Review
Otorhinolaryngology
M. Alwan, G. Hurtado
Summary: Sensorineural hearing loss following spinal anesthesia, epidural anesthesia or lumbar puncture is a rare but significant complication that requires prompt attention and management.
JOURNAL OF LARYNGOLOGY AND OTOLOGY
(2022)
Article
Chemistry, Medicinal
Wan-Yi Rao, Fang Xu, Shao-Bing Dai, Zhong Mei, Xiao-Ping Chen, Chang-Cheng Lv, Chun-Lei Liu, Warwick Ngan Kee, Xin-Zhong Chen
Summary: This study compared three different anesthesia techniques and found that DPE anesthesia had a faster onset, shorter duration of surgical sensory block, lower incidence of intraoperative pain, and higher patient satisfaction compared to EA anesthesia. Additionally, DPE anesthesia had less impact on maternal hemodynamic parameters compared to CSE anesthesia, suggesting its effectiveness in obstetric surgery.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Anesthesiology
Jessica R. Ansari, Meredith Barad, Steven Shafer, Pamela Flood
Summary: The study found that women who experienced unintentional dural puncture had a higher prevalence of chronic disabling headache at 2 and 6 months postpartum, but there was no significant difference in back pain prevalence.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Article
Agriculture, Dairy & Animal Science
Fernando Martinez-Taboada, Tsim Christopher Sun, Jose Ignacio Redondo
Summary: This study compared the technical aspects of epidural anaesthesia, spinal anaesthesia, and dural puncture epidural anaesthesia in animals. Results showed no difference in the number of attempts required between the techniques, but epidural injections tended to be shorter. The onset of action was longest in sacrococcygeal epidural injections.
Article
Clinical Neurology
D. Veiga-Canuto, M. Cifrian-Perez, I Pitarch-Castellano, J. F. Vazquez-Costa, F. Aparici
Summary: The study demonstrates that ultrasound-guided lumbar puncture is a safe and effective method for treating spinal muscular atrophy patients with complex spine diseases, with a high success rate and few observed adverse events.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Medicine, General & Internal
Motaz Hamed, Harun Asoglu, Tim Lampmann, Lena Marie Winkelmann, Abdallah Salemdawod, Martin Mueller, Hartmut Vatter, Mohammed Banat, Lars Eichhorn
Summary: This study compared epidural analgesia (EA) with systemic analgesia (SA) for pain reduction and early postoperative complications after SDI. The SA group had significantly lower pain rating scores and lower cumulative opioid use compared to the EA group. There were no differences in infection, length of hospital stay, or surgery-related complications between the two groups.
Article
Medicine, General & Internal
Keshi Yang, Changbin Ji, Dawei Luo, Kunpeng Li, Hui Xu
Summary: Lumbar spinal epidural lipomatosis (SEL) is a rare condition characterized by excessive overgrowth of extradural fat within the lumbar spinal canal. Surgical decompression is commonly performed to treat symptomatic SELs. In this study, a new surgical approach was introduced for treating lumbar SEL, which resulted in significant improvement in symptoms for the patient.
Article
Medicine, General & Internal
Yin Zhou, Zhiyu Geng, Linlin Song, Dongxin Wang
Summary: This study evaluated the role of hydroxyethyl starch (HES) in preventing postdural puncture headache (PDPH) after accidental dural puncture (ADP) during obstetric epidural procedures. It found that the incorporated prophylactic strategy, including epidural catheter re-siting, continuous epidural analgesia, and two doses of epidural HES, was associated with a significant decrease in the risk of PDPH, and no neurological deficits were reported.
CHINESE MEDICAL JOURNAL
(2023)
Article
Computer Science, Artificial Intelligence
Jiaxin Lu, Zekai Huang, Baiyang Zhuang, Zhuoqi Cheng, Jing Guo, Haifang Lou
Summary: This study introduces a novel robot-assisted puncture system that utilizes tissue recognition to enhance the precision and security of lumbar punctures and related procedures.
FRONTIERS IN NEUROROBOTICS
(2023)
Article
Medicine, General & Internal
Gisha V. Mathew, Khalil Shibli, Noureddine Korichi, Venkatesh B. Thippeswamy
Summary: Post-dural puncture headache can progress to subdural hematoma, necessitating vigilance and prompt diagnosis and treatment.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Medicine, General & Internal
Emmanuel Oladeji, Kuran Rati, Kamila Rakhimova, Nigel Day
Summary: This article reports a case of a middle-aged female patient presenting as a surgical emergency with abdominal pain and a positive Obraztsova's sign. A lumbar puncture had been performed a week prior to the presentation to investigate severe headaches. The patient was found to have an acute lumbar arterial bleed causing haemodynamic instability and a psoas haematoma. An emergency lumbar artery embolisation procedure was performed to stabilise the bleed, and the patient made a full recovery before discharge.
