Article
Optics
Shu-cheng Lo, Chia-wei Lee, Ruey-lin Chern, Pei-kuen Wei
Summary: In this work, high-performance surface plasmonic sensors using gold nanostructures and Bragg photonic structures are presented. The hybrid Tamm-plasmon mode, resulting from the Fano coupling between higher order Tatum plasmon states and Bloch-wave surface plasmon polariton on the gold nanoslit array, demonstrates high surface sensitivity and resonant quality. The experimental results show that the hybrid mode has significantly higher sensitivity and better signal-to-noise ratios in biomolecular interaction measurement.
Article
Chemistry, Analytical
Meng-Qi He, Yongjian Ai, Wanting Hu, Xiaomeng Jia, Lei Wu, Mingyu Ding, Qionglin Liang
Summary: By using DNA as an etching agent, it is possible to control the morphology and optical properties of plasmonic nanoparticles, while also introducing fluorescence properties. This strategy allows for precise tuning of localized surface plasmon resonance (LSPR) and fluorescence-composited dual-mode signals.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Richard Robinson, Virginia Krause, Shan Wang, Shan Yan, Guojun Shang, Justine Gordon, Serena Tycko, Chuan-Jian Zhong
Summary: There is an increasing need to reduce the silver content in silver-based inks or pastes and achieve low-temperature sintering for scalable and low-cost production of printed wearable electronics. This study reports a scalable wet chemical synthesis method for the preparation of bimetallic silver-copper alloy nanoinks with room temperature sintering properties. It is found that the nanoinks can sinter on paper substrates at room temperature.
Article
Chemistry, Physical
Tomas Zikmund, Jiri Bulir, Michal Novotny, Ladislav Fekete, Sergii Chertopalov, Stefan Andrei Irimiciuc, Mariana Klementova, Jarmila Balogova, Jan Lancok
Summary: This study reports on the formation of silver nanoparticles by gas aggregation in a reaction chamber at room temperature. The size distribution of the nanoparticles was analyzed using atomic force microscopy, while their physical shape and optical properties were characterized using scanning and transmission electron microscopy and spectral ellipsometry. The nanoparticles were then incorporated into various materials to study their influence on emission spectra and transmittance at different annealing temperatures.
Article
Chemistry, Physical
Xiao-Gang Wang, Jian Wang, Zi-Jin Jiang, Dai-Wen Tao, Xu-Qiang Zhang, Cheng-Wei Wang
Summary: This study successfully fabricated SERS-active substrates with dual-bandgap photonic crystal structures, demonstrating ultra-high sensitivity and stability for trace detection of Rhodamine B, providing significant potential for applications in biomolecular detection and chemical analysis.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Analytical
Aleksei A. Furletov, Vladimir V. Apyari, Valeriy D. Zaytsev, Anna O. Sarkisyan, Stanislava G. Dmitrienko
Summary: Recently, non-spherical nanoobjects known as silver triangular nanoplates (AgTNPs) have gained significant attention as promising reagents in optical molecular spectroscopy. This review covers various methods for synthesis of AgTNPs, including classical approaches (citrate and borohydride), novel microwave/ultrasound-assisted methods, synthesis in organic solvents, photochemical, biological, and biochemical methods. The advantages and shortcomings of each approach are discussed, along with the applications of AgTNPs in UV-Vis spectrometry, diffuse reflectance spectroscopy, and test analysis. Additionally, the methods for detecting metal ions, anions, and organic compounds using AgTNPs are examined, as well as the current trends in these areas.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Matthew N. Creyer, Zhicheng Jin, Maurice Retout, Wonjun Yim, Jiajing Zhou, Jesse V. Jokerst
Summary: This study investigates the optical shifts and color changes of gold-silver core-shell nanoparticles, as well as their application in enzyme concentration detection.
Article
Materials Science, Multidisciplinary
Azeem Ullah, Perveen Fazil, Gul Rukh, Munira Taj Muhammad, Muhammad Rahim, Muhammad Ateeq, Rozina Khattak, Muhammad Sufaid Khan, Ola A. Abu Ali, Dalia Saleh
Summary: In this study, Ferene-S-conjugated silver nanoparticles were synthesized and showed selective quenching effects in the presence of Fe2+, along with substantial selectivity towards Fe2+ in the presence of other competitive ions. The system followed Beer's law over a concentration range of 110-190 nM with a detection limit of 110 nM.
Article
Chemistry, Analytical
Nour Beydoun, Yann Niberon, Laurent Arnaud, Julien Proust, Komla Nomenyo, Shuwen Zeng, Gilles Lerondel, Aurelien Bruyant
Summary: This research demonstrates that applying a thin layer of aluminum oxide to copper films can effectively slow down the oxidation rate. This simple method could provide a new approach for producing alternative and more sustainable biochips.
