Article
Biochemistry & Molecular Biology
Amelie I. S. Sobczak, Ramzi A. Ajjan, Alan J. Stewart
Summary: The presence of zinc ions can affect the neutralization of GAGs by HRG and fibrinogen, which is essential for the initiation of coagulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Oluwadolapo D. Lawal, Herbert D. Aronow, Fisayomi Shobayo, Anne L. Hume, Tracey H. Taveira, Kelly L. Matson, Yichi C. Zhang, Xuerong R. Wen
Summary: This study compared the effectiveness and safety of direct oral anticoagulants (DOACs) with warfarin in patients with atrial fibrillation (AF) and chronic liver disease. The results showed that DOACs as a class were associated with lower risks of hospitalization for ischemic stroke/systemic embolism and major bleeding compared to warfarin. However, the outcomes varied between different DOACs and in head-to-head comparisons with warfarin.
Article
Cardiac & Cardiovascular Systems
Thomas A. Zelniker, Maddalena Ardissino, Felicita Andreotti, Michelle L. O'Donoghue, Ophelia Yin, Jeong-Gun Park, Sabina A. Murphy, Christian T. Ruff, Hans J. Lanz, Elliott M. Antman, Eugene Braunwald, Robert P. Giugliano, Piera Angelica Merlini
Summary: Despite baseline differences and higher endogenous factor Xa levels in women, anticoagulation intensity with edoxaban was similar between sexes. Higher-dose edoxaban regimen showed greater reduction in hemorrhagic stroke and serious bleeding outcomes in women compared to men. Efficacy profile was similar between sexes.
Article
Primary Health Care
Angel Y. S. Wong, Laurie Tomlinson, Jeremy P. Brown, William Elson, Alex J. Walker, Anna Schultze, Caroline E. Morton, David Evans, Peter Inglesby, Brian MacKenna, Krishnan Bhaskaran, Christopher Rentsch, Emma Powell, Elizabeth Williamson, Richard Croker, Seb Bacon, William Hulme, Chris Bates, Helen J. Curtis, Amir Mehrkar, Jonathan Cockburn, Helen McDonald, Rohini Mathur, Kevin Wing, Harriet Forbes, Rosalind M. Eggo, Stephen J. W. Evans, Liam Smeeth, Ben Goldacre, Ian J. Douglas
Summary: This study investigated the association between routinely prescribed oral anticoagulants (OACs) and COVID-19 outcomes in patients with atrial fibrillation. The results showed that individuals receiving OACs had a lower risk of COVID-19 infection and severe outcomes compared to non-users.
BRITISH JOURNAL OF GENERAL PRACTICE
(2022)
Article
Biochemistry & Molecular Biology
Vera G. Matveeva, Evgenia A. Senokosova, Viktoriia V. Sevostianova, Mariam Yu Khanova, Tatiana Glushkova, Tatiana N. Akentieva, Larisa Antonova, Leonid S. Barbarash
Summary: This study presents a protocol for preparing autologous fibrin without the use of endogenous thrombin and compares its properties with traditionally prepared fibrin. The results show that the proposed approach leads to the fabrication of a completely autologous coating material with improved mechanical properties, higher resistance to proteolysis, and lower thrombogenicity.
Article
Cardiac & Cardiovascular Systems
Karlyn A. Martin, Nicola Lancki, Celina Li, M. Elaine Eyster, Kristen Sanfilippo, Isabela A. Woller, Scott C. Woller, Lisa Baumann Kreuziger, Rachel P. Rosovsky
Summary: This study compared the effectiveness and safety of DOACs and warfarin for the treatment of VTE in obese patients. It found that DOACs and warfarin had similar rates of VTE recurrence in obese patients, but DOACs were associated with lower rates of major bleeding.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Cardiac & Cardiovascular Systems
Lauren Cline, Erika Marie G. Generoso, Nicholas D'Apice, Sara K. Dellinger, Amber Tovey, Nathan P. Clark, Fang Nui, Rita Hui, Stephanie A. Hale, Tanya Ramsey, Kimi Pontoppidan, Hasmig Ekmekdjian, Kristen Fink, Daniel M. Witt, Mark A. Crowther, Thomas Delate
Summary: This study aimed to compare the efficacy and safety of direct oral anticoagulants (DOAC) and warfarin in patients with advanced renal insufficiency. The study showed that there was no significant difference in effectiveness and safety between DOAC and warfarin for the treatment of venous thromboembolism in patients with a creatinine clearance < 30 mL/min.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2023)
Article
Hematology
Gregory Pon, Brittany Pelsue, Sujan Teegala Reddy, Kaushik Parsha, Xu Zhang, Brian Gulbis, Andrew Barreto, Sean I. Savitz, Miguel Escobar, Teresa A. Allison
Summary: This study aimed to evaluate the hemostatic efficacy of 4-F PCC in intracerebral hemorrhage patients who received factor Xa inhibitors versus warfarin. The results showed no significant difference in hemostatic efficacy or clinical outcomes between patients taking warfarin or a factor Xa inhibitor following reversal with 4-F PCC.
