Article
Dermatology
Martina Ulrich, Uwe Reinhold, Rolf Dominicus, Roland Aschoff, Rolf-Markus Szeimies, Thomas Dirschka
Summary: The study demonstrated that BF-200 ALA was more effective than the vehicle in clearing AK on the extremities, trunk, and neck, with patients expressing higher satisfaction with the cosmetic outcome. Despite some limitations in the study, the results indicate that BF-200 ALA has a good clearance effect on AK in these areas.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Oncology
Jon Chim Bai-Habelski, Karla Medrano, Ariana Palacio, Uwe Reinhold
Summary: The study demonstrated that simulated daylight photodynamic therapy (SDL-PDT) using the IndoorLux (R) system in combination with BF-200 ALA is effective and nearly pain-free in treating patients with AK. This approach has the potential for widespread use in clinical practice.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Dermatology
Miguel Fernando Garcia-Gil, Tamara Gracia-Cazana, Paulina Cerro-Munoz, Laura Bernal-Masferrer, Alba Navarro-Bielsa, Yolanda Gilaberte
Summary: This study evaluates the effectiveness and safety of methyl aminolevulinate daylight photodynamic therapy (MAL DL-PDT) performed at home. The results show that MAL DL-PDT is highly effective for the long-term treatment of nonhyperkeratotic actinic keratosis (AK), with a high level of patient satisfaction.
DERMATOLOGIC THERAPY
(2022)
Article
Oncology
Linglin Zhang, Zijun Zhao, Peiru Wang, Guolong Zhang, Bo Wang, Lei Shi, Xiaojing Liu, Zhongxia Zhou, Xiuli Wang
Summary: In this study, the long-term improvement effect of ALA-PDT on photoaging in AK patients was evaluated. Results showed significant improvements in fine lines and mottled pigmentation, with no relapse observed during the 24-month follow-up period. However, the small sample size was a limitation, and further research is needed to confirm the reliability of the results.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Dermatology
Soledad Saenz-Guirado, Carlos Cuenca-Barrales, Jorge Vega-Castillo, Laura Linares-Gonzalez, Teresa Rodenas-Herranz, Alejandro Molina-Leyva, Ricardo Ruiz-Villaverde
Summary: The study demonstrates that combined PDT (daylight PDT followed by conventional PDT) for the treatment of actinic keratosis is as effective as conventional PDT in reducing lesions, but shows superior results in reducing pain and local skin reactions. The primary endpoint results show no significant difference between the two treatments in reducing actinic keratosis.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2022)
Article
Dermatology
Jon Chim Bai-Habelski, Annette Ko, Christoph Ortland, Marcus Stocker, Andrea Ebeling, Uwe Reinhold
Summary: Photodynamic therapy with 5-aminolevulinic acid hydrochloride is an established method for treating actinic keratosis (AK). Occlusion during ALA incubation can improve the clinical outcome of PDT for AK on hands and arms. Two PD P 506 A-PDT sessions 1-2 weeks apart are an efficacious treatment for AK on hands and arms.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
C. Meierhofer, K. Silic, M. V. Urban, Adrian Tanew, Sonja Radakovic
Summary: This study compares the efficacy and tolerability of occlusive versus non-occlusive application of ALA for PDT treatment of multiple AK on the scalp or face. Results show that occlusive PDT significantly improves clearance rates compared to non-occlusive PDT, but is associated with higher pain levels and phototoxicity.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2021)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This analysis reviewed the literature related to the management of AK to provide evidence-based recommendations for treatment. Strong recommendations were made for using ultraviolet protection, topical medications, and cryosurgery to treat AK. Conditional recommendations were made for photodynamic therapy and diclofenac for the treatment of AK.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Dermatology
