Article
Endocrinology & Metabolism
Cicely V. M. Barron, Helen F. Heenan, Harmony Thompson, Huan Chan, Jeffrey Ngu, Helen Lunt
Summary: In individuals with compensated cirrhosis, OGTT and HbA(1c) remain the standard screening tests for diabetes, but multiple studies indicate that OGTT diagnoses more people with dysglycaemia than HbA(1c). Additionally, using blinded CGM in an ambulatory, real world setting provides additional insights into glycaemic excursions but is not suitable for diagnosing dysglycaemia.
Article
Endocrinology & Metabolism
Guanhua Chen, Rui Zhang, Chunlu Tan, Xubao Liu, Lei Yu, Yonghua Chen
Summary: Using HbA1c alone as a diagnostic criterion for diabetes may not be sensitive enough in patients with pancreatic diseases. The optimal values of 5.8% and 6.0% for HbA1c improved the accuracy of diagnosing prediabetes and diabetes and should be considered. Furthermore, combining HbA1c and FPG tests is advocated for diagnosing diabetes in patients with pancreatic diseases.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Daria Di Filippo, Justine Darling, Melissa Han Yiin Chang, Amanda Henry, Alec Welsh
Summary: This study aimed to assess the perception of the oral glucose tolerance test (OGTT) and continuous glucose monitoring as diagnostic tools for gestational diabetes mellitus (GDM). The results showed that continuous glucose monitoring was better tolerated than OGTT and 93% of participants recommended it for GDM diagnosis. However, concerns were raised about the cost, accessibility, and accuracy of continuous glucose monitoring for GDM diagnosis.
ARCHIVES OF GYNECOLOGY AND OBSTETRICS
(2023)
Review
Endocrinology & Metabolism
Jared G. Friedman, Kasey Coyne, Grazia Aleppo, Emily D. Szmuilowicz
Summary: Hemoglobin A1c (HbA1c) is an important indicator for diabetes management, but its interpretation is often confounded by non-glycemic factors. It only provides average glycemic information and cannot reflect glucose trends or hypoglycemia/hyperglycemia episodes. Therefore, HbA1c alone is not sufficient to guide targeted therapy for many diabetes patients.
ENDOCRINE CONNECTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Adam G. Tabak, Eric J. Brunner, Joni Lindbohm, Archana Singh-Manoux, Martin J. Shipley, Naveed Sattar, Mika Kivimaki
Summary: The study found that more than 40% of OGTT-diagnosed diabetes cases were not confirmed by HbA1c during extended follow-up, but these individuals had a risk of cardiovascular disease and chronic kidney disease similar to that of the diabetes-free population, supporting the replacement of OGTT with HbA1c-based diagnosis.
Article
Pediatrics
Bojana Gojsina, Predrag Minic, Sladjana Todorovic, Ivan Soldatovic, Aleksandar Sovtic
Summary: The study evaluated the impact of cystic fibrosis-related diabetes (CFRD) on lung disease and nutritional status. It was found that continuous glucose monitoring is a useful tool for insight into glucose impairment and diagnosis of CFRD, and early recognition and therapeutic intervention of CFRD has favorable effects on the clinical course of the disease.
FRONTIERS IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, Aini H. Bloigu, Auni Juutilainen, Cristina Bianchi, Lucia La Sala, Ranjit Mohan Anjana, Rajendra Pradeepa, Ulagamadesan Venkatesan, Sarvanan Jebarani, Viswanathan Baskar, Teresa Vanessa Fiorentino, Patrick Timpel, Ralph A. DeFronzo, Antonio Ceriello, Stefano Del Prato, Muhammad Abdul-Ghani, Sirkka Keinanen-Kiukaanniemi, Rachel Dankner, Peter H. Bennett, William C. Knowler, Peter Schwarz, Giorgio Sesti, Rie Oka, Viswanathan Mohan, Leif Groop, Jaakko Tuomilehto, Samuli Ripatti, Michael Bergman, Tiinamaija Tuomi
Summary: The 1-h PG of >= 11.6 mmol/L during OGTT has good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator is suggested to reduce the proportion of false-positive cases, with further studies needed for other ethnic groups and complication risk assessment.
