Article
Medicine, General & Internal
Pawel Zebryk, Piotr Przymuszala, Jan Krzysztof Nowak, Tomasz Piorunek, Tatiana Mularek-Kubzdela, Mariusz Puszczewicz
Summary: This study evaluated the prevalence and clinical significance of SSc-related autoantibodies and compared the sensitivity of two line immunoblot assays. The findings indicate that different autoantibodies are associated with specific characteristics of SSc.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Aurelien Chepy, Louisa Bourel, Vincent Koether, David Launay, Sylvain Dubucquoi, Vincent Sobanski
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by extensive fibrosis of the skin and internal organs. Antinuclear antibodies (ANA) are found in almost all SSc patients, but the exact role they play in the disease remains unclear. However, studies have shown that ANA may be associated with disease subtypes, appear before disease onset, correlate with disease activity and severity, and have a response to B-cell targeting therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Valdirene S. Siqueira, Mariely F. S. Helbingen, Ana Cristina Medeiros-Ribeiro, Henrique Carrico da Silva, Renata Miossi, Ana Paula Luppino-Assad, Percival D. Sampaio-Barros
Summary: This study analyzed the early characteristics of SSc in RP patients and identified predictors for the progression to SSc. Combinations of RP + PF + positive ANA + SD-NFC and/or SSc-specific antibody (VEDOSS level 2), as well as RP + PF + positive ANA (VEDOSS level 1; "red flags") were most associated with progression to SSc. Combinations without non-RP clinical symptoms, such as RP + SD-NFC and RP + anticentromere + SD-NFC, were associated with non-progression to SSc.
Article
Multidisciplinary Sciences
Muxue Gong, Li Dai, Zhuobei Xie, Dengxiao Hong, Ning Li, Xiaoyun Fan, Changhao Xie
Summary: In order to explore the clinical significance of autoantibodies in Chinese patients with new-onset systemic lupus erythematosus (SLE), a total of 526 patients who met the criteria for SLE were included in a retrospective cohort study. The study found that the presence of anti-ribosomal P protein (anti-P) antibody was higher in female patients compared to male patients. Additionally, the presence of certain autoantibodies was associated with liver enzyme levels, pulmonary arterial hypertension, interstitial lung disease, neuropsychiatric symptoms, and serositis. The study identified new associations and confirmed previously reported associations of SLE-related autoantibodies.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Carmen Bobeica, Elena Niculet, Carmina Liana Musat, Mihaela Craescu, Bogdan Ioan Stefanescu, Ciprian Dinu, Iulia Chiscop, Silvia Chirobocea, Luiza Nechita, Alina Viorica Iancu, Victorita Stefanescu, Gabriela Balan, Ioana Anca Stefanopol, Ana Maria Pelin, Alin Laurentiu Tatu
Summary: Systemic sclerosis is a chronic inflammatory disease that affects the skin and internal organs. The inflammatory process is sustained by various cytokines and chemokines, leading to fibrosis and vascular changes. Confocal microscopy helps understand the molecular mechanisms involved. Immunological profile is used for classification. Multisystem damage requires specific investigations for evaluation.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Rheumatology
Robin Arcani, Daniel Bertin, Nathalie Bardin, Karin Mazodier, Rodolphe Jean, Pierre Suchon, Geoffroy Venton, Aurelie Daumas, Estelle Jean, Patrick Villani, Gilles Kaplanski, Pierre-Andre Jarrot
Summary: The study shows that anti-NuMA antibodies are mainly associated with pSS and SLE, and patients with these antibodies have less severe clinical profiles and require less treatment. Anti-NuMA antibodies may be a useful diagnostic marker when other auto-antibodies are negative and could indicate a good prognosis in autoimmune diseases.
Article
Medicine, Research & Experimental
Anna Stochmal, Joanna Czuwara, Michal Zaremba, Lidia Rudnicka
Summary: The study aimed to investigate the possible link between different types of systemic sclerosis-specific antinuclear antibodies, adipokines, and endothelial molecules. The results showed associations between specific antibodies and increased serum concentrations of certain molecules, indicating metabolic and vascular factors may serve as mediators between immunological abnormalities and non-immune driven clinical symptoms in systemic sclerosis.
