Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Shihao Hu, Yuzhi Lu, Andrea Tura, Giovanni Pacini, David Z. D'Argenio
Summary: Glucose effectiveness, the ability of glucose to regulate glucose utilization and production in the body, plays a significant role in maintaining normal blood sugar levels. Hierarchical statistical analysis revealed that individuals with type 2 diabetes had a decreased glucose effectiveness compared to non-diabetic individuals. This finding suggests that glucose effectiveness could be a potential marker for glucose metabolism disorders and a target for diabetes treatment.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daniela Vejrazkova, Marketa Vankova, Petra Lukasova, Martin Hill, Josef Vcelak, Andrea Tura, Denisa Chocholova, Bela Bendlova
Summary: The shape of glycemic curve during OGTT predicts impaired glucose homeostasis and metabolic syndrome. Men are more likely to have biphasic curves, while women are more likely to have triphasic curves. Monophasic curves are associated with higher risk of impaired glucose regulation and metabolic syndrome.
Article
Endocrinology & Metabolism
Lewin Small, Amy Ehrlich, Jo Iversen, Stephen P. Ashcroft, Kajetan Trost, Thomas Moritz, Bolette Hartmann, Jens J. Holst, Jonas T. Treebak, Juleen R. Zierath, Romain Barres
Summary: The study compares the effect of different routes of glucose administration (oral and intraperitoneal) on glucose and insulin kinetics during a glucose tolerance test in mice. The results show that intraperitoneal glucose administration resulted in significantly elevated blood glucose levels, but had a lesser effect on insulin and incretin hormone levels compared to oral administration.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Tao Yuan, Shuoning Song, Tianyi Zhao, Yanbei Duo, Shihan Wang, Junxiang Gao, Shixuan Liu, Yingyue Dong, Rui Li, Yong Fu, Weigang Zhao
Summary: The study identified two different patterns of FPIS among subjects with normal glucose tolerance, indicating that individuals with later time to glucose peak during FPIS may have a lower risk of developing type 2 diabetes in the future.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Lais Monteiro Rodrigues Loureiro, Eugenio dos Santos Neto, Guilherme Eckhardt Molina, Angelica Amorim Amato, Sandra Fernandes Arruda, Caio Eduardo Goncalves Reis, Teresa Helena Macedo da Costa
Summary: The study showed that consuming a coffee beverage with milk after exhaustive cycling exercise can lead to increased muscle glycogen recovery, glucose, and insulin response during the 4-hour recovery period.
Article
Endocrinology & Metabolism
Claudia Piona, Sonia Volpi, Chiara Zusi, Enza Mozzillo, Antonella Tosco, Adriana Franzese, Valeria Raia, Maria Linda Boselli, Maddalena Trombetta, Marco Cipolli, Riccardo C. Bonadonna, Claudio Maffeis
Summary: In patients with cystic fibrosis, each of the 5 glucose tolerance stages demonstrates a distinct pattern of defects in the direct determinants of glucose regulation. Early elevation of AGT140 patients significantly differ from NGT and are similar to IGT.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Environmental Sciences
Qiang Ma, Houguo Xu, Samwel Mchele Limbu, Yuliang Wei, Mengqing Liang
Summary: In this study, the ability of fish to utilize carbohydrates was evaluated by intraperitoneal injection or oral administration of glucose or fructose to tiger puffer and turbot. The results showed that glucose and fructose stimulated insulin secretion and improved hypoxia tolerance in the two marine fishes.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Nutrition & Dietetics
Jennifer L. LaBarre, Emily Hirschfeld, Tanu Soni, Maureen Kachman, Janis Wigginton, William Duren, Johanna Y. Fleischman, Alla Karnovsky, Charles F. Burant, Joyce M. Lee
Summary: The study indicates that obesity and insulin resistance may influence the metabolic dynamics in response to a glucose challenge in adolescents. Obese adolescents showed a blunted decline in fatty acid oxidation intermediates during OGTT.
Article
Food Science & Technology
Masanobu Hibi, Yuji Matsui, Sachiko Niwa, Sachiko Oishi, Aya Yanagimoto, Takahiro Ono, Tohru Yamaguchi
Summary: Corosolic acid has been found to improve glucose tolerance in both healthy individuals and prediabetic subjects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Environmental Sciences
Pengfei Gong, Danielle Bailbe, Stefania Tolu, Gaelle Pommier, Junjun Liu, Jamileh Movassat
Summary: Since the restricted use of BPA due to its endocrine disruptor properties, BPS has been widely used as a substitute. However, BPS has similar effects on metabolic health as BPA. Previous studies have documented the effects of maternal exposure to BPA and BPS on offspring, but the impact of preconceptional paternal exposure to BPS remains unexplored. This study showed that preconceptional paternal exposure to BPS had non-monotonic and sex-specific effects on the metabolic health of offspring, suggesting that BPS is not a safe substitute for BPA regarding the inter-generational transmission of metabolic disorders through the paternal lineage.
Article
Health Care Sciences & Services
Andrea Foppiani, Fabiana Ciciriello, Arianna Bisogno, Silvia Bricchi, Carla Colombo, Federico Alghisi, Vincenzina Lucidi, Maria Ausilia Catena, Mariacristina Lucanto, Andrea Mari, Giorgio Bedogni, Alberto Battezzati
Summary: This study aimed to describe the distribution and provide reference quartiles of OGTT-related variables in the Italian cystic fibrosis population. The results showed the deterioration of glucose tolerance and insulin secretion with age according to sex and pancreatic insufficiency, highlighting a deviation from linearity for patients 35 years of age.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
A. Tate Lasher, Hemant Srivastava, Liou Y. Sun
Summary: Recent studies have shown that glucagon not only regulates glycemia, but also plays a role in amino acid and lipid metabolism, systemic endocrine and paracrine function, and the response to cardiovascular injury. Inhibition of glucagon receptor signaling through the use of glucagon receptor antagonists and tissue-specific genetic knockout models has provided valuable insights into the role of glucagon.
Article
Nutrition & Dietetics
Marie-Therese Weiser-Fuchs, Elena Maggauer, Mireille N. M. van Poppel, Bence Csapo, Gernot Desoye, Harald C. Koefeler, Andrea Groselj-Strele, Slave Trajanoski, Herbert Fluhr, Barbara Obermayer-Pietsch, Evelyn Jantscher-Krenn
Summary: This study found that sialylated human milk oligosaccharides (HMOs) are associated with impaired glucose homeostasis in pregnancy, suggesting potential implications for gestational diabetes mellitus (GDM).
Article
Nutrition & Dietetics
Bret M. Rust, Joseph O. Riordan, Franck G. Carbonero, Patrick M. Solverson
Summary: Obesity in the United States is getting worse, and fruits and vegetables containing anthocyanins can slow down its metabolic complications. This study aimed to determine the effects of elderberry juice on measures of indirect calorimetry and insulin sensitivity/glucose tolerance. The results showed that average carbohydrate oxidation significantly increased after 1-week elderberry juice consumption, while average fat oxidation significantly decreased. However, there was no effect on serum glucose or insulin response.