Article
Dermatology
Takeshi Fukumoto, Jianhuang Lin, Nail Fatkhutdinov, Pingyu Liu, Rajasekharan Somasundaram, Meenhard Herlyn, Rugang Zhang, Chikako Nishigori
Summary: The study demonstrates that ARID2 knockout enhances melanoma sensitivity to immune checkpoint inhibitors by increasing infiltration of cytotoxic CD8(+) T cells and upregulating expression of T-cell-attracting chemokines. These findings suggest that ARID2 acts as an immunomodulator and a potential biomarker for predicting the effectiveness of immune checkpoint inhibitors in melanoma patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Ida M. Heerfordt, Peter A. Philipsen, Jeppe D. Andersen, Linnea Langhans, Grethe Schmidt, Niels Morling, Hans Christian Wulf
Summary: Using tape strip derived RNA, this study developed a technique to differentiate cutaneous malignant melanoma (CMM) from nevi with 100% sensitivity. The technique reduced the unnecessary surgical removal of benign lesions by one-third without overlooking any CMMs.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Oncology
Fernanda Costa Svedman, Ishani Das, Rainer Tuominen, Eva Darai Ramqvist, Veronica Hoiom, Suzanne Egyhazi Brage
Summary: The introduction of targeted therapies and immunotherapies has greatly improved the clinical outcomes for patients with advanced cutaneous melanoma. However, only a subset of patients benefit from these treatments in the long term. This study aims to identify gene signatures that can predict the treatment outcomes in melanoma patients. The findings suggest that up-regulation of immune-related genes is associated with better outcomes in targeted therapy, while down-regulation of proliferation and up-regulation of allograft rejection genes favor patients treated with immune checkpoint inhibitors.
Article
Oncology
Sipeng Zuo, Huixue Wang, Lin Li, Hui Pan, Linna Lu
Summary: This study investigated the role of TK1 in skin cutaneous melanoma (SKCM) and found that TK1 promoted the proliferation and migration of SKCM cells, and was strongly associated with multiple metabolic pathways. The results suggest that TK1 may serve as a therapeutic target for SKCM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dermatology
M. Scatolini, A. Patel, E. Grosso, M. Mello-Grand, P. Ostano, R. Coppo, M. Vitiello, T. Venesio, A. Zaccagna, A. Pisacane, I Sarotto, D. Taverna, L. Poliseno, D. Bergamaschi, G. Chiorino
Summary: The study identified a significant association between metastases, BRAF mutation, and low GJB5 expression in melanoma, suggesting a potential prognostic role for GJB5 in cutaneous melanoma.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Juan Tang, Youling Gong, Xuelei Ma
Summary: The discovery of oncogenes and immune checkpoints has revolutionized the treatment of melanoma in the past 10 years. However, the current PD-L1 checkpoints lack specificity for tumors and target normal cells expressing PD-L1, thus reducing the efficacy on malignant melanoma and increasing the side effects. In addition, the treatment options for primary or secondary drug-resistant melanoma are limited. Bispecific antibodies bind tumor cells and immune cells by simultaneously targeting two antigens, enhancing the anti-tumor targeting effect and cytotoxicity and reducing drug-resistance in malignant melanoma, thus representing an emerging strategy to improve the clinical efficacy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ida M. Heerfordt, Jeppe D. Andersen, Peter A. Philipsen, Linnea Langhans, Torben Tvedebrink, Grethe Schmidt, Thomas Poulsen, Catharina M. Lerche, Niels Morling, Hans Christian Wulf
Summary: This study aims to use RNA analysis to improve early diagnostic accuracy of suspicious lesions and enhance the management of CMM.
Article
Oncology
Wei Zheng, Wei Ju, Xi-Hu Yang, Zhi-Xin Yan
Summary: This study aimed to investigate the expression of Angiopoietin-2 (Ang-2/ANGPT2) and its relationship with lymphangiogenesis and clinicopathological characteristics in cutaneous malignant melanoma (CMM). The results showed that high expression of Ang-2 was associated with poor prognosis and lymph node metastasis in CMM. Evaluation of Ang-2 expression and lymphatic vessel density can be used to predict the risk of tumor lymphatic metastasis and determine the prognosis of CMM.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Zijun Wang, Mou Peng
Summary: LCP2 expression is upregulated in metastatic skin cutaneous melanoma and associated with good overall survival. It is involved in multiple immune response pathways and positively correlated with molecules in TCR signaling and immune checkpoints in melanoma. High LCP2 expression is positively correlated with tumor-infiltrating CD8(+) T cells and acts as a prognostic biomarker for progression-free survival in patients receiving anti-PD1 immunotherapy.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Akiyoshi Hoshino, Chika Nakayama, Shi-Xu Jiang, Yasutaka Sakurai, Takuya Kato, Yoshiko Numata, Atsuko Umezawa, Masaaki Ichinoe, Yoshiki Murakumo
Summary: The expression of REV7 is associated with disease progression in malignant melanoma, with its depletion suppressing cell proliferation and migration while affecting signaling pathways activation.
