skeletal sites, which can assist healthcare providers in allocating resources for osteoporotic fractures in a more effective and cost-efficient manner.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Geriatrics & Gerontology
Francine Toye, Cathy Jenkins, Karen Barker
Summary: The study explored the quality of life of patients over the age of 85 in the second decade following unicompartmental knee replacement surgery, using a hermeneutic phenomenological approach with a priori themes. Results indicated that health outcomes for older people should include measures of participation and well-being, emphasize the importance of kindness in healthcare, and support open conversations about dying well.
Article
Nutrition & Dietetics
Sarah Hakeem, Nuno Mendonca, Terry Aspray, Andrew Kingston, Carmen Martin-Ruiz, Louise Robinson, Tom R. Hill
Summary: The study found inconsistent relationships between circulating 25(OH)D concentration and telomere length over time in very-old adults (85+ years old). Positive significant association was found at baseline, negative at 18 months, but non-significant at 36 months.
Article
Biochemistry & Molecular Biology
Tereza Kauzalova, Oldrich Tomasek, Ellis Mulder, Simon Verhulst, Tomas Albrecht
Summary: Barn swallows' telomere length shows a negative relationship with sexual ornamentation, indicating a trade-off between the two.
Article
Psychology, Multidisciplinary
Amanda Roestorf, Patricia Howlin, Dermot M. Bowler
Summary: This study found that mental health difficulties in older autistic adults persisted and did not improve over time, and were closely related to their everyday life quality. These findings have important implications for providing mental health services for older autistic adults.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
R. Andujar-Espinosa, M. Aparicio-Vicente, F. J. Ruiz-Lopez, L. Salinero-Gonzalez
Summary: The ACVID clinical trial demonstrated the efficacy of calcifediol in improving asthma control for asthma patients with vitamin D deficiency. Supplemented patients showed improved quality of life compared to a placebo group, with initial mini-AQLQ scores improving for both groups.
RESPIRATORY MEDICINE
(2021)
Review
Immunology
Vincent Gauthier, Maria Kyriazi, Meriam Nefla, Valentina Pucino, Karim Raza, Christopher D. D. Buckley, Ghada Alsaleh
Summary: Fibroblasts, derived from the embryonic mesenchyme, have diverse roles in development, homeostasis, repair, and disease. They maintain micro-environmental homeostasis and create tissue niches through the production of a complex extracellular matrix (ECM). Recent advancements in single cell transcriptomics have revealed phenotypic heterogeneity and different cellular states in fibroblasts, highlighting their involvement in tissue regulation and inflammation. This recognition has increased the importance of discovering new therapies targeting fibroblasts in various diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Quentin Leyrolle, Fanny Decoeur, Cyril Dejean, Galadriel Briere, Stephane Leon, Ioannis Bakoyiannis, Emilie Baroux, Tony-Lee Sterley, Clementine Bosch-Bouju, Lydie Morel, Camille Amadieu, Cynthia Lecours, Marie-Kim St-Pierre, Maude Bordeleau, Veronique De Smedt-Peyrusse, Alexandran Sere, Leslie Schwendimann, Stephane Gregoire, Lionel Bretillon, Niyazi Acar, Corinne Joffre, Guillaume Ferreira, Raluca Uricaru, Patricia Thebault, Pierre Gressens, Marie-Eve Tremblay, Sophie Laye, Agnes Nadjar
Summary: Westernized dietary habits leading to reduced intake of n-3 PUFAs may be associated with neurodevelopmental disorders and disruptions in brain functional connectivity. Lifelong n-3 PUFA deficiency can interfere with oligodendrocyte maturation and myelination processes, resulting in long-term detrimental effects on white matter organization and hippocampus-prefrontal functional connectivity. Promoting developmental myelination through clemastine could rescue memory deficits in n-3 PUFA deficient animals.
