Article
Medicine, General & Internal
Sandra Wittleder, Shea Smith, Binhuan Wang, Jeannette M. Beasley, Stephanie L. Orstad, Victoria Sweat, Allison Squires, Laura Wong, Yixin Fang, Paula Doebrich, Damara Gutnick, Craig Tenner, Scott E. Sherman, Melanie Jay
Summary: This study aims to test the efficacy of the Peer-Assisted Lifestyle (PAL) intervention compared with enhanced usual care (EUC) to improve body mass loss, clinical and behavioral outcomes among US veterans. The study also aims to identify predictors of body mass loss and increase primary care provider counseling.
Article
Biochemistry & Molecular Biology
Thomas A. Wadden, Ariana M. Chao, Sriram Machineni, Robert Kushner, Jamy Ard, Gitanjali Srivastava, Bruno Halpern, Shuyu Zhang, Jiaxun Chen, Mathijs C. Bunck, Nadia N. Ahmad, Tammy Forrester
Summary: This study aimed to investigate the effects of tirzepatide, a glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist, on weight reduction after successful intensive lifestyle intervention. The results showed that tirzepatide significantly reduced body weight compared to placebo, with the most common adverse events being mild to moderate gastrointestinal reactions.
Article
Multidisciplinary Sciences
Lauren Oshman, Amal Othman, Wendy Furst, Michele Heisler, Andrew Kraftson, Yousra Zouani, Cheryl Hershey, Tsai-Chin Cho, Timothy Guetterman, Gretchen Piatt, Dina H. Griauzde
Summary: This study aimed to understand primary care physicians' perspectives on barriers to obesity treatment and opportunities to overcome them. The study found that many primary care physicians lack the ability to use evidence-based guidelines for obesity treatment decisions, but they believe that improvements can be made through education, team-based care, and policy changes.
Article
Public, Environmental & Occupational Health
Marie Spreckley, Judith de Lange, Jaap Seidell, Jutka Halberstadt
Summary: This qualitative interview study explores the factors and strategies for successful long-term weight loss in a primary care-led intervention. The findings indicate that clear and evolving self-monitoring strategies, strong routines, and a long-term focus contribute to successful outcomes. Challenges such as stress and disappointment are faced, but the benefits of weight loss, such as improved health and self-esteem, fuel motivation. Continuous support and encouragement from healthcare practitioners play a significant role in long-term success.
INTERNATIONAL JOURNAL OF QUALITATIVE STUDIES ON HEALTH AND WELL-BEING
(2023)
Article
Public, Environmental & Occupational Health
Alisa Weiland, Lena Kasemann Nannette, Stephan Zipfel, Stefan Ehehalt, Katrin Ziser, Florian Junne, Isabelle Mack
Summary: This study systematically reviewed the predictors of body weight loss and weight loss maintenance in children and adolescents after behavioral weight loss intervention. The results showed that genetics and blood parameters were significant predictors in physiology, while behavior and environment factors were less investigated.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Obstetrics & Gynecology
Annemieke Hoek, Zheng Wang, Anne M. van Oers, Henk Groen, Astrid E. P. Cantineau
Summary: Obesity can negatively impact natural fertility in both men and women, as well as pregnancy chances. Lifestyle intervention is recommended as the first-line treatment for obesity, with or without medical treatments. Investigating the effects of lifestyle intervention on reproductive outcomes is crucial.
FERTILITY AND STERILITY
(2022)
Article
Food Science & Technology
Christopher Papandreou, Jesus Garcia-Gavilan, Lucia Camacho-Barcia, Thea Toft Hansen, Joanne A. Harrold, Anders Sjodin, Jason C. G. Halford, Monica Bullo
Summary: This study examines the relationship between changes in circulating metabolites during diet-induced weight loss and changes in adiposity, finding significant associations between lipid species and citric acid with body weight and adiposity reduction. The results also show that changes in lysophosphatidylcholines and citric acid concentrations during weight loss are linked to adiposity regain and loss during the maintenance period, highlighting the importance of adipose lipid metabolism in weight and adiposity maintenance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Geriatrics & Gerontology
Xinran Liu, Jennifer King, Brandi Boak, Michelle E. Danielson, Robert M. Boudreau, Anne B. Newman, Elizabeth M. Venditti, Steven M. Albert
Summary: Despite the challenges posed by caregiving, older informal caregivers can benefit from behavioral weight management interventions.