Article
Obstetrics & Gynecology
L. Hiersch, B. R. Shah, H. Berger, M. Geary, S. D. McDonald, B. Murray-Davis, J. Guan, I Halperin, R. Retnakaran, J. Barrett, N. Melamed
Summary: This study identified potential twin-specific OGTT thresholds for gestational diabetes mellitus that are associated with a similar risk of future type-2 diabetes to that observed in women diagnosed with GDM in singleton pregnancies based on standard OGTT thresholds.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Endocrinology & Metabolism
Feng Yu Kuo, Kai-Chun Cheng, Yingxiao Li, Juei-Tang Cheng
Summary: The oral glucose tolerance test (OGTT) is widely used for diagnosing impaired glucose tolerance and type 2 diabetes, as well as studying glucose utilization and insulin sensitivity. Recent clinical practice recommendations include using 30-min or 1-h post-glucose load glycemia. In basic research, the incremental area under the curve is not suitable for studies involving animals receiving repeated or chronic treatment.
WORLD JOURNAL OF DIABETES
(2021)
Article
Pediatrics
Erin Finn, Cameron Severn, Laura Pyle, Justin Garrish, Timothy Vigers, Cecilia G. Diniz Behn, Philip S. Zeitler, Scott D. Sagel, Kristen J. Nadeau, Christine L. Chan
Summary: This study evaluated hypoglycemia in children and young adults with CF using OGTT and CGM. The results showed that the rate of hypoglycemia on OGTT was similar in CF patients compared to healthy controls. CF patients had higher A1c, glucose peaks, and insulin peaks on OGTT, as well as more glucose variability on CGM. CF patients with hypoglycemia on OGTT had better lung function, higher insulin sensitivity, and lower CGM variability. However, their glucagon response to hypoglycemia was blunted. OGTT hypoglycemia was not associated with free-living hypoglycemia.
PEDIATRIC PULMONOLOGY
(2023)
Article
Obstetrics & Gynecology
Daria Di Filippo, Amanda Henry, Chloe Bell, Sarah Haynes, Melissa Han Yiin Chang, Justine Darling, Alec Welsh
Summary: This study aimed to evaluate the acceptability of Freestyle Libre Pro 2 as a diagnostic test for gestational diabetes mellitus (GDM), and to validate its results with OGTT and GDM risk factors. The results showed that CGM was a more acceptable alternative for GDM diagnosis. Triangulation analysis revealed both false positive and false negative results from OGTT screening.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Endocrinology & Metabolism
Anne Bonhoure, Kathryn J. Potter, Johann Colomba, Valerie Boudreau, Cindy Bergeron, Katherine Desjardins, Maite Carricart, Francois Tremblay, Annick Lavoie, Remi Rabasa-Lhoret
Summary: In cystic fibrosis patients, maximum OGTT glucose (Gmax) is strongly associated with the risk of developing CFRD; Gmax < 8 mmol/l may identify those at very low risk of future CFRD; additionally, individuals with higher Gmax are more likely to have pancreatic insufficiency, poor insulin secretory capacity, and impaired pulmonary function.
Article
Obstetrics & Gynecology
Tatiana A. Zaccara, Fernanda C. F. Mikami, Cristiane F. Paganoti, Rossana P. Francisco, Rafaela A. Costa
Summary: The study found that there are distinct characteristics in pregnant women with gestational diabetes who require insulin treatment, such as higher BMI, history of previous gestational diabetes, and chronic hypertension. By analyzing patient data, we can predict the risk of needing insulin treatment, which can help allocate resources and provide closer follow-up to high-risk patients.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Chemistry, Analytical
Yiqun Liu, Li Yang, Yue Cui
Summary: Diabetes is a prevalent and chronic metabolic disease, and continuous monitoring is crucial for its management. Transdermal glucose biosensors offer accurate monitoring, but face challenges in biosensing principles, device configuration, and material integration. This review aims to address these questions and explore the practical applications of transdermal glucose biosensors.
Article
Endocrinology & Metabolism
Viral N. Shah, Halis K. Akturk, Tim Vigers, Laura Pyle, Nick Oliver, David C. Klonoff
Summary: Daytime versus nighttime glycemic control has similar influence on A1C in adults with T1D.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
