Article
Endocrinology & Metabolism
Jinqian Mao, Jin Hu, Yanting Zhang, Jian Shen, Fang Dong, Ximeng Zhang, Jie Ming, Tao Huang, Xiaoqin Run
Summary: This study compared single hormone receptor-positive breast cancer to other subtypes and found clinically and biologically distinct features. The prognosis of single hormone receptor-positive tumors was similar to hormone receptor-negative and hormone receptor-positive tumors in patients with or without HER2 overexpression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Yuping Tan, Biao Yang, Yuhong Chen, Xi Yan
Summary: This study compares the survival outcomes of metaplastic breast cancer (MPBC) with triple-negative breast cancer (TNBC) and identifies prognostic factors for both types of cancer. The study finds that MPBC is associated with worse overall survival (OS) and disease-free survival (DFS) compared to TNBC. Additionally, within the MPBC group, the subtype with mesenchymal differentiation has a worse DFS compared to other subtypes.
WORLD JOURNAL OF SURGERY
(2023)
Article
Medical Laboratory Technology
Evi Abada, Fayez Daaboul, Kingsley Ebare, Hyejeong Jang, Ziad Fehmi, Seongho Kim, Rouba Ali-Fehmi, Sudeshna Bandyopadhyay
Summary: Metaplastic breast carcinoma is a rare and aggressive form of breast cancer, with tumor size and distant metastatic disease being key prognostic factors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2022)
Article
Multidisciplinary Sciences
Lin-Yu Xia, Wei-Yun Xu, Qing-Lin Hu
Summary: The study compared the survival outcomes of metaplastic breast cancer (MBC) patients who underwent breast conserving surgery plus radiotherapy (BCS+RT) or mastectomy. It was found that BCS+RT resulted in higher overall survival rates compared to mastectomy, while there was no difference in breast cancer-specific survival rates between the two surgical methods.
Article
Oncology
Audree B. Tadros, Varadan Sevilimedu, Dilip D. Giri, Emily C. Zabor, Monica Morrow, George Plitas
Summary: Metaplastic breast carcinoma (MBC) is a rare and aggressive subtype of breast cancer with poorer survival compared to other triple-negative breast cancers. Among MBC patients, those with heterologous mesenchymal subtype had the best survival, while those with squamous subtype had the worst survival. This calls for further research to identify tailored therapies for MBC's unique biology.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Kae Kawachi, Xiaoyan Tang, Rika Kasajima, Takashi Yamanaka, Eigo Shimizu, Kotoe Katayama, Rui Yamaguchi, Kazuaki Yokoyama, Kiyoshi Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Emi Yoshioka, Kota Washimi, Yoichiro Okubo, Shinya Sato, Tomoyuki Yokose, Yohei Miyagi
Summary: Whole-genome sequencing analysis was performed on five cases of low-grade adenosquamous carcinoma (LGASC) of the breast, revealing genetic differences between LGASC and associated high-grade breast cancer compared to de novo high-grade cancer, potentially involving driver mutation concentration and inactivation of tumor-suppressor genes.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Oncology
Giovanni Corso, Samuele Frassoni, Antonia Girardi, Elisa De Camilli, Emilia Montagna, Mattia Intra, Luca Bottiglieri, Alessandra Margherita De Scalzi, Denise Mattar Fanianos, Francesca Magnoni, Alessandra Invento, Antonio Toesca, Fabio Conforti, Vincenzo Bagnardi, Giuseppe Viale, Marco Angelo Colleoni, Paolo Veronesi
Summary: The study found that metaplastic and ductal breast cancers with triple-negative phenotype are similar in terms of overall and disease-free survival. Metaplastic cancers show poor response to neoadjuvant treatment, and in the absence of novel targeted therapies, surgical treatment remains the preferred choice.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Jin Hu, Fang Dong, Yanting Zhang, Jian Shen, Jie Ming, Tao Huang
Summary: The study investigated the impact of surgery type on the prognosis of TNMBC patients. Results revealed that patients undergoing BCS had the best prognoses among early and locally advanced TNMBC patients. Additionally, the more radical the operation, the worse the prognosis for patients in the entire cohort.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Caihong Zheng, Chengbin Fu, Yahui Wen, Jiameng Liu, Shunguo Lin, Hui Han, Zhonghua Han, Chunsen Xu
Summary: A nomogram was developed and validated to predict the overall survival of patients with metaplastic breast cancer (MBC). MBC patients had worse clinical prognosis compared to infiltrating ductal carcinoma. This nomogram can assist clinicians in making more accurate individualized survival analyses.
