Article
Cell Biology
Jun Xie, Ying Du, Dewang Liu, Jianfeng Wu, Kang Yang, Xiaoyu He, Jiayi Zhao, Peicheng Hong, Kunyu Liao, Huanrong Zhang, Yazhen Hong, John R. Teijaro, Seung Goo Kang, Changchun Xiao, Wen-Hsien Liu
Summary: The miR-17 similar to 92 family microRNAs play a key role in T cell and plasma cell differentiation. In this study, researchers found that the miR-17 similar to 92 family also has important functions in B cell differentiation and function, regulating the key target gene Socs3 in plasma cell differentiation.
Article
Plant Sciences
Caixia Li, Yuhong Li, Han Zhang, Yuzhen Zhuo, Lanqiu Zhang, Lei Yang, Qiaoying Gao, Zhengwei Tu, Rui Shao, Yu Wang, Junhua Zhang, Lihua Cui, Shukun Zhang
Summary: The study found that Xuanfei Baidu Decoction (XFBD) has significant clinical efficacy in treating patients with COVID-19. XFBD alleviates lung injury and inflammation by inhibiting the JAK2/STAT3/SOCS3 and NF-kappa B signaling pathways. These findings contribute to understanding the mechanisms of XFBD in COVID-19 treatment.
Article
Cell Biology
Laia Sadeghi, Anthony P. H. Wright
Summary: Multiple signaling pathways regulate the migration and adhesion of malignant B-cells, including the dysregulated NF-?B pathways in mantle cell lymphoma (MCL). Using a co-culture model system, it was found that KDM6B histone demethylase is associated with MCL cell adhesion to stromal cells. Inhibition of KDM6B reduces MCL adhesion and impairs the NF-?B pathway, suggesting KDM6B as a potential therapeutic target for MCL.
Article
Biochemistry & Molecular Biology
Lipei Wang, Mingqian Zhou, Xiangyu Kong, Shouzhen Wu, Chuanlin Ding, Xiaoling Hu, Haixun Guo, Jun Yan
Summary: Researchers developed an anti-CD19-N-(4-carboxycyclohexylmethyl) maleimide N-hydroxysuccinimide ester (SMCC)-protamine (CSP)-STAT3 small interfering RNA (siRNA) conjugate that specifically binds to B cell lymphoma cells. This conjugate reduced STAT3 expression and inhibited tumor growth and weight in vitro and in an A20 lymphoma model. The findings suggest the potential of this targeted STAT3 siRNA for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jingjing Hu, Ke Chen, Fangfang Hong, Guosheng Gao, Xiaoyu Dai, Hua Yin
Summary: METTL3 modifies SOCS3 mRNA with m6A to promote the stemness and tumorigenicity of LCSCs.
CANCER GENE THERAPY
(2023)
Article
Oncology
Xin-Xin Zeng, Wan-Wei Guo, Jue Shen, Yu-Ying Jiang, Shuang Liu, Xu-Hui Zhang
Summary: REG gamma regulates p-STAT3 expression and downregulates the NF-KB signaling pathway to promote MCL cell apoptosis by negatively regulating STAT3-mediated PSMB5 expression and subsequently upregulating IKB expression.
TRANSLATIONAL CANCER RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Yang Du, Chuize Kong
Summary: In this study, it was demonstrated that miR-93-3p plays an oncogenic role in RCC by enhancing cell proliferation and suppressing apoptosis. STAT3 was found to regulate the transcription of miR-93 and influence the expression of DAPK1. Overexpression of DAPK1 was shown to suppress the entry of activated STAT3 into the cell nucleus.
CANCER GENE THERAPY
(2021)
Review
Oncology
Khalil Saleh, Morgane Cheminant, David Chiron, Barbara Burroni, Vincent Ribrag, Clementine Sarkozy
Summary: This article reviews the role of the tumor microenvironment (TME) in mantle cell lymphoma (MCL) and the different therapeutic strategies.
