Article
Oncology
Emanuela Teveroni, Fiorella Di Nicuolo, Edoardo Vergani, Giada Bianchetti, Carmine Bruno, Giuseppe Maulucci, Marco De Spirito, Tonia Cenci, Francesco Pierconti, Gaetano Gulino, Pierfrancesco Bassi, Alfredo Pontecorvi, Domenico Milardi, Francesca Mancini
Summary: This study investigated the role of PTTG1 in the EMT process in seminoma. The results showed that PTTG1 transcriptionally represses E-Cadherin through its cooperation with the transcriptional repressor ZEB1. It also demonstrated that PTTG1 and ZEB1 strongly localize together in the periphery of the tumors. These findings suggest that PTTG1 is a prognostic factor in seminoma clinical management.
Article
Multidisciplinary Sciences
Ying Huang, Yun Guo, Yi Xu, Fei Liu, Suli Dai
Summary: In this study, the upregulation of Flotillin-1 in gastric cancer was observed and correlated with a worse prognosis. Overexpression of Flotillin-1 enhanced the migration and invasion ability of gastric cancer cells, while knockdown of Flotillin-1 inhibited metastasis. Flotillin-1 promoted gastric cancer cell metastasis through inducing EMT process.
Article
Oncology
Xiaofang Cui, Xueying Shang, Jia Xie, Chenyi Xie, Zhanyun Tang, Qing Luo, Chongchao Wu, Guangxing Wang, Na Wang, Kunyan He, Lan Wang, Liyu Huang, Bingbing Wan, Robert G. Roeder, Ze-Guang Han
Summary: The study reveals a novel mechanism in which elevated IRTKS levels enhance tumor progression by promoting SETDB1-mediated H3K9 trimethylation, leading to a decrease in CDH1 transcription, epithelial-mesenchymal transition (EMT), and malignant cell metastasis. This study also suggests a potential approach to reduce the activity and stability of the known therapeutic target SETDB1 through regulating IRTKS or the deubiquitinase OTUD4.
Article
Oncology
Qing Li, Zhi-Wei Zhou, Wei Duan, Cheng-Yuan Qian, Shu-Nan Wang, Meng-Sheng Deng, Dan Zi, Jian-Min Wang, Cheng-Yi Mao, Guanbin Song, Dong Wang, Kenneth D. Westover, Cheng-Xiong Xu
Summary: High APE1 expression is associated with lymph node metastasis in cervical cancer and linked to epithelial to mesenchymal transition (EMT). APE1 promotes invasion and metastasis of cervical cancer cells, while inhibiting APE1 may suppress EMT. Targeting APE1 redox function could be a novel strategy for inhibiting cervical cancer metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Review
Medicine, General & Internal
Katarzyna Wieczorek-Szukala, Andrzej Lewinski
Summary: Despite the usually indolent behavior and relatively good overall prognosis of thyroid carcinomas, they can exhibit high invasiveness and metastatic tendencies in some cases. The zinc-finger transcription factor Snail-1 is a well-known regulator of cancer invasiveness, playing a key role in inducing EMT and regulating chemoresistance and CSC formation in thyroid cancer cells.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Yingtong Feng, Zhiqiang Ma, Minghong Pan, Liqun Xu, Junjun Feng, Yimeng Zhang, Changjian Shao, Kai Guo, Hongtao Duan, Yujing Zhang, Yuxi Zhang, Jiao Zhang, Di Lu, Xiaoya Ren, Jing Han, Xiaofei Li, Xiaolong Yan
Summary: This study found that the expression of WNT5A and SNAIL was significantly increased in esophageal squamous cell carcinoma (ESCC), and correlated positively with lymphatic metastasis and poor prognosis. Further investigation revealed that WNT5A could induce the epithelial-mesenchymal transition and promote ESCC cell metastasis through upregulating HDAC7 expression. Therefore, targeting WNT5A and HDAC7 might be potential therapeutic strategies for ESCC.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Laura Casalino, Francesco Talotta, Ilenia Matino, Pasquale Verde
Summary: FRA-1, encoded by FOSL1, is a key regulator of invasion and metastasis in breast cancer. It controls the transcriptional regulation of EMT and is overexpressed in the TNBC/basal subtypes. Through interactions with EMT-regulating transcription factors, miRNAs, RNA binding proteins, and cytokines, FRA-1 plays a role in the plasticity, stemness, and metastatic potential of cancer cells. The diagnostic, prognostic, and therapeutic implications of the FRA-1 transcriptome related to EMT are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Xin Tian, Hua Yu, Dong Li, Guojiang Jin, Shundong Dai, Pengchao Gong, Cuicui Kong, Xiongjun Wang
Summary: The study revealed the suppressive role of AF9 in breast cancer metastasis, potentially by interfering with Snail's transcriptional activity to prevent epithelial-mesenchymal transition. Furthermore, miR-5694 was found to degrade AF9 mRNA, enhancing its expression in BLBC.
