Review
Immunology
Chunping Liu, Huiqi Chen, Yanjiao Liu, Haiding Huang, Wanling Yu, Tingting Du, Xinyao Long, Xinming Chen, Zhijun Chen, Sien Guo, Jinxin Li, Zebo Jiang, Lei Wang, Chuanjian Lu
Summary: Psoriasis is a persistent inflammatory disease with a genetic predisposition, and it is often associated with the involvement of multiple organs. Atherosclerosis is a common complication in severe psoriasis patients. The specific pathogenesis of psoriasis is still unclear, but it is believed to be a polygenic genetic disease influenced by factors such as heredity and environment. Immune-mediated inflammatory pathways are involved in the proliferation of keratinocytes and the release of inflammatory factors. Psoriasis and atherosclerosis are closely related, and systemic inflammation may be a common feature of both conditions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Bo Ram Mok, A-Ram Kim, Seung Hwa Baek, Ji Hae Ahn, Seung Hui Seok, Jung U. Shin, Dong Hyun Kim
Summary: This study reveals that PFN1 expression is increased in both skin and serum of patients with psoriasis, and it positively correlates with the severity of psoriasis. Both IL-17A and TNF-alpha can regulate PFN1 expression and secretion. PFN1 acts as a negative regulator of psoriatic inflammation through the suppression of I kappa B zeta, and the balanced level of PFN1 is important for I kappa B zeta regulation. Therefore, PFN1 expression can be used as a biomarker for psoriasis severity and may serve as a potential target for psoriasis treatment.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Piotr Ostrowski, Bartlomiej Pala, Ewa Gromowska, Klaudia Gurazda, Pawel Dec, Andrzej Modrzejewski, Andrzej Pawlik
Summary: Psoriasis is a chronic skin condition mediated by the immune system, characterized by inflammation and excessive skin cell growth. Dendritic cells, T lymphocytes, and keratinocytes play key roles in the development of psoriasis, while the IL-23/IL-17 pathway contributes to disease progression. Adipokines secreted by adipose tissue, such as adiponectin, leptin, visfatin, and resistin, have immunomodulatory effects and may influence the progression or suppression of psoriasis. Understanding the relationship between psoriasis and adipokines could lead to new diagnostic and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Xiaohan Liu, Peiyi Luo, Weiyun Zhang, Shuxian Zhang, Shulong Yang, Fenfang Hong
Summary: Pyroptosis is a pro-inflammatory type of regulated cell death that is closely related to the formation and development of atherosclerosis. It not only causes local inflammation, but also amplifies the inflammatory response, leading to plaque instability and eventually resulting in acute cardiovascular events.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Wenxing Su, Ying Zhao, Yuqian Wei, Xiaoyan Zhang, Jiang Ji, Shun Yang
Summary: This study identified common differentially expressed genes in psoriasis and atherosclerosis, highlighting the important roles of chemokines and cytokines in both diseases. The study also found that the lipopolysaccharide-mediated signaling pathway is closely related to both diseases. Furthermore, 16 important hub genes were identified which may provide new insights for further mechanism research.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yoshitaka Kimura, Daisuke Tsukui, Hajime Kono
Summary: Hyperuricemia is associated with numerous diseases such as gout, hypertension, chronic kidney diseases, and cardiovascular diseases. Research has shown that intracellular uric acid production can lead to the generation of reactive oxygen species, which regulate intracellular signaling pathways and may contribute to the development of atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Beatriz Burger, Roberta Nicolli Sagiorato, Isabella Cavenaghi, Hosana Gomes Rodrigues
Summary: Psoriasis is an immune-mediated skin disorder, and alterations in sphingolipids synthesis have been observed in psoriatic skin. By analyzing gene expression in psoriatic skin, several genes related to lipid metabolism, specifically sphingolipids, were found to be up-regulated in lesioned skin. These genes could potentially serve as prognostic biomarkers and therapeutic targets for psoriasis treatment.
