Review
Behavioral Sciences
Sarah Kittel-Schneider, Boris B. Quednow, Anna Linda Leutritz, Rhiannon McNeill, Andreas Reif
Summary: This review focuses on analyzing the association of maternal ADHD with pregnancy, birth outcomes, early parent-child interaction, and child development in the first 3 years, as well as the impact of parental ADHD on early parent-child interaction and child development. Additionally, it also reviews the risks of stimulant and non-stimulant treatment for ADHD in pregnancy and lactation.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Toxicology
Satoru Aoki, Asuka Kaizaki-Mitsumoto, Natsumi Hattori, Satoshi Numazawa
Summary: This study investigated the effects of fetal exposure to methylphenidate on infant development and behavior in mice. The research found that this exposure might lead to ADHD-like phenotypes in offspring, which were alleviated by treatment with methylphenidate and atomoxetine. The study suggests that continuous use of methylphenidate during pregnancy could induce ADHD phenotypes in the offspring.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Luis C. Farhat, Jose M. Flores, Emily Behling, Victor J. Avila-Quintero, Adam Lombroso, Samuele Cortese, Guilherme Polanczyk, Michael H. Bloch
Summary: We conducted a large-scale systematic review and meta-analysis to examine the effects of stimulant dose and dosing strategies on clinical outcomes in children/adolescents with ADHD. Our findings suggest that flexible titration of stimulant medications can improve efficacy and acceptability.
MOLECULAR PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Marcelo Gomes Davanco, Jessica Meulman, Thalita Martins da Silva, Fernando Costa, Karini Bruno Bellorio, Iram Moreira Mundim, Ana Carolina Costa Sampaio, Leonardo de Souza Teixeira, Celso Francisco Pimentel Vespasiano
Summary: This study aimed to evaluate the bioequivalence between two methylphenidate extended-release tablets and found that the test formulation was considered bioequivalent to the reference formulation in both fasting and fed conditions. Both formulations were safe and well tolerated.
Review
Behavioral Sciences
Sara Carucci, Carla Balia, Antonella Gagliano, Angelico Lampis, Jan K. Buitelaar, Marina Danckaerts, Ralf W. Dittmann, Peter Garas, Chris Hollis, Sarah Inglis, Kerstin Konrad, Hanna Kovshoff, Elizabeth B. Liddle, Suzanne McCarthy, Peter Nagy, Pietro Panei, Roberta Romaniello, Tatiana Usala, Ian C. K. Wong, Tobias Banaschewski, Edmund Sonuga-Barke, David Coghill, Alessandro Zuddas
Summary: The study reviewed the association of long-term MPH exposure with height, weight, and timing of puberty in ADHD individuals. MPH was found to have consistent significant effects on reducing height and weight, with more prominent impacts observed in the initial months of treatment. Limited data were available on the timing of puberty. Prospective studies are needed to further explore the underlying biological mechanisms and potential clinical implications.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Olivia J. Mellahn, Rachael Knott, Jeggan Tiego, Kathryn Kallady, Katrina Williams, Mark A. Bellgrove, Beth P. Johnson
Summary: The study revealed differences in symptom profiles and medication use reported by parents of children with ADHD, autism, and ADHD + autism, suggesting a greater complexity of symptoms and management needs in the ADHD + autism group.
FRONTIERS IN PSYCHIATRY
(2022)
Editorial Material
Clinical Neurology
Gisel Bello, Jessica Poirier, Katherine M. Sharkey
Summary: This article explores the impact of resuming methylphenidate medication on breastmilk production and infant growth in a new mother with narcolepsy. Using a tracking app, it was found that restarting methylphenidate did not decrease breastmilk volumes or have a negative impact on the infant.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)
Article
Psychiatry
Ekachaeryanti Zain, Atsunori Sugimoto, Jun Egawa, Toshiyuki Someya
Summary: This article reports a rare case that suggests methylphenidate (MPH) may be effective in treating chronic pain. The patient in this case had both attention deficit hyperactivity disorder (ADHD) and chronic pain, and the pain significantly improved after treating the ADHD. This study suggests that MPH may have therapeutic potential for chronic pain.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychology, Developmental
Margaret D. Weiss, Ann C. Childress, Graeme A. E. Donnelly
Summary: PRC-063 demonstrated good tolerability and significant improvement in ADHD symptoms in adults, with a notable impact on symptom reduction. There was no significant impact on sleep quality.
