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Oncology
Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Sonia Fernandez-Ruiz, Cristina Viera, Onintza Carlevaris, Amaia Ercilla, Isabel Mendizabal, Teresa Martin, Alice Macchia, Laura Camacho, Mikel Pujana-Vaquerizo, Pilar Sanchez-Mosquera, Veronica Torrano, Natalia Martin-Martin, Patricia Zuniga-Garcia, Mireia Castillo-Martin, Aitziber Ugalde-Olano, Ana Loizaga-Iriarte, Miguel Unda, Jose M. Mato, Edurne Berra, Maria L. Martinez-Chantar, Arkaitz Carracedo
Summary: This study investigates the regulation and function of Glycine N-Methyltransferase (GNMT) in prostate cancer and discovers that the enzyme is repressed when the oncogenic PI3K pathway is activated, adding complexity to its dependency on androgen signaling. Additionally, the study demonstrates the requirement of GNMT expression for the onset of invasive prostate cancer in a genetic mouse model.
Article
Multidisciplinary Sciences
Mariel C. Paul, Christian Schneeweis, Chiara Falcomata, Chuan Shan, Daniel Rossmeisl, Stella Koutsouli, Christine Klement, Magdalena Zukowska, Sebastian A. Widholz, Moritz Jesinghaus, Konstanze K. Heuermann, Thomas Engleitner, Barbara Seidler, Katia Sleiman, Katja Steiger, Markus Tschurtschenthaler, Benjamin Walter, Soeren A. Weidemann, Regina Pietsch, Angelika Schnieke, Roland M. Schmid, Maria S. Robles, Geoffroy Andrieux, Melanie Boerries, Roland Rad, Guenter Schneider, Dieter Saur
Summary: SNAIL promotes tumour metastasis through inducing epithelial to mesenchymal transition (EMT). Here the authors report that SNAIL bypasses senescence and regulates cell cycle progression to promote pancreatic carcinogenesis and this is independent of EMT induction.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Ioana Stejerean-Todoran, Katharina Zimmermann, Christine S. Gibhardt, Adina Vultur, Christian Ickes, Batool Shannan, Zurine Bonilla del Rio, Anna Wolling, Sabrina Cappello, Hsu-Min Sung, Magdalena Shumanska, Xin Zhang, Maithily Nanadikar, Muhammad U. Latif, Anna Wittek, Felix Lange, Andrea Waters, Patricia Brafford, Jorg Wilting, Henning Urlaub, Dorthe M. Katschinski, Peter Rehling, Christof Lenz, Stefan Jakobs, Volker Ellenrieder, Alexander Roesch, Michael P. Schon, Meenhard Herlyn, Hedwig Stanisz, Ivan Bogeski
Summary: MCUA expression correlates with melanoma patient survival and MCUA knockdown suppresses melanoma cell growth and stimulates migration and invasion. Knockdown of MCUA reduces tumor volumes but promotes lung metastases.
Article
Biochemistry & Molecular Biology
Karina A. Miller, Seamus Degan, Yanqing Wang, Joseph Cohen, Sheng Yu Ku, David W. Goodrich, Irwin H. Gelman
Summary: PTEN loss is a common mutation in prostate cancer, driving disease progression through AKT activation. Different transgenic prostate cancer models with Akt activation and Rb loss exhibit different metastatic outcomes. PTEN deficiency is correlated with increased dependence on p110 beta and AKT2 for metastatic growth or motility, and downregulation of the metastasis suppressor SMAD4. On the other hand, PTEN expression is associated with greater dependence on p110 alpha and AKT1.
Article
Biochemistry & Molecular Biology
Qun Xie, Ruirui Zhang, Dandan Liu, Jing Yang, Qiang Hu, Chao Shan, Xiaohan Li
Summary: MiR-331-3p is downregulated in melanoma and its upregulation inhibits cell proliferation, migration, drug resistance, tumour growth and metastasis, possibly through the regulation of NRP2 and E-cadherin levels.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Article
Dermatology
Karthic Swaminathan, Andrew Campbell, Vassilis Papalazarou, Farah Jaber-Hijazi, Colin Nixon, Ewan McGhee, Douglas Strathdee, Owen J. Sansom, Laura M. Machesky
Summary: The study reveals that NCKAP1 plays a crucial role in the progression and maintenance of tissue integrity in BRAF(V600E)-driven melanoma, with its depletion delaying tumor onset and progression, reducing proliferation and tumor growth, and leading to increased collagen deposition and immune infiltration.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Haiyang Wang, Ding Wang, Yongfeng Shen, Chenglong Sun, Qiang Hu, Li Jiang, Quan Du
Summary: Glioma stem-like cells (GSCs) play a crucial role in the malignant progression of glioma, and long non-coding RNAs (lncRNAs) are closely associated with glioma development. This study found that the downregulation of lncRNA growth arrest-specific 5 (GAS5) was correlated with poor patient survival in GSCs and high-grade glioma tissues. Functional assays revealed that downregulation of GAS5 promoted the malignant characteristics of GSCs. Mechanistically, GAS5 acted as a suppressor by directly targeting the miR-23a/E-cadherin axis.