Article
Surgery
Stefan Wallen, Gustaf Bruze, Johan Ottosson, Claude Marcus, Johan Sundstrom, Eva Szabo, Torsten Olbers, Maria Palmetun-Ekback, Ingmar Naslund, Martin Neovius
Summary: This study aimed to compare the use of opioids in patients with obesity who underwent bariatric surgery versus those who underwent intensive lifestyle modification. The results showed that patients who underwent bariatric surgery had a higher proportion of opioid users and a larger total opioid dose, especially in those who received additional surgery during follow-up.
Article
Endocrinology & Metabolism
Christoph K. Hoechsmann, Corby W. Martin, John L. Apolzan, James L. Dorling, Robert L. D. Newton Jr, Kara F. Denstel, Emily D. Mire, William Johnson, Dachuan L. Zhang, Connie C. Arnold, Terry Davis, Vivian K. Fonseca, Tina J. Thethi, Carl Lavie, Benjamin T. Springgate, Peter Katzmarzyk, PROPEL Research Group
Summary: This study examined the relationship between initial weight change (WC), self-weighing, adherence to the expected WC trajectory, and longer-term WC in an underserved primary-care population with obesity. The results showed that percentage WC during the initial weeks predicted WC at 6, 12, and 24 months, and self-weighing and adherence to the expected WC trajectory improved WC prediction.
Article
Medicine, General & Internal
Jessica Gokee LaRose, Tricia M. Leahey, Autumn Lanoye, Melanie K. Bean, Joseph L. Fava, Deborah F. Tate, Ronald K. Evans, Edmond P. Wickham, Megan M. Henderson
Summary: In this randomized clinical trial, all interventions produced clinically significant benefit, but neither of the motivational enhancements promoted greater reductions in adiposity compared with the developmentally adapted standard group.
Article
Multidisciplinary Sciences
Carmen Martin-Ridaura, Dario Ochoa-Esteban, Carmen Berlinches-Zapero, Dolores Ruiz-Fernandez, Vanessa Sanz-Martin, Rosario Gavira-Izquierdo, Sebastia March, Maria Lopez-Toribio, Mercedes Ceinos-Arcones
Summary: The effectiveness of the ALAS program in reducing weight and preventing the risk of developing Type 2 diabetes was evaluated under real-life conditions. The intervention showed positive results in terms of weight loss and improvement in glycemic status for prediabetic participants. The effectiveness of the intervention varied according to gender, access route, and educational level of the participants.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Sai Krupa Das, Rachel E. Silver, Taylor A. Vail, Meghan K. Chin, Caroline M. Blanchard, Stephanie L. Dickinson, Xiwei Chen, Lisa Ceglia, Edward Saltzman, David B. Allison, Susan B. Roberts
Summary: This study assessed the effectiveness of a new lifestyle intervention in work sites, which focuses on reducing hunger and building healthy food preferences without calorie counting. The results showed that this intervention led to clinically impactful weight loss in employees.
Article
Nutrition & Dietetics
Alexa Lisevick, Brenda Cartmel, Maura Harrigan, Fangyong Li, Tara Sanft, Miklos Fogarasi, Melinda L. Irwin, Leah M. Ferrucci
Summary: Lifestyle interventions have been successful in achieving short-term weight loss among breast cancer survivors with obesity. Both the intervention and usual care groups maintained their initial weight loss even during long-term follow-up, without experiencing significant weight gain.
Article
Medicine, General & Internal
Eugenia Espinel, Maria Antonia Azancot, Alba Gomez, Anna Beneria, Anna Caraben, Laura Andurell, Pilar Delgado, Helena Castane, Jorge Joven, Daniel Seron
Summary: A multidisciplinary intervention involving lifestyle changes and medication adherence can effectively reduce blood pressure and improve cardiovascular risk markers in patients with resistant hypertension.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Dorthe Skovgaard, Poul-Martin Haahr, Robert Lester, Katherine Clark, Sabina Paglialunga, Nick Finer, Martin H. H. Friedrichsen, Julie B. B. Hjerpsted, Mads D. M. Engelmann
Summary: Although prevalence of cardiac arrhythmias in healthy volunteers has been estimated, there is limited baseline data for populations such as overweight and obese individuals, who are increasingly participating in clinical trials. This study examined the baseline prevalence of arrhythmias in overweight or obese participants in two phase 1 trials of weight management medications. The findings showed that most arrhythmias were rare, and the prevalence mirrored that of healthy participants with normal weight. Knowledge of the baseline prevalence of arrhythmias in overweight and obese individuals can inform trial eligibility criteria and improve decision-making in weight management clinical trials.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan Hong, Petra B. Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe Muilwijk, Marieke T. Blom, Leen M. T. Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian Forgie, Giuseppe N. Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil Dermitzakis, Paul W. Franks, Jochen M. Schwenk, Jerzy Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
Summary: The application of multiple omics technologies in biomedical cohorts can reveal patient-level disease characteristics and individualized response to treatment. We developed a deep-learning-based framework, MOVE, to integrate and analyze multi-omics data from a cohort of newly diagnosed type 2 diabetes patients. By using in silico perturbations, we identified drug-omics associations in the multi-modal datasets with higher sensitivity than univariate statistical tests.