Article
Polymer Science
Mohd Hafiz Abu Bakar, Nur Hidayah Azeman, Nadhratun Naiim Mobarak, Nur Afifah Ahmad Nazri, Tengku Hasnan Tengku Abdul Aziz, Ahmad Rifqi Md Zain, Norhana Arsad, Ahmad Ashrif A. Bakar
Summary: This research investigates the physicochemical properties of biopolymer succinyl-kappa-carrageenan as a potential sensing material for NH4+ Localized Surface Plasmon Resonance (LSPR) sensor. The results show that AgNP-Succinyl-kappa-carrageenan LSPR has higher performance than AgNP-kappa-carrageenan LSPR, broader detection range than the conventional method, and high selectivity toward NH4+. The adsorption of NH4+ on kappa-carrageenan and succinyl-kappa-carrageenan were through multilayer and chemisorption process that follows Freundlich and pseudo-second-order kinetic model.
Article
Thermodynamics
Smita Mahadevappa Nyamgoudar, Vasavi Prasuna Silaparasetti, M. P. Shilpa, K. S. Pavithra, Shridhar Mundinamani, K. M. Eshwarappa, Srivathsava Surabhi, Koduri Ramam, Ravikirana, A. Ganesha, S. C. Gurumurthy
Summary: Nanofluids are a type of fluid prepared by dispersing nanoparticles in conventional base fluids, which have excellent thermo-physical properties and potential applications in manufacturing industries. In this study, silver nanoparticles and nanorods were prepared using a simple chemical reduction method, and their effect on the thermal conductivity of the base fluids was investigated. The results showed that nanofluids containing 2% of silver nanoparticles and nanorods exhibited the optimal heat conductivity.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
Article
Engineering, Environmental
Ankita Ojha, Pardeep Singh, Ramesh Oraon, Dhanesh Tiwary, Ajay K. Mishra, Ayman A. Ghfar, Mu Naushad, Tansir Ahamad, Binota Thokchom, K. Vijayaraghavan, S. Rangabhashiyam
Summary: This study focuses on the synthesis of TiO2-rGO-Ag hybrid nanocomposite and characterizes its photocatalytic efficiency for degrading organic pollutants. The nanocomposite was well characterized using various analytical techniques and showed significant photocatalytic activity for degrading petrochemical pollutants under visible light. The study suggests a promising potential for the practical application of this ternary nanocomposite in waste treatment.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Mohamed Abdel Hamid, Ahmed Habib, Mokhtar Mabrouk, Sherin Hammad, Mahmoud Elshahawy
Summary: This study developed a novel method for synthesizing silver nanoparticles using glucosamine as a reducing agent, and applied the nanoparticles for colorimetric detection and quantitative determination of the non-chromophoric drug, glucosamine. The method showed good sensitivity and accuracy.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Physical
Bin Yu, Yan Wang, Ying Zhang, Zhonghua Zhang
Summary: Solar water evaporation using nanostructured metals, such as the black nanoporous silver film, holds promise for addressing the challenges of freshwater shortage. The highly porous and low-density NP-Ag film exhibited efficient solar steam generation and acceptable seawater desalination properties, offering a new approach for metal-based photothermal films in solar evaporation applications.
Article
Materials Science, Multidisciplinary
Shahid Ali, Muhammad Rahim, Perveen Fazil, Malik Shoaib Ahmad, Azeem Ullah, Muhammad Raza Shah, Gul Rukh, Muhammad Ateeq, Rozina Khattak, Muhammad Sufaid Khan, Ola A. Abu Ali, Dalia I. Saleh
Summary: The study focused on synthesizing silver nanoparticles, functionalizing them with afzelechin, and analyzing their differences in surface plasmon resonance and morphology. Characterization was done using UV-Visible spectroscopy and atomic force microscopy.
Article
Chemistry, Multidisciplinary
Junyue Chen, Gerile Oudeng, Hongtao Feng, Sixi Liu, Hung-Wing Li, Yi-Ping Ho, Yan Chen, Ying Tan, Mo Yang
Summary: Current strategies for detecting circulating tumor cells (CTCs) based on surface epithelial markers have low specificity in distinguishing between CTCs and epithelial cells in the hematopoietic cell population. As tumor-associated miRNAs are highly correlated with tumor development and progression, they are emerging as new biomarkers. However, simultaneous analysis of multiple miRNAs in a single CTC cell is still challenging. In this study, a digital droplet microfluidic flow cytometry platform based on biofunctionalized 2D metal-organic framework nanosensors (Nano-DMFC) was developed for in situ detection of dual miRNAs simultaneously in single living breast cancer cells. This platform successfully detected dual miRNAs at single-cell resolution and showed good reproducibility in the recovery experiment of spiked blood samples, demonstrating its high potential for CTC-based cancer early diagnosis and prognosis.