CANCER GENE THERAPY
(2022)
Article
Medicine, Research & Experimental
Tao Xu, Ting Rao, Wei-Ming Yu, Jin-Zhuo Ning, Xi Yu, Shao-Ming Zhu, Kang Yang, Tao Bai, Fan Cheng
Summary: The study revealed that NFKBIZ has low expression in bladder cancer and inhibits the proliferation of bladder cancer cells through the PTEN/PI3K/Akt signaling pathway. This suggests that NFKBIZ may serve as a novel prognostic biomarker and potential therapeutic target for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Oncology
Rania Alaaeldin, Gamal El-Din A. Abuo-Rahma, Qing-Li Zhao, Moustafa Fathy
Summary: The new ciprofloxacin chalcone showed significant inhibitory effects on the proliferation, migration, and colony formation abilities of MCF-7 and MDA-MB-231 breast cancer cell lines. It induced apoptosis and cell cycle arrest, while also regulating the expression of apoptotic and anti-apoptotic factors and inhibiting epithelial-mesenchymal transition.
ANTICANCER RESEARCH
(2021)
Article
Oncology
Chaochao Wang, Hao Xue, Rongrong Zhao, Zhongzheng Sun, Xiao Gao, Yanhua Qi, Huizhi Wang, Jianye Xu, Lin Deng, Gang Li
Summary: It has been confirmed that RGS16 is upregulated in glioma tissues and its high expression is associated with poor survival. Deleting RGS16 significantly suppresses glioma cell proliferation and migration. Moreover, RGS16 has been validated as a direct target gene of miR let-7c-5p. Therefore, the inhibition of RGS16 may promote glioma progression and could potentially serve as a prognostic biomarker and therapeutic target for glioma.
FRONTIERS OF MEDICINE
(2023)
Article
Oncology
Weimin Wang, Jun Jin, Zhen Zhou, Yunfan Wang, Ke Min, Xin Zuo, Jiaping Jiang, Yan Zhou, Jun Shi
Summary: The overall survival rate of colorectal cancer patients is low, and the identification of valuable prognostic markers is urgently needed. This study investigated the clinical significance of Snail and E-cad expression in colorectal cancer and found that low Snail and high E-cad expression are associated with better prognosis.
Article
Oncology
Alessandra Pagano, Gilles Breuzard, Fabrice Parat, Aurelie Tchoghandjian, Dominique Figarella-Branger, Tiphany Coralie De Bessa, Francoise Garrouste, Alexis Douence, Pascale Barbier, Herve Kovacic
Summary: This study highlights the crucial role of Tau in glioblastoma, showing its involvement in tumor progression and regulation of 3D cell organization, growth, and migration via the PI3K/AKT signaling pathway. Depletion of Tau led to increased survival in a mouse model, inhibited multicellular spheroid growth and cell evasion, and resulted in defective activation of the PI3K/AKT pathway. The study suggests a potential therapeutic target in glioblastoma by targeting Tau and its downstream signaling pathway.
Article
Endocrinology & Metabolism
Shuaibin Wang, Chao Zhang, Zhifang Xu, Michael H. Chen, Haiyan Yu, Lizhong Wang, Runhua Liu
Summary: The study compared the impact of different signaling nodes in the PI3K/AKT/mTOR pathway on prostate cancer initiation and progression using genetically engineered mouse models. The results suggest that these signaling nodes have differential roles in prostate cancer, but the underlying molecular mechanisms remain unclear.
Article
Biotechnology & Applied Microbiology
Xuehan Bi, Xiao Lv, Dajiang Liu, Hongtao Guo, Guang Yao, Lijuan Wang, Xiaolei Liang, Yongxiu Yang
Summary: METTL3 promotes the maturation of miR-126-5p through m6A modification, which in turn targets PTEN to activate the PI3K/Akt/mTOR pathway in ovarian cancer progression. This study provides potential targets for future ovarian cancer treatment and reveals tumorigenic mechanisms regulated by m6A modification.
CANCER GENE THERAPY
(2021)
Article
Cell Biology
Pengling Wang, Ting Liu, Zhendan Zhao, Zhiling Wang, Shujie Liu, Xingsheng Yang
Summary: The study demonstrated that SPTBN2 is overexpressed in EEC and associated with poor prognosis, with its knockdown inhibiting cell proliferation, migration, and invasion. SPTBN2 interacts with CLDN4 to promote endometrial cancer metastasis via the PI3K/AKT pathway.
CELL DEATH DISCOVERY
(2021)