期刊
BRITISH JOURNAL OF HAEMATOLOGY
卷 156, 期 3, 页码 383-387出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2141.2011.08914.x
关键词
paroxysmal nocturnal haemoglobinuria; clonal expansion; haemolytic anaemia; haematopoietic stem cell; HMGA2
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology
- Ministry of Health, Labour and Welfare of Japan
- Grants-in-Aid for Scientific Research [22791813, 22591067, 21590326, 23590363, 21247018, 22591044] Funding Source: KAKEN
Patients with paroxysmal nocturnal haemoglobinuria (PNH) have expanded clonal cells bearing a somatic mutation in the PIGA gene. Our previous study on two PNH patients with chromosome 12 rearrangements demonstrated the involvement of HMGA2 expression in clonal expansion. The present study investigated HMGA2 expression in PNH patients without chromosomal abnormalities. The expression of short HMGA2 with latent exon was significantly high in peripheral blood cells from 18 of 24 patients. Over-expression of truncated HMGA2 in mouse bone marrow cells caused expansion in recipient mice. These results support the idea that deregulated expression of HMGA2 causes expansion of PNH cells.
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