Article
Cell Biology
Min Wang, Yuqian Wang, Mengdi Zhang, Qiqi Duan, Caifeng Chen, Qiong Sun, Meng Liu, Yan Zheng, Yongping Shao
Summary: KYNU is upregulated in psoriatic skin samples and plays a crucial role in the production of inflammatory factors and the development of psoriasis-like skin inflammation. The microRNA miR-203a can inversely regulate KYNU and reduce psoriasis-related inflammatory factors. KYNU inhibitors can alleviate pathological phenotypes in IMQ-mice.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Cell Biology
Xue Zhou, Youdong Chen, Lian Cui, Yuling Shi, Chunyuan Guo
Summary: This article reviews the crucial role of keratinocytes in the pathogenesis of psoriasis, emphasizing the significance of targeting keratinocytes for the treatment of psoriasis.
CELL DEATH & DISEASE
(2022)
Review
Immunology
Qian Shen, Rong Liu, Shiyu Tan, Xiaoding Xu, Junyue Fang, Rong Li
Summary: This article presents the pathogenesis of psoriasis and various treatment methods, with a focus on the recent advances in nanoparticles-mediated drug delivery for psoriasis treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jiadong Yu, Qixiang Zhao, Xiaoyan Wang, Hong Zhou, Jing Hu, Linna Gu, Yawen Hu, Fanlian Zeng, Fulei Zhao, Chengcheng Yue, Pei Zhou, Guolin Li, Ya Li, Wenling Wu, Yifan Zhou, Jiong Li
Summary: Psoriasis is a common inflammatory skin disease characterized by interactions between keratinocytes and immune cells. The immune mechanism underlying psoriasis has been elucidated, and an increasing number of signaling pathways have been found to be involved in its pathogenesis. Current research focuses on developing targeted and effective therapies, as well as exploring the genomics and epigenetics of the disease.
JOURNAL OF AUTOIMMUNITY
(2022)
Review
Immunology
Xiaoqian Liang, Caixin Ou, Jiayi Zhuang, Jinsheng Li, Fangfei Zhang, Yuanqiu Zhong, Yongfeng Chen
Summary: Psoriasis is a multifactorial immune-mediated disease with incompletely elucidated specific pathogenesis, and the skin microbiota may play a significant role in its provocation or exacerbation, interacting with innate immunity to stimulate T-cell populations and trigger immune cascade responses that ultimately lead to psoriasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Kajetan Kielbowski, Estera Bakinowska, Andrzej Pawlik
Summary: Connexins are involved in intercellular communication through hemichannels and gap junctions, playing a crucial role in regulating cell homeostasis, proliferation, and differentiation. Changes in Cx distribution, degradation, and post-translational modifications have been linked to cancer, cardiovascular, and neurological diseases. Depending on the isoform, Cx can either promote or suppress the development of atherosclerosis by affecting endothelial dysfunction, monocyte recruitment, vascular smooth muscle cell activation, or autophagy inhibition. Inhibition or modulation of specific Cx isoforms could potentially serve as therapeutic targets in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Hannah Hinkley, Daniel A. Counts, Elizabeth Voncanon, Michael Lacy
Summary: Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipid-rich plaques within arterial walls. T cells play a pivotal role in the pathogenesis of atherosclerosis in which they help orchestrate immune responses and contribute to plaque development and instability. This article discusses the recognition of atherosclerosis-related antigens that may trigger T cell activation and the roles of diverse subsets of T cells in atherosclerosis.
Review
Biochemistry & Molecular Biology
Subhapradha Rangarajan, Davit Orujyan, Patrida Rangchaikul, Mohamed M. Radwan
Summary: Recent research on resolving inflammation in the body is providing new insights for the management of cardiovascular diseases. This narrative review discusses the pathophysiology of atherosclerosis, the discovery of specialized pro-resolving mediators (SPMs), and the potential impact on cardiovascular treatment options. Further research is expected to translate these findings into clinical trials for conditions with an inflammatory basis.