Daniel B. Eisen, Maryam M. Asgari, Daniel D. Bennett, Suzanne M. Connolly, Robert P. Dellavalle, Esther E. Freeman, Gary Goldenberg, David J. Leffell, Sue Peschin, James E. Sligh, Peggy A. Wu, Lindsy Frazer-Green, Sameer Malik, Todd E. Schlesinger
Summary: This study provides a summary of 18 evidence-based recommendations for the treatment of actinic keratoses, highlighting the effectiveness of treatments such as ultraviolet protection, topical medications, and cryosurgery. The recommendations are subject to limitations, and future research may alter current treatment guidelines.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Oncology
Peiru Wang, Fang Xie, Linglin Zhang, Shuang Zhao, Lude Zhu, Shuzhan Shen, Dongsheng Li, Zhou Chen, Rong Xiao, Yan Lu, Xia Lei, Yan Li, Guolong Zhang, Weihui Zeng, Xiuli Wang
Summary: This study found that plum-blossom needle-assisted photodynamic therapy can enhance the efficacy of 5-aminolevulinic acid (ALA) treatment for actinic keratosis, especially for grade III lesions. Vertical tapping with a plum-blossom needle can promote the transdermal delivery of ALA and reduce the required treatment sessions. Plum-blossom needle-assisted photodynamic therapy is safe and effective for treating facial actinic keratosis in the Chinese population.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Oncology
Stefano Piaserico, Antonella Piccioni, Carlota Gutierrez Garcia-Rodrigo, Giorgia Sacco, Cristina Pellegrini, Maria Concetta Fargnoli
Summary: Topical calcitriol and methyl aminolevulinate (MAL) daylight photodynamic therapy (CAL-DL-PDT) showed higher efficacy for thicker actinic keratoses (AKs) on acral sites compared to placebo and MAL-DL-PDT (P-DL-PDT), especially for grouped grade II/III AKs. However, CAL-DL-PDT was associated with more frequent local skin reactions.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2021)
Article
Pharmacology & Pharmacy
Joanna Bartosinska, Paulina Szczepanik-Kulak, Dorota Raczkiewicz, Marta Niewiedziol, Agnieszka Gerkowicz, Dorota Kowalczuk, Miroslaw Kwasny, Dorota Krasowska
Summary: The study evaluated the efficacy and cosmetic outcome of different photosensitizers in AK patients, indicating that ALA-P may have better effects and lower pain intensity compared to ALA-HCl and MAL-HCl.
Article
Biochemistry & Molecular Biology
Elena Campione, Monia Di Prete, Cosimo Di Raimondo, Gaetana Costanza, Vincenzo Palumbo, Virginia Garofalo, Sara Mazzilli, Chiara Franceschini, Emi Dika, Luca Bianchi, Augusto Orlandi
Summary: This study evaluated the clinical efficacy of three different therapeutic modalities for actinic keratosis and assessed the expression of matrix metalloproteinases through histopathological examination and immunohistochemistry. The results showed a gradual decrease in actinic keratosis assessment scores at the end of treatments and a reduction in matrix metalloproteinase expression in treated skin lesions compared to baseline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Francisco Jose Navarro-Trivino, Angela Ayen-Rodriguez, Jose Maria Llamas-Molina, Soledad Saenz-Guirado, Ricardo Ruiz-Villaverde
Summary: Photodynamic therapy with 7.8% 5-aminolaevulinic acid nanoemulsion-based gel is shown to be an effective and safe treatment option for superficial basal cell carcinoma. Treatment responses were evaluated at different time points post-PDT, with complete clearance rates higher in patients who received only one PDT cycle. The results are consistent with findings in other publications.
DERMATOLOGIC THERAPY
(2021)
Review
Dermatology
Nathaniel Lampley III, Rachel Rigo, Todd Schlesinger, Anthony M. Rossi
Summary: This study reviewed the literature on field-directed therapies for actinic keratosis, comparing efficacy, cost, and adherence data for topical and in-office treatments. The results showed that topical 5-fluorouracil and photodynamic therapy have similar effective cost, and photodynamic therapy is a cost-effective alternative to topical therapies with comparable efficacy.
