Article
Dermatology
Yoko Endo, Hiroyuki Yoshida, Yukiko Ota, Yumiko Akazawa, Tetsuya Sayo, Ushio Hanai, Kotaro Imagawa, Masashi Sasaki, Yoshito Takahashi
Summary: The study investigated the effects of a newly developed inducer, beta-NAG2, on epidermal proliferation and differentiation by increasing HA production. The results showed that beta-NAG2 significantly increased HA production in the skin, leading to accelerated keratinocyte proliferation and differentiation, which plays a key role in epidermal morphogenesis and homeostasis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Review
Cell Biology
Hanxiao Yin, Mingzheng Hu, Dengwen Li
Summary: The epidermis is a barrier in the outermost layer of the skin that protects against pathogens. Basal keratinocytes, acting as stem cells, are crucial for epidermal development and skin damage recovery. Understanding the molecular mechanism of basal keratinocytes in epidermal development and stratification is important for preventing and treating skin lesions.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biology
Marie-Claire Mechin, Michel Simon
Summary: This article discusses the role of peptidylarginine deiminases (PADs) in physiological processes and their involvement in human diseases. PAD1 and PAD3 are important for keratinocyte differentiation and epidermal barrier function, while mutations in the PADI3 gene are associated with hair disorders and alopecia. The study highlights the significance of PADs in skin health and disease.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Review
Dermatology
Mao-Qiang Man, Joan S. Wakefield, Theodora M. Mauro, Peter M. Elias
Summary: Nitric oxide (NO) plays a regulatory role in epidermal permeability barrier functions, affecting processes such as barrier homeostasis and wound healing. While insufficient NO can lead to disorders like diabetes and hypertension, excessive levels can induce cellular oxidative stress. iNOS remains essential for epidermal permeability barrier homeostasis.
EXPERIMENTAL DERMATOLOGY
(2022)
Review
Immunology
Kaixuan Ren, Yumin Xia
Summary: Lipocalin 2 plays a crucial role in the pathogenesis of psoriatic inflammation by exerting versatile effects on skin resident cells and infiltrating immune cells. Neutralizing lipocalin 2 or relevant cytokines can alleviate psoriasis, highlighting lipocalin 2 as an effective interfering target.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Pathology
Shunsuke Iriyama, Saori Nishikawa, Junichi Hosoi, Satoshi Amano
Summary: This study demonstrates the influence of basement membrane (BM) integrity on the level of hyaluronan (HA) in the epidermis, showing that BM structure impairment in sun-exposed skin of older subjects is associated with decreased epidermal HA content. In experimental models, inhibitors of BM-degrading matrix metalloproteinases and heparanase lead to increased epidermal HA levels, highlighting the importance of BM in maintaining epidermal HA levels.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Immunology
Daniel Toerocsik, Fruzsina Fazekas, Szilard Poliska, Andrea Gregus, Eszter Anna Janka, Katalin Dull, Andrea Szegedi, Christos C. Zouboulis, Dora Kovacs
Summary: The study revealed that EGF is a potent stimulator of sebocyte proliferation and induces the secretion of interleukin 6, while down-regulating genes involved in steroid and retinoid metabolism. Additionally, when combined with palmitic acid, EGF can decrease the lipid accumulation induced by palmitic acid and increase IL6 secretion.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Jung Hwa Lim, Dae Hun Kim, Kyung Hee Noh, Cho-Rok Jung, Hyun Mi Kang
Summary: This study identified epidermal progenitor cells that possess unlimited proliferation and multipotent differentiation capacity. These cells can form organotypic skin models and mimic the morphologic and biochemical processes of human epidermis. The proliferation and differentiation of these cells rely on the expression of Integrin beta 1 (ITGB1). Furthermore, the in vitro and in vivo wound healing capacity of these cells was examined.
