Article
Dermatology
Nikolett Vasas, Zsofia Penzes, Kornel Kistamas, Peter Pal Nanasi, Szabolcs Molnar, Andrea Szegedi, Attila Gabor Szollosi, Tamas Biro
Summary: TRPV3, a pro-inflammatory ion channel, is significantly upregulated in the skin of atopic dermatitis patients. This study provides the first evidence of TRPV3 expression and function in non-lesional AD skin.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Yao Ke, Ben-Zheng Li, Khoa Nguyen, Donna Wang, Suyan Wang, Christian D. Young, Xiao-Jing Wang
Summary: This study aimed to identify the mechanisms and developmental therapeutics for inflammatory skin diseases using genetic models and pharmacological approaches. The researchers found that overexpression of SMAD7 in keratinocytes can inhibit inflammation and topical application can reduce inflammation. SMAD7 can also upregulate the transcription levels of IL-22 antagonist IL-22RA2 and inhibit associated inflammatory responses. This study provides both the mechanism and feasibility for developing SMAD7-based biologics as topical therapy for skin inflammatory disorders.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Chloe Grolleau, Andreea Calugareanu, Sarah Demouche, Audrey Nosbaum, Delphine Staumont-Salle, Helene Aubert, Charles Cassius, Marie Jachiet, Anne Saussine, Martine Bagot, Herve Bachelez, Maxime Battistella, Claire Hotz, Aurelie Du Thanh, Marie-Noelle Crepy, David Bergerat, Marine Merandet, Rachel Onifarasoaniaina, Antonio Alberdi, Alexandre How-Kit, Jean-David Bouaziz, Helene Le-Buanec
Summary: Dupilumab, a therapeutic antibody targeting IL-4 and IL-13 receptor subunit alpha, has been used for treating atopic dermatitis (AD). Recent reports have shown cases of psoriasis-like reactions induced by dupilumab treatment for AD. The pathogenesis of dupilumab-induced psoriatic eruption (DI-Pso) involves a shift in skin immune responses from T helper 2 to IL-36 and T helper 17 polarization, as well as intensified skin barrier alterations.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Nitin Bayal, Sunil Nagpal, Mohammed Monzoorul Haque, Milind S. Patole, Yogesh Shouche, Shekhar C. Mande, Sharmila S. Mande
Summary: The skin microbiome plays a crucial role in the pathogenesis of leprosy, with studies showing that leprosy patients have disrupted skin microbiota. Differences in skin microbiota between healthy controls and leprosy patients indicate a potential correlation between skin microbiota and leprosy pathogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
V. V. Sobolev, A. V. Mezentsev, R. H. Ziganshin, A. G. Soboleva, M. Denieva, I. M. Korsunskaya, O. A. Svitich
Summary: This study compared protein expression patterns in lesional and normally looking skin of psoriasis patients with healthy volunteers, revealing differentially expressed proteins. The findings explain the metabolic changes in skin lesions caused by the disease and suggest downregulation of kallikrein-kinin system in normally looking skin of patients to delay disease exacerbation.
Article
Rheumatology
Alba Boix-Amoros, Michelle H. Badri, Julia Manasson, Rebecca B. Blank, Rebecca H. Haberman, Andrea L. Neimann, Parvathy Girija, Anthony Jimenez Hernandez, Adriana Heguy, Sergei Koralov, Richard Bonneau, Jose C. Clemente, Jose U. Scher
Summary: This study investigated the differences in cutaneous microbiome between healthy individuals and patients with psoriasis and psoriatic arthritis. The results showed significant differences in diversity and bacterial composition between healthy skin and psoriatic skin, both lesional and non-lesional. Bacterial biomarkers were also identified that could potentially aid in predicting disease progression from psoriasis to psoriatic arthritis.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Hematology
Juan Li, Matthew J. Williams, Hyun Jung Park, Hugo P. Bastos, Xiaonan Wang, Daniel Prins, Nicola K. Wilson, Carys Johnson, Kendig Sham, Michelle Wantoch, Sam Watcham, Sarah J. Kinston, Dean C. Pask, Tina L. Hamilton, Rachel Sneade, Amie K. Waller, Cedric Ghevaert, George S. Vassiliou, Elisa Laurenti, David G. Kent, Berthold Gottgens, Anthony R. Green
Summary: Adult hematopoietic stem cells (HSCs) respond to acute stress and STAT1 plays a pivotal role in regulating their function. STAT1-dependent functional HSC heterogeneity exists, highlighting the importance of understanding stem cell heterogeneity and its interaction with the immune system.