PATHOLOGY INTERNATIONAL
(2022)
Article
Multidisciplinary Sciences
Asma Chikhaoui, Meriem Jones, Tadeja Rezen, Melika Ben Ahmed, Chokri Naouali, Radovan Komel, Mohamed Zghal, Samir Boubaker, Sonia Abdelhak, Houda Yacoub-Youssef
Summary: Xeroderma pigmentosum (XP) is a DNA repair disease associated with early skin cancers like melanoma. Inflammatory genes in the melanoma microenvironment have potential as biomarkers for prognosis and identifying therapeutic targets. This study used PCR array to evaluate the expression of inflammatory genes in XP patients and sporadic melanoma, identifying potential biomarkers for tumorigenesis and patient survival. The study also observed alterations in immune response in XP patients, suggesting a potential prognostic biomarker for melanoma outcome.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Ke-Jun Chen, Feng-Zeng Li, Qian Ye, Meng Jia, Sheng Fang
Summary: Heat shock protein 105 (HSP105) is overexpressed in cutaneous malignant melanoma (CMM) and is closely associated with different clinicopathological variables. Lesions in exposed sites, recurrent and metastatic lesions, nodular melanoma, and lentigo maligna melanoma show higher HSP105 expression, suggesting HSP105 as a potential target for the diagnosis, treatment, and prognostic prediction of CMM.
Article
Biochemistry & Molecular Biology
Jia Chen, Shu-Fen Hou, Feng-Jie Tang, Dai-Song Liu, Zi-Zi Chen, Hong-Lian Zhang, Shao-Hua Wang
Summary: HOTAIR, through up-regulating Sp1 and targeting miR-199a, promotes stemness and progression of CSCC. Targeting HOTAIR, Sp1 or the underlying mechanisms may benefit CSCC treatment, as shown by functional assays and in vivo models.
Article
Oncology
Susi Zhu, Xu Zhang, Yeye Guo, Ling Tang, Zhe Zhou, Xiang Chen, Cong Peng
Summary: This study found that increased expression of NETO2 in melanoma patients is associated with poor prognosis. Inhibiting NETO2 expression significantly suppressed melanoma proliferation, malignant growth, migration, and invasion. Pharmacological inhibition of CaMKII/CREB activity can suppress NETO2-induced proliferation and melanoma metastasis.
FRONTIERS OF MEDICINE
(2023)
Article
Cell Biology
Silvia Muccioli, Valentina Brillo, Tatiana Varanita, Federica Rossin, Elisabetta Zaltron, Angelo Velle, Giorgia Alessio, Beatrice Angi, Filippo Severin, Anna Tosi, Manuela D'Eletto, Luca Occhigrossi, Laura Falasca, Vanessa Checchetto, Roberto Ciaccio, Amelia Fasci, Leonardo Chieregato, Ana Paula Rebelo, Marta Giacomello, Antonio Rosato, Ildiko Szabo, Chiara Romualdi, Mauro Piacentini, Luigi Leanza
Summary: This article investigates the plasticity of melanoma and the role of Transglutaminase Type-2 (TG2) in regulating melanoma formation and invasiveness. The results suggest that TG2 expression can affect melanoma invasiveness and may contribute to unraveling the vulnerabilities of melanoma.
CELL DEATH & DISEASE
(2023)
Review
Geriatrics & Gerontology
Piergiacomo Calzavara-Pinton, Irene Calzavara-Pinton, Chiara Rovati, Mariateresa Rossi
Summary: Actinic keratosis is a disease caused by excessive sun exposure, which needs to be treated to prevent the development of cancer. Different treatments, including physical ablative techniques and medication, are used for various lesions. There is no difference in treatment efficacy and tolerability between older and younger patients, but older patients often require more motivation for treatment.