Article
Biochemistry & Molecular Biology
Abdulraheem Alshareef, Anthea C. Peters, Pascal Gelebart, Will Chen, Raymond Lai
Summary: The constitutive activation of the Wnt canonical pathway (WCP) in mantle cell lymphoma (MCL) is mainly due to gene methylation/silencing of WIF1, which promotes cell growth. Gene transfection of WIF1 into cells significantly reduces cell growth and results in downregulation of various proteins in WCP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Olga Kersy, Mali Salmon-Divon, Ofer Shpilberg, Oshrat Hershkovitz-Rokah
Summary: B-lymphocytes play a crucial role in the immune response, while aberrantly expressed non-coding RNAs in mantle cell lymphoma affect cellular growth and survival pathways. Researchers have summarized the role of non-coding RNAs in B-cell development and malignant transformation, as well as discussed their potential for clinical use.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Tobias Roider, Xi Wang, Katrin Huettl, Carsten Mueller-Tidow, Wolfram Klapper, Andreas Rosenwald, James Peter Stewart, David Gonzalez de Castro, Peter Dreger, Olivier Hermine, Hanneke C. Kluin-Nelemans, Niels Grabe, Martin Dreyling, Christiane Pott, German Ott, Eva Hoster, Sascha Dietrich
Summary: SAMHD1 protein expression was not significantly associated with the outcome of mantle cell lymphoma (MCL) patients upon cytarabine-based treatment, but inversely correlated with the in vitro response to cytarabine in B cell lymphoma cell lines. This correlation could be reversed by combining cytarabine with other chemotherapeutics.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Cell Biology
Shasha Liu, Siya Liu, Ziding Yu, Wenzhuo Zhou, Meichun Zheng, Rongrong Gu, Jinxuan Hong, Zhou Yang, Xiaojuan Chi, Guijie Guo, Xinxin Li, Na Chen, Shile Huang, Song Wang, Ji-Long Chen
Summary: This study reveals that early-stage infection with various viruses, including influenza A virus, leads to IL-6-independent phosphorylation of STAT3 Y705, which is critical for antiviral immunity. Knockin mice with STAT3Y705F/1 mutation show suppressed antiviral response, lung tissue injury, and poor survival upon IAV infection. The phosphorylation of STAT3 Y705 restrains IAV pathogenesis by repressing excessive IFN production, and blocking the phosphorylation enhances IFN expression and potentiates IAV virulence in mice. Knockout of IFNAR1 or IFNLR1 in STAT3Y705F/1 mice protects them from lung injury and reduces viral load.
Article
Oncology
Jun Wang, Hui Xu, Shuang Ge, Chaoshuai Xue, Hailing Li, Xiaotong Jing, Ke Liang, Xiaoying Zhang, Cuijuan Zhang
Summary: This study revealed that EHMT2 is overexpressed in mantle cell lymphoma (MCL) compared to reactive hyperplasia (RH), affecting cell cycle and apoptosis-related proteins. EHMT2 also regulates multiple genes involved in the Tec kinase signaling pathway and influences the methylation status of various genes in MCL.
CANCER BIOLOGY & MEDICINE
(2022)
Article
Microbiology
Zhike Liu, Li Wang, Pei Gao, Yan Yu, Yanhong Zhang, Anatoliy Fotin, Qiuxia Wang, Zhiyong Xu, Xiaobing Wei, Tetiana Fotina, Jinyou Ma
Summary: Salmonella enterica serovar Pullorum can regulate host immunity via special effectors such as the anti-inflammatory effector SteE. It has been found that SteE can diminish the expression of Th1-related cytokines and promote the expression of Th2-related cytokines in both cells and chicken models infected with S. Pullorum. SteE achieves these effects by modulating the STAT3/SOCS3 and NF-KB pathways.
VETERINARY MICROBIOLOGY
(2023)
Article
Oncology
Takahiro Maeta, Tsuyoshi Sato, Kazuya Asano, Shigeki Ito
Summary: This study found that dimethyl fumarate (DMF) has anti-tumor effects on HTLV-1-infected and transformed T-cells, inhibiting cell proliferation and inducing apoptosis by suppressing the NF-??B and STAT3 signaling pathways. These results suggest that DMF could be a novel agent for treating ATL.
ANTICANCER RESEARCH
(2022)
Article
Engineering, Biomedical
Samira Khaledi, Sevda Jafari, Samin Hamidi, Ommoleila Molavi, Soodabeh Davaran
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2020)
Article
Biochemistry & Molecular Biology
Abdulraheem Alshareef, Anthea C. Peters, Pascal Gelebart, Will Chen, Raymond Lai
Summary: The constitutive activation of the Wnt canonical pathway (WCP) in mantle cell lymphoma (MCL) is mainly due to gene methylation/silencing of WIF1, which promotes cell growth. Gene transfection of WIF1 into cells significantly reduces cell growth and results in downregulation of various proteins in WCP.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Letter
Hematology
Sahba Shafiee, Pascal Gelebart, Mihaela Popa, Monica Hellesoy, Randi Hovland, Rakel Brendsdal Forthun, Jungwoo Lee, Kaoru Tohyama, Anders Molven, Biju Parekkadan, Bjorn Tore Gjertsen, Astrid Olsnes Kittang, Emmet McCormack
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Genetics & Heredity
Mohsen Rashid, Leila Rostami Zadeh, Behzad Baradaran, Ommoleila Molavi, Zeinab Ghesmati, Mehdi Sabzichi, Fatemeh Ramezani
Summary: Hypoxia inducible factor-1 alpha (HIF-1 alpha) plays a crucial role in cancer progression, functioning differently in cells depending on oxygen levels. Targeting HIF-1 alpha and its downstream signaling molecules is a potential strategy for modulating cancer development and progression. Inhibitors of HIF-1 alpha and agents that suppress mTOR, PI3k/Akt, and MAPK pathways could be effective in cancer treatment.
Article
Oncology
Samira Hasanbeiglu, Kamran Hosseini, Ommoleila Molavi, Parina Asgharian, Vahideh Tarhriz
Summary: This study explores the anti-cancer properties of Eryngium billardieri on melanoma and breast cancer cell lines, finding that its non-terpenoid compounds exhibit significant cytotoxic effects and apoptotic mechanisms.