Article
Cell Biology
Meijunzi Luo, Pan Huang, Yi Pan, Zhu Zhu, Rong Zhou, Zhibo Yang, Chang Wang
Summary: The study identified SPRR2C as a key gene in the pathogenesis and treatment of psoriasis, and it modulates the IL-22-stimulated HaCaT cell phenotype through the miR-330/STAT1/S100A7 axis. Additionally, WGCNA may uncover crucial biological pathways in the pathogenesis and treatment response of psoriasis.
CELL DEATH & DISEASE
(2021)
Article
Cell Biology
Ning-Sheng Lai, Hui-Chun Yu, Hsien-Bin Huang, Hsien-Yu Huang Tseng, Ming-Chi Lu, Mirella Giovarelli
Summary: This study identified abnormal expression of long noncoding RNAs (lncRNAs) in T cells from patients with vitiligo and investigated their functional roles in the immune system. The study revealed that the expression of LOC100506314 was elevated in CD4+ T cells from patients with vitiligo and associated with the severity of the condition. LOC100506314 interacted with STAT3 and MIF, inhibiting the expression of immune-related pathways and cytokines. Enhanced expression of LOC100506314 in T cells may serve as a potential treatment strategy for vitiligo.
MEDIATORS OF INFLAMMATION
(2023)
Article
Rheumatology
Hanna Johnsson, John Cole, Iain B. McInnes, Gerard Graham, Stefan Siebert
Summary: This study compares transcriptional changes in psoriasis and PsA skin for the first time, finding that immunoglobulin genes are upregulated in PsA skin lesions, which may have implications for its spread to other tissues.
Article
Biochemistry & Molecular Biology
Sara Rosendahl, Rima Sulniute, Michaela Eklund, Cecilia Koskinen Holm, Marcus J. O. Johansson, Elin Kindstedt, Susanne Lindquist, Pernilla Lundberg
Summary: CCR3 deficiency influences osteoblast and osteoclast differentiation, leading to thinner cortical bone in adult male mice.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Dermatology
Renata Bozo, Lili Borbala Flink, Nora Belso, Barbara Guban, Marta Szell, Lajos Kemeny, Zsuzsanna Bata-Csorgo
Summary: The tissue microenvironment plays a crucial role in regulating immune functions. Studying the constitutively abnormal functions of clinically uninvolved psoriatic skin can provide insights into psoriasis pathobiology. Abnormalities at the dermal-epidermal junction region in non-lesional skin may contribute to the development of the disease.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Min Li, Yanqin Xu, Jie Liang, Hao Lin, Xinyue Qi, Fanlin Li, Ping Han, Yanfeng Gao, Xuanming Yang
Summary: The study utilized CRISPR-Cas9 technology to screen melanoma cells, revealing that deletion or overexpression of specific genes can affect cell sensitivity to T cell-mediated killing. USP22 may regulate tumor cell escape ability through the interferon pathway. This research uncovers a novel immune evasion mechanism.
Review
Oncology
Daniel Octavian Costache, Horia Bejan, Marcela Poenaru, Raluca Simona Costache
Summary: Psoriasis is a chronic, immune-mediated, inflammatory disease that is associated with various comorbidities, including psoriatic arthritis, cardiovascular disease, metabolic syndrome, and depression. Recent studies have also explored the relationship between psoriasis and specific-site cancers. Inflammation plays a crucial role in the development of neoplastic foci, as chronic inflammation leads to the accumulation of inflammatory cells and the production of reactive oxygen species that cause mutations in cellular DNA. It is important to assess the risk of skin cancer development in psoriasis patients and provide proper management strategies.