JOURNAL OF ATTENTION DISORDERS
(2021)
Article
Neurosciences
Frank R. Wendt, Miguel Garcia-Argibay, Brenda Cabrera-Mendoza, Unnur A. Valdimarsdottir, Joel Gelernter, Murray B. Stein, Michel G. Nivard, Adam X. Maihofer, Caroline M. Nievergelt, Henrik Larsson, Manuel Mattheisen, Renato Polimanti, Sandra M. Meier
Summary: Genetic analyses and sibling comparisons confirm a causal relationship between attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD), with ADHD genetic liability leading to increased risk of developing PTSD. Early and effective treatment of ADHD is crucial in preventing the occurrence of PTSD.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Sevim Berrin Inci Izmir, Melis Ipci, Eyup Sabri Ercan
Summary: This study investigated the effects of methylphenidate (MPH) on neurocognitive test scores in individuals with different presentations of attention deficit/hyperactivity disorder (ADHD), as well as the impact of comorbidities on executive function. The results showed that MPH treatment improved neurocognitive test scores in patients with different presentations of ADHD, and the treatment was effective even in the presence of comorbidities.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Biological
Cecilia Mazzetti, Christienne Gonzales Damatac, Emma Sprooten, Niels ter Huurne, Jan K. Buitelaar, Ole Jensen
Summary: This study aimed to identify the white matter tracts that mediate the effect of methylphenidate (MPH) on ADHD patients. The results showed that the anterior thalamic radiation (ATR), superior longitudinal fasciculus (parietal endings) (SLFp), and superior longitudinal fasciculus (temporal endings) (SLFt) were significantly associated with the effects of MPH. In addition, ADHD symptom severity was related to lower fractional anisotropy (FA) within the ATR, and individuals with higher FA in SLFp compared to SLFt exhibited stronger behavioral effects of MPH and beta power modulation.
Article
Clinical Neurology
Bonita P. Klein-Tasman, Kristin Lee, Heather L. Thompson, Jennifer Janusz, Jonathan M. Payne, Sara Pardej, Peter de Blank, Tess Kennedy, Kelly M. Janke, Allison del Castillo, Karin S. Walsh
Summary: Children with NF1 are at increased risk for attention problems, with preschool-aged children offering a unique opportunity for clinical studies and early interventions. The Observer-rated Attention-Deficit/Hyperactivity Disorder Rating Scale-Preschool version is recommended as a primary outcome measure, with additional secondary outcome measures also suggested. Specific methodologic recommendations for including preschoolers in clinical trials research are also provided.
Article
Psychiatry
Benjamin Selaskowski, Christian Staerk, Niclas Braun, Swantje Matthies, Erika Graf, Michael Colla, Christian Jacob, Esther Sobanski, Barbara Alm, Michael Roesler, Wolfgang Retz, Petra Retz-Junginger, Bernhard Kis, Mona Abdel-Hamid, Michael Huss, Thomas Jans, Ludger Tebartz van Elst, Mathias Berger, Silke Lux, Andreas Mayr, Alexandra Philipsen
Summary: Tailoring therapy options for adult ADHD based on individual patient's needs and symptoms is crucial for improving treatment outcomes. Methylphenidate is effective in improving inattention symptoms, while clinical management psychotherapy shows benefits in reducing inattention and impulsivity in the early treatment phase. Considering individual core symptom profiles may enhance the efficacy of treatments for adult ADHD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Orit Levi-Shachar, Hila Z. Gvirts, Yiftach Goldwin, Yuval Bloch, Simone Shamay-Tsoory, Dennis Boyle, Hagai Maoz
Summary: The study investigated the correlation between ADHD symptom severity and impairments in theory of mind (ToM) and empathy, as well as the improvement in these functions following the administration of methylphenidate (MPH). The results showed a negative correlation between ADHD symptom severity, particularly behavioral symptoms, and deficits in ToM. MPH administration led to improvements in ToM performance, especially in children with more severe behavioral symptoms.
PSYCHIATRY RESEARCH
(2021)
Editorial Material
Psychiatry
Sean Hood, Simon J. C. Davies
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2019)
Article
Psychology, Developmental
Blanca Bolea-Alamanac, Simon J. C. Davies, Jonathan Evans, Carol Joinson, Rebecca Pearson, Petros Skapinakis, Alan Emond
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2019)
Article
Psychology, Clinical
Simon J. C. Davies, Tomisin Iwajomo, Claire de Oliveira, Judith Versloot, Robert J. Reid, Paul Kurdyak
Summary: A population-based cohort study in Ontario, Canada found that individuals with psychiatric disorders, especially those with persistent/recurrent and unstable symptoms, had a significantly increased risk of mortality.