THROMBOSIS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xu Wang, Dai-Yan Zhang, Shi-Jun Yin, Hui Jiang, Min Lu, Feng-Qing Yang, Yuan-Jia Hu
Summary: In this study, a spectrum-effect relationship analysis combined with LC-MS was used to identify active components in Danshen-Chuanxiong herbal pair that can inhibit thrombin and factor Xa. Six potential compounds were tested, with chlorogenic acid showing good THR inhibitory activity, and tanshinone I and tanshinone IIA identified as potential FXa inhibitors. Molecular docking results suggest the interaction of tanshinone I and tanshinone IIA with FXa by forming H-bonds with specific residues.
Article
Pharmacology & Pharmacy
J. Robert Powell, Farah Al Qaraghuli, Jill Fiedler-Kelly, Daniel Gonzalez, Daniel Weiner
Summary: Dabigatran, a direct-acting oral anticoagulant, is more effective than warfarin in stroke reduction and has similar bleeding risk in adult patients with atrial fibrillation. Its efficacy and safety correlate with steady-state plasma concentrations. A population pharmacokinetic model based on clinical trial patients was used to compare different dosing regimens, and an improved regimen requiring five different dosing schedules was identified. This information can better inform patient outcomes and guide future dabigatran development.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Cardiac & Cardiovascular Systems
Hugo ten Cate, Tomasz J. Guzik, John Eikelboom, Henri M. H. Spronk
Summary: Atherosclerosis is a chronic inflammatory disease that leads to cardiovascular morbidity and mortality. Endothelial dysfunction, vascular smooth muscle cell activation, and vascular inflammation play essential roles in the development of acute cardiovascular events. The effects of the coagulation system on vascular biology extend beyond thrombosis.
CARDIOVASCULAR RESEARCH
(2021)
Article
Hematology
Emma G. Bouck, Frederik Denorme, Lori A. Holle, Elizabeth A. Middelton, Antoinette M. Blair, Bas de Laat, Joshua D. Schiffman, Christian Con Yost, Matthew T. Rondina, Alisa S. Wolberg, Robert A. Campbell
Summary: COVID-19 and sepsis both involve activation of endogenous coagulation and fibrinolysis, but impact plasma procoagulant and fibrinolytic potential differently. Dysregulation of procoagulant and fibrinolytic pathways may uniquely contribute to the pathophysiology of COVID-19 and sepsis.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Obstetrics & Gynecology
Ana Luisa Areia, Anabela Mota-Pinto
Summary: The use of direct oral anticoagulants (DOACs) during pregnancy poses safety concerns despite their practical advantages over low molecular weight heparin. A systematic review of studies on DOACs usage in pregnancy found a higher rate of fetal loss and fetal abnormalities compared to LMWH, although bleeding complications were similar.
JOURNAL OF PERINATAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander C. Fanaroff, Amit N. Vora, Renato D. Lopes
Summary: Non-vitamin K antagonist oral anticoagulants (NOACs) have revolutionized the management of atrial fibrillation (AF), but their use in patients with valvular heart disease remains controversial. While NOACs are recommended over vitamin K antagonists (VKAs) in patients with valvular heart disease other than mechanical prosthetic valves or severe mitral stenosis, more research is needed to determine their safety and effectiveness in other types of valvular heart disease.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2022)
Article
Chemistry, Applied
Yuting Shi, Wenwen Yu, Xiaoqin Liang, Ju Cheng, Yufei Cao, Mingsheng Liu, Yu Fang, Zheng Yang, Hongbin Liu, Hua Wei, Guanghui Zhao
Summary: Preventing arterial hemorrhage is crucial, but current hemostatic materials are not effective in extreme conditions. Therefore, we developed an expansion sponge based on chitosan and plasma, which provides a simpler and more efficient method for treating high-pressure arterial bleeding wounds.
CARBOHYDRATE POLYMERS
(2023)