Article
Medicine, General & Internal
Elena Di Pierro, Francesca Granata, Michele De Canio, Mariateresa Rossi, Andrea Ricci, Matteo Marcacci, Giacomo De Luca, Luisa Sarno, Luca Barbieri, Paolo Ventura, Giovanna Graziadei
Summary: Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are inherited disorders resulting from defects in enzymes of the heme biosynthetic pathway. They both lead to the systemic accumulation of protoporphyrin IX (PPIX) and cause cutaneous photosensitivity. This review provides an overview of established facts and latest findings on these rare diseases.
Article
Dermatology
L. Stingeni, L. Bianchi, E. Antonelli, E. S. Caroppo, S. M. Ferrucci, M. Ortoncelli, G. Fabbrocini, E. Nettis, D. Schena, M. Napolitano, M. Gola, L. Bonzano, M. Rossi, A. Belloni Fortina, A. Balato, K. Peris, C. Foti, F. Guarneri, M. Romanelli, C. Patruno, P. Savoia, M. C. Fargnoli, F. Russo, E. Errichetti, T. Bianchelli, L. Bianchi, G. Pellacani, C. Feliciani, A. Offidani, M. Corazza, G. Micali, N. Milanesi, G. Malara, A. Chiricozzi, M. Tramontana, K. Hansel
Summary: This study validated the effectiveness and safety of Dupilumab in the treatment of moderate-to-severe AD in adolescents and investigated the main clinical phenotypes of AD.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
Mariachiara Arisi, Benedetta Galli, Edoardo Guasco Pisani, Giuseppe La Rosa, Gaetano Licata, Sara Rovaris, Cesare Tomasi, Mariateresa Rossi, Marina Venturini, Luigi Spiazzi, Piergiacomo Calzavara-Pinton
Summary: The study compares the efficacy and tolerability of conventional photodynamic therapy (c-PDT) and indoor daylight photodynamic therapy (idl-PDT) for the treatment of actinic cheilitis (AC). Both treatment options were found to be highly effective, with idl-PDT showing milder inflammatory reaction and pain scores.
DERMATOLOGY AND THERAPY
(2022)
Letter
Dermatology
Luca Stingeni, Leonardo Bianchi, Elettra Antonelli, Elena Sofia Caroppo, Silvia Mariel Ferrucci, Carlotta Gurioli, Michela Ortoncelli, Gabriella Fabbrocini, Eustachio Nettis, Donatella Schena, Maddalena Napolitano, Massimo Gola, Laura Bonzano, MariaTeresa Rossi, Anna Belloni Fortina, Anna Balato, Ketty Peris, Caterina Foti, Fabrizio Guarneri, Marco Romanelli, Cataldo Patruno, Paola Savoia, Maria Esposito, Filomena Russo, Enzo Errichetti, Tommaso Bianchelli, Luca Bianchi, Giovanni Pellacani, Claudio Feliciani, Annamaria Offidani, Monica Corazza, Giuseppe Micali, Nicola Milanesi, Giovanna Malara, Andrea Chiricozzi, Marta Tramontana, Katharina Hansel
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, G. Avila Valle, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara Pinton, S. Christen-Zach, M. Deleuran, M. Dittmann, C. Dressler, A. H. Fink-Wagner, N. Fosse, K. Gaspar, L. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, M. Redding, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
Summary: The evidence- and consensus-based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. It provides recommendations and detailed information on basic therapy and other treatments for atopic eczema, covering various aspects such as provocation factors, dietary interventions, and occupational and psychodermatological aspects. The guideline also includes specific guidance for pediatric and adolescent patients, as well as pregnant or breastfeeding women.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, G. Avila Valle, S. Barbarot, T. Bieber, H. A. Brough, P. Calzavara Pinton, S. Christen-Zach, M. Deleuran, M. Dittmann, C. Dressler, A. H. Fink-Wagner, N. Fosse, K. Gaspar, L. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, M. Redding, E. M. Rehbinder, J. Ring, M. Rossi, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
Summary: The evidence- and consensus-based guideline on atopic eczema, developed according to the EuroGuiDerm Guideline and Consensus Statement Development Manual, involves the participation of 29 experts from 12 European countries. The first part of the guideline provides general information, guidance, and detailed information on systemic treatment options, including conventional immunosuppressive drugs, biologics, and janus kinase inhibitors. The second part will cover other aspects of treatment.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2022)
Article
Medicine, General & Internal
Niccolo Gori, Andrea Chiricozzi, Franco Marsili, Silvia Mariel Ferrucci, Paolo Amerio, Vincenzo Battarra, Salvatore Campitiello, Antonio Castelli, Maurizio Congedo, Monica Corazza, Antonio Cristaudo, Gabriella Fabbrocini, Giampiero Girolomoni, Giovanna Malara, Giuseppe Micali, Giovanni Palazzo, Aurora Parodi, Annalisa Patrizi, Giovanni Pellacani, Paolo Pigatto, Eugenio Provenzano, Pietro Quaglino, Marco Romanelli, Mariateresa Rossi, Paola Savoia, Ketty Peris
Summary: Atopic dermatitis (AD) is a common and serious inflammatory skin disease that can significantly impair a patient's quality of life. The study revealed that AD patients experience more severe itching, sleep disturbances, and interference with activities compared to non-AD patients. Despite the high burden of the disease, AD patients are undertreated, with almost one-third of patients receiving no treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Gaetano Licata, Mariachiara Arisi, Marina Venturini, Mariateresa Rossi, Cesare Tomasi, Irene Calzavara-Pinton, Piergiacomo Calzavara-Pinton
Summary: Cal/BD foam combined with NB-UVB phototherapy is a highly effective treatment for psoriasis, producing rapid improvement in symptoms and requiring fewer treatments and a lower cumulative UVB dose.