Article
Biology
Renata Bozo, Judit Danis, Lili Borbala Flink, Daniel Laszlo Vidacs, Lajos Kemeny, Zsuzsanna Bata-Csorgo
Summary: The stress response of keratinocytes in uninvolved psoriatic epidermis is altered compared to healthy cells, affecting pathways related to FOXO-mediated transcription and cell-cycle genes. Increased expression of p27/CDKN1B and FOXO1 in the uninvolved epidermis may indicate a compensatory mechanism to inhibit cell proliferation and maintain symptomless skin phenotype in psoriasis.
Article
Hematology
Maria Gluud, Emil M. H. Pallesen, Terkild B. Buus, Lise Mette Rahbek Gjerdrum, Lise M. Lindahl, Maria R. Kamstrup, Michael Bzorek, Maria Danielsen, Rikke Bech, Madalena N. Monteiro, Edda Blumel, Andreas Willerslev-Olsen, Anders Lykkebo-Valloe, Chella Krishna Vadivel, Thorbjorn Krejsgaard, Charlotte Menne Bonefeld, Carsten Geisler, Juergen C. Becker, Sergei B. Koralov, Lars Iversen, Thomas Litman, Anders Woetmann, Niels Odum
Summary: Cutaneous T-cell lymphoma (CTCL) is a devastating lymphoid malignancy characterized by the accumulation of malignant T cells in the dermis and epidermis. Skin lesions cause serious symptoms and increase the risk of bacterial infection. The study found that malignant T cells secrete cytokines that downregulate the expression of filaggrin and filaggrin-2, leading to compromised skin barrier. Treatment with JAK inhibitors can reverse this effect and increase filaggrin expression in patients with advanced CTCL.
Article
Dermatology
Cathrine Dawn Buttner Elgaard, Lars Iversen, Kasper Fjellhaugen Hjuler
Summary: This study retrospectively analyzed the drug survival and effectiveness of interleukin-23 inhibitors in the treatment of psoriasis and psoriatic arthritis in a real-world setting. The results showed that these drugs have high and similar drug survival and effectiveness in patients with difficult-to-treat psoriasis and PsA.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Dermatology
Lars Iversen, Curdin Conrad, Liv Eidsmo, Antonio Costanzo, Joanna Narbutt, Andreas Pinter, Kulli Kingo, Raquel Rivera Diaz, Frank Kolbinger, ManikPrabhu Nanna, Jennifer Annika Frueh, Piotr Jagiello
Summary: The purpose of this study was to compare the effectiveness of early intervention with secukinumab and traditional nb-UVB phototherapy in patients with new-onset moderate to severe plaque psoriasis. The results showed that secukinumab was more effective than nb-UVB, and early use of biologic treatment may be more effective in treating psoriasis.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Article
Dermatology
Catalina Hartmann Skovsgard, Trine Bay Laurberg, Anders Dige, Lars Iversen, Kasper Fjellhaugen Hjuler
Summary: The aim of this study was to determine the proportion of psoriasis patients with suspicion of PsA who are diagnosed with PsA or other rheumatologic conditions following referral from a dermatology department. A total of 23.6% of patients with psoriasis with symptoms suggestive of PsA were diagnosed with axial and/or peripheral arthritis following rheumatologic evaluation.
Article
Dermatology
Emil M. H. Pallesen, Maria Gluud, Chella Krishna Vadivel, Terkild B. Buus, Bob de Rooij, Ziao Zeng, Sana Ahmad, Andreas Willerslev-Olsen, Christian Roehrig, Maria R. Kamstrup, Lene Bay, Lise Lindahl, Thorbjorn Krejsgaard, Carsten Geisler, Charlotte M. Bonefeld, Lars Iversen, Anders Woetmann, Sergei B. Koralov, Thomas Bjarnsholt, Johan Frieling, Mathias Schmelcher, Niels Odum
Summary: This study investigates the effect of a recombinant, antibacterial protein, endolysin (XZ.700), on S. aureus skin colonization and malignant T-cell activation in cutaneous T-cell lymphomas. The results show that endolysin strongly inhibits S. aureus proliferation in the skin of lymphoma patients and reduces bacterial cell counts in a dose-dependent manner. Moreover, endolysin also inhibits the colonization of S. aureus on healthy and lesional skin and has a significant inhibitory effect on the activation and proliferation of malignant T cells induced by S. aureus.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cathrine Dawn Buttner Elgaard, Lars Iversen, Kasper Fjellhaugen Hjuler
Summary: This study investigates the drug survival and clinical effectiveness of brodalumab in real-world patients with psoriasis and psoriatic arthritis. The results show that brodalumab is effective in treating these conditions, but the drug survival rate is lower compared to other studies.