NATURE BIOTECHNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sarah Marshall, Brittany J. J. Johnson, Kylie D. D. Hesketh, Karen J. J. Campbell, Kylie Fraser, Penelope Love, Elizabeth Denney-Wilson, Jo Salmon, Zoe McCallum, Rachel Laws
Summary: This study compared the original RCT and the scaled-up version of the INFANT program and found that while delivery features and behavior change techniques were modified, the target behaviors and behavior change techniques remained the same.
FRONTIERS IN PUBLIC HEALTH
(2023)
Review
Nutrition & Dietetics
Maria Shahid, Allison Gaines, Daisy Coyle, Roberta Alessandrini, Tim Finnigan, Gary Frost, Matti Marklund, Bruce Neal
Summary: This study systematically reviewed and meta-analyzed the effects of mycoprotein intake on selected biomarkers of human health. The results suggest that mycoprotein intake may have important effects on blood lipids, but the evidence base is limited by small sample sizes and short intervention periods.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Food Science & Technology
Anna Cherta-Murillo, Nathan P. Danckert, Maria Valdivia-Garcia, Edward S. Chambers, Lauren Roberts, Jesus Miguens-Blanco, Julie A. K. McDonald, Julien R. Marchesi, Gary S. Frost
Summary: High-fibre diets, including mycoprotein (Quorn), have positive effects on glycemic control and appetite. However, the underlying mechanisms are not well understood.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2023)
Article
Nutrition & Dietetics
Yessica Abigail Tronco Hernandez, Anna Julian, Elizabeth C. Weekes, Jane Murphy, Gary Frost, Mary Hickson
Summary: This paper describes the use of nominal group technique (NGT) to develop consensus statements addressing the nutritional needs of COVID-19 patients. The research highlights the need for a freely accessible knowledge hub for guidelines and recommendations.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Neurosciences
James Frampton, Jose Ivan Serrano-Contreras, Isabel Garcia-Perez, Georgia Franco-Becker, Jack Penhaligan, Abbigail S. Y. Tan, Ana Claudia Cepas de Oliveira, Annabelle J. Milner, Kevin G. Murphy, Gary Frost, Edward S. Chambers
Summary: Understanding the metabolic determinants of postexercise appetite regulation is important for developing therapeutics to suppress overeating behaviors and enhance the efficacy of exercise as a weight-loss treatment. This study found that dietary carbohydrate and exercise independently influenced gastrointestinal hormones associated with appetite regulation. Plasma acetate and succinate were identified as potential mediators of exercise-induced appetite and energy intake responses.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Correction
Biotechnology & Applied Microbiology
Rosa Lundbye Allesoe, Agnete Troen Lundgaard, Ricardo Hernandez Medina, Alejandro Aguayo-Orozco, Joachim Johansen, Jakob Nybo Nissen, Caroline Brorsson, Gianluca Mazzoni, Lili Niu, Jorge Hernansanz Biel, Cristina Leal Rodriguez, Valentas Brasas, Henry Webel, Michael Eriksen Benros, Anders Gorm Pedersen, Piotr Jaroslaw Chmura, Ulrik Plesner Jacobsen, Andrea Mari, Robert Koivula, Anubha Mahajan, Ana Vinuela, Juan Fernandez Tajes, Sapna Sharma, Mark Haid, Mun-Gwan B. Hong, Petra Musholt, Federico De Masi, Josef Vogt, Helle Krogh Pedersen, Valborg Gudmundsdottir, Angus Jones, Gwen Kennedy, Jimmy Bell, E. Louise Thomas, Gary Frost, Henrik Thomsen, Elizaveta Hansen, Tue Haldor Hansen, Henrik Vestergaard, Mirthe T. Muilwijk, Marieke M. Blom, Leen 't Hart, Francois Pattou, Violeta Raverdy, Soren Brage, Tarja Kokkola, Alison Heggie, Donna McEvoy, Miranda Mourby, Jane Kaye, Andrew Hattersley, Timothy McDonald, Martin Ridderstrale, Mark Walker, Ian N. Forgie, Giuseppe Giordano, Imre Pavo, Hartmut Ruetten, Oluf Pedersen, Torben Hansen, Emmanouil W. Dermitzakis, Paul M. Franks, Jochen Schwenk, Jerzy I. Adamski, Mark McCarthy, Ewan Pearson, Karina Banasik, Simon Rasmussen, Soren Brunak
