Article
Hematology
Wenjing Cao, Aria R. Trask, Antonia I. Bignotti, Lindsey A. George, Bhavya S. Doshi, Denise E. Sabatino, Noritaka Yada, Liang Zheng, Rodney M. Camire, X. Long Zheng
Summary: This study aims to determine the effect of FVIII on VWF proteolysis and homeostasis. Through mouse models, recombinant FVIII infusion, and patients with hemophilia A, the study concludes that FVIII plays a pivotal role in regulating VWF proteolysis and homeostasis under various conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Cornelia Englisch, Florian Moik, Stephan Nopp, Markus Raderer, Ingrid Pabinger, Cihan Ay
Summary: Non-O blood type is associated with increased VTE risk in cancer patients, particularly after 3 months and in patients with intermediate and low-risk tumor types.
Review
Hematology
Salah Elsherif, Ali Zidan, Olivia Saville, Maha Othman
Summary: Cancer-associated thrombosis, especially venous thromboembolism, is associated with ABO blood groups, with non-O blood type and increased VWF levels showing a strong correlation with increased VTE risk. However, there are varying results in different studies and more research is needed to understand the role of ABO blood groups and other risk factors in different cancer types.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Article
Medicine, General & Internal
Aurore Collet, Christophe Zawadzki, Emmanuelle Jeanpierre, Caroline Kitel, Sylvain Dubucquoi, Eric Hachulla, Sophie Susen, David Launay
Summary: Systemic sclerosis (SSc) is associated with endothelial activation and fibrosis. Non-O blood group is linked to higher risk of thrombosis, fibrosis and autoimmune diseases. The distribution of ABO groups in SSc patients is similar to the general population, but non-O groups are associated with inflammation and endothelial activation, and a slightly higher frequency of pulmonary and vascular complications in SSc.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Louisa Goumidi, Florian Thibord, Kerri L. Wiggins, Ruifang Li-Gao, Mickael R. Brown, Astrid van Hylckama Vlieg, Joan-Carles Souto, Jose-Manuel Soria, Manal Ibrahim-Kosta, Noemie Saut, Delphine Daian, Robert Olaso, Philippe Amouyel, Stephanie Debette, Anne Boland, Pascal Bailly, Alanna C. Morrison, Denis O. Mook-Kanamori, Jean-Francois Deleuze, Andrew Johnson, Paul S. de Vries, Maria Sabater-Lleal, Jacques Chiaroni, Nicholas L. Smith, Frits R. Rosendaal, Daniel Chasman, David-Alexandre Tregouet, Pierre-Emmanuel Morange
Summary: Genetic risk score analysis is commonly used to predict individual risk for complex diseases. In the case of venous thrombosis, it is recommended to use 4 SNPs to assess the impact of the ABO locus on risk, as different haplotypes have varying associations with VT risk. Further research is needed to fully understand the biological effects of the ABO locus on cardiovascular traits.
Article
Biochemistry & Molecular Biology
Marcela Montilla, Isabel Atienza-Navarro, Francisco Jose Garcia-Cozar, Carmen Castro, Francisco Javier Rodriguez-Martorell, Felix A. Ruiz
Summary: Polyphosphate (polyP) plays an important modulatory role in the binding of von Willebrand factor (VWF) and Factor VIII (FVIII) in blood coagulation, and may be used in developing new therapies to activate VWF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Eugenia Biguzzi, Simona Maria Siboni, Saskia le Cessie, Luciano Baronciani, Frits R. Rosendaal, Astrid van Hylckama Vlieg, Flora Peyvandi
Summary: The study evaluated the differential increase of VWF and FVIII:C with age among different ages and types of VWD.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Magnus S. Edvardsen, Ellen-Sofie Hansen, Thor Ueland, Pal Aukrust, Sigrid K. Braekkan, Vania M. Morelli, John-Bjarne Hansen