CELL PROLIFERATION
(2022)
Article
Multidisciplinary Sciences
Mandy Laube, Diana Dornis, Fine Wenzel, Ulrich H. Thome
Summary: Male sex is an independent risk factor for respiratory distress syndrome in preterm infants, and EGF has sex-specific effects on Na+ transport in fetal alveolar cells. Although EGF showed certain gender- and time-dependent effects in FDLE cells, it is unlikely to be the primary cause of sex-specific differences in Na+ transport.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Sarah M. Lloyd, Daniel B. Leon, Mari O. Brady, Deborah Rodriguez, Madison P. McReynolds, Junghun Kweon, Amy E. Neely, Laura A. Blumensaadt, Patric J. Ho, Xiaomin Bao
Summary: In this study, the researchers found that the Super Elongation Complex (SEC) controls fate decisions of progenitor cells by suppressing a group of rapid response genes. The repressive role of SEC depends on the AFF1 scaffold, but not AFF4. The expression of these rapid response genes is regulated by CDK9 activity. The findings suggest that the activity switch of SEC-associated CDK9 is a key initial process in determining the fate of progenitor cells.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Joana F. da Rocha, Luisa Bastos, Sara C. Domingues, Ana R. Bento, Uwe Konietzko, Odete A. B. da Cruz e Silva, Sandra I. Vieira
Summary: The study revealed that the APP protein interacts with HB-EGF and EGF EGFR ligands, affecting ERK activation and neurite outgrowth. The interaction between APP and HB-EGF was confirmed, with implications for ERK pathway activation and neuronal differentiation. The synergistic effect of EGF and APP on neuritogenesis was shown to involve the EGFR pathway and has potential implications for Alzheimer's disease and adult neuroregeneration.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Xuan Wang, Shuyong Wang, Baolin Guo, Yuxin Su, Zuolong Tan, Mingyang Chang, Jinmei Diao, Yi Zhao, Yunfang Wang
Summary: The study presents a method for establishing and expanding human primary epidermal organoids under a chemically defined condition, which show tolerance to dermatophyte infections caused by Trichophyton Rubrum. This experimental model provides new insights into the pathogenesis of T. rubrum infections and serves as a potential tool for studying and testing antifungal drugs.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Michael L. Samulevich, Rambon Shamilov, Brian J. Aneskievich
Summary: Intrinsically disordered proteins (IDPs) in keratinocytes, especially those associated with the cornified envelope, demonstrate high levels of intrinsic disorder and potential for liquid-liquid phase separation (LLPS).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Maryam Khanehzad, Roya Abbaszadeh, Marzieh Holakuyee, Mohammad Hossein Modarressi, Seyed Mehdi Nourashrafeddin
Summary: The interaction between FSH and RA signaling may trigger and influence the differentiation and initiation of meiosis in spermatogonia.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Yeon Sun Kim, Jia Yuan, Amanda Dewar, Jean-Paul Borg, David W. Threadgill, Xiaofei Sun, Sudhansu K. Dey
Summary: HB-EGF recruits VANGL2 for tyrosine phosphorylation through binding to ERBB2 and ERBB3, thereby influencing uterine epithelial cell polarity and regulating the implantation process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Dermatology
Evelyne De Vuyst, Severine Giltaire, Catherine Lambert de Rouvroit, Jeremy Malaisse, Abdallah Mound, Maureen Bourtembourg, Yves Poumay, Arjen F. Nikkels, Aline Chretien, Michel Salmon
EXPERIMENTAL DERMATOLOGY
(2018)
Review
Dermatology
Emilie Faway, Catherine Lambert de Rouvroit, Yves Poumay
EXPERIMENTAL DERMATOLOGY
(2018)
Article
Archaeology
Vladimir Vilde, Marc Fourneau, Catherine Charles, Daniel Van Vlaender, Julie Bouhy, Yves Poumay, Olivier Deparis
STUDIES IN CONSERVATION
(2019)
Article
Dermatology
Emilie Faway, Ludivine Cambier, Evelyne De Vuyst, Celine Evrard, Marc Thiry, Catherine Lambert de Rouvroit, Bernard Mignon, Yves Poumay
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2019)
Article
Dermatology
Joachim G. S. Veit, Valerie De Glas, Benoit Balau, Haoming Liu, Florence Bourlond, Amy S. Paller, Yves Poumay, Philippe Diaz
Summary: DX314 is a promising compound that inhibits RA metabolism and protects epidermal barrier integrity, offering a potential therapeutic option for keratinization disorders with similarities to topical retinoids.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Humanities, Multidisciplinary
Marc Fourneau, Caroline Canon, Daniel Van Vlaender, Matthew J. Collins, Sarah Fiddyment, Yves Poumay, Olivier Deparis
Review
Cell Biology
Celine Evrard, Catherine Lambert de Rouvroit, Yves Poumay
Summary: In the skin, the extracellular matrix (ECM) plays a crucial role in forming and maintaining the epidermal barrier. Hyaluronan (HA) is a key ECM molecule in the epidermis, involved in formation, organization, and stabilization of the ECM. However, the exact functions of HA in keratinocyte proliferation and differentiation are still controversial.