ADVANCES IN MEDICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Carmen Bobeica, Elena Niculet, Alina Halip, Laura Gheuca-Solovastru, Miruna Draganescu, Ioana Popescu, Cristian Onisor, Silvia Chirobocea, Mihaela Lungu, Mihaela Craescu
Summary: Although systemic sclerosis (SSc) is characterized by specific autoantibodies associated with each subset, our study indicates that there is sometimes inconsistency between the disease subsets and the specific autoantibodies. Larger studies on the immunological profile in SSc are needed to further understand this relationship.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Rheumatology
Andres Gonzalez Garcia, Martin Fabregate, Luis Manzano, Alfredo Guillen del Castillo, Manuel Rubio Rivas, Ana Argibay, Adela Marin Ballve, Ignasi Rodriguez Pinto, Xavier Pla Salas, Begona Mari-Alfonso, Eduardo Callejas Moraga, Dolores Colunga Arguelles, Luis Saez Comet, Cristina Gonzalez-Echavarri, Norberto Ortego-Centeno, Jose Antonio Vargas Hitos, Jose Antonio Todoli Parra, Luis Trapiella Martinez, Maria Teresa Herranz Marin, Mayka Freire, Antonio-J Chamorro, Isabel Perales Fraile, Ana Belen Madronero Vuelta, Sabela Sanchez Trigo, Carles Tolosa Vilella, Vicent Fonollosa Pla, Carmen Pilar Simeon Aznar
Summary: The study found that LVDD is relatively common in SSc patients and is associated with older age, longer time from SSc diagnosis, presence of telangiectasia, and specific medication use. Additionally, SSc patients with LVDD had increased mortality rates and shortened survival from the first SSc symptom, although LVDD was not an independent risk factor for death.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Article
Rheumatology
Raquel Freitas, Patricia Martins, Eduardo Dourado, Tania Santiago, Francisca Guimaraes, Bruno Miguel Fernandes, Salome Garcia, Beatriz Samoes, Ana Sofia Pinto, Nuno Goncalves, Maria Helena Lourenco, Emanuel Costa, Margarida Rocha, Maura Couto, Ana Catarina Duarte, Filipe Araujo, Ines Cordeiro, Fatima Godinho, Catarina Resende, Maria Joao Salvador, Ana Cordeiro, Maria Jose Santos
Summary: Evidence suggests that male SSc patients have more severe disease and worse survival compared to females, with higher prevalence of diffuse cutaneous SSc and anti-topoisomerase antibodies. Male SSc patients also tend to have higher rates of myositis, interstitial lung disease, and gastric involvement.
CLINICAL RHEUMATOLOGY
(2022)
Letter
Immunology
Xavier Bossuyt, Jean-Baptiste Vulsteke, Jan Van Elslande, Lise Boon, Greet Wuyts, Silke Willebrords, Glynis Frans, Nick Geukens, Sebastien Carpentier, Sabine Tejpar, Hans Wildiers, Daniel Blockmans, Ellen De Langhe, Pieter Vermeersch, Rita Derua
Summary: A high prevalence of antinuclear antibodies (ANA) was found in COVID-19 patients, with the target antigens poorly understood. Through immunoprecipitation combined with liquid-chromatography-mass spectrometry, novel autoimmune antigens were identified in systemic sclerosis and malignant disease. This in-depth analysis of high titer ANA targets provides valuable insights into the autoimmune response in COVID-19.