PSYCHOLOGICAL MEDICINE
(2021)
Editorial Material
Psychology, Clinical
Simon J. C. Davies, Benoit H. Mulsant
INTERNATIONAL PSYCHOGERIATRICS
(2020)
Article
Multidisciplinary Sciences
Venkata Yellepeddi, Casey Sayre, Anna Burrows, Kevin Watt, Simon Davies, John Strauss, Marco Battaglia
Article
Neurosciences
Shadi Zarei, Sarah Colman, Aviva Rostas, Amer M. Burhan, Li Chu, Simon J. C. Davies, Peter Derkach, Sarah Elmi, Maria Hussain, Philip Gerretsen, Ariel Graff-Guerrero, Zahinoor Ismail, Donna Kim, Linda Krisman, Rola Moghabghab, Benoit H. Mulsant, Vasavan Nair, Bruce G. Pollock, Soham Rej, Jyll Simmons, Lisa Van Bussel, Tarek K. Rajji, Sanjeev Kumar
Summary: The StaN study aims to compare the effectiveness of an Integrated Care Pathway with treatment-as-usual in treating agitation in dementia patients. Structured behavioral interventions in the study are designed and implemented based on considerations including personalization, evidence base, dose, duration, measurement, and environmental factors.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Simon J. C. Davies, David Rudoler, Claire de Oliveira, Anjie Huang, Paul Kurdyak, Andrea Iaboni
Summary: A study comparing the risks associated with chronic and intermittent benzodiazepine usage in older adults found that chronic use was associated with significantly higher risks of falls and other adverse events. This has important implications for decision-making regarding long-term benzodiazepine use for symptom management in older adults.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Mahmoud Azzeh, Marco Battaglia, Simon Davies, John Strauss, Prashant Dogra, Venkata Yellepeddi
Summary: This study developed a physiologically based pharmacokinetic (PBPK) model for amiloride and simulated its pharmacokinetics in plasma and the central nervous system after intranasal administration. The results suggest that a 75-mg intranasal dose of amiloride can achieve the target concentration for maximal ASIC inhibition. However, further validation with clinical data is needed.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
(2022)
Article
Psychology, Clinical
Sanjeev Kumar, Amruta Shanbhag, Amer M. Burhan, Sarah Colman, Philip Gerretsen, Ariel Graff-Guerrero, Donna Kim, Clement Ma, Benoit H. Mulsant, Bruce G. Pollock, Vincent L. Woo, Simon J. C. Davies, Tarek K. Rajji
Summary: This study examined the effectiveness of using an integrated care pathway (ICP) to treat agitation associated with dementia, and found that patients in the ICP group experienced a reduction in agitation and neuropsychiatric symptoms, with no changes in motor symptoms. Compared to the control group that received treatment-as-usual (TAU), the ICP group had a higher chance of early discharge, a lower rate of psychotropic polypharmacy, and a lower chance of falls during hospital stay.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Clinical Neurology
Crystal Zhou, David J. Nutt, Simon J. C. Davies
Summary: The study constructed a subway map of drugs used to treat psychotic disorders, categorizing them based on structure and epoch of introduction, as well as evaluating the binding affinities of key receptors. This classification method helps prescribers and patients understand the biological features and mechanisms of different drugs, and may promote more logical groupings for systematic reviews and meta-analyses.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Simon J. C. Davies, Blanca Bolea-Alamanac, Kaori Endo, Yu Yamamoto, Syudo Yamasaki, Alex Malins, Jonathan Evans, Sarah Sullivan, Shuntaro Ando, Atsushi Nishida, Kiyoto Kasai
Summary: This study found that the distance between home and railway stations is associated with mental health symptoms in children, specifically hyperactivity/inattention. The farther the distance, the higher the likelihood of these symptoms, particularly in boys. This suggests that access to high-frequency rail transit in urban environments may have a positive impact on children's mental health.
JOURNAL OF TRANSPORT & HEALTH
(2023)
Article
Medicine, Research & Experimental
Venkata K. K. Yellepeddi, Marco Battaglia, Simon J. C. Davies, Jeremiah Alt, Shaelene Ashby, Paige Shipman, David J. J. Anderson, Joseph E. Rower, Christopher Reilly, Michael Voight, Sabiha Rahman Mim
Summary: Anxiety and panic disorders are common mental illnesses with limited treatment options in the United States. Acid-sensing ion channels (ASICs) in the brain play a role in fear conditioning and anxiety responses, making them potential targets for treating panic disorder. Amiloride, an ASICs inhibitor, has shown promise in reducing panic symptoms in animal models. This study evaluated the pharmacokinetics and safety of intranasal amiloride in healthy human volunteers, demonstrating its rapid absorption and safety at various doses.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Psychiatry
Emily Eyles, Ruta Margelyte, Hannah B. Edwards, Paul A. Moran, David S. Kessler, Simon J. C. Davies, Blanca Bolea-Alamanac, Maria Theresa Redaniel, Sarah A. Sullivan
Summary: This study investigated the association between combined use of two antipsychotic drugs and the risk of developing diabetes, hypertension, or hyperlipidemia in adults with schizophrenia. The results showed that compared to monotherapy, polypharmacy increased the risk of hypertension in patients.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Clinical Neurology
Raphael Rifkin-Zybutz, Stephanie MacNeill, Simon J. C. Davies, Christopher Dickens, John Campbell, Ian M. Anderson, Carolyn A. Chew-Graham, Tim J. Peters, Glyn Lewis, Nicola Wiles, David Kessler
JOURNAL OF PSYCHOPHARMACOLOGY
(2020)
Review
Medicine, General & Internal
Johanna Breilmann, Francesca Girlanda, Giuseppe Guaiana, Corrado Barbui, Andrea Cipriani, Mariasole Castellazzi, Irene Bighelli, Simon J. C. Davies, Toshi A. Furukawa, Markus Koesters
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2019)