NATURE BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Aditi Sharma, Nikoleta Papanikolaou, Sara Abou Sherif, Anastasia Dimakopolou, Thilipan Thaventhiran, Cara Go, Olivia Holtermann Entwistle, Adrian Brown, Rong Luo, Rama Jha, Anavi Prakash, Dalia Khalifa, Hannah Lewis, Sruthi Ramaraju, Anthony R. Leeds, Harvinder Chahal, Sanjay Purkayastha, Ralf Henkel, Sukhbinder Minhas, Gary Frost, Waljit S. Dhillo, Channa N. Jayasena
Summary: Obesity increases the risk of male infertility, but bariatric surgery does not improve semen quality. Recent studies suggest that a low-energy diet may enhance semen quality. This randomized controlled trial compares the effects of a low-energy diet with a brief dietary intervention on semen parameters in obese men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Linda Wedlake, Duane Mellor, Tom Marriott, Kate Maslin, Gary Frost, Mary Hickson
Summary: This study surveyed the opinions of members of the British Dietetic Association and other relevant groups on the scope, content, and presentation of the Manual of dietetic practice. The majority of respondents were satisfied with the structure and content, but identified areas that were lacking or outdated, such as mental health and sustainability. Professionals suggested the next edition should focus more on practical information for clinical practice, while students wanted more summarized information and visual formats.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2023)
Article
Multidisciplinary Sciences
Andrew A. Brown, Juan A. Fernandez-Tajes, Mun-gwan W. Hong, Caroline A. Brorsson, Robert W. Koivula, David Davtian, Theo Dupuis, Ambra M. Sartori, Theodora-Dafni Michalettou, Ian H. Forgie, Jonathan Adam, Kristine Allin, Robert Caiazzo, Henna Cederberg, Federico N. De Masi, Petra J. M. Elders, Giuseppe Giordano, Mark Haid, Torben Hansen, Tue H. Hansen, Andrew T. Hattersley, Alison G. Heggie, Cedric Howald, Angus G. Jones, Tarja Kokkola, Markku Laakso, Anubha Mahajan, Andrea Mari, Timothy J. McDonald, Donna McEvoy, Miranda Mourby, Petra B. Musholt, Birgitte Nilsson, Francois Pattou, Deborah Penet, Violeta Raverdy, Martin Ridderstrale, Luciana Romano, Femke Rutters, Sapna Sharma, Harriet D. Teare, Leen 't Hart, Konstantinos D. Tsirigos, Jagadish Vangipurapu, Henrik Vestergaard, Soren Brunak, Paul Franks, Gary Frost, Harald I. Grallert, Bernd Jablonka, Mark McCarthy, Imre Pavo, Oluf Pedersen, Hartmut Ruetten, Mark Walker, Jerzy Adamski, Jochen M. Schwenk, Ewan R. Pearson, Emmanouil T. Dermitzakis, Ana Vinuela, Kofi Adragni, Rosa Lundbye L. A. Allesoe, Anna Artati, Manimozhiyan Arumugam, Naeimeh Atabaki-Pasdar, Tania Baltauss, Karina Banasik, Anna L. Barnett, Patrick Baum, Jimmy D. Bell, Joline B. Beulens, Susanna Bianzano, Roberto Bizzotto, Amelie Bonnefond, Louise Cabrelli, Matilda Dale, Adem Y. Dawed, Nathalie de Preville, Koen F. Dekkers, Harshal A. Deshmukh, Christiane Dings, Louise Donnelly, Avirup Dutta, Beate Ehrhardt, Line Engelbrechtsen, Rebeca Eriksen, Yong Fan, Jorge Ferrer, Hugo Fitipaldi, Annemette Forman, Andreas Fritsche, Philippe Froguel, Johann Gassenhuber, Stephen Gough, Ulrike Graefe-Mody, Rolf Grempler, Lenka Groeneveld, Leif