DERMATOLOGY AND THERAPY
(2022)
Article
Dermatology
PierGiacomo Calzavara-Pinton, Mariachiara Arisi, Francesco Tonon, Irene Calzavara-Pinton, Marina Venturini, Mariateresa Rossi
Summary: Bath-PUVA is an effective and safe treatment option for psoriatic patients who do not respond to other therapies or have contraindications.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Letter
Dermatology
Andrea Chiricozzi, Anna Balato, Gabriella Fabbrocini, Lucia Di Nardo, Graziella Babino, Mariateresa Rossi, Maria Esposito, Alberto Maria Bertoldi, Giampiero Girolomoni, Alessio Gambardella, Flaminia Antonelli, Cataldo Patruno, Maria Concetta Fargnoli, Giuseppe Argenziano, Ketty Peris
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Medicine, General & Internal
Mariateresa Rossi, Caterina Damiani, Mariachiara Arisi, Cesare Tomasi, Francesco Tonon, Marina Venturini, Piergiacomo Calzavara-Pinton
Summary: NB-UVB and UVA1 have been effective for treating AD since the 1980s, but their clinical use in the biologic era needs further evaluation. 145 patients undergoing phototherapy achieved a median EASI score of 9.90 with UVA1 and 13.70 with NB-UVB. The rates of patients achieving IGA 0/1 were 33% (UVA1) and 28% (NB-UVB) for at least 6 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Piergiacomo Calzavara-Pinton, Jarmila Celakovska, Hilde Lapeere, Gregor Holzer, Mona Al-Ahmad, Chia-Yu Chu, Silvia M. Ferrucci, Yoko Kataoka, Mariateresa Rossi, Daria S. Fomina, Wen-Hung Chung, Thrasyvoulos Tzellos, Anne-Claire Fougerousse, Jiangming Wu, Marius Ardeleanu, Zafer E. Ozturk
Summary: This study aimed to characterize patients receiving dupilumab for atopic dermatitis (AD) in a real-world setting. The findings showed that patients had a high disease burden before starting dupilumab treatment, and a significant proportion had type 2 inflammatory comorbidities.
ADVANCES IN THERAPY
(2023)
Article
Dermatology
Luca Stingeni, Andrea Chiricozzi, Piergiacomo Calzavara-Pinton, Maddalena Napolitano, Ketty Peris, Donatella Schena, Cataldo Patruno, Mariateresa Rossi, Caterina Foti, Maria C. Fargnoli, Monica Corazza, Silvia M. Ferrucci, Paolo D. Pigatto, Marco Romanelli, Gabriella Fabbrocini, Giampiero Girolomoni, Maria Passante, Paolo Romita, Maria Esposito, Natale Schettini, Angelo V. Marzano, Giulia Tonini, Rossella Marietti, Gabriele Casciola, Giuseppe Argenziano, Katharina Hansel
Summary: This study, AtopyReg((R)), provides baseline data on moderate-to-severe atopic dermatitis patients in Italy, confirming the high burden of atopic dermatitis and its significant impact on patients' quality of life.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2023)
Meeting Abstract
Dermatology
Silvia M. Ferrucci, M. Rossi, Daria S. Fomina
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)