Article
Microbiology
Emilie Faway, Cindy Staerck, Celya Danzelle, Sophie Vroomen, Christel Courtain, Bernard Mignon, Yves Poumay
Summary: This paper discusses the research methods for the pathogenesis of dermatophytes and obtains infectious spores suitable for in vitro and in vivo experimental models by optimizing culture conditions. This provides a foundation for standardizing the study of dermatophyte pathology.
Article
Dermatology
Audrey Progneaux, Celine Evrard, Valerie De Glas, Alix Fontaine, Celine Dotreppe, Evelyne De Vuyst, Arjen F. Nikkels, Vicente Garcia-Gonzalez, Laure Dumoutier, Catherine Lambert de Rouvroit, Yves Poumay
Summary: Atopic dermatitis (AD) is an inflammatory disease characterized by an alteration of epidermal barrier due to the release of IL-4 and IL-13. IL-2R gamma, a cytokine receptor subunit, is induced in keratinocytes and contributes to the alteration of the epidermal barrier and regulation of IL-13R alpha 2 expression. The expression of IL-2R gamma is observed in keratinocytes of AD lesional skin, suggesting its role in the disease.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Jos P. H. Smits, Noa J. M. van den Brink, Luca D. Meesters, Hadia Hamdaoui, Hanna Niehues, Patrick A. M. Jansen, Ivonne M. J. J. van Vlijmen-Willems, Diana Rodijk-Olthuis, Celine Evrard, Yves Poumay, Michel van Geel, Wiljan J. A. J. Hendriks, Joost Schalkwijk, Patrick L. J. M. Zeeuwen, Ellen H. van den Bogaard
Summary: This study demonstrates the phenotypical and functional consequences of FLG deficiency, showing its crucial role in epidermal barrier function and differentiation. The results provide insights into the exact role of FLG in skin biology and disease.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Dermatology
Yves Poumay, Emilie Faway
Summary: For the past half-century, human epidermal keratinocyte cultures have played a significant role in advancing research in skin biology and dermatology. The evolution of tissue culture methodologies has led to a variety of procedures, presenting researchers with the challenge of choosing the most suitable approach for their specific investigations. Staying updated on technological advancements in epidermal cell culture is crucial for selecting the appropriate methodology or developing new, more specialized techniques.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Biophysics
Xavier Delvaux, Celine Noel, Yves Poumay, Laurent Houssiau
Summary: The mammalian organism has a defense system called the epidermis to protect it from biological and chemical threats. Skin-related pathologies can disrupt the proper formation and function of the epidermal barrier. This study used ToF-SIMS to characterize a reconstructed human epidermis (RHE) model and successfully extracted meaningful biological information from the data.
Article
Cell Biology
Celine Warnon, Karim Bouhjar, Noelle Ninane, Mathilde Verhoyen, Antoine Fattaccioli, Maude Fransolet, Catherine Lambert de Rouvroit, Yves Poumay, Geraldine Piel, Denis Mottet, Florence Debacq-Chainiaux
Summary: This study reveals that the expression levels of HDACs are significantly altered during the aging process of dermal fibroblasts. Treatment with HDAC inhibitor or specific downregulation of HDAC2 and HDAC7 can induce the appearance of senescence biomarkers. Moreover, re-expression of HDAC7 can extend the proliferative lifespan of cells.
Meeting Abstract
Dermatology
B. Tirtiaux, Y. Poumay, C. Lambert de Rouvroit, E. Faway
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Meeting Abstract
Dermatology
C. Evrard, E. Faway, E. De Vuyst, O. Svensek, O. De Backer, B. Flamion, C. Lambert de Rouvroit, Y. Poumay
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)