Review
Cell & Tissue Engineering
Gabriela Sanchez-Petitto, Katayoun Rezvani, May Daher, Hind Rafei, Partow Kebriaei, Elizabeth J. Shpall, Amanda Olson
Summary: Umbilical cord blood transplantation is an attractive alternative source of hematopoietic stem cells, with unique immune tolerance and engraftment kinetics. It has a lower risk of GvHD and comparable clinical outcomes to bone marrow transplantation. However, limitations in cell numbers and delayed engraftment pose challenges for its wider application. Research is being conducted to address these limitations and explore the potential of cord blood in treating various disorders.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Review
Cell & Tissue Engineering
Elisha Purcell, Timothy Nguyen, Madeleine Smith, Tayla Penny, Madison C. B. Paton, Lindsay Zhou, Graham Jenkin, Suzanne L. Miller, Courtney A. McDonald, Atul Malhotra
Summary: This study systematically reviewed the effects of UCBCs on brain outcomes in animal models of perinatal brain injury. It found differential benefits of UCBCs across different subgroups, such as greater efficacy in IVH model compared to HI model, UCB-MSCs compared to UCB-MNCs, and local administrative routes compared to systemic routes. However, the study identified a serious risk of bias and overall low certainty of evidence.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Veterinary Sciences
Paulo Henrique Utumi, Leticia Fracaro, Alexandra Cristina Senegaglia, Felipe Yukio Ishikawa Fragoso, Dayane Mayumi Miyasaki, Carmen Lucia Kuniyoshi Rebelatto, Paulo Roberto Slud Brofman, Jose Ademar Villanova Junior
Summary: The study isolated, characterized, and evaluated canine dental pulp and umbilical cord tissue-derived mesenchymal stem cells, showing both sources possess MSC characteristics and can be safely used as alternative sources in cell therapy.
RESEARCH IN VETERINARY SCIENCE
(2021)
Review
Oncology
Jiasheng Wang, Leland Metheny
Summary: Cord blood is an important source for allogeneic hematopoietic cell transplantation and is also being developed for cell therapy products. The unique cellular composition of cord blood, including higher percentages of hematopoietic stem cells and progenitor cells, offers advantages in immune tolerance and off-the-shelf cell therapy development. In addition, cord blood-derived mesenchymal stem cells have potential in regenerative medicine and inflammatory/autoimmune conditions. This review focuses on recent clinical development of cord blood-derived therapies in oncology.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell & Tissue Engineering
Ying Yang, Ming Zhang, Mengqi Li, Yingchun Li, Wei Yang, Zhuogang Liu, Hongtao Wang
Summary: This study found that adding an unrelated umbilical cord blood unit to haploidentical hematopoietic stem cell transplantation can improve the prognosis and enhance the graft versus leukemia effect without increasing the incidence of graft versus host disease.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Ximena Bonilla, Ana Milena Lara, Manuela Llano-Leon, David A. Lopez-Gonzalez, David G. Hernandez-Mejia, Rosa Helena Bustos, Bernardo Camacho-Rodriguez, Ana-Maria Perdomo-Arciniegas
Summary: Umbilical cord blood is an important source of hematopoietic stem and progenitor cells, and recent research has focused on developing ex vivo expansion strategies for these cells. Co-culturing the cells with specific mesenchymal stromal cells has been found to significantly increase their cellular dose and regulate their proliferation capacity. Additionally, the secretory profile of umbilical cord blood-derived cells closely resembles that of bone marrow-derived cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Jingyue Zhang, Shiheng Zhang, Yueming Yang, Ling Liu
Summary: The study found that umbilical cord blood-derived mesenchymal stem cells (UCBMSCs) can effectively treat adriamycin-induced cardiomyopathy by restoring myocardial function and alleviating inflammatory response.
Review
Cell & Tissue Engineering
Xiaoyu Zhu, Baolin Tang, Zimin Sun
Summary: Umbilical cord blood transplantation (UCBT) has been successfully used in clinics for over 30 years, offering advantages such as reliable source, ease of use, improved outcomes. Over time, UCBT has seen an increasing trend in Asia and China, while decreasing in the United States and Europe annually.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Pei Tian, Andrew Elefanty, Edouard G. Stanley, Jennifer C. Durnall, Lachlan H. Thompson, Ngaire J. Elwood
Summary: Clinical-grade induced pluripotent stem cells (iPSCs) can be efficiently created using small volumes of thawed cord blood from public cord blood banks. This study presents a protocol that involves ex-vivo expansion and reprogramming of erythroid progenitor cells derived from cord blood, resulting in iPSC lines that are tested for pluripotency, genomic integrity, and stability.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Medicine, General & Internal
Diana Vanegas, Laura Nino-Quiroga, Mauricio Chaparro, Bernardo Camacho-Rodriguez, Marcela Estupinan, Ana-Maria Perdomo-Arciniegas
Summary: The translated article discusses the main issues associated with using unrelated umbilical cord blood and haploidentical grafts as alternative donors, emphasizing that selecting the best donor depends on various factors.
FRONTIERS IN MEDICINE
(2021)
Review
Cell & Tissue Engineering
Lindsay Zhou, Courtney McDonald, Tamara Yawno, Graham Jenkin, Suzanne Miller, Atul Malhotra
Summary: Cell therapies using umbilical cord blood and cord tissue have emerged as a promising approach for preventing and treating neonatal morbidities. Published clinical studies mainly focus on safety and feasibility, with limited assessment of efficacy. There are ongoing trials investigating the potential of these therapies in neonates.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Hematology
Hao Wang, Kristin N. Berger, Elizabeth L. Miller, Wei Fu, Larisa Broglie, Frederick D. Goldman, Heiko Konig, Su Jin Lim, Arthur S. Berg, Julie-An Talano, Melanie A. Comito, Sherif S. Farag, Jeffrey J. Pu
Summary: This study evaluated the impact of total body irradiation (TBI) on umbilical cord blood transplantation (UCBT) outcomes. The results showed that TBI can improve overall survival and progression-free survival in one condition of UCBT, but no significant differences in the other condition.
THERAPEUTIC ADVANCES IN HEMATOLOGY
(2023)
Article
Medicine, General & Internal
Yangyan Wang, Yuanyuan Dai, Huaiwei Lu, Wenjiao Chang, Fan Ma, Ziran Wang, Zhican Liu, Xiaoling Ma
Summary: This case study presents a hospital-acquired Legionella pneumonia in a 7-year-old girl after umbilical cord blood stem cell transplantation, detected through metagenomic next-generation sequencing (mNGS). Timely identification of pathogens using mNGS is crucial for the survival of immunocompromised patients.
FRONTIERS IN MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Yong Xie, Yi Sun, Yudong Liu, Jinyun Zhao, Quanbo Liu, Jiaqi Xu, Yiming Qin, Rundong He, Feifei Yuan, Tianding Wu, Chunyue Duan, Liyuan Jiang, Hongbin Lu, Jianzhong Hu
Summary: This study explores a specific targeted treatment approach for spinal cord injury by identifying stable subpopulations of exosomes that can improve blood-spinal cord barrier integrity and promote neural function recovery.
Review
Cell & Tissue Engineering
Yufeng Xi, Guang Yue, Shuqiang Gao, Rong Ju, Yujia Wang
Summary: Perinatal brain injury is a major cause of death and disability in children. Transplantation of human umbilical cord blood mononuclear cells has shown significant efficacy and safety in animal and clinical trials for the treatment of perinatal brain injury.
STEM CELL RESEARCH & THERAPY
(2022)