Article
Surgery
Xiao Han, Derong Xu, ZhiNan Ren, Xin Chen, Zheng Li, Shugang Li
Summary: This study presented a severe case of lumbar spinal stenosis and spinal epidural lipomatosis, with outstanding clinical outcomes achieved by posterior decompression, internal fixation, and a modified articular fusion technique.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eric M. Christiansen, Paul Kang, Jeremy N. Hughes
Summary: The purpose of this study was to determine the incidence of epidural fluid signal on spinal MRI after image-guided lumbar puncture in adults and to correlate these findings with clinical status. The results showed that younger patients with larger needle size were more likely to have epidural fluid signal, but this signal did not significantly correlate with symptoms.
Article
Medicine, General & Internal
Park Manakul, Koopong Siribumrungwong, Naphakkhanith Dhanachanvisith
Summary: This study evaluated the short-term spinal sagittal alignment change after transforaminal epidural steroid injection (TFESI) in lumbar spinal stenosis patients. The results showed that TFESI significantly improves pain and sagittal alignment in these patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Wenqian Lin, Yongyong Yang, Jun Lin, Jianxing Chen, Qun Lin
Summary: This study compared the effect of Dural puncture epidural (DPE) and conventional epidural (EP) in combination with programmed intermittent epidural bolus (PIEB) and low-concentration ropivacaine strategy on labor analgesia. The results showed that the DPE group had a higher percentage of adequate analgesia at 8, 12, 14, and 16 minutes, with a more significant decrease in NPRS scores within the first 30 minutes. However, there was no significant difference in the percentage of adequate analgesia at 30 minutes. The incidence of S2 sensory blocks at 20 and 30 minutes was higher in the DPE group, while there were no differences in patient satisfaction, delivery mode, adverse effects, fetal bradycardia, and Apgar scores at 1 and 5 minutes.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Hematology
Christine L. Kempton, Michael Makris, Pal Andre Holme
Summary: The introduction of clotting factor concentrates in the early 1970s led to significant improvements in the quality of life and life expectancy of persons with haemophilia (PWH). Unfortunately, the transmission of HIV and hepatitis C virus (HCV) in the 1980s resulted in the loss of these gains. With four decades of PWH unexposed to contaminated factor products and current treatments capable of suppressing and eliminating HIV and HCV, the survival rate is once again increasing, but elderly PWH still face specific comorbidities such as cardiovascular disease and osteoporosis.
Article
Hematology
Steven W. Pipe, Radoslaw Kaczmarek, Alok Srivastava, Glenn F. Pierce, Mike Makris, Cedric Hermans
Summary: COVID-19 associated coagulopathy in patients with hemophilia is complex, requiring a balance of antithrombotic and hemostatic treatments. Recommendations include continued hemostatic treatment, intensified prophylaxis with factor concentrates and LMWH based on bleeding risk, and possibly combining emicizumab with factor VIII and LMWH depending on individual patient needs. Dosage escalation of LMWH tailored to thrombosis risk may be considered, but lacks strong evidence support.
Editorial Material
Hematology
Radoslaw Kaczmarek, Magdy El Ekiaby, Daniel P. Hart, Cedric Hermans, Mike Makris, Declan Noone, Brian O'Mahony, David Page, Flora Peyvandi, Steven W. Pipe, Thomas Sannie, Uwe Schlenkrich, Mark W. Skinner, Alok Srivastava, Amanda Bok, Glenn F. Pierce
Letter
Hematology
Mike Makris, Cedric Hermans
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Daniel P. Hart, Jayanthi Alamelu, Neha Bhatnagar, Tina Biss, Peter W. Collins, Georgina Hall, Charles Hay, Ri Liesner, Michael Makris, Mary Mathias, Jayashree Motwani, Ben Palmer, Jeanette Payne, Charles Percy, Michael Richards, Anne Riddell, Kate Talks, Oliver Tunstall, Elizabeth Chalmers
Summary: The International Immune Tolerance Study showed equal efficacy between high and low dose immune tolerance induction regimens in good risk patients, but was stopped early due to excessive bleed rate in the low dose arm. The UKHCDO guideline revision now recommends using emicizumab as a prophylaxis agent for reduced bleeding rates during ITI. This consensus protocol aims to facilitate future evaluation of ITI outcomes in the changing landscape of haemophilia therapeutics and strategies.
