Article
Hematology
Sara Beygi, George E. Duran, Sebastian Fernandez-Pol, Alain H. Rook, Youn H. Kim, Michael S. Khodadoust
Summary: Resistance to mogamulizumab in mycosis fungoides and Sezary syndrome is often associated with loss of CCR4 expression and emergence of CCR4 genomic alterations. This finding has significant implications for the management and monitoring of patients receiving mogamulizumab and the development of future CCR4-directed therapies.
Article
Biochemistry & Molecular Biology
Karolina Rassek, Katarzyna Izykowska, Magdalena Zurawek, Monika Pieniawska, Karina Nowicka, Xing Zhao, Grzegorz K. Przybylski
Summary: TMEM244 is a transmembrane protein that belongs to the TMEM family and is involved in various cellular processes. It has been identified as a diagnostic marker for Sezary syndrome. In this study, it was found that TMEM244 is a necessary long non-coding RNA for the growth of CTCL cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Hematology
Margarita Sanchez-Beato
Summary: This study expands the list of potential driver genes in CTCL and demonstrates that PDCD1 deletion can reverse T-cell exhaustion signatures, leading to a worse prognosis.
Review
Dermatology
Maarten H. Vermeer, Helene Moins-Teisserenc, Martine Bagot, Pietro Quaglino, Sean Whittaker
Summary: Mycosis fungoides (MF) and Sezary syndrome (SS) are subtype of cutaneous T-cell lymphoma, their blood involvement in the assessment and staging has evolved in recent years. The use of flow cytometry (FC) and polymerase chain reaction (PCR) is providing more accurate prognosis and appropriate management.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Helen M. Wise, Adam Harris, Nisha Kriplani, Adam Schofield, Helen Caldwell, Mark J. Arends, Ian M. Overton, Nick R. Leslie
Summary: Loss of PTEN function is a common event in aggressive prostate cancers, and PTEN has both lipid phosphatase and protein phosphatase activities. Loss of PTEN protein phosphatase activity leads to lymphocyte infiltration and an increased immune cell gene expression signature.
Article
Hematology
Jerome Giustiniani, Gabor Dobos, Helene Moins-Teisserenc, Tiago Eustaquio, Maxime Battistella, Nicolas Ortonne, Caroline Ram-Wolff, Jean-David Bouaziz, Anne Marie-Cardine, Samia Mourah, Martine Bagot, Thomas S. Kupper, Rachael A. Clark, Armand Bensussan, Adele de Masson
Summary: This study investigates the expression of CCR8 in T-cell lymphomas and suggests that therapeutic depletion of CCR8-expressing cells may be an effective treatment strategy, eliminating tumor cells and activating anti-tumor immunity while avoiding immune side effects.
Article
Oncology
Boris Klimovich, Laura Meyer, Nastasja Merle, Michelle Neumann, Alexander M. Konig, Nikolaos Ananikidis, Corinna U. Keber, Sabrina Elmshauser, Oleg Timofeev, Thorsten Stiewe
Summary: The study found that the p53 variant E177R has the potential to inhibit proliferation and viability, induce immune cell infiltration, and trigger cancer regression in p53-deficient leukemia and lymphomas. Even the low-level activity of E177R is detrimental to cancer growth, indicating a high dependence of cancer cells on the absence of p53.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Adele de Masson, Marie Beylot-Barry, Caroline Ram-Wolff, Jean-Baptiste Mear, Stephane Dalle, Michel d'Incan, Saskia Ingen-Housz-Oro, Corentin Orvain, Julie Abraham, Olivier Dereure, Amandine Charbonnier, Jerome Cornillon, Christine Longvert, Stephane Barete, Serge Boulinguez, Ewa Wierzbicka-Hainaut, Francois Aubin, Marie-Therese Rubio, Marc Bernard, Aline Schmidt-Tanguy, Roch Houot, Anne Pham-Ledard, David Michonneau, Pauline Brice, Helene Labussiere-Wallet, Jean-David Bouaziz, Florent Grange, Helene Moins-Teisserenc, Katayoun Jondeau, Laurence Michel, Samia Mourah, Maxime Battistella, Etienne Daguindau, Michael Loschi, Alexandra Picard, Nathalie Franck, Natacha Maillard, Anne Huynh, Stephanie Nguyen, Ambroise Marcais, Guillaume Chaby, Patrice Ceballos, Yannick Le Corre, Sebastien Maury, Jacques-Olivier Bay, Henri Adamski, Emmanuel Bachy, Edouard Forcade, Gerard Socie, M. Bagot, S. Chevret, R. P. de Latour
Summary: This study aimed to investigate the effect of allogeneic haematopoietic stem cell transplantation (HSCT) compared with non-HSCT therapy on the outcome of individuals with advanced-stage cutaneous T-cell lymphomas (CTCLs). The results showed that allogeneic HSCT was significantly associated with longer progression-free survival in individuals with advanced-stage CTCLs.