Article
Biochemistry & Molecular Biology
Jiuhai Wang, Yutian Gu, Xu Liu, Yadi Fan, Yu Zhang, Changqing Yi, Changming Cheng, Mo Yang
Summary: This study introduces a novel approach for inhibiting amyloid aggregation through photothermally assisted photo-oxygenation treatment, achieving lower neurotoxicity and significant inhibition of Aβ aggregation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Kamyar Yazdani, Deondre Jordan, Mo Yang, Christopher R. Fullenkamp, David R. Calabrese, Robert Boer, Thomas Hilimire, Timothy E. H. Allen, Rabia T. Khan, John S. Schneekloth Jr
Summary: This study presents a new library of nucleic acid binders called ROBIN, which was identified through small molecule microarray (SMM) screening. The complete results of 36 SMM screens against a library of 24,572 small molecules were reported, resulting in the identification of 2,003 RNA-binding small molecules. Machine learning was used to develop predictive and interpretable models for characterizing these RNA-binding molecules. This work highlights the power of machine learning in informing the field of RNA-targeted chemistry.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Chao Cai, Feng Tian, Junping Ma, Zipei Yu, Mo Yang, Changqing Yi
Summary: This study demonstrated a facile synthesis of Ir/Gd bimetallic oxide nanotheranostics (BSA@Gd2O3/IrO2 NPs) with good biocompatibility using a biomineralization method. BSA@Gd2O3/IrO2 NPs showed high longitudinal relaxivity and X-ray absorption capability, making them suitable for MR and CT dual-modal imaging. Additionally, BSA@Gd2O3/IrO2 NPs acted as efficient photothermal conversion agents and photosensitizers, and could decompose endogenous H2O2 to produce O-2, improving the phototherapeutic effect. This work is important for the development of versatile nanotheranostic systems using mild and robust biomineralization methods.
Article
Biochemical Research Methods
Jingyu Shi, Yu Zhang, Mo Yang
Summary: With the global outbreak of SARS-CoV-2, there is a need for rapid and accurate detection methods for respiratory viruses. Traditional methods are time-consuming and labor-intensive, while microfluidics-based techniques offer simple, rapid, and cost-effective analysis of intact virus, viral antigen/antibody, and viral nucleic acids. This review summarizes the recent development of microfluidics-based techniques for detection of respiratory viruses and discusses the future prospects.
Article
Biophysics
Qin Zhang, Bohan Yin, Yingying Huang, Yutian Gu, Jiaxiang Yan, Jiareng Chen, Chuanqi Li, Yu Zhang, Siu Hong Dexter Wong, Mo Yang
Summary: In this study, a dual turn-on fluorescence biosensor based on TPET-DNA@Dex-MoS2 nanocomposite was developed for sensitive and rapid detection of miR-125b. The nanoprobes exhibited excellent imaging capabilities for real-time monitoring of miR-125b in PC12 cells and brain tissues of mice AD model. The results indicated spatial association between miR-125b and p-tau, providing mechanistic insight into the early prognosis of AD.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Medicinal
Mo Yang, Feyisola P. Olatunji, Curran Rhodes, Sumirtha Balaratnam, Kara Dunne-Dombrink, Srinath Seshadri, Xiao Liang, Christopher P. Jones, Stuart F. J. Le Grice, Adrian R. Ferre-D'Amare, Jr John S. Schneekloth
Summary: In this study, small molecules that target the frameshifting element (FSE) in the SARS-CoV-2 RNA genome were discovered and characterized using high-throughput small-molecule microarray (SMM) screening. These compounds showed mid-micromolar binding affinity to the FSE RNA and had a binding mode distinct from previously reported FSE binders. Furthermore, these compounds were active in in vitro and in-cell dual-fluorescent-reporter frameshifting assays, indicating the potential of targeting RNA structural elements with druglike compounds to alter viral protein expression.
ACS MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Sigitas Mikutis, Maria Rebelo, Eliza Yankova, Muxin Gu, Cong Tang, Ana R. Coelho, Mo Yang, Madoka E. Hazemi, Marta Pires de Miranda, Maria Eleftheriou, Max Robertson, George S. Vassiliou, David J. Adams, J. Pedro Simas, Francisco Corzana, John S. Schneekloth Jr, Konstantinos Tzelepis, Goncalo J. L. Bernardes
Summary: Researchers report a new approach called proximity-induced nucleic acid degrader (PINAD) to target and degrade RNA using small molecules. They have designed two families of RNA degraders that target two different RNA structures in SARS-CoV-2: G-quadruplexes and the betacoronaviral pseudoknot. These novel molecules have been shown to degrade their targets in vitro, in cellulo, and in vivo SARS-CoV-2 infection models. PINAD enables the conversion of any RNA binding small molecule into a degrader, potentially expanding the space of druggable targets and diseases by targeting and destroying disease-related RNA species.