Article
Immunology
Hakim Ben Abdallah, Sabine Seeler, Anne Bregnhoj, Gautam Ghatnekar, Lasse S. Kristensen, Lars Iversen, Claus Johansen
Summary: RGRN-305, an HSP90 inhibitor, exhibits anti-inflammatory effects by suppressing key proinflammatory cytokines and signaling pathways in TPA-induced skin inflammation. This study suggests that HSP90 inhibition may be a novel mechanism of action for treating immune-mediated skin diseases beyond psoriasis, and it may serve as a topical treatment option.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Josephine F. F. Iversen, Soren S. -R. Bohr, Henrik D. D. Pinholt, Matias E. E. Moses, Lars Iversen, Sune M. M. Christensen, Nikos S. S. Hatzakis, Min Zhang
Summary: We investigated the diffusion behavior of Thermomyces lanuginosus lipase (TLL) variants with different lid structures in a laundry-like application condition using single-particle tracking (SPT). Our findings reveal that surface binding and lipase mobility when bound are crucial factors affecting the overall activity variation in the application condition. These mechanistic insights provide new perspectives on the development of enzyme-based detergents.
Article
Biology
Marlene Uglebjerg Fruergaard, Christine Juul Faelled Nielsen, Cecilia Rosada Kjeldsen, Lars Iversen, Jacob Lauwring Andersen, Poul Nissen
Summary: The p90 ribosomal S6 kinases (RSKs) consist of N-terminal and C-terminal kinase domains (NTKD and CTKD). CTKD activation is regulated by phosphorylation by extracellular signal-regulated kinase (ERK1/2) and an autoinhibitory alpha L helix. Through mutational experiments, a mechanism of lifting autoinhibition was discovered, leading to the design of constitutively active RSK CTKDs. These findings provide insights into the characterization of inhibitors and determination of specificity constants of covalent CTKD inhibitors.
LIFE SCIENCE ALLIANCE
(2023)
Article
Dermatology
Mark Lebwohl, Lars Iversen, Liv Eidsmo, James G. Krueger, Mayte Suarez-Farinas, Lewis Tomalin, Frank Kolbinger, Ruquan You, Marina Milutinovic
Summary: A proportion of patients stayed relapse-free following discontinuation of secukinumab, and patients with shorter disease duration remained relapse-free for longer, suggesting that earlier treatment with secukinumab may result in long-term clinical control of moderate-to-severe psoriasis.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2023)
Review
Dermatology
Tiago Torres, Jordi Galvan, Nigel Crutchley, Morten Praestegaard, Lars Iversen, Paolo Gisondi, Jose Manuel Carrascosa, Bruno Halioua, Anthony Bewley, Andreas Pinter
Summary: Topical treatment of psoriasis is important but non-adherence is a challenge. CAL/BDP PAD-cream, based on PAD Technology, offers a more convenient and effective treatment. This formulation ensures stability, increases penetration, and improves cosmetic acceptability. Clinical trials have shown high efficacy, safety, and patient satisfaction with CAL/BDP PAD-cream, potentially leading to improved adherence and outcomes.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Flora Nicol Balieva, Louise Catton, Birgitta W. W. Clareus, Kjersti Danielsen, Frederik Fierens, Lars Iversen, Leena Koulu, Amra Osmanecevic, Rafael Pasternack, Lone Skov
Summary: This study aimed to explore treatment preferences and patient characteristics in young bio-naive adults with moderate to severe psoriasis in the Nordic countries. The interviews revealed that patient preferences focused on both symptom relief and reducing the burden of treatment. Understanding the reasons behind these preferences is crucial for individualized psoriasis management.
DERMATOLOGY AND THERAPY
(2023)
