Review
Chemistry, Medicinal
Justine Tang, Li-Ru Chen, Kuo-Hu Chen
Summary: Dehydroepiandrosterone (DHEA) and its metabolite, dehydroepiandrosterone sulfate ester (DHEAS), are circulating steroid hormones that play multiple roles in the human body. While DHEA supplementation may have benefits for postmenopausal women, such as alleviating vasomotor symptoms and preserving immune system integrity, its effects on cardiovascular disease and insulin sensitivity are still uncertain. Further research is needed to determine the physiological role, optimal dosage, and effects on women for DHEA.
Review
Biochemistry & Molecular Biology
Fidel Orlando Buendia-Gonzalez, Martha Legorreta-Herrera
Summary: Androgens are steroids that regulate various processes in the body, including reproduction, metabolism, and immune response. The main androgens are testosterone, dihydrotestosterone (DHT), and dehydroepiandrosterone (DHEA). These hormones have concentration-dependent effects on the immune response and can both suppress and promote it. DHEA and testosterone have similar effects in activating regulatory T cells and suppressing the Th17-type immune response, but testosterone suppresses inflammation while DHEA promotes it.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Endocrinology & Metabolism
Ilaria Cellai, Vincenza Di Stasi, Paolo Comeglio, Elisa Maseroli, Tommaso Todisco, Chiara Corno, Sandra Filippi, Sarah Cipriani, Flavia Sorbi, Massimiliano Fambrini, Felice Petraglia, Irene Scavello, Giulia Rastrelli, Gabriele Acciai, Fabio Villanelli, Giovanna Danza, Erica Sarchielli, Giulia Guarnieri, Annamaria Morelli, Mario Maggi, Linda Vignozzi
Summary: This study confirmed that the human vagina is an androgen-target organ with the ability to synthesize androgens, thus providing support for the use of androgens for local symptoms of genitourinary syndrome in menopause.
Article
Neurosciences
Natalina H. Contoreggi, Sanoara Mazid, Lily B. Goldstein, John Park, Astrid C. Ovalles, Elizabeth M. Waters, Michael J. Glass, Teresa A. Milner
Summary: The study reveals the important role of estrogen receptor (ER) beta in the hypothalamic paraventricular nucleus (PVN), with its interactions with other gonadal hormone receptors being influenced by sex and age. There are significant differences in the distribution of ER beta-enhanced green fluorescent protein (EGFP) neurons in the PVN among different sexes and age groups.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tae Jin Kim, Young Hwa Lee, Kyo Chul Koo
Summary: The androgen receptor (AR) plays a crucial role in the development and progression of prostate cancer (PCa), and treatment for hormone-sensitive prostate cancer (HSPC) relies heavily on androgen deprivation therapy (ADT). Despite most patients progressing to castration-resistant prostate cancer (CRPC), studies suggest that manipulating alternative molecular pathways can help improve current treatments and develop novel therapies for CRPC management.
Review
Biochemistry & Molecular Biology
Haozhe Zhang, Yi Zhou, Zengzhen Xing, Rajiv Kumar Sah, Junqi Hu, Hailiang Hu
Summary: This review discusses the close relationship between the evolution of prostate cancer and androgen levels and the status of the androgen receptor. It also explores how alterations in androgen metabolism contribute to the resistance to anti-androgen therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Jing Wang, Ling Wang
Summary: Vulvovaginal atrophy (VVA) mainly occurs in postmenopausal women, caused by insufficient sex hormones leading to anatomical and physiological changes in the vagina. Dehydroepiandrosterone (DHEA) shows promise as a treatment for VVA, especially in women with contraindications to estrogen therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Dermatology
Erin Kamp, Mariha Ashraf, Esra Musbahi, Claudia DeGiovanni
Summary: Menopause has an impact on the hair cycle and can lead to hair loss in postmenopausal women. Female pattern hair loss and frontal fibrosing alopecia are commonly associated with the perimenopausal and postmenopausal states. Further research is needed to understand the therapeutic targets and role of hormonal therapy.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Oncology
Xiaolei Shi, Abderrahman Day, Hannah E. Bergom, Sydney Tape, Sylvan C. Baca, Zoi E. Sychev, Gabrianne Larson, Asha Bozicevich, Justin M. Drake, Nicholas Zorko, Jinhua Wang, Charles J. Ryan, Emmanuel S. Antonarakis, Justin Hwang
Summary: The study identifies B7-H3 as an immune checkpoint overexpressed in prostate cancer, particularly in metastatic castration-resistant prostate cancer (mCRPC). Enzalutamide-resistant mCRPC cells show increased expression of B7-H3, and it is associated with resistance signaling pathways. The gene network of B7-H3 is strongly correlated with androgen receptor (AR) and its co-factors, suggesting potential therapeutic targets for mCRPC.
NPJ PRECISION ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shiting Zhao, Tao Nie, Lei Li, Qiaoyun Long, Ping Gu, Yuwei Zhang, Wei Sun, Zexin Lin, Qing Liu, Yue Qi, Wei Wang, Mengyuan Xie, Kerry Loomes, Chenleng Cai, Donghai Wu, Hannah Xiaoyan Hui
Summary: PRDM16 is a dominant activator of brown and beige adipocytes. The regulation of PRDM16 expression is not fully understood. Androgen receptor (AR) is negatively correlated with PRDM16 expression. Sex differences in PRDM16 mRNA expression are observed in human WAT, with females having higher expression than males. Androgen-AR signaling inhibits PRDM16 expression and beige adipocyte browning. AR directly binds to the intronic region of PRDM16, but not to Ucp1 and other browning-related genes. Adipocyte-specific deletion of Ar promotes beige cell biogenesis, while adipocyte-specific overexpression of AR attenuates white adipose beiging.
Article
Obstetrics & Gynecology
Claudia Colla Ruvolo, Olimpia Gabrielli, Carmen Formisano, Gianluigi Califano, Paolo Manna, Roberta Venturella, Costantino Di Carlo
Summary: This study assessed the effects of prasterone compared with hyaluronic acid on urinary urgency symptoms in women with genitourinary syndrome of menopause. The results showed that prasterone had a better effect in improving urinary urgency symptoms and quality of life compared to hyaluronic acid. However, further studies with a larger population are needed to confirm these findings.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Article
Gastroenterology & Hepatology
Donghee Kim, Richie Manikat, George Cholankeril, Aijaz Ahmed
Summary: In men, low total testosterone levels and increasing T/E2 ratio were associated with higher odds of NAFLD, while decreasing SHBG levels were independently associated with increased risk of NAFLD in both men and postmenopausal women. Increasing FAI was also independently associated with NAFLD, with a dose-dependent inverse association between T/E2 ratio and NAFLD.
LIVER INTERNATIONAL
(2023)
Review
Biochemistry & Molecular Biology
Mu Lv, Juanjuan Yu, Yan Huang, Jie Ma, Jun Xiang, Yanqiu Wang, Linxia Li, Zhenbo Zhang, Hong Liao
Summary: Uterine diseases, such as endometriosis and uterine fibroids, have a significant impact on women's health. Androgens, primarily synthesized in the ovaries and adrenal glands, play a crucial role in the development of these diseases. However, further research is needed to understand the signaling pathways involved and develop targeted therapeutic strategies.
Review
Obstetrics & Gynecology
Farhana Sultana, Susan R. Davis, Rakibul M. Islam
Summary: This systematic review evaluates the effect of exogenous dehydroepiandrosterone (DHEA) on cognitive performance in postmenopausal women. The overall findings suggest that DHEA does not have a therapeutic benefit on cognitive performance, although it may improve visual-spatial performance in a small study.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2023)