Editorial Material
Hematology
Mike Makris, Cedric Hermans
Article
Hematology
Paul van der Valk, Michael Makris, Kathelijn Fischer, Robert C. Tait, Pratima Chowdary, Peter W. Collins, Karina Meijer, Lize F. D. van Vulpen, Eveline Mauser-Bunschoten, Roger E. G. Schutgens
Summary: This study compared the incidence of cardiovascular disease (CVD) in individuals with hemophilia to the predicted incidence, and found that the actual incidence was lower than predicted. There was no statistically significant relationship between the severity of hemophilia and the incidence of CVD.
Article
Hematology
Brian Craven, William Lester, Sara Boyce, Will Thomas, Angela Kanny, Claire Davies, Sue Pavord, Joannes Hermans, Michael Makris, Emily Bart-Smith, Sarah Arnott, Beverley J. Hunt, Pavel Chudakou, Anthony Calvert, Deepak Singh, Marie Scully
Summary: The COVID-19 pandemic has led to the rapid development of vaccines against SARS-CoV-2. Vaccine-induced immune thrombocytopenia and thrombosis (VITT) is a rare but life-threatening complication. This study measured the levels of antibodies, platelets, and D-dimer in a large cohort of patients and examined their relation to relapse. The results showed that most patients remained positive after diagnosis, but the relapse rate was low and did not result in a recurrence of severe clinical symptoms.
Editorial Material
Hematology
Sue Pavord, Michael Makris
Summary: In the current issue of Blood, Krzywicka et al convincingly demonstrate for the first time that vaccine-induced immune thrombocytopenia and thrombosis (VITT) can occur after a second dose of the AstraZeneca/Oxford ChAdOx1 nCoV-19 vaccine.
Letter
Hematology
Wolfgang Miesbach, Fariba Baghaei, Ana Boban, Pratima Chowdary, Michiel Coppens, Daniel P. Hart, Victor Jimenez-Yuste, Robert Klamroth, Mike Makris, Declan Noone, Flora Peyvandi
Article
Hematology
Christopher Reilly-Stitt, Ian Jennings, Steve Kitchen, Mike Makris, Piet Meijer, Moniek de Maat, Marie Scully, Tamam Bakchoul, Isobel D. Walker
Summary: This study conducted a collaborative external quality assessment (EQA) exercise to evaluate the performance of different testing methods for the diagnosis of VITT. The results showed that ELISA-based methods have superior sensitivity compared to functional assays.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Indraraj Umesh Doobaree, Katherine Conway, Haroon Miah, Atiqa Miah, Michael Makris, Quentin Hill, Nicola Cooper, Charlotte Bradbury, Adrian Newland, Drew Provan, Vickie McDonald
Summary: The study found a rising incidence of primary ITP, with the most significant increases among young women and elderly men. These findings are important for understanding the impact of ITP on patients' lives and healthcare services in England, particularly as 17%-50% of patients may develop chronic ITP and require long-term care.
EUROPEAN JOURNAL OF HAEMATOLOGY
(2022)
Article
Hematology
Jamie M. M. O'Sullivan, Ellia Tootoonchian, Baiba Ziemele, Michael Makris, Augusto B. B. Federici, Claudia Khayat Djambas, Magdy El Ekiaby, Dawn Rotellini, Robert F. F. Sidonio, Alfonso Iorio, Donna Coffin, Glenn F. F. Pierce, Jeffrey Stonebraker, Paula D. D. James, Michelle Lavin
Summary: Recent guidelines for von Willebrand Disease (VWD) highlighted the challenges in diagnosis and management. Identifying the number of persons with VWD (PwVWD) internationally will help target support to aid diagnosis of PwVWD. Registration rates of PwVWD vary internationally and are influenced by national income status.
Review
Hematology
Jeffrey S. Stonebraker, Alfonso Iorio, Michelle Lavin, Suely M. Rezende, Alok Srivastava, Glenn F. Pierce, Donna Coffin, Ellia Tootoonchian, Michael Makris
Summary: This study analyzed the reported prevalence of von Willebrand disease (VWD) worldwide in relation to income classification. The results showed that the prevalence of VWD was significantly higher in high-income countries compared to other income classifications, and the prevalence was higher in females than males. The detection and diagnosis of type 1 VWD presented challenges in forming a consistent prevalence value across countries and income classifications.
Article
Hematology
Charles R. M. Hay, Michael Makris, Midori Shima, Azusa Nagao, Victor Jimenez-Yuste, Mark Skinner, Craig M. Kessler, Sylvia von Mackensen
Summary: This study investigates the associations between patient-reported outcomes (PROs) and patient, treatment, and disease characteristics in people living with haemophilia A (PLWHA). The results show that older age, poorer joint health, and higher body mass index (BMI) adversely affect multiple aspects of participant well-being.