An oral TRPV1 antagonist attenuates laser radiant-heat-evoked potentials and pain ratings from UVB-inflamed and normal skin

Highly Sensitive LC--MS--MS Analysis of a Pharmaceutical Compound in Human Plasma Using Monolithic Phase-Based On-line Extraction

(2013) R. N. Xu et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

A Phase 1 Study to Evaluate the Bioavailability and Food Effect of 2 Solid-Dispersion Formulations of the TRPV1 Antagonist ABT-102, Relative to the Oral Solution Formulation, in Healthy Human Volunteers

(2012) A. A. Othman et al.   Clinical Pharmacology in Drug Development

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacokinetics of the TRPV1 Antagonist ABT-102 in Healthy Human Volunteers: Population Analysis of Data From 3 Phase 1 Trials

(2011) Ahmed A. Othman et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Oral and cutaneous thermosensory profile of selective TRPV1 inhibition by ABT-102 in a randomized healthy volunteer trial

(2011) Michael C. Rowbotham et al.   PAIN

TRPV1: On the Road to Pain Relief

(2010) Andres Jara-Oseguera et al.   Current Molecular Pharmacology

Predicting therapeutic efficacy — Experimental pain in human subjects

(2009) Boris A. Chizh et al.   BRAIN RESEARCH REVIEWS

TRPV1 controls acid- and heat-induced calcitonin gene-related peptide release and sensitization by bradykinin in the isolated mouse trachea

(2009) Tatjana I. Kichko et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Repeated dosing of ABT-102, a potent and selective TRPV1 antagonist, enhances TRPV1-mediated analgesic activity in rodents, but attenuates antagonist-induced hyperthermia

(2009) Prisca Honore et al.   PAIN

Opioid Analgesics for Pain Control: Wisconsin Physicians' Knowledge, Beliefs, Attitudes, and Prescribing Practices

(2009) Marla Z. Wolfert et al.   PAIN MEDICINE

Dilemmas in Chronic/Persistent Pain Management

(2008) Warren A Katz et al.   AMERICAN JOURNAL OF THERAPEUTICS

Increased expression of TRPV1 channel in intrinsically aged and photoaged human skinin vivo

(2008) Young Mee Lee et al.   EXPERIMENTAL DERMATOLOGY

Identification of (R)-1-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a Potent TRPV1 Antagonist for Pain Management

(2008) Arthur Gomtsyan et al.   JOURNAL OF MEDICINAL CHEMISTRY

(R)-(5-tert-Butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)-urea (ABT-102) Blocks Polymodal Activation of Transient Receptor Potential Vanilloid 1 Receptors in Vitro and Heat-Evoked Firing of Spinal Dorsal Horn Neurons in Vivo

(2008) C. S. Surowy et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS