Review
Immunology
SuHyeon Oh, SangJoon Lee
Summary: Innate immunity is a crucial defense against pathogens, including viruses, and ZBP1 plays a central role in regulating inflammatory cell death during viral infection. By sensing viral RNA, ZBP1 induces PANoptosis to protect host cells, but some viruses, like coronaviruses, can exploit this process to cause harm to the host. Understanding the molecular mechanism of ZBP1-derived PANoptosis is important for improving therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Lydia Bellmann, Claudia Zelle-Rieser, Paul Milne, Anastasia Resteu, Christoph H. Tripp, Natascha Hermann-Kleiter, Viktoria Zaderer, Doris Wilflingseder, Paul Hoertnagl, Maria Theochari, Jessica Schulze, Mareike Rentzsch, Barbara Del Frari, Matthew Collin, Christoph Rademacher, Nikolaus Romani, Patrizia Stoitzner
Summary: Langerhans cells in the skin, critical for immune response and skin homeostasis, can be generated from monocytes with specific cytokines and ligands. These monocyte-derived LCs show potential for vaccine testing and can be an effective tool for future research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Immunology
Nina Kessler, Susanne F. Viehmann, Calvin Krollmann, Karola Mai, Katharina M. Kirschner, Hella Luksch, Prasanti Kotagiri, Alexander M. C. Boehner, Dennis Huugen, Carina C. de Oliveira Mann, Simon Otten, Stefanie A. Weiss, Thomas Zillinger, Kristiyana Dobrikova, Dieter E. Jenne, Rayk Behrendt, Andrea Ablasser, Eva Bartok, Gunther Hartmann, Karl-Peter Hopfner, Paul A. Lyons, Peter Boor, Angela Roesen-Wolff, Lino L. Teichmann, Peter Heeringa, Christian Kurts, Natalio Garbi
Summary: The study identifies abnormal DNA recognition and IFN-I production as drivers of severe ANCA-associated vasculitis, and demonstrates that blocking this pathway can ameliorate the disease and accelerate recovery, suggesting potential therapeutic targets for patients.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Alice Coillard, Elodie Segura
Summary: This study reviews the research on mouse mo-DC, evaluates the in vivo evidence for monocyte-derived antigen-presenting cells, and proposes that mo-DC may present antigens to effector T cells locally in tissues, playing a complementary role to cDCs.
MOLECULAR IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Ousman Jobe, Jiae Kim, Daniel O. Pinto, Zuzana Villar, Tiffany Hewitt, Elizabeth H. Duncan, Alexander Anderson, Neelakshi Gohain, Hua Gong, Courtney Tucker, Carl R. Alving, Gary R. Matyas, Elke Bergmann-Leitner, Mangala Rao
Summary: Monocyte-derived macrophages (MDM) are highly susceptible to HIV-1 infection due to the downregulation of innate factors during differentiation. Activation of MDM and upregulation of anti-viral factors, particularly APOBEC3A, can decrease permissiveness to HIV-1 infection. This study highlights the relationship between innate immune activation, proinflammatory environment, and upregulation of anti-HIV proteins, which can switch MDM into a less susceptible phenotype.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Alexandre Poirier, Michel L. Tremblay
Summary: Dendritic cells have the ability to mount T cell responses against tumors, but their effectiveness in vaccination against established malignancies is limited. New insights into signaling cascades and targeted strategies have been found to enhance dendritic cell activity and promote anti-tumor therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Maria Teresa Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona, Daniela Peruzzu
Summary: Silibinin exhibits immunosuppressive activity by inhibiting the maturation and activation of human dendritic cells, suggesting its potential application as an adjuvant therapy for autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Organic
Nanquan Jiang, Du Chen, Chao Liu
Summary: Organoboron compounds are important building blocks in synthetic chemistry due to their ability to transform C-B bonds. Alpha-oxylboronates, a special type of organoboronate, have geminal hydroxyl and boryl functionalities, which make them versatile reagents for chemical synthesis. This review mainly focuses on the synthesis and transformation of alpha-oxylboronates, particularly the transformations of their C-B and C-O bonds.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Multidisciplinary
Jingjing Li, Sheng Zhang, Kun Xu
Summary: This review discusses the recent breakthroughs achieved in the electrochemical transformations of alpha-keto acids, showcasing their improved efficiencies and selectivities in electrochemical acylation, cyclization, and reductive amination reactions.