Article
Biochemistry & Molecular Biology
Alessia Costa, Barbara Rani, Thomaz F. S. Bastiaanssen, Francesco Bonfiglio, Eoin Gunnigle, Gustavo Provensi, Moira Rossitto, Marcus Boehme, Conall Strain, Clara S. Martinez, Patrizio Blandina, John F. Cryan, Sophie Laye, Renato Corradetti, Maria Beatrice Passani
Summary: Exposure to repeated social stress may cause maladaptive emotional reactions that can be reduced by healthy nutritional supplementation. This study found that brain histamine plays a role in the protective effects of a diet enriched with polyunsaturated fatty acids and vitamin A on chronic stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Fanny Decoeur, Katherine Picard, Marie-Kim St-Pierre, Andrew D. Greenhalgh, Jean-Christophe Delpech, Alexandra Sere, Sophie Laye, Marie-Eve Tremblay, Agnes Nadjar
Summary: The westernization of dietary habits has led to a decrease in the intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnant and lactating women, resulting in defects in the formation of brain myelin in infants. This study found that these deficits may be related to alterations in the structure and function of microglial cells in the white matter of the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Chemistry, Medicinal
Frederike T. Fellendorf, Nina Bonkat, Nina Dalkner, Elena M. D. Schoenthaler, Mirko Manchia, Dietmar Fuchs, Eva Z. Reininghaus
Summary: This review highlights the inconsistent findings on KYN/TRP ratio in severe mental disorders. Although there are indications of inflammation associated with elevated IDO activity, no conclusive statements can be made. Considering factors such as inflammatory processes, metabolic activities, and psychological/neuropsychiatric symptoms are crucial for a deeper understanding of the underlying mechanisms.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Mathieu Di Miceli, Maud Martinat, Moira Rossitto, Agnes Aubert, Shoug Alashmali, Clementine Bosch-Bouju, Xavier Fioramonti, Corinne Joffre, Richard P. Bazinet, Sophie Laye
Summary: Long-chain (LC) n-3 polyunsaturated fatty acids (PUFAs) have been studied in the field of neuropsychiatric disorders, particularly depression. The effect of LC n-3 PUFA supplementation on behavior and synaptic plasticity was investigated in mice exposed to chronic social defeat stress (CSDS). The results showed that LC n-3 PUFA supplementation influenced the fatty acid profile in the NAc, altered emotional behavior and synaptic plasticity, and promoted resilience, independently of CSDS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Hany Ahmed, Quentin Leyrolle, Ville Koistinen, Olli Karkkainen, Sophie Laye, Nathalie Delzenne, Kati Hanhineva
Summary: Alterations in gut microbiota composition have been linked to various neurological disorders, and the gut-brain axis plays a crucial role in this communication. While the specific mechanisms are not fully understood, existing data suggests that metabolites from gut microbiota may be key factors in the gut-brain axis communication. Further research is needed to understand the molecular mechanisms and explore intervention approaches for prevention and treatment of neurological disorders.
Article
Biochemistry & Molecular Biology
Hugo Martin, Sebastien Bullich, Maud Martinat, Mathilde Chataigner, Mathieu Di Miceli, Vincent Simon, Samantha Clark, Jasmine Butler, Mareike Schell, Simran Chopra, Francis Chaouloff, Andre Kleinridders, Daniela Cota, Philippe De Deurwaerdere, Luc Penicaud, Sophie Laye, Bruno P. Guiard, Xavier Fioramonti
Summary: Insulin directly modulates the activity of DR 5-HT neurons to dampen 5-HT neurotransmission and control emotional behaviors. However, in T2D animal models, the anxiolytic effect of intranasal insulin and the response of 5-HT neurons to insulin are both blunted.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Cornelia A. Karg, Lucia Parrakova, Dietmar Fuchs, Harald Schennach, Bernhard Kraeutler, Simone Moser, Johanna M. Gostner
Summary: Phyllobilins, derived from the degradation of chlorophyll, are natural products with antioxidant and immunomodulatory properties. However, their mechanisms of action and in vivo effects require further investigation.
