期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 157, 期 3, 页码 321-330出版社
WILEY
DOI: 10.1111/j.1365-2141.2012.09067.x
关键词
Hodgkin lymphoma; lymphocytes; monocytes; prognostic factors
类别
The pathological background in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) consists of lymphocytes and histocytes. This study analysed the peripheral blood absolute lymphocyte count/absolute monocyte count ratio at diagnosis (ALC/AMC-DX) on the impact of survival in NLPHL. One hundred and three consecutive NLPHL patients that were followed at Mayo Clinic from 1974 to 2010 were included in the study. Receiver operating characteristic and area under the curve were used for ALC/AMC-DX cut-off value analysis and proportional-hazards models were used to compare survival based on the ALC/AMC-DX ratio. With a median follow-up of 8.9 years (range: 0.331 years), an ALC/AMC-DX =2.1 was the best cut-off value for survival with an area under the curve of 0.82, a sensitivity of 70% and specificity of 84%. After adjusting for the International Prognostic Score (IPS), ALC/AMC-DX remained an independent prognostic factor for overall survival [Hazard Ratio (HR), 0.33, 95% confidence interval (CI), 0.150.71%, P < 0.004]; lymphoma-specific survival (HR, 0.05; 95%CI, 0.010.68%, P < 0.002); progression-free survival (HR, 0.30; 95%CI, 0.140.60%, P < 0.006), and time to progression (HR, 0.06, 95%CI, 0.040.30%, P < 0.004). ALC/AMC-DX is a low cost, already standarized, biomarker to predict clinical outcomes in NLPHL.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据