DERMATOLOGIC SURGERY
(2023)
Article
Surgery
Matteo Mombelli, Brian M. Lang, Dionysios Neofytos, John-David Aubert, Christian Benden, Christoph Berger, Katia Boggian, Adrian Egli, Paola M. Soccal, Laurent Kaiser, Cedric Hirzel, Manuel Pascual, Michael Koller, Nicolas J. Mueller, Christian van Delden, Hans H. Hirsch, Oriol Manuel
Summary: The study described the epidemiology and outcomes of respiratory viral infection (RVI) in solid organ transplant (SOT) recipients in Switzerland. The research found that RVI caused important morbidity and may affect long-term outcomes, highlighting the need for improved preventive strategies.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Kris Denhaerynck, Alexander S. Goldfarb-Rumyantzev, Gurprataap Sandhu, Sonja Beckmann, Uyen Huynh-Do, Isabelle Binet, Sabina De Geest
Summary: This study analyzed the impact of pre-transplant social determinants of health on post-transplant outcomes using data from the Swiss Transplant Cohort Study (STCS), and found that there was no significant association between SAI score and mortality or return to dialysis in this Swiss sample.
CLINICAL TRANSPLANTATION
(2021)
Article
Dermatology
Nadja Angela Stenz, Susanne Stampf, Andreas W. Arnold, Antonio Cozzio, Michael Dickenmann, Olivier Gaide, Mirjam Harms, Robert E. Hunger, Emmanuel Laffitte, Michael Muhlstadt, Mirjam Nageli, Gunther F. L. Hofbauer
Summary: This study in Switzerland found an increased risk of skin cancer among solid organ transplant recipients, with key risk factors including age, gender, history of skin cancer before transplantation, previous transplantations, and the number of immunosuppressive drugs used.
Article
Public, Environmental & Occupational Health
Philipp Kohler, Aline Wolfensberger, Susanne Stampf, Andreas Bronnimann, Katia Boggian, Christian van Delden, Melody Favre, Cedric Hirzel, Nina Khanna, Stefan P. Kuster, Oriol Manuel, Dionysios Neofytos, Silvio Ragozzino, Peter W. Schreiber, Laura Walti, Nicolas J. Mueller
Summary: The study found an increasing proportion of infections caused by ESBL-producing non-E. coli Enterobacterales in Swiss SOT recipients in recent years. Antibiotic pre-treatment is a risk factor for ESBL-E. Improving the appropriateness of empiric antibiotic treatment may be an important measure to reduce unfavorable outcomes in SOT recipients with ESBL-E infections, as observed in almost half of the cases.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Surgery
Lorena van den Bogaart, Brian M. Lang, Dionysios Neofytos, Adrian Egli, Laura N. Walti, Katia Boggian, Christian Garzoni, Christoph Berger, Manuel Pascual, Christian van Delden, Nicolas J. Mueller, Oriol Manuel, Matteo Mombelli
Summary: This study describes the epidemiology and outcomes of bacterial foodborne infections in solid organ transplant (SOT) recipients. The infections occurred late post-transplant and were associated with significant morbidity.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Melisa Dirchwolf, Chiara Becchetti, Sarah G. Gschwend, Christian Toso, Philipp Dutkowski, Franz Immer, Franziska Beyeler, Simona Rossi, Jonas Schropp, Jean-Francois Dufour, Vanessa Banz
Summary: This study analyzed the impact of the MELD Upgrade rule and all other MELD exceptions on liver transplant waiting list outcomes in Switzerland. The results indicated that only patients with MELD Upgrade exceptions had higher waiting list mortality and quicker access to liver transplantation.
Article
Immunology
Benjamin Speich, Frederique Chammartin, Irene A. Abela, Patrizia Amico, Marcel P. Stoeckle, Anna L. Eichenberger, Barbara Hasse, Dominique L. Braun, Mace M. Schuurmans, Thomas F. Mueller, Michael Tamm, Annette Audige, Nicolas J. Mueller, Andri Rauch, Huldrych F. Guenthard, Michael T. Koller, Alexandra Trkola, Matthias Briel, Katharina Kusejko, Heiner C. Bucher
Summary: This randomized trial compared the efficacy of Pfizer-BioNTech's BNT162b2 and Moderna's mRNA-1273 vaccines in immunocompromised patients. The results showed that the antibody response of mRNA-1273 was noninferior to BNT162b2, but a high proportion of transplant recipients had no antibody response.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Dermatology
Ugur Sahin, Kelly Reeve, Giulia Tochtermann, Kamilla Kilanowski, Alexander Navarini, Laurence Imhof, Ulrike Held, Guenther F. L. Hofbauer
Summary: This randomized controlled trial investigated the effects of a 9-week educational program on patients with chronic skin diseases. The results showed that the program may improve the quality of life and depression status of patients with psoriasis or atopic dermatitis.