Summary: This study found that decreased ADAMTS-13 levels and an imbalance in the VWF/ADAMTS-13 ratio were associated with an increased risk of future venous thromboembolism, suggesting the involvement of the VWF-ADAMTS-13 axis in the pathogenesis of VTE.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Einas Elsheikh, Michelle Lavin, Lilian Antunes Heck, Niamh Larkin, Brendan Mullaney, Dearbhla Doherty, Megan Kennedy, Catriona Keenan, Thomas Guest, Brian O'Mahony, Judicael Fazavana, Padraic G. Fallon, Roger J. S. Preston, John Gormley, Kevin Ryan, Niamh M. O'Connell, Evelyn Singleton, Mary Byrne, Mark McGowan, Sheila Roche, Mairead Doyle, Maeve P. Crowley, Susan I. O'Shea, Birgit M. Reipert, Jill M. Johnson, Steven W. Pipe, Jorge Di Paola, Peter L. Turecek, James S. O'Donnell, iPATH study Grp
Summary: This study found that the variability in the half-life of FVIII concentrates in patients with hemophilia A is primarily due to differences in clearance of endogenous VWF. ABO blood group and age have significant impacts on FVIII clearance. The effect of ABO blood group on FVIII half-life is modulated through its impact on clearance rates of endogenous VWF, while age-related effect on FVIII clearance is partly independent of VWF.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Linru Xu, Yanyang Qiu, Yanqing Li, Yaxuan Wei, Yan Wan, Wei Deng
Summary: A new fluorescent protein-VWF chimera (FP-VWF) was developed to monitor the tissue dynamics of VWF distribution, showing similar hematologic function to wild-type VWF. The results indicated the value of FP-VWF in probing the tissue dynamics of VWF in various biological and pharmaceutical applications.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Editorial Material
Hematology
Emma-Ruoqi Xu, Jonas Emsley
Summary: In this issue of Blood, Fuller et al reveal the first detailed structure of the key hemostatic complex formed between factor VIII (FVIII) and von Willebrand factor (VWF).
Article
Hematology
Hiroaki Yaoi, Yasuaki Shida, Takehisa Kitazawa, Midori Shima, Keiji Nogami
Summary: Patients with Type 2N von Willebrand disease showed defective thrombus formation correlated with bleeding phenotype, which was improved by Emicizumab, enhancing thrombin generation and fibrin formation. The interactions between FVIII and VWF play an important role in platelet-fibrin interactions during thrombus formation and may be targeted as an alternative therapy for these patients.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Justine H. Ryu, Kenneth A. Bauer, Sol Schulman
Summary: This report describes the successful perioperative management of a patient with type 2N VWD using the recombinant FVIII product efanesoctocog alfa. By decoupling the FVIII-VWF interaction, efanesoctocog alfa achieves prolonged FVIII circulation and mitigates potential cardiovascular risks.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Samuel G. Rayner, Zackary Scholl, Christian J. Mandrycky, Junmei Chen, Karina N. LaValley, Peter J. Leary, William A. Altemeier, W. Conrad Liles, Dominic W. Chung, Jose A. Lopez, Hongxia Fu, Ying Zheng
Summary: This study investigates the interaction between VWF and fibrin and suggests that rapid release of endothelial VWF during clotting may support fibrin polymerization and accelerate thrombosis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Engineering, Biomedical
Noel G. Tsyu, Aleksey V. Belyaev
Summary: A multi-subunit glycoprotein called Von Willebrand factor (VWF) in blood plasma is responsible for mediating platelet adhesion to damaged blood vessel walls. The adhesion of VWF to collagen is crucial for platelet hemostasis and thrombosis, acting as a molecular bridge between injury and platelet adhesion receptors. This study proposes a simulation framework for VWF-mediated platelet adhesion under the influence of shear flow, using particles representing VWF multimers and platelets immersed in a viscous fluid. The model considers the flattened platelet shape and balances detail of description with computational complexity.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
