期刊
BRITISH JOURNAL OF CANCER
卷 110, 期 8, 页码 2021-2029出版社
SPRINGERNATURE
DOI: 10.1038/bjc.2014.93
关键词
polypeptide N-acetylgalactosaminyl transferase-5 (GalNAc-T5); prognostic; glycosylation; gastric cancer; overall survival
类别
资金
- National Natural Science Fund [31100629, 31270863, 31300671]
- Program for New Century Excellent Talents in University [NCET-13-0146]
- Shanghai Rising-Star Program [13QA1400300]
- Key Project of Science and Technology Commission of Shanghai Municipality [09DZ1950101, 11411951000]
- Shanghai Municipal Health Bureau Fund [20124290]
Background: The family of polypeptide N-acetylgalactosaminyl transferases is responsible for the altered O-linked glycosylation occurring during the development of various cancers and their progression via altering O-glycan biosynthesis. Our studies were designed to investigate the expression and prognostic values of GalNAc-T5 and improve the risk stratification in patients with gastric cancer. Methods: Tissue samples from a training set and a validation set of patients with gastric adenocarcinoma from China were used for analyses. GalNAc-T5 expression was retrospectively analysed by immunohistochemistry. Results were assessed for association with clinicopathological parameters and overall survival by using Kaplan-Meier analysis. Prognostic values of GalNAc-T5 expression and clinical outcomes were evaluated by Cox regression analysis. A molecular prognostic stratification scheme incorporating GalNAc-T5 expression was determined by using receiver operating characteristic analysis. Results: GalNAc-T5 expression was markedly reduced in gastric cancer tissues compared with non-malignant gastric mucosa. Low intratumoral GalNAc-T5 density, which was associated with tumour cell differentiation, T classification, N classification, and TNM stage in the two independent sets, was an independent prognosticator for poor prognosis of gastric cancer patients. Applying the prognostic value of intratumoral GalNAc-T5 density to the conventional clinicopathologic TNM stage system showed a better prognostic value in patients with gastric cancer. Conclusions: Intratumoral GalNAc-T5 expression was recognised as an independent prognostic marker for the overall survival of gastric cancer patients. Detection of GalNAc-T5 expression in gastric cancer tissues might add some prognostic information for patients with this disease and lead to a more accurate classification under the TNM stage system.
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