CHINESE CHEMICAL LETTERS
(2021)
Review
Chemistry, Analytical
Gengjun Liu, Jing Liu, Hong Zhou, Haiyan Wang
Summary: This paper reviews the research progress of AFP biosensors with enhanced sensitivity and selectivity using nanoparticles. Representative examples are presented to demonstrate the applications of nanotechnology in the early detection of AFP. The clinical application of AFP biosensors based on nanotechnology faces challenges, but also presents development opportunities in the future.
Review
Biochemistry & Molecular Biology
Sachchidanand Soaham Gupta, Vivek Mishra, Maumita Das Mukherjee, Parveen Saini, Kumar Rakesh Ranjan
Summary: Amino acids have emerged as promising biomaterials for synthesizing functional polymers, offering a wide range of applications in drug delivery, tissue engineering, and biosensing. These polymers, such as polyamides, polyesters, and polyurethanes, allow for control of functionality, conjugation, crosslinking, and mechanical/thermal properties.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Oncology
Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud
Summary: This article focuses on the role of myeloid-derived suppressor cells (MDSCs) in pathological inflammatory conditions, discussing their definition, characterization, technical issues, origin, distribution, expansion and accumulation factors, as well as their Yin and Yang roles.
FRONTIERS OF MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Makoto Sahara
Summary: Cardiac organoids are three-dimensional structures composed of multiple cardiac cells that mimic the native heart more effectively than conventional two-dimensional culture systems. They have a wide range of applications in cardiogenesis, cardiac disease modeling, drug screening, and regenerative medicine. This mini-review summarizes recent advances in cardiac organoid technologies, discussing formation methods, current limitations, and future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Applied
Sandip Naskar, Kanchan Mal, Rajib Maity, Indrajit Das
Summary: Alpha-ketothioesters have gained widespread attention as synthetic intermediates and have shown impressive growth in their utilization in synthetic and medicinal chemistry. Their diverse reactivities allow for various important reactions, making them valuable in the synthesis of heterocycles, pharmaceutically relevant anticancer drugs, and natural products. Despite being less appreciated compared to other 1,2-dicarbonyl derivatives, they have demonstrated significant advancements and applications in forming C-C, C-N, and C-O bonds through multiple bond-forming processes.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Green & Sustainable Science & Technology
Yucheng Zhou, Jiajun He, Ruoxi Chen, Xiaodong Li
Summary: This article provides an overview of the recent advances in biomass-derived graphene and CNTs and their applications in electrochemistry, photocatalysis, and water purification, offering new avenues for innovative ecosystems and opportunities.
