Advances in megakaryocytopoiesis and thrombopoiesis: from bench to bedside

Polycythemia vera and essential thrombocythemia: 2012 update on diagnosis, risk stratification, and management

(2012) Ayalew Tefferi   AMERICAN JOURNAL OF HEMATOLOGY

Hereditary thrombocythemia caused by a thrombopoietin (THPO) gain-of-function mutation associated with multiple myeloma and congenital limb defects

(2012) Clemens Stockklausner et al.   ANNALS OF HEMATOLOGY

Thrombopoietin/MPL participates in initiating and maintaining RUNX1-ETO acute myeloid leukemia via PI3K/AKT signaling

(2012) J. A. Pulikkan et al.   BLOOD

How I treat immune thrombocytopenia: the choice between splenectomy or a medical therapy as a second-line treatment

(2012) W. Ghanima et al.   BLOOD

Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis

(2012) L. C. Dore et al.   BLOOD

Safety and efficacy of eltrombopag for treatment of chronic immune thrombocytopenia: results of the long-term, open-label EXTEND study

(2012) M. N. Saleh et al.   BLOOD

VEGFR1 stimulates a CXCR4-dependent translocation of megakaryocytes to the vascular niche, enhancing platelet production in mice

(2012) S. C. Pitchford et al.   BLOOD

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

(2012) M. J. White et al.   BLOOD

Front-line therapy in polycythemia vera and essential thrombocythemia

(2012) Tiziano Barbui et al.   BLOOD REVIEWS

Venous thromboembolism and coagulation activity in patients with immune thrombocytopenia treated with thrombopoietin receptor agonists

(2012) Waleed Ghanima et al.   BRITISH JOURNAL OF HAEMATOLOGY

Biology and Clinical Management of Myeloproliferative Neoplasms and Development of the JAK Inhibitor Ruxolitinib

(2012) J. Mascarenhas et al.   CURRENT MEDICINAL CHEMISTRY

Thrombopoietin-receptor agonists

(2012) Paul A. Basciano et al.   CURRENT OPINION IN HEMATOLOGY

TPO, but not soluble-IL-6 receptor, levels increase after anagrelide treatment of thrombocythemia in chronic myeloproliferative disorders

(2012) Jan Palmblad et al.   International Journal of Medical Sciences

Preoperative use of romiplostim in thrombocytopenic patients with chronic hepatitis C and liver cirrhosis

(2012) Mohamed M Moussa et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Contemporary management of primary immune thrombocytopenia in adults

(2012) S. LAKSHMANAN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A randomized controlled trial of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving decitabine

(2012) Peter L. Greenberg et al.   LEUKEMIA & LYMPHOMA

Cofactor-Mediated Restriction of GATA-1 Chromatin Occupancy Coordinates Lineage-Specific Gene Expression

(2012) Timothy M. Chlon et al.   MOLECULAR CELL

Eltrombopag before Procedures in Patients with Cirrhosis and Thrombocytopenia

(2012) Nezam H. Afdhal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Promising New Treatment for Refractory Aplastic Anemia

(2012) Donald Metcalf   NEW ENGLAND JOURNAL OF MEDICINE

Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia

(2012) Matthew J. Olnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Autocrine Role of Angiopoietins during Megakaryocytic Differentiation

(2012) Ernestina Saulle et al.   PLoS One

Cotransplantation of Ex Vivo Expanded Progenitors with Nonexpanded Cord Blood Cells Improves Platelet Recovery

(2012) Hélène Émond et al.   STEM CELLS AND DEVELOPMENT

Short-term eltrombopag for surgical preparation of a patient with inherited thrombocytopenia deriving from MYH9 mutation

(2012) Serena Barozzi et al.   THROMBOSIS AND HAEMOSTASIS

Emerging targeted therapies in myelofibrosis

(2012) Giovanni Barosi   Expert Review of Hematology

RUNX1-induced silencing of non-muscle myosin heavy chain IIB contributes to megakaryocyte polyploidization

(2012) Larissa Lordier et al.   Nature Communications

Romiplostim in children with chronic refractory ITP: randomized placebo controlled study

(2011) Mohsen Saleh Elalfy et al.   ANNALS OF HEMATOLOGY

What is the potential for thrombopoietic agents in acute leukemia?

(2011) David J. Kuter   BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY

Calcium- and integrin-binding protein 1 regulates megakaryocyte ploidy, adhesion, and migration

(2011) J. C. Kostyak et al.   BLOOD

A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia

(2011) J. B. Bussel et al.   BLOOD

SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis

(2011) H. Chagraoui et al.   BLOOD

MicroRNAs in platelet production and activation

(2011) L. C. Edelstein et al.   BLOOD

Coordinate loss of a microRNA and protein-coding gene cooperate in the pathogenesis of 5q- syndrome

(2011) M. S. Kumar et al.   BLOOD

The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia

(2011) C. Neunert et al.   BLOOD

Advances in understanding the pathogenesis of familial thrombocythaemia

(2011) Luciana Teofili et al.   BRITISH JOURNAL OF HAEMATOLOGY

Thrombopoietin and hematopoietic stem cells

(2011) Carolyn A. de Graaf et al.   CELL CYCLE

Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling

(2011) Andre Scott Jung et al.   CELL CYCLE

Embryonic origin of the adult hematopoietic system: advances and questions

(2011) A. Medvinsky et al.   DEVELOPMENT

Metabolism and Disposition of Eltrombopag, an Oral, Nonpeptide Thrombopoietin Receptor Agonist, in Healthy Human Subjects