AUTOIMMUNITY REVIEWS
(2023)
Review
Hematology
Guillaume Moulis, Nathalie Aladjidi, Bertrand Godeau
Summary: There is inconsistency in guidelines regarding the usefulness of antinuclear antibodies (ANAs) dosage in the diagnosis of primary immune thrombocytopenia (ITP). This review provides an overview of the current understanding of ANA prevalence in patients with primary ITP and their potential role as biomarkers for ITP progression, treatment response, and increased risk of developing systemic lupus and thrombosis.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Immunology
Ying Zhu, Benqiao Wang, Yuehan Hao, Ruixia Zhu
Summary: Multiple reports have shown the co-existence of autoimmune diseases and myasthenia gravis (MG). This review explores the clinical presentations of autoimmune diseases in MG and investigates whether the presence of autoimmune diseases affects the severity and treatment strategies of MG. The review reveals a higher frequency of autoimmune diseases in MG patients, particularly in women. Most autoimmune comorbidities are linked to AChR-MG, with thyroid disorders, systemic lupus erythematosus, and vitiligo being the most common. MG can also coexist with neurological autoimmune diseases, with neuromyelitis optica (NMO) being the most common. The review suggests that autoimmune diseases occur more often in early-onset MG and do not influence the clinical course of MG.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Elvira Favoino, Paola Cipriani, Vasiliki Liakouli, Addolorata Corrado, Luca Navarini, Marta Vomero, Adriana Sisto, Rosa Daniela Grembiale, Francesco Ciccia, Francesco P. Cantatore, Piero Ruscitti, Roberto Giacomelli, Federico Perosa
Summary: This study characterized the fine specificity of anti-fibroblast antibodies (AFA) and found that anti-p121 antibodies were associated with clinical parameters of systemic sclerosis (SSc), including diffuse cutaneous SSc (dcSSc), reduced FVC, and interstitial lung disease (ILD). This suggests that the antigen recognized by anti-p121 antibodies could be a potential therapeutic target for ILD.
CLINICAL IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Kholoud Almaabdi, Zareen Ahmad, Sindhu R. Johnson
Summary: Systemic sclerosis is an autoimmune disease characterized by immune abnormalities, vasculopathy, and fibrosis. Autoantibody testing, including ANA, anti-Scl-70, and anticentromere antibodies, has become increasingly important for diagnosis and prognostication. This review examines the epidemiology, clinical associations, and prognostic value of advanced autoantibody testing in systemic sclerosis.
Editorial Material
Dermatology
Yuri Shimizu, Yorihisa Kotobuki, Noriko Arase, Hisashi Arase, Ichiro Katayama, Manabu Fujimoto
ANNALS OF DERMATOLOGY
(2022)
Letter
Dermatology
Emi Kaneda, Kyoko Tonomura, Yorihisa Kotobuki, Ikuko Ueda-Hayakawa, Kanako Tasaka, Manabu Fujimoto
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Motoki Horii, Natsumi Fushida, Tomoyuki Ikeda, Kyosuke Oishi, Yasuhito Hamaguchi, Yuichi Ikawa, Akito Komuro, Takashi Matsushita
Summary: This study investigated the levels of effector and regulatory B cells in patients with SSc and found that an increase in effector B cells and a decrease in regulatory B cells were associated with the severity of SSc. These results suggest that B cells play an important role in the pathogenesis of SSc.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Kazunori Yokoi, Noriko Arase, Takashi Shimbo, Manabu Fujimoto, Atsushi Tanemura
ACTA DERMATO-VENEREOLOGICA
(2023)
Letter
Dermatology
Takashi Matsushita, Natsumi Fushida, Motoki Horii, Kie Mizumaki
JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Yutaka Matsumura, Rei Watanabe, Hanako Koguchi-Yoshioka, Yuumi Nakamura, Aki Saito, Miki Kume, Shuichi Nakai, Yosuke Ishitsuka, Junichi Furuta, Manabu Fujimoto
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Review
Allergy
Wah Wah Aung, Yasuhito Hamaguchi, Takashi Matsushita
Summary: This review provides an overview of the immune pathogenesis of systemic sclerosis (SSc) and discusses targeted anti-cytokine therapy, with a focus on the emerging role of JAK-STAT inhibitors as potential therapeutic agents for reversing the disease.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2023)