Article
Medicine, Research & Experimental
Alyxzandria M. Gaydosik, Connor J. Stonesifer, Tracy Tabib, Robert Lafyatis, Larisa J. Geskin, Patrizia Fuschiotti
Summary: By analyzing the transcriptomes of cutaneous microenvironment in advanced-stage mycosis fungoides (MF) skin tumors, we identified distinct cell-type compositions and interactions between malignant T lymphocytes and immune and stromal cells. This heterogeneity has implications for cancer cell growth, migration, invasion, and antitumor immunity.
Review
Cell Biology
Cen Zhang, Juan Liu, Jianming Wang, Tianliang Zhang, Dandan Xu, Wenwei Hu, Zhaohui Feng
Summary: Hypoxia is crucial in solid tumors, with HIF and p53 signaling pathways playing key roles in regulating cellular responses to hypoxia. The interplay between hypoxia and p53 pathways can impact cancer progression, with p53 regulating hypoxia and HIF signaling in various ways, while mutant p53 can promote cancer progression through interaction with hypoxia and HIF signaling.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anders O. Larsson, Michael Hultstrom, Robert Frithiof, Miklos Lipcsey, Mats B. Eriksson
Summary: This study investigated the Shrunken Pore Syndrome (SPS) as a risk marker in severely ill COVID-19 patients. The results showed that SPS was common in critically ill patients, with a higher proportion found in female patients. Demographic factors and illness severity were independent predictors of SPS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Qingfan Mo, Ke Xu, Chenghao Luo, Qia Zhang, Long Wang, Guosheng Ren
Summary: BTNL9 expression decreased in breast cancer tissues and cell lines, significantly associated with early T stage progression, relapse-free survival, and poor overall survival. BTNL9 inhibited cell proliferation, colony formation, and metastasis, induced apoptosis, and may serve as a new biomarker for early breast cancer diagnosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Robert Stuver, Shamir Geller
Summary: Skin-directed treatments for MF/SS have been optimized and new systemic agents have been introduced in recent years, leading to exciting progress in the management of these cutaneous T-cell lymphomas.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Katarina Lopusna, Pawel Nowialis, Jana Opavska, Ajay Abraham, Alberto Riva, Rene Opavsky
Summary: The study revealed that Dnmt3b's catalytic activity is largely dispensable for mouse development but critical for preventing tumorigenesis by controlling events involved in cellular transformation. The lack of Dnmt3b's catalytic activity promoted fibroblast transformation in vitro and accelerated the development of certain types of leukemia and lymphoma in vivo.
Article
Biochemistry & Molecular Biology
Rinka Nakajima, Reika Deguchi, Hideyuki Komori, Lin Zhao, Yaxuan Zhou, Mashiro Shirasawa, Arlene Angelina, Yasuko Goto, Fumiya Tohjo, Kengo Nakahashi, Kimi Nakata, Ritsuko Iwanaga, Andrew P. Bradford, Keigo Araki, Tomoko Warita, Kiyoshi Ohtani
Summary: The TFDP1 gene codes for the heterodimeric partner DP1 of the transcription factor E2F, which plays important roles in cell proliferation. Over-expression of E2F1 and inactivation of the tumor suppressor pRB induce TFDP1 gene expression, suggesting that TFDP1 is a target of E2F. Serum stimulation also induces TFDP1 expression, but with different kinetics compared to other E2F target genes. The TFDP1 promoter contains E2F1-responsive elements, and mutation of GC-rich elements reduces E2F1 responsiveness. Knockdown of DP1 expression enhances ARF gene expression, indicating that TFDP1 activation by deregulated E2F may function as a feedback mechanism to suppress deregulated E2F activity and maintain normal cell growth.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Immunology
Veronica Delgado-Benito, Maria Berruezo-Llacuna, Robert Altwasser, Wiebke Winkler, Devakumar Sundaravinayagam, Sandhya Balasubramanian, Marieta Caganova, Robin Graf, Ali Rahjouei, Marie-Therese Henke, Madlen Driesner, Lisa Keller, Alessandro Prigione, Martin Janz, Altuna Akalin, Michela Di Virgilio
JOURNAL OF EXPERIMENTAL MEDICINE
(2020)
Article
Multidisciplinary Sciences
Florian Scholz, Michael Grau, Lutz Menzel, Annika Graband, Myroslav Zapukhlyak, Achim Leutz, Martin Janz, Georg Lenz, Armin Rehm, Uta E. Hoepken
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Correction
Oncology
Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Moebs, Philip Bischoff, Matthias Kloor, Hendrik Blaeker
Article
Pathology
Cleo Keppens, Elke Boone, Paula Gameiro, Veronique Tack, Elisabeth Moreau, Elizabeth Hodges, Paul Evans, Monika Brueggemann, Ian Carter, Dido Lenze, Maria Eugenia Sarasquete, Markus Moebs, Hongxiang Liu, Elisabeth M. C. Dequeker, Patricia J. T. A. Groenen
Summary: Clonality analysis of IG or TR gene rearrangements is important for diagnosing lymphoid malignancies. Participation in EQA helps labs identify and address systematic deficiencies. Results show improvement in analysis scores with more EQA rounds, and EuroClonality labs outperformed non-EuroClonality labs in overall performance.
Article
Oncology
Sophy Denker, Aitomi Bittner, Mareike Frick, Julia Kase, Joerg Hoffmann, Corinna Trenker, Ulrich Keller, Christian Bogner, Andreas Huettmann, Jan Duerig, Martin Janz, Stephan Mathas, Reinhard Marks, Ulrike Krohn, Il-Kang Na, Lars Bullinger, Clemens A. Schmitt
Summary: DLBCL is the most common lymphoid malignancy, with a portion of patients not being cured by standard immune-chemotherapy. Survival in younger patients can be enhanced by adding Ibrutinib, but this also leads to increased toxicity in all age groups.
LEUKEMIA & LYMPHOMA
(2022)
Article
Multidisciplinary Sciences
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W. Zimmerman, Elisabeth Gurnhofer, Ivonne A. Montes-Mojarro, Brian J. Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel-Adriano Silva, K. Christopher Garcia, David Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Sarka Pospisilova, Andrea Janikova, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knorr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D. Turner, A. Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Summary: The study highlights the importance of the BATF3/IL-2R module in ALCL biology and identifies IL-2R alpha targeting as a promising treatment strategy for ALCL.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
M. R. Bishop, M. Dickinson, D. Purtill, P. Barba, A. Santoro, N. Hamad, K. Kato, A. Sureda, R. Greil, C. Thieblemont, F. Morschhauser, M. Janz, I Flinn, W. Rabitsch, Y-L Kwong, M. J. Kersten, M. C. Minnema, H. Holte, E. H. L. Chan, J. Martinez-Lopez, A. M. S. Mueller, R. T. Maziarz, J. P. McGuirk, E. Bachy, S. Le Gouill, M. Dreyling, H. Harigae, D. Bond, C. Andreadis, P. McSweeney, M. Kharfan-Dabaja, S. Newsome, E. Degtyarev, R. Awasthi, C. del Corral, G. Andreola, A. Masood, S. J. Schuster, U. Jaeger, P. Borchmann, J. R. Westin
Summary: Tisagenlecleucel did not demonstrate superiority over standard salvage therapy in this trial. Further studies are needed to evaluate which patients may benefit the most from each approach.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pathology
Korinna Joehrens, Josephine Fischer, Markus Moebs, Klaus Junker, Jutta Kirfel, Sven Perner, Silke Lassmann, Martin Werner, Vanessa Borgmann, Hendrik Blaeker, Michael Hummel
Summary: Round robin testing plays a crucial role in precision oncology to ensure reliable detection of genetic mutations that impact treatment decisions. Recent studies have shown that molecular detection of the BRAF V600E mutation is more superior in accuracy compared to immunohistochemical detection in metastatic colorectal carcinoma patients.
Article
Clinical Neurology
Asmaa Foda, Elias Kellner, Asanka Gunawardana, Xiang Gao, Martin Janz, Anna Kufner, Ahmed A. Khalil, Rohat Geran, Ralf Mekle, Jochen B. Fiebach, Ivana Galinovic
Summary: Vessel size imaging (VSI) is a helpful technique for distinguishing between different types of brain tumors. In this study, MLC tumors were found to have larger and less dense microvasculature compared to PCNSL, while GBM tumors showed no significant differences compared to PCNSL.