(2011) Y. Deng et al.   DRUG METABOLISM AND DISPOSITION

Exome sequencing identifies MPL as a causative gene in familial aplastic anemia

(2011) A. J. Walne et al.   HAEMATOLOGICA

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

(2011) Emma C. Josefsson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Megakaryocytes, malignancy and bone marrow vascular niches

(2011) B. PSAILA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Risk of pulmonary embolism in patients with autoimmune disorders: a nationwide follow-up study from Sweden

(2011) Bengt Zöller et al.   LANCET

Hierarchical Differentiation of Myeloid Progenitors Is Encoded in the Transcription Factor Network

(2011) Jan Krumsiek et al.   PLoS One

Congenital Amegakaryocytic Thrombocytopenia: Clinical Presentation, Diagnosis, and Treatment

(2011) Matthias Ballmaier et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Romiplostim efficacy in an acute myeloid leukemia patient with transfusion refractory thrombocytopenia

(2011) Maxime Berthelot-Richer et al.   TRANSFUSION

Hereditary thrombocytosis not as innocent as thought? Development into acute leukemia and myelofibrosis

(2010) H. L. A. Posthuma et al.   BLOOD

Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy

(2010) H. M. Kantarjian et al.   BLOOD

Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations

(2010) A. Pecci et al.   BLOOD

Thrombopoietic agents

(2010) Roberto Stasi et al.   BLOOD REVIEWS

Mimicking the haematopoietic niche microenvironment provides a novel strategy for expansion of haematopoietic and megakaryocyte-progenitor cells from cord blood

(2010) Varda Deutsch et al.   BRITISH JOURNAL OF HAEMATOLOGY

Guideline for investigation and management of adults and children presenting with a thrombocytosis

(2010) Claire N. Harrison et al.   BRITISH JOURNAL OF HAEMATOLOGY

Risk of venous thromboembolism in patients with primary chronic immune thrombocytopenia: a Danish population-based cohort study

(2010) Marianne T. Severinsen et al.   BRITISH JOURNAL OF HAEMATOLOGY

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

(2010) Yohei Morita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of bleeding and thrombotic events during long-term use of romiplostim in patients with chronic immune thrombocytopenia (ITP)

(2010) T. B. GERNSHEIMER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study

(2010) Gregory Cheng et al.   LANCET

Reduced proliferation of non-megakaryocytic acute myelogenous leukemia and other leukemia and lymphoma cell lines in response to eltrombopag

(2010) Connie L. Erickson-Miller et al.   LEUKEMIA RESEARCH

Genetic Analysis of Hierarchical Regulation for Gata1 and NF-E2 p45 Gene Expression in Megakaryopoiesis

(2010) Mariko Takayama et al.   MOLECULAR AND CELLULAR BIOLOGY

Romiplostim or Standard of Care in Patients with Immune Thrombocytopenia

(2010) David J. Kuter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Efficacy of Romiplostim in the Treatment of Chemotherapy Induced Thrombocytopenia (CIT) in a Patient with Mantle Cell Lymphoma

(2010) Judit Demeter et al.   PATHOLOGY & ONCOLOGY RESEARCH

Biology and Chemistry of Thrombopoietic Agents

(2010) David J. Kuter   SEMINARS IN HEMATOLOGY

Apoptotic Processes in Megakaryocytes and Platelets

(2010) Michael J. White et al.   SEMINARS IN HEMATOLOGY

Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation

(2009) M. Dominici et al.   BLOOD

Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim

(2009) D. J. Kuter et al.   BLOOD

Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation

(2009) C. Graziano et al.   BLOOD

Effect of the nonpeptide thrombopoietin receptor agonist Eltrombopag on bone marrow cells from patients with acute myeloid leukemia and myelodysplastic syndrome

(2009) B. Will et al.   BLOOD

International consensus report on the investigation and management of primary immune thrombocytopenia

(2009) D. Provan et al.   BLOOD

Comparative analyses of the small molecule thrombopoietin receptor agonist eltrombopag and thrombopoietin on in vitro platelet function

(2009) Joseph A. Erhardt et al.   EXPERIMENTAL HEMATOLOGY

Hereditary thrombocytosis caused by MPLSer505Asn is associated with a high thrombotic risk, splenomegaly and progression to bone marrow fibrosis

(2009) L. Teofili et al.   HAEMATOLOGICA

Infectious Causes of Chronic Immune Thrombocytopenia

(2009) Roberto Stasi et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Safety and Efficacy of Romiplostim in Patients With Lower-Risk Myelodysplastic Syndrome and Thrombocytopenia

(2009) Hagop Kantarjian et al.   JOURNAL OF CLINICAL ONCOLOGY

Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial

(2009) James B Bussel et al.   LANCET

Identification of miR-145 and miR-146a as mediators of the 5q– syndrome phenotype

(2009) Daniel T Starczynowski et al.   NATURE MEDICINE

Myeloproliferative neoplasms: contemporary diagnosis using histology and genetics

(2009) Ayalew Tefferi et al.   Nature Reviews Clinical Oncology

Management of Chemotherapy-Induced Thrombocytopenia: Current Status of Thrombopoietic Agents

(2009) Saroj Vadhan-Raj   SEMINARS IN HEMATOLOGY

Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP

(2008) J. B. Bussel et al.   BLOOD

Familial thrombocytosis caused by the novel germ-line mutation p.Pro106Leu in theMPLgene

(2008) El-Harith Abdelghaffar El-Harith et al.   BRITISH JOURNAL OF HAEMATOLOGY

MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors

(2008) Jun Lu et al.   DEVELOPMENTAL CELL

Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

(2008) David J Kuter et al.   LANCET

Preclinical Activity of Eltrombopag (SB-497115), an Oral, Nonpeptide Thrombopoietin Receptor Agonist

(2008) Connie L. Erickson-Miller et al.   STEM CELLS