Groop, Valborg Gudmundsdottir, Ramneek Gupta, Anita M. H. Hennige, Anita V. Hill, Reinhard W. Holl, Michelle Hudson, Ulrik Plesner Jacobsen, Christopher Jennison, Joachim Johansen, Anna Jonsson, Tugce Karaderi, Jane Kaye, Gwen Kennedy, Maria Klintenberg, Teemu Kuulasmaa, Thorsten Lehr, Heather Loftus, Agnete Troen T. Lundgaard, Gianluca Mazzoni, Nicky McRobert, Ian McVittie, Rachel Nice, Claudia Nicolay, Giel N. Nijpels, Colin K. Palmer, Helle H. Pedersen, Mandy H. Perry, Hugo Pomares-Millan, Cornelia P. Prehn, Anna Ramisch, Simon Rasmussen, Neil Robertson, Marianne Rodriquez, Peter Sackett, Nina Scherer, Nisha Shah, Iryna Sihinevich, Roderick C. Slieker, Nadja B. Sondertoft, Birgit Steckel-Hamann, Melissa K. Thomas, Cecilia Engel E. Thomas, Elizabeth Louise L. Thomas, Barbara Thorand, Claire E. Thorne, Joachim Tillner, Andrea Tura, Mathias Uhlen, Nienke van Leeuwen, Sabine van Oort, Helene Verkindt, Josef Vogt, Peter W. Wad Sackett, Agata Wesolowska-Andersen, Brandon Whitcher, Margaret W. White
Summary: This study integrates local and distal genetic associations with multi-omics datasets to provide a roadmap for understanding the underlying mechanisms of GWAS variants on complex traits.
NATURE COMMUNICATIONS
(2023)
Article
Nutrition & Dietetics
Modou L. Jobarteh, Megan A. Mccrory, Benny Lo, Konstantinos K. Triantafyllidis, Jianing Qiu, Jennifer P. Griffin, Edward Sazonov, Mingui Sun, Wenyan Jia, Tom Baranowski, Alex K. Anderson, Kathryn Maitland, Gary Frost
Summary: This study validated an objective, passive image-based method for assessing dietary intake in London, UK and demonstrated its potential applicability in low- and middle-income countries (LMICs). The findings showed good agreement between the image-based method and weighed food records, indicating that this method can provide a comparable assessment of nutritional intake.
Article
Endocrinology & Metabolism
Adem Y. Dawed, Andrea Mari, Andrew Brown, Timothy J. McDonald, Lin Li, Shuaicheng Wang, Mun-Gwan Hong, Sapna Sharma, Neil R. Robertson, Anubha Mahajan, Xuan Wang, Mark Walker, Stephen Gough, Leen M. 't Hart, Kaixin Zhou, Ian Forgie, Hartmut Ruetten, Imre Pavo, Pallav Bhatnagar, Angus G. Jones, Ewan R. Pearson, for the D. I. R. E. C. T. consortium DIRECT consortium
Summary: This study identified genetic variants associated with the response to GLP-1 receptor agonist treatment in patients with type 2 diabetes, which provides valuable insights for clinical decision making and personalized medicine.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Automation & Control Systems
Jianing Qiu, Frank P. -W. Lo, Xiao Gu, Modou L. Jobarteh, Wenyan Jia, Tom Baranowski, Matilda Steiner-Asiedu, Alex K. Anderson, Megan A. McCrory, Edward Sazonov, Mingui Sun, Gary Frost, Benny Lo
Summary: Camera-based passive dietary intake monitoring captures eating episodes, recording visual information on food type, volume, and eating behavior. However, no method incorporates these clues to provide a comprehensive dietary context. Privacy is a concern with wearable cameras. This paper proposes a privacy-preserved solution for dietary assessment, using egocentric image captioning to convert images into text descriptions and reduce privacy risks. A dataset is built for egocentric dietary image captioning, and a transformer-based architecture is designed and evaluated for effectiveness.
IEEE TRANSACTIONS ON CYBERNETICS
(2023)
Meeting Abstract
Nutrition & Dietetics
B. Lu, M. Christian, A. Hanyaloglu, A. Frampton, G. Frost
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)