FRONTIERS IN ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Brijesh Kumar, Aditi S. Khatpe, Guanglong Jiang, Katie Batic, Poornima Bhat-Nakshatri, Maggie M. Granatir, Rebekah Joann Addison, Megan Szymanski, Lee Ann Baldridge, Constance J. Temm, George Sandusky, Sandra K. Althouse, Michele L. Cote, Kathy D. Miller, Anna Maria Storniolo, Harikrishna Nakshatri
Summary: This study explores the characteristics and functions of stromal cells that are particularly enriched in breast cancer patients with genetic ancestry. The researchers found that these cells can trans-differentiate into different cell types and can be transformed into metaplastic carcinoma.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Jin Hu, Huiqiong Zhang, Fang Dong, Ximeng Zhang, Shuntao Wang, Jie Ming, Tao Huang
Summary: This study found that molecular subtype of breast cancer is not associated with prognosis, and patients can benefit from radiotherapy. However, after receiving radiotherapy, triple-negative patients had superior survival compared to HR-positive or HER2-positive patients.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Pathology
Bryce Parkinson, Wei Chen, Tiansheng Shen, Anil Parwani, Zaibo Li
Summary: TRPS1 is a highly sensitive and specific marker for breast carcinomas, and its expression is associated with tumor subtypes and HER2 protein.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Multidisciplinary Sciences
Vrutant V. Shah, Aundrietta D. Duncan, Shiming Jiang, Sabrina A. Stratton, Kendra L. Allton, Clinton Yam, Abhinav Jain, Patrick M. Krause, Yue Lu, Shirong Cai, Yizheng Tu, Xinhui Zhou, Xiaomei Zhang, Yan Jiang, Christopher L. Carroll, Zhijun Kang, Bin Liu, Jianjun Shen, Mihai Gagea, Sebastian M. Manu, Lei Huo, Michael Gilcrease, Reid T. Powell, Lei Guo, Clifford Stephan, Peter J. Davies, Jan Parker-Thornburg, Guillermina Lozano, Richard R. Behringer, Helen Piwnica-Worms, Jeffrey T. Chang, Stacy L. Moulder, Michelle Craig Barton
Summary: Overexpression of histone reader TRIM24 in mouse mammary epithelia can drive the development of mammary carcinosarcoma tumors with similarities to human MpBC tumors. The direct oncogenic target of TRIM24 is Met, leading to aberrant PI3K/mTOR activation, and targeting these pathways may have therapeutic potential in TRIM24-expressing TNBC.
NATURE COMMUNICATIONS
(2021)
Review
Oncology
Horatio R. Thomas, Bonnie Hu, Baris Boyraz, Andrew Johnson, Veerle I. Bossuyt, Laura Spring, Rachel B. Jimenez
Summary: Metaplastic breast cancer (MpBC) is a rare aggressive malignancy with poor prognosis. The relationships between clinical and pathological features, treatment approach, and outcomes of MpBC remain underexplored. In this review article, existing data on MpBC regarding clinical, pathological and genomic features, management, and outcomes are synthesized, and potential targets for future clinical trials are identified.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Willard Wong, Edi Brogi, Jorge S. Reis-Filho, George Plitas, Mark Robson, Larry Norton, Monica Morrow, Hannah Y. Wen
Summary: The study evaluated the response to neoadjuvant chemotherapy in 44 patients with metaplastic breast carcinoma, finding that only 2% achieved a pathologic complete response, indicating poor response to NAC in most MpBC patients.