Article
Immunology
Katherine Picard, Giorgio Corsi, Fanny Decoeur, Maria Amalia Di Castro, Maude Bordeleau, Marine Persillet, Sophie Laye, Cristina Limatola, Marie-Eve Tremblay, Agnes Nadjar
Summary: Sleep is regulated by various neuroanatomical and neurochemical systems, with microglia playing a significant role in sleep regulation. Depletion of microglia in female mice results in longer NREM sleep duration and increased number of sleep episodes.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Microbiology
Laura P. Kincer, Sarah Beth Joseph, Maria M. Gilleece, Blake M. Hauser, Sabrina Sizemore, Shuntai Zhou, Clara Di Germanio, Henrik Zetterberg, Dietmar Fuchs, Steven G. Deeks, Serena Spudich, Magnus Gisslen, Richard W. Price, Ronald Swanstrom
Summary: HIV-1 can persist in a latent reservoir in individuals receiving antiretroviral therapy, and rebound virus can be detected in the cerebrospinal fluid during treatment interruption. In this study, we found that high viral loads and clonally amplified viral lineages in the cerebrospinal fluid were correlated with the influx of white blood cells. Additionally, we did not observe rebound macrophage-tropic virus in the cerebrospinal fluid, indicating that the CNS may not be a source of this virus. We propose a model in which R5 T cell-tropic virus is released from infected T cells in the CNS during treatment interruption.
NATURE MICROBIOLOGY
(2023)
Article
Immunology
Arvid Eden, Frida Rydberg, Aylin Yilmaz, Lars Hagberg, Johanna Gostner, Staffan Nilsson, Dietmar Fuchs, Magnus Gisslen
Summary: For people with HIV initiating ART during chronic infection, the occurrence of residual CNS immune activation is not correlated with pretreatment immune status, even when treatment is initiated at high CD4(+) T-cell counts, suggesting that the CNS reservoir is not differentially affected by the timing of ART initiation during chronic infection.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Katharina Obermoser, Natascha Brigo, Andrea Schroll, Pablo Monfort-Lanzas, Johanna M. Gostner, Sabine Engl, Simon Geisler, Miriam Knoll, Harald Schennach, Guenter Weiss, Dietmar Fuchs, Rosa Bellmann-Weiler, Katharina Kurz
Summary: This pilot study investigated the effects of a multi-strain probiotic preparation on fatigue, depression, and quality of life in patients with post-infectious fatigue. The results showed that both the probiotic and placebo groups experienced improvements, but the probiotic group had greater improvements. After 6 months, the probiotic group had significantly lower fatigue and depression scores, as well as improved quality of life.
Article
Multidisciplinary Sciences
Valentine Turpin, Maud Schaffhauser, Mathieu Thabault, Agnes Aubert, Corinne Joffre, Eric Balado, Jean-Emmanuel Longueville, Maureen Francheteau, Christophe Burucoa, Maxime Pichon, Sophie Laye, Mohamed Jaber
Summary: This study compared the effects of n-3 long-chain polyunsaturated fatty acid (PUFA) dietary supplementation from fatty fish with n-3 PUFA precursor diet from plant oils in an autism spectrum disorder (ASD) mouse model. The results showed that regardless of the diet, n-3 PUFA-based diets can prevent certain behavioral and cellular symptoms related to ASD.
SCIENTIFIC REPORTS
(2023)
Review
Environmental Sciences
Boushra Dalile, Curie Kim, Andy Challinor, Lucie Geurts, Eileen R. Gibney, Marcelo Galdos, Giorgio La Fata, Sophie Laye, John C. Mathers, David Vauzour, J. Martin Verkuyl, Sandrine Thuret
Summary: This review assesses the evidence for the impact of diet on cognitive function and finds that the current evidence base is weak with mixed conclusions. Long-term intervention and prospective cohort studies are needed to fill this knowledge gap and revise dietary recommendations for maintaining healthy cognitive function across the life course.
LANCET PLANETARY HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Saziye Sezin Palabiyik-Yucelik, Simone Moser, Kathrin Becker, Zekai Halici, Yasin Bayir, Marlies Stonig, Harald Schennach, Dietmar Fuchs, Johanna M. Gostner, Katharina Kurz
Summary: Oxyresveratrol influences inflammatory and metabolic processes by suppressing tryptophan breakdown and neopterin formation. It shows distinct effects on different immune cell types and can modulate the activity of IDO-1.