(2023)
Letter
Hematology
M. Lavin, P. V. Jenkins, C. Keenan, B. White, D. R. Betts, J. S. O'Donnell, N. M. O'Connell
Letter
Hematology
M. Lavin, P. V. Jenkins, M. L. Healy, M. Byrne, N. M. O'Connell, J. S. O'Donnell
Article
Hematology
Jamie M. O'Sullivan, P. Vince Jenkins, Orla Rawley, Kristina Gegenbauer, Alain Chion, Michelle Lavin, Barry Byrne, Richard O'Kennedy, Roger J. S. Preston, Teresa M. Brophy, James S. O'Donnell
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2016)
Letter
Hematology
R. C. Trickey, C. Percy, P. V. Jenkins, R. Harris, C. Loran, P. W. Collins
Article
Biochemistry & Molecular Biology
Sarah N. Lauder, Keith Allen-Redpath, David A. Slatter, Maceler Aldrovandi, Anne O'Connor, Daniel Farewell, Charles L. Percy, Jessica E. Molhoek, Sirpa Rannikko, Victoria J. Tyrrell, Salvatore Ferla, Ginger L. Milne, Alastair W. Poole, Christopher P. Thomas, Samya Obaji, Philip R. Taylor, Simon A. Jones, Phillip G. de Groot, Rolf T. Urbanus, Sohvi Horkko, Stefan Uderhardt, Jochen Ackermann, P. Vince Jenkins, Andrea Brancale, Gerhard Kronke, Peter W. Collins, Valerie B. O'Donnell
Article
Biochemistry & Molecular Biology
Sarah N. Lauder, Keith Allen-Redpath, David A. Slatter, Maceler Aldrovandi, Anne O'Connor, Daniel Farewell, Charles L. Percy, Jessica E. Molhoek, Sirpa Rannikko, Victoria J. Tyrrell, Salvatore Ferla, Ginger L. Milne, Alastair W. Poole, Christopher P. Thomas, Samya Obaji, Philip R. Taylor, Simon A. Jones, Phillip G. de Groot, Rolf T. Urbanus, Sohvi Horkko, Stefan Uderhardt, Jochen Ackermann, P. Vince Jenkins, Andrea Brancale, Gerhard Kronke, Peter W. Collins, Valerie B. O'Donnell
Editorial Material
Biochemistry & Molecular Biology
Steve Keeney, Tony Cumming, P. Vincent Jenkins, James S. O'Donnell, Michael J. Nash
EUROPEAN JOURNAL OF HUMAN GENETICS
(2011)
Editorial Material
Biochemistry & Molecular Biology
Anthony M. Cumming, Stephen Keeney, P. Vincent Jenkins, Michael J. Nash, James S. O'Donnell
EUROPEAN JOURNAL OF HUMAN GENETICS
(2011)
Editorial Material
Biochemistry & Molecular Biology
Peter Vincent Jenkins, Catriona Keenan, Steve Keeney, Tony Cumming, James S. O'Donnell
EUROPEAN JOURNAL OF HUMAN GENETICS
(2012)
Article
Hematology
Leanne F. Harris, Vanessa Castro-Lopez, P. Vince Jenkins, James S. O'Donnell, Anthony J. Killard
THROMBOSIS RESEARCH
(2011)
Article
Hematology
P. Vincent Jenkins, Annette Bowyer, Clive Burgess, Elaine Gray, Steve Kitchen, Paul Murphy, Sean Platton, Anne Riddell, Pratima Chowdary, Will Lester
Review
Hematology
Elaine Gray, Steve Kitchen, Annette Bowyer, Pratima Chowdary, P. Vincent Jenkins, Paul Murphy, Sean Platton, Anne Riddell, Will Lester
Article
Hematology
Annette Bowyer, Elaine Gray, Anna Lowe, Paul Murphy, Sean Platton, Anne Riddell, Pratima Chowdary, Will Lester, Peter Vincent Jenkins
Summary: This guideline examines the laboratory monitoring of rpFVIII in patients with acquired haemophilia A (AHA) and recommends the use of a one-stage clotting FVIII assay for measurement and regular monitoring. The evaluation of cross-reacting rpFVIII inhibitors using a one-stage porcine Bethesda assay is also recommended for initial diagnosis or prior to rpFVIII treatment. It is important to consider the underestimation of rpFVIII using chromogenic FVIII assays in patients receiving Emicizumab.
Article
Medicine, Research & Experimental
David A. Slatter, Charles L. Percy, Keith Allen-Redpath, Joshua M. Gajsiewicz, Nick J. Brooks, Aled Clayton, Victoria J. Tyrrell, Marcela Rosas, Sarah N. Lauder, Andrew Watson, Maria Dul, Yoel Garcia-Diaz, Maceler Aldrovandi, Meike Heurich, Judith Hall, James H. Morrissey, Sebastien Lacroix-Desmazes, Sandrine Delignat, P. Vincent Jenkins, Peter W. Collins, Valerie B. O'Donnell