Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Marie, Irene Hernandez-Lozano, Oliver Langer, Nicolas Tournier
Summary: Hepatocyte transporters play a crucial role in the hepatobiliary elimination of various substances, influenced by different pathophysiological conditions and specific drugs; Tc-99m-mebrofenin has been used for hepatobiliary scintigraphy for years, but the specific transporters controlling its liver kinetics have only recently been characterized; Pharmacokinetic modeling offers a translational method to study transporter-mediated drug interactions, providing insights into liver function as a biomarker.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Fengqing Zhu, Guanglei Chang, Xiaoqiong Tang, Lingyun Gao, Nan Zhang
Summary: Doxorubicin (DOX) is used for cancer treatment but can cause cardiovascular toxicity. This study examined whether DOX promotes atherosclerosis by impairing cardiac function. The results showed that DOX increased miR-33 expression and reduced the protein level of ATP binding cassette transporter A1 (ABCA1). DOX also suppressed cholesterol efflux, especially under high-cholesterol conditions. Transfection of miR-33 mimics or inhibitors into cells respectively decreased or increased ABCA1 protein expression and regulated intracellular lipid accumulation. Overall, DOX upregulates miR-33 to suppress ABCA1 expression, leading to intracellular lipid deposition in macrophages, which is an early sign of atherosclerosis. This study provides new insights for the clinical observation and evaluation of DOX side effects.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Genetics & Heredity
Michael Dean, Karobi Moitra, Rando Allikmets
Summary: The ATP-binding cassette (ABC) transporter superfamily consists of membrane proteins that transport various substances across cell membranes. Mutations in ABC genes can lead to various human disorders and phenotypes, and mouse models with disrupted ABC genes mimic these human diseases. New genomic studies and tumor sequencing have provided additional insights into the functions of ABC genes.
Article
Plant Sciences
Fiza Liaquat, Muhammad Farooq Hussain Munis, Samiah Arif, Muhammad Aamir Manzoor, Urooj Haroon, Iftikhar Hussain Shah, Muhammad Ashraf, Hyun Seok Kim, Shengquan Che, Liu Qunlu
Summary: This study investigated the differential gene expression of Schima superba under Mn metal stress through transcriptomic analysis. The differentially expressed genes were found to be involved in defense, signaling pathways, oxidative burst, transcription factors, and stress responses. The results provide insights into the metal resistance mechanisms and contribute to the understanding of heavy metal tolerance and detoxification.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yaolei Mi, Xue Cao, Xuewen Zhu, Weiqiang Chen, Xiangxiao Meng, Huihua Wan, Wei Sun, Sifan Wang, Shilin Chen
Summary: This study identified and characterized 113 ABC transporters in C. sativa, and proposed seven core transporters that may participate in cannabinoid transport. These candidate genes showed high correlation with cannabinoid biosynthetic pathway genes and content, and were highly expressed in cannabinoid biosynthesis and accumulation sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Microbiology
Jie Chen, Shan Han, Shujiang Li, Ming Wang, Hanmingyue Zhu, Tianmin Qiao, Tiantian Lin, Tianhui Zhu
Summary: The ABC1 gene in the N. parvum strain plays a crucial role in stress response and virulence, and may be associated with heavy metal resistance.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Chemistry, Medicinal
Meiao Tan, Jintong Ye, Min Zhao, Xuehong Ke, Keer Huang, Huabao Liu
Summary: Dysregulation of cholesterol metabolism poses high risks for NAFLD, dyslipidemia, and AS. Cholesterol transport is crucial for maintaining whole-body cholesterol homeostasis. Natural products and their derived molecules show potential in regulating cholesterol transport and could be therapeutic targets, although further high-quality studies are needed to confirm their clinical efficacies.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Latifa Alketbi, Abeer Al-Ali, Iman M. Talaat, Qutayba Hamid, Khuloud Bajbouj
Summary: Colorectal cancer (CRC) is a common malignancy worldwide, ranked fourth in cancer-related deaths. Mutations in oncogenes, tumor suppressor genes, and DNA repair genes contribute to the development of CRC. Chemoresistance is one of the major challenges in CRC treatment, and the overexpression of ATP-binding cassette (ABC) transporters has been identified as a facilitating mechanism for chemoresistance. ABC transporters are involved in lipid transport and homeostasis, which play a crucial role in tumor development and progression. Altered expression of ABCA transporters in CRC is associated with poor prognosis and overall survival. This minireview suggests that ABCA transporters could serve as potential diagnostic and therapeutic targets in CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Aissatou Maty Diagne, Anais Pelletier, Claire Durmort, Agathe Faure, Kerstin Kanonenberg, Celine Freton, Adeline Page, Frederic Delolme, Jaroslav Vorac, Sylvain Vallet, Laure Bellard, Corinne Vives, Franck Fieschi, Thierry Vernet, Patricia Rousselle, Sebastien Guiral, Christophe Grangeasse, Jean-Michel Jault, Cedric Orelle
Summary: This study demonstrates that TCS01 cooperates with the BceAB-type ABC transporter to sense and induce resistance to bacterial-derived antimicrobial peptides, ultimately enhancing the survival of Streptococcus pneumoniae in the human host.
Article
Biochemistry & Molecular Biology
Silpa Narayanan, Zhuo-Xun Wu, Jing-Quan Wang, Hansu Ma, Nikita Acharekar, Jagadish Koya, Sabesan Yoganathan, Shuo Fang, Zhe-Sheng Chen, Yihang Pan
Summary: In this study, GS-9973 showed efficacy in overcoming ABCG2-mediated multidrug resistance in non-small cell lung cancer cells. The drug reversed drug resistance by blocking ABCG2 efflux activity and downregulating ABCG2 expression at the protein level, suggesting it as a potential strategy to overcome MDR in cancers.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Applied
Alba M. Garcia-Lino, Alex Gomez-Gomez, Dafne Garcia-Mateos, Alvaro de la Fuente, Ana I. Alvarez, Oscar J. Pozo, Gracia Merino
Summary: ABCG2 is involved in the secretion of several compounds in milk, with higher levels of tryptophan-related compounds in wild-type mice compared to Abcg2(-/-) mice. The milk-to-plasma ratio of these compounds was also higher in dairy cows carrying the ABCG2 Y581S polymorphism compared to noncarrier animals. In vitro transport assays confirmed these findings and validated differences in the bovine protein variants.
Article
Pharmacology & Pharmacy
Louise Breuil, Nora Ziani, Sarah Leterrier, Gaelle Hugon, Fabien Caille, Viviane Bouilleret, Charles Truillet, Maud Goislard, Myriam El Biali, Martin Bauer, Oliver Langer, Sebastien Goutal, Nicolas Tournier
Summary: This study investigated the impact of CYP inducers and inhibitors on the brain and plasma kinetics of [C-11]metoclopramide using PET imaging. The results showed that CYP induction or inhibition had negligible effects on the plasma kinetics and metabolism of [C-11]metoclopramide, but ritonavir significantly increased brain penetration.
Article
Nutrition & Dietetics
Yoon-Young Sung, Dong-Seon Kim
Summary: The study found that eggshell membrane (EM) exhibits antihyperuricemic effects by promoting renal urate excretion and regulating renal urate transporters, resulting in reduced serum uric acid levels in hyperuricemic rats.