ACS CENTRAL SCIENCE
(2023)
Review
Pharmacology & Pharmacy
Bohan Yin, Wai-Ki Wong, Yip-Ming Ng, Mo Yang, Franco King-Chi Leung, Dexter Siu-Hong Wong
Summary: Tumor immunotherapy shows promise in oncology, but faces limitations including low response rates and potential off-target effects. Nanotechnology can enhance tumor immunogenicity and improve the success rate of immunotherapy. This review emphasizes the integration of anticancer drugs with multifunctional nanomedicines to upregulate tumor immunogenicity, triggering immune memory and the activation of tumor-specific T-cells. Challenges and personal perspectives on bioengineered nanomaterials for future cancer immunotherapy are also discussed.
Article
Chemistry, Multidisciplinary
Bohan Yin, Qin Zhang, Jiaxiang Yan, Yingying Huang, Chuanqi Li, Jiareng Chen, Chunyi Wen, Siu Hong Dexter Wong, Mo Yang
Summary: Nanosubstrate engineering can modulate stem cell differentiation in tissue engineering through biomechanical means. The effect of clathrin-mediated processes on this behavior has not been explored. In this study, we developed integrin-binding nanosubstrates with confined nanogeometries to regulate clathrin-mediated signaling pathways for modulating stem fates. Isotropic ligand presentation on the nanoscale enhanced clathrin expression and facilitated uptake of dexamethasone-loaded nanoparticles, promoting osteogenesis. In contrast, anisotropic ligand nanogeometry suppressed clathrin-mediated nanoparticle entry and reinforced mechanotransduced signaling by strengthening the association between clathrin and adhesion spots. Inhibiting focal adhesion formation hindered cell spreading and increased endocytosis efficiency.
Article
Multidisciplinary Sciences
Wei Liu, Qiyan Yao, Xiaonan Su, Yafang Deng, Mo Yang, Bo Peng, Fan Zhao, Chao Du, Xiulan Zhang, Jinsong Zhu, Daliang Wang, Wenhui Li, Haitao Li
Summary: The study demonstrates how the HBx protein exploits a histone methylation reader, Spindlin1, to overcome heterochromatin barriers and enhance HBV transcription. The molecular interplay between host epigenetic factors and viral proteins is an intriguing mechanism for sustaining the hepatitis B virus life cycle and its chronic infection.
NATURE COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Dangui Zhang, Honglian Wu, Tianci Wang, Yuting Wang, Sixi Liu, Feiqiu Wen, Gerile Oudeng, Mo Yang
Summary: This article introduces a multifunctional nanoprobe for immune checkpoint blockade and immune response monitoring in acute myeloid leukemia cells. The nanoprobe can trigger ICB therapy and detect immune responses simultaneously, allowing for accurate evaluation of heterogeneous immune responses without additional drug treatment or probe processes.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Qin Zhang, Bohan Yin, Jianhua Hao, Linjie Ma, Yingying Huang, Xueying Shao, Chuanqi Li, Zhiqin Chu, Changqing Yi, Siu Hong Dexter Wong, Mo Yang
Summary: A highly sequence-specific biosensor based on nanocomposites has been developed for one step-detection of SARS-CoV-2-specific nucleic acid sequences. The method is rapid, inexpensive, and sensitive, with detection completed within 1 hour without amplification.
Article
Medicine, Research & Experimental
Bohan Yin, Qin Zhang, Xinyue Xia, Chuanqi Li, Willis Kwun Hei Ho, Jiaxiang Yan, Yingying Huang, Honglian Wu, Pui Wang, Changqing Yi, Jianhua Hao, Jianfang Wang, Honglin Chen, Siu Hong Dexter Wong, Mo Yang
Summary: This study overcomes the steric hindrance of nanomaterials to CRISPR-Cas12a by designing specific DNA/RNA hairpins, and constructs a nucleic acid biosensor with high sensitivity and selectivity.
Article
Materials Science, Multidisciplinary
Zhenjia Huang, Gary Chi-Pong Tsui, Yu Deng, Chak-Yin Tang, Mo Yang, Miao Zhang, Wai-Yeung Wong
Summary: Light-responsive liquid crystal elastomers (LCEs) are attractive materials for developing untethered and dexterous bioinspired robotic systems. In this study, a novel organic photothermal dopant, conjugated polymers (CPs), was introduced in LCE to improve the aggregation issue of inorganic nanoparticles. The resulting CPs/LCE actuators exhibited ultrafast response and repeatable shape change.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