MATERIALS TODAY SUSTAINABILITY
(2022)
Article
Dermatology
Nemanja Damjanov, Sarolta Karpati, Lajos Kemeny, Noemi Bakos, Branislav Bobic, Maria Majdan, Witold Tlustochowicz, Petr Vitek, Eva Dokoupilova, Emre Aldinc, Annette Szumski
JOURNAL OF DERMATOLOGICAL TREATMENT
(2018)
Article
Dermatology
Flora N. Balieva, Andrew Y. Finlay, Jorg Kupfer, Lucia Tomas Aragones, Lars Lien, Uwe Gieler, Francoise Poot, Gregor B. E. Jemec, Laurent Misery, Lajos Kemeny, Francesca Sampogna, Henriet Van Middendorp, Jon Anders Halvorsen, Thomas Ternowitz, Jacek C. Szepietowski, Nikolay Potekaev, Servando E. Marron, Ilknur K. Altunay, Sam S. Salek, Florence J. Dalgard
ACTA DERMATO-VENEREOLOGICA
(2018)
Letter
Dermatology
Gyozo Szolnoky, Anita Altmayer, Jozsef Varga, Henriette Gavaller, Lajos Kemeny, Tamas Forster, Attila Nemes
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2018)
Article
Dermatology
M. Mattii, M. Lovaszi, N. Garzorz, A. Atenhan, M. Quaranta, F. Lauffer, A. Konstantinow, M. Kuepper, C. C. Zouboulis, L. Kemeny, K. Eyerich, C. B. Schmidt-Weber, D. Torocsik, S. Eyerich
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Letter
Dermatology
Z. R. Csoma, L. Kemeny
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Article
Dermatology
Edit Payer, Judit Szabo-Papp, Lidia Ambrus, Attila Gabor Szollosi, Monika Andrasi, Shabtay Dikstein, Lajos Kemeny, Istvan Juhasz, Andrea Szegedi, Tamas Biro, Attila Olah
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Dermatology
Eszter Szlavicz, Peter Olah, Kornelia Szabo, Franco Pagani, Zsuzsanna Bata-Csorgo, Lajos Kemeny, Marta Szell
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Judit Danis, Luca Janovak, Barbara Guban, Aniko Goebloes, Kornelia Szabo, Lajos Kemeny, Zsuzsanna Bata-Csorgo, Marta Szell
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Dermatology
Lajos Kemeny, Lovisa Berggren, Martin Dossenbach, Yves Dutronc, Carle Paul
JOURNAL OF DERMATOLOGICAL TREATMENT
(2019)
Article
Dermatology
Attila Gabor Szollosi, Nikolett Vasas, Agnes Angyal, Kornel Kistamas, Peter Pal Nanasi, Johanna Mihaly, Gabriella Beke, Erika Herczeg-Lisztes, Andrea Szegedi, Naoki Kawada, Takashi Yanagida, Takahiro Mori, Lajos Kemeny, Tamas Biro
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Dermatology
Klara Megyeri, Laszlo Orosz, Szilvia Bolla, Lilla Erdei, Zsolt Razga, Gyorgy Seprenyi, Edit Urban, Kornelia Szabo, Lajos Kemeny
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2018)
Article
Sport Sciences
Gyozo Szolnoky, Henriette Gavaller, Anna Gonczy, Imre Bihari, Lajos Kemeny, Tamas Forster, Attila Nemes
Summary: The application of graduated medical compression stockings with different pressures can significantly reduce aortic pulse wave velocity, indicating a beneficial cardiovascular influence.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Dermatology
Diane M. Thiboutot, Brigitte Dreno, Abdullah Abanmi, Andrew F. Alexis, Elena Araviiskaia, Maria Isabel Barona Cabal, Vincenzo Bettoli, Flordeliz Casintahan, Steven Chow, Adilson da Costa, Tam El Ouazzani, Chee-Leok Goh, Harald P. M. Gollnick, Minerva Gomez, Nobukazu Hayashi, Maria Isabel Herane, Juan Honeyman, Sewon Kang, Lajos Kemeny, Raj Kubba, Julien Lambert, Alison M. Layton, James J. Leyden, Jose Luis Lopez-Estebaranz, Nopadon Noppakun, Falk Ochsendorf, Cristina Oprica, Beatriz Orozco, Montserrat Perez, Jaime Piquero-Martin, Jo-Ann See, Dae Hun Suh, Jerry Tan, Vicente Torres Lozada, Patricia Troielli, Leihong Flora Xiang
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2018)
Article
Dermatology
Eszter Karg, Laszlo Kovacs, Ferenc Ignacz, Erika Varga, Maria Hocsi, Peter Szuts, Lajos Kemeny, Csaba Bereczki, Judit Olah
PEDIATRIC DERMATOLOGY
(2018)
Article
Pharmacology & Pharmacy
M. Manczinger, V. A. Bodnar, B. T. Papp, S. B. Bolla, K. Szabo, B. Balazs, E. Csanyi, E. Szel, G. Eros, L. Kemeny
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2018)