Article
Dermatology
Yasushi Kikuchi, Tomoki Tamakoshi, Ryuichi Ishida, Ryosuke Kobayashi, Shiho Mori, Akemi Ishida-Yamamoto, Manabu Fujimoto, Yasufumi Kaneda, Katsuto Tamai
Summary: In this study, researchers developed an ex vivo gene therapy for recessive dystrophic epidermolysis bullosa (RDEB) using autologous mesenchymal stromal cells (MSCs). The gene-modified MSCs were injected into mice with type VII collagen deficiency, leading to continuous and widespread expression of type VII collagen. The therapy showed successful application in both early blistering skin and advanced ulcerative lesions in the RDEB mouse model.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Oncology
Kazunori Yokoi, Yoshiaki Yasumizu, Naganari Ohkura, Koei Shinzawa, Daisuke Okuzaki, Nene Shimoda, Hideya Ando, Nanako Yamada, Manabu Fujimoto, Atsushi Tanemura
Summary: In this study, it was found that the skin tightness of hypopigmented lesions in vitiligo patients was more evident compared to uninvolved perilesional skin. Collagen homeostasis in vitiligo lesions appeared to be maintained despite the excessive oxidative stress associated with the disease. The expression of collagen-related genes and anti-oxidative enzymes was upregulated, collagen degeneration was attenuated, and the NRF2 signaling pathway was activated in vitiligo dermis.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Editorial Material
Rheumatology
Manabu Fujimoto
ARTHRITIS & RHEUMATOLOGY
(2023)
Article
Dermatology
Natsumi Fushida, Motoki Horii, Kyosuke Oishi, Takashi Matsushita
Summary: This study investigated the effectiveness of anifrolumab in treating systemic lupus erythematosus (SLE). The results showed that anifrolumab was effective in treating SLE, reducing SLEDAI-2 K and CLASI activity scores, and facilitating tapering of corticosteroid dosage.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Yasuhito Hamaguchi, Yukari Yoshimura, Motoki Horii, Natsumi Fushida, Tasuku Kitano, Kaori Sawada, Kyosuke Oishi, Shintaro Maeda, Satoshi Watanabe, Takashi Matsushita
Summary: Interstitial lung disease is a prognostic factor and leading cause of death in patients with systemic sclerosis. This study found that the presence of interstitial lung disease at an initial visit is an independent factor associated with disease deterioration.
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Mari Wataya-Kaneda, Shinichirou Maeda, Ayumi Nakamura, Misa Hayashi, Manabu Fujimoto
Summary: A pilot study was conducted to evaluate the safety and efficacy of 0.2% sirolimus gel for venous and capillary malformations, and to compare its efficacy with systemic sirolimus treatment. The results showed that the gel was as clinically effective as systemic treatment and more effective for early active lesions, even systemic venous malformations.
JOURNAL OF DERMATOLOGY
(2023)
Review
Immunology
Yutaka Matsumura, Rei Watanabe, Manabu Fujimoto
Summary: B cells, including regulatory B cells (Bregs), regulate inflammation through an inhibitory mechanism mediated by interleukin 10 (IL-10). Bregs have been reported in various disease models and play a role in autoimmune diseases, infectious diseases, cancer, and organ-transplant rejection. In addition to IL-10, other cytokines and membrane-binding molecules are also involved in the suppressive functions of Bregs. The identification and classification of Breg fractions remains challenging due to the variations in their activity and differentiation stages in different disease models.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Rheumatology
Jucier Goncalves Junior, Naoki Mugii, Pleiades Tiharu Inaoka, Renata Miossi, Fernando Henrique Carlos De Souza, Joao Calvino Soares De Oliveira, Fujiko Someya, Yasuhito Hamaguchi, Takashi Matsushita, Percival Degrava Sampaio-Barros, Samuel Katsuyuki Shinjo
Summary: This study describes and compares the demographic, clinical, and laboratory characteristics of patients with Myo-SSc from two tertiary centers. The study found that Myo-SSc mainly affects middle-aged women and the manifestation spectrum varies according to geographic distribution.
ARCHIVES OF RHEUMATOLOGY
(2023)