Article
Infectious Diseases
Katharina Kusejko, Frederique Chammartin, Daniel Smith, Marc Odermatt, Julian Schuhmacher, Michael Koller, Huldrych F. Guenthard, Matthias Briel, Heiner C. Bucher, Benjamin Speich
Summary: This study developed a trial platform based on two established national cohort studies, allowing for fast implementation of clinical trials for new treatments and preventive interventions for COVID-19.
BMC INFECTIOUS DISEASES
(2022)
Article
Public, Environmental & Occupational Health
P. W. Schreiber, M. Laager, K. Boggian, D. Neofytos, C. van Delden, A. Egli, M. Dickenmann, C. Hirzel, O. Manuel, M. Koller, S. Rossi, B. Schmied, L. Gurke, M. Matter, T. Berney, O. de Rougemont, S. P. Kuster, S. Stampf, N. J. Mueller
Summary: Surgical site infections (SSIs) are common hospital-acquired infections, posing a significant threat to transplant recipients. This study aimed to determine the incidence, risk factors, and impact of SSI on post-transplant outcomes and pancreas transplant recipients. Among 130 transplant recipients, 14% developed SSI within the first 90 days after transplantation, with Enterococcus spp. being the most prevalent pathogen. SSI was independently associated with a longer hospitalization.
JOURNAL OF HOSPITAL INFECTION
(2022)
Article
Gastroenterology & Hepatology
Chiara Becchetti, Melisa Dirchwolf, Jonas Schropp, Giulia Magini, Beat Muellhaupt, Franz Immer, Jean-Francois Dufour, Vanessa Banz, Annalisa Berzigotti, Jaume Bosch
Summary: Statin use may confer a survival advantage for liver transplant recipients and should be encouraged when clinically indicated.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Surgery
Truong-Thanh Pham, Diego O. Andrey, Susanne Stampf, Sara H. Burkhard, Cedric Hirzel, Johnathan Tschopp, Kathrin Ullrich, Carol Strahm, Peter W. Schreiber, Noemie Boillat-Blanco, Christian Garzoni, Nina Khanna, Oriol Manuel, Nicolas J. Mueller, Domizio Suva, Christian van Delden, Ilker Uckay, Dionysios Neofytos
Summary: The study described the epidemiology of bone and joint infections in solid organ transplant recipients, finding a higher incidence of BJI in heart and kidney-pancreas recipients, with diabetic foot osteomyelitis being the most common type of infection, and associations with male gender and diabetes.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Dermatology
Colin Morton, Samira Baharlou, Nicole Basset-Seguin, Piergiacomo Calzavara-Pinton, Thomas Dirschka, Yolanda Gilaberte, Merete Haedersdal, Gunther Hofbauer, Sheetal Sapra, Rick Waalboer-Spuij, Leona Yip, Rolf-Markus Szeimies
Summary: Actinic keratoses are pre-malignant skin lesions that require personalized care. Lack of personalized care may lead to poor treatment adherence and suboptimal outcomes. The Personalizing Actinic Keratosis Treatment panel developed recommendations to support personalized, long-term management of actinic keratoses lesions, including tailoring treatment to patient priorities and goals and supporting shared decision-making.
ACTA DERMATO-VENEREOLOGICA
(2023)
Meeting Abstract
Dermatology
B. Meier-Schiesser, D. Jankovic, C. Surber, G. Hofbauer, E. Contassot, L. E. French
EXPERIMENTAL DERMATOLOGY
(2023)
Meeting Abstract
Dermatology
B. Meier-Schiesser, D. Jankovic, G. Hofbauer, C. Surber, E. Contassot, L. E. French
EXPERIMENTAL DERMATOLOGY
(2021)