Review
Cell Biology
Joshua J. X. Li, Gary M. Tse
Summary: This article reviews the clinicopathological features of ER-positive breast cancers, with a focus on ER-low positive breast cancers. It also provides updates on the assessment, reporting, and interpretation of ER immunohistochemical staining, correlations of ER status with other diagnostic and theragnostic markers, as well as implications for treatment selection and response. Despite advancements in IHC and molecular techniques, ER immunostaining remains a core component in the prognostic and theragnostic assessment of breast cancers.
Article
Oncology
Ivan K. Poon, Ronald C. K. Chan, Joseph S. H. Choi, Joanna K. M. Ng, Katsie T. Tang, Yolanda Y. H. Wong, Ka Pang Chan, Wing Ho Yip, Gary M. Tse, Joshua J. X. Li
Summary: This study reviewed matched pleural biopsy and effusion cytology specimens to compare the performance of these two methods. The results suggest that effusion cytology may be better for confirming benignity and diagnosing carcinomatous pleural effusion, while pleural biopsy should be considered for suspected hematolymphoid malignancies and mesothelioma.
Article
Medical Laboratory Technology
Yunbi Ni, Gary M. Tse
Summary: Spindle cell lesions of the breast are a wide range of diseases, from nonneoplastic reactive conditions to high-grade malignant tumors, making diagnosis difficult. This study reviews the classification of breast spindle cell lesions, including clinical features, morphologic characteristics, and the role of immunohistochemistry and molecular tools in assisting differential diagnosis.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2023)
Article
Pathology
Joshua J. X. Li, Joanna K. M. Ng, Billy S. W. Lai, Conrad H. C. Lee, Ka-Ho Shea, Julia Y. Y. Tsang, Gary M. M. Tse
Summary: This study reviewed the largest cohort of histologically confirmed aspirates of tubular adenomas and compared them with aspirates of fibroadenomas. The findings further defined the cytological features of tubular adenoma and allowed for differentiation from fibroadenoma.
Article
Oncology
Joshua J. X. Li, Gary M. Tse
CANCER CYTOPATHOLOGY
(2023)
Review
Cell Biology
Julia Y. Tsang, Gary M. Tse
Summary: TNBC is a major challenge in breast cancer management due to its heterogeneity and diversity. Expression profiling has identified at least four predominant subtypes with specific genomic alterations and tumor microenvironment. Recognizing these subtypes can improve prognosis and guide treatment decisions.
Review
Cell Biology
Ian O. Ellis, Emad A. Rakha, Gary M. Tse, Puay Hoon Tan
Summary: The International Collaboration on Cancer Reporting (ICCR) has developed an international dataset for breast cancer pathology reporting, aiming to provide a unified approach worldwide. The dataset includes essential and optional data items based on a critical review and discussion of current evidence. The process concludes with international public consultation and publication on the ICCR website to promote high-quality, standardised pathology reporting globally.
Article
Pathology
Joshua J. X. Li, Wing Cheung, Joanna K. M. Ng, Gary M. Tse
Summary: The ISRSFC has demonstrated strong diagnostic performance in pericardial fluid cytology. Disease composition and applicable cytological subcategories differ from its peritoneal and pleural counterparts for pericardial effusion. Incorporating immunocytochemistry by an algorithmic approach improves diagnostic accuracy. Cytomorphology is accurate for identifying adenocarcinomas, but further typing necessitates immunocytochemistry.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Correction
Pathology
Arianna Di Napoli, Lori Soma, Leticia Quintanilla-Martinez, Laurence de Leval, Lorenzo Leoncini, Alberto Zamo, Siok-Bian Ng, Sarah L. Ondrejka, Fina Climent, Andrew Wotherspoon, Stefan Dirnhofer
Article
Pathology
Natalia Papaleo, Fina Climent, Gustavo Tapia, Luis Luizaga, Juan Azcarate, Jan Bosch-Schips, Ana M. Munoz-Marmol, Marta Salido, Carmen Lome-Maldonado, Ivonne Vazquez, Luis Colomo
Summary: Aggressive large B-cell lymphomas (aLBCL) comprise a group of lymphomas with diverse biological features. A previous study showed a strong association between the profile CD10 positive/LMO2 negative expression and the presence of MYC rearrangements (MYC-R) in aLBCL, indicating good intralaboratory reproducibility. In this study, external reproducibility was evaluated and found to have high agreement among observers. The utility of LMO2 as a useful and reproducible marker to screen MYC-R in aLBCL was confirmed.