Review
Biochemistry & Molecular Biology
Huichen Zhao, Huihui Hu, Beibei Chen, Weifeng Xu, Jing Zhao, Chen Huang, Yishu Xing, Huifang Lv, Caiyun Nie, Jianzheng Wang, Yunduan He, Sai-Qi Wang, Xiao-Bing Chen
Summary: Gastric cancer ranks fifth in global cancer incidence and third in cancer mortality. E-cadherin is crucial in tumorigenesis, tumor progression, metastasis, with soluble E-cadherin playing a role in promoting invasion and metastasis in gastric cancer.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Environmental Sciences
Maija Pesonen, Kirsi Vahakangas
Summary: Many chemicals, including EDCs, can leach out from plastic consumer products and waste, and have widespread presence in the environment. These EDCs can interfere with hormonal metabolism or function, and may contribute to tumor progression through promoting epithelial-mesenchymal transition (EMT). Plastic-related EDCs, such as phthalates, bisphenol A, and alkylphenols, have been shown to induce EMT in human cells by reducing E-cadherin and increasing N-cadherin and matrix metalloproteinases. In animal studies, EDCs can also increase cell migration and metastatic growth. Understanding the molecular mechanisms underlying EDC-induced EMT and tumor progression is important for public health due to the ubiquitous exposure to these chemicals.
Article
Obstetrics & Gynecology
Mike R. Wilson, Jake J. Reske, Ronald L. Chandler
Summary: This study suggests that the AP-1 subunit JUNB plays a crucial role in promoting invasive phenotypes in endometriosis, and its dysregulation may contribute to the progression of the disease. The findings highlight the potential of therapeutic inhibition of AP-1 to prevent deep infiltrating endometriosis.
REPRODUCTIVE SCIENCES
(2022)
Article
Cell Biology
Xiuqun Zou, Li Ma, Yihong Zhang, Qun Zhang, Chu Xu, Dan Zhang, Yimin Chu, Jie Zhang, Mengying Li, Hui Zhang, Jiamin Wang, Chicheng Peng, Gang Wei, Yingjie Wu, Zhaoyuan Hou, Hao Jia
Summary: In this study, it was found that Snail, a transcriptional repressor, cooperates with GATA zinc finger protein p66β to activate gene transcription in breast cancer cells. Depletion of p66β reduces cell migration and lung metastasis. Snail directly binds to G-box elements in the promoters of genes induced by Snail and p66β enhances Snail's binding affinity, resulting in the transcription of Snail-induced genes.
CELL DEATH & DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Li Han, Huaiqing Luo, Wenjie Huang, Jiang Zhang, Di Wu, Jinmei Wang, Jiao Pi, Chi Liu, Xiangping Qu, Huijun Liu, Xiaoqun Qin, Yang Xiang
Summary: Persistent injury and improper repair in bronchial epithelial cells contribute to airway inflammation and remodeling in asthma. E-cadherin plays a role in regulating the balance between EMT and MET during injury repair by inhibiting EMT features, enhancing MET features, and decreasing TGF-beta 1 secretion and Snail expression, ultimately facilitating epithelial repair.
Article
Cell Biology
Yuanping Zhang, Dinglan Zuo, Jiliang Qiu, Kai Li, Yi Niu, Yichuan Yuan, Yuxiong Qiu, Liang Qiao, Wei He, Chenwei Wang, Yunfei Yuan, Binkui Li
Summary: This study reveals that nucleoredoxin plays a significant role in suppressing the proliferation and metastasis of hepatocellular carcinoma (HCC) by inhibiting the deubiquitylation of Snail protein, suggesting a potential therapeutic approach for the treatment of HCC metastasis.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jingjing Zhu, Huang Cheng, Lan Wang, Weide Xu, Junqing Wang, Qing Han