CLINICAL NEURORADIOLOGY
(2022)
Article
Oncology
Kathrin D. Wurster, Mariantonia Costanza, Stephan Kreher, Selina Glaser, Bjoern Lamprecht, Nikolai Schleussner, Ioannis Anagnostopoulos, Michael Hummel, Korinna Joehrens, Harald Stein, Arturo Molina, Arjan Diepstra, Bernd Gillissen, Karl Koechert, Reiner Siebert, Olaf Merkel, Lukas Kenner, Martin Janz, Stephan Mathas
Summary: Anaplastic large cell lymphoma (ALCL) is a type of lymphoid malignancy derived from T cells, which can be divided into ALK(+) and ALK(-) categories. Despite genomic and molecular differences, both ALK(+) and ALK(-) ALCL share similarities in key biological and molecular features. Aberrant expression of CD74 in ALCL may provide insights for developing new treatment strategies.
Letter
Clinical Neurology
David Wasilewski, Martin Janz, Arend Koch, Andreas Rosenwald, Ulrich Keller, Peter Vajkoczy, Katharina Faust, Ioannis Anagnostopoulos, Josefine Radke
ACTA NEUROLOGICA BELGICA
(2023)
Article
Multidisciplinary Sciences
Josefine Radke, Elisa Schumann, Julia Onken, Randi Koll, Guliz Acker, Bohdan Bodnar, Carolin Senger, Sascha Tierling, Markus Moebs, Peter Vajkoczy, Anna Vidal, Sandra Hoegler, Petra Kodajova, Dana Westphal, Friedegund Meier, Frank Heppner, Susanne Kreuzer-Redmer, Florian Grebien, Karsten Juerchott, Torben Redmer
Summary: This study uses a multi-OMICS approach and targeted sequencing to uncover the potential programs that control the development of melanoma brain metastases (MBM). The expression of E-cadherin and NGFR is found to classify MBM into different subtypes, and these subtypes control cell migration and proliferation through downstream transcription factors. Additionally, differential methylation analysis can distinguish between different types of MBM.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Wiebke Winkler, Carlota Farre Diaz, Eric Blanc, Hanna Napieczynska, Patrick Langner, Marvin Werner, Barbara Walter, Brigitte Wollert-Wulf, Tomoharu Yasuda, Arnd Heuser, Dieter Beule, Stephan Mathas, Ioannis Anagnostopoulos, Andreas Rosenwald, Klaus Rajewsky, Martin Janz
Summary: By targeting the expression of genes involved in MM subgroup-specific chromosomal translocations into mouse GC B cells, we have generated distinct MM-like disease models that recapitulate key features of human tumors, which provides insights into the pathogenesis and therapeutic vulnerabilities of different MM subgroups.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Hematology
Cristina Lopez, Nikolai Schleussner, Stephan H. Bernhart, Kortine Kleinheinz, Stephanie Sungalee, Henrike L. Sczakiel, Helene Kretzmer, Umut H. Toprak, Selina Glaser, Rabea Wagener, Ole Ammerpohl, Susanne Bens, Maciej Giefing, Juan C. Gonzalez Sanchez, Gordana Apic, Daniel Huebschmann, Martin Janz, Markus Kreuz, Anja Mottok, Judith M. Mueller, Julian Seufert, Steve Hoffmann, Jan O. Korbel, Robert B. Russell, Roland Schuele, Lorenz Truemper, Wolfram Klapper, Bernhard Radlwimmer, Peter Lichter, Ralf Kueppers, Matthias Schlesner, Stephan Mathas, Reiner Siebert
Summary: Histone methylation-modifiers, including EZH2 and KMT2D, are frequently altered in B-cell lymphomas. In this study, we examined the whole genome and transcriptome data of 186 cases and identified recurrent alterations in KDM4C, a histone demethylase encoding gene on chromosome 9p24. We demonstrated that these structural variants in KDM4C result in loss-of-function and provide evidence that KDM4C can act as a tumor suppressor. Thus, our findings expand the mutational landscape of lymphomas and highlight the importance of KDM4C in B-cell derived lymphomas.
Letter
Respiratory System
Matthias Obenaus, Oliver Schildgen, Dirk Schuermann, Ann-Christin von Bruenneck, Martin Janz, Ulrich Keller, Bernhard Gebauer, Johannes Schilling, Stefan Schwartz, Benedikt Weissbrich, Thomas Schneider, Joerg Hofmann, Stephan Mathas