Review
Pathology
Alberto Zamo, Michiel van den Brand, Fina Climent, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Siok-Bian Ng, Sarah L. Ondrejka, Leticia Quintanilla-Martinez, Lorinda Soma, Andrew Wotherspoon
Summary: Session 3 of the lymphoma workshop at the joint meeting of the European Association for Haematopathology and the Society for Hematopathology discussed splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas. The case review emphasized the challenges in diagnosing marginal zone lymphomas, including distinguishing between different types and the need for molecular studies to establish a final diagnosis. The workshop also addressed the overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma.
Review
Pathology
Sarah L. Ondrejka, Catalina Amador, Fina Climent, Siok-Bian Ng, Lorinda Soma, Alberto Zamo, Stefan Dirnhofer, Leticia Quintanilla-Martinez, Andrew Wotherspoon, Lorenzo Leoncini, Laurence de Leval
Summary: Follicular helper T-cell lymphomas (TFH lymphomas), including their morphologic spectrum and subtypes, were discussed at the EA4HP/SH 2022 meeting. The relationship between TFH lymphoma and clonal hematopoiesis was highlighted, as well as the distinction between TFH lymphoma and PTCL, NOS. The challenges of differentiating TFH lymphoma from other established lymphoma types were presented, and the importance of immunophenotyping and next-generation sequencing in understanding and classifying TFH lymphomas was emphasized.
Article
Pathology
Arianna Di Napoli, Lori Soma, Leticia Quintanilla-Martinez, Laurence de Leval, Lorenzo Leoncini, Alberto Zamo, Siok-Bian Ng, Sarah L. Ondrejka, Fina Climent, Andrew Wotherspoon, Stefan Dirnhofer
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop session discussed various disease entities related to cavity-based lymphomas, including primary effusion lymphomas, HHV8-negative effusion-based lymphomas, and fibrin-associated diffuse large B-cell lymphoma, among others. The workshop focused on understanding the challenges in classifying and diagnosing specific subtypes, such as ECPEL, HHV8-negative effusion-based lymphomas, and FA-DLBCL. The case submissions provided valuable insights into the diagnosis, classification, and prognosis of these lymphomas.
Review
Pathology
Fina Climent, Alina Nicolae, Laurence de Leval, Stefan Dirnhofer, Lorenzo Leoncini, Sarah L. Ondrejka, Lorinda Soma, Andrew Wotherspoon, Alberto Zamo, Leticia Quintanilla-Martinez, Siok-Bian Ng
Summary: The 2022 European Association for Haematopathology/Society for Hematopathology lymphoma workshop discussed cytotoxic peripheral T-cell lymphomas and EBV-positive T/NK-cell lymphoproliferative diseases. Primary nodal-EBV-TNKL is a newly recognized entity associated with underlying immune deficiency/immune dysregulation. cPTCL-NOS demonstrates the TBX21 phenotype and shows an unexpected association with TFH lymphomas/LPDs.
Review
Cell Biology
Joshua J. X. Li, Gary M. Tse
Summary: This review summarizes the applications of immunocytochemistry-detection of carcinoma cells, confirmation of breast primary, assessment of surrogate immunostains and theragnostic biomarkers, with discussion on potential diagnostic pitfalls, followed by the application of molecular tests and digital cytopathologic techniques for assessing metastatic breast carcinoma in cytology.