Plant stanol ester consumption and arterial elasticity and endothelial function

We evaluated whether plant stanol esters mixed with different vegetable oil spreads improved arterial health. A total of 200 adults with serum cholesterol > 5 mmol/l were randomised to consume camelina, rapeseed or sunflower oil spread with stanol (2 g/d) ester or sunflower oil spread without stanol ester (controls) for 3 months. Non-invasive ultrasound was used to measure carotid artery compliance (CAC) and brachial artery flow-mediated endothelial dependent vasodilatation (FMD) at baseline and after the intervention as markers of arterial health. Plant stanol esters reduced LDL-cholesterol by 9 % compared with controls (P < 0.001) similarly in the different treatment groups. In the combined treatment groups (n 147), CAC or FMD were not changed from controls (n 47). In a subgroup analysis, division Of Subjects at baseline into below and over sex-specific 50th percentiles of CAC and FIVID revealed that low CAC was improved from 1.23 to 1.59 % per 10 mmHg in the treatment group (11 69) and from 1.42 to 1.47 % per 10 mmHg in controls (n 25), (P=0.0035 between groups). Low FMD was improved from 6.9 % to 8.6 % in the treatment group (n 73) and from 6.6 % to 6.8 % in controls (n 24) (P=0.05 between groups). In the respective high-median groups, CAC and FMD were not changed in spite of significantly lowered LDL-cholesterol. In conclusion, consumption of plant stanol ester for 3 months had no overall significant effect on arterial elasticity and endothelial function. A controlled study is needed to test whether beneficial changes are obtained in subjects with initially reduced arterial elasticity and endothelial function.