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Leila Rostamizadeh, Ommoleila Molavi, Mohsen Rashid, Fatemeh Ramazani, Behzad Baradaran, Afsaneh Lavasanaifar, Raymond Lai
Summary: Immunotherapy, particularly cancer vaccines, shows great potential for cancer treatment. However, the presence of immunosuppressive tumor microenvironment limits their therapeutic effects. Overcoming immunosuppression can enhance the efficacy of cancer immunotherapy.
Article
Pharmacology & Pharmacy
Sevda Jafari, Saba Heydarian, Raymond Lai, Elnaz Mehdizadeh Aghdam, Ommoleila Molavi
Summary: In this study, it was found that silibinin can induce immunogenic cell death and enhance the effectiveness of chemotherapy-induced cell death in cancer cells. Additionally, silibinin was found to stimulate IL-12 secretion in dendritic cells, suggesting a potential link to the induction of Th1 response.
Article
Chemistry, Multidisciplinary
Monireh Ghorbanpour, Behzad Soltani, Ommoleila Molavi, Ali Shayanfar, Elnaz Mehdizadeh Aghdam, Christopher John Ziegler
Summary: Copper-based complexes have diverse applications in pharmaceutical and biochemistry. In this study, four types of bis(pyrazolyl) borate-based ligands and their copper(II) complexes were synthesized and characterized. One of the complexes showed promising anticancer potential and molecular docking studies revealed better binding energy for copper complexes.
Article
Pharmacology & Pharmacy
Kamran Hosseini, Mahtab Partovi Ariya, Ommoleila Molavi, Parina Asgharian, Vahideh Tarhriz
Summary: The methanolic extract of E. thyrsoideum showed cytotoxic effects on breast cancer cells and inhibited their growth by inducing apoptosis.
JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Monireh Ghorbanpour, Behzad Soltani, Ali Mota, Jaber Jahanbin Sardroodi, Elnaz Mehdizadeh Aghdam, Ali Shayanfar, Ommoleila Molavi, Rahim Mohammad-Rezaei, Mostafa Ebadi-Nahari, Christopher J. Ziegler
Summary: A group of bidentate nitrogen and sulfur donor pyrazole derivative ligands and their Cu (II) complexes were synthesized and characterized. The Cu (II) complexes exhibited significant cytotoxicity against MCF-7 cell lines and showed better interactions with EGFR and CDK2 proteins compared to the free ligands. These findings suggest that the developed copper complexes could be potential chemotherapeutic agents for cancer treatment.
Article
Biochemical Research Methods
Sevda Jafari, Atabak Bakhshaei, Morteza Eskandani, Ommoleila Molavi
Summary: In this study, nanostructured lipid carriers (NLCs) containing silibinin were prepared and tested in combination with cisplatin against ovarian cancer cells. The combination showed enhanced inhibitory effects on drug-resistant cells. The optimized silibinin-NLCs can be considered an effective drug delivery system for inhibiting cisplatin-resistant ovarian cancer cells.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES
(2022)
Article
Hematology
Pascal Gelebart, May Eriksen Gjerstad, Susanne Benjaminsen, Jianhua Han, Ida Karlsen, Mireia Mayoral Safont, Calum Leitch, Zinayida Fandalyuk, Mihaela Popa, Lars Helgeland, Bela Papp, Fanny Baran-Marszak, Emmet McCormack
Summary: This study reports the identification and expression of a new AXL splice variant, AXL3, in MCL cells, which is constitutively activated and is essential for MCL cell survival. Inhibition of AXL3 leads to apoptosis of MCL cells and significantly reduces the activation of proproliferative and survival pathways. Bemcentinib shows promise as a targeted therapy for MCL, demonstrating higher efficacy than ibrutinib in reducing tumor burden and increasing overall survival in preclinical studies.
Article
Pharmacology & Pharmacy
Monireh Ghorbanpour, Behzad Soltani, Ommoleila Molavi, Elnaz Mehdizadeh Aghdam
Summary: In this study, a series of pyrazole-based metal complexes were synthesized and their antibacterial and anticancer activities were investigated. The results showed that one particular complex exhibited high cytotoxicity and bacterial inhibition. These metal complexes have potential applications for further evaluations in the field of biology.
PHARMACEUTICAL SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Haleh Forouhandeh, Zahra Rezaei Param, Ommoleila Molavi, Parina Asgharian, Vahideh Tarhriz
Summary: This study evaluated the anti-proliferative activity of E. caucasicum on melanoma cancer cells and non-cancerous cells. The n-Hexane extract and its 40% and 60% fractions showed the highest cytotoxic effect against the B16F10 cell line, inhibiting growth through induction of apoptosis.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Review
Cell Biology
Mehdi A. Vostakolaei, Leila Hatami-Baroogh, Ghader Babaei, Ommoleila Molavi, Shirafkan Kordi, Jalal Abdolalizadeh
Summary: The heat shock protein superfamily, also known as molecular chaperones, are highly conserved and play vital roles in protein fate across all living organisms. Hsp70, a member of this superfamily, is expressed at low levels in normal cells but has been found to be overexpressed in various tumor cells, contributing to resistance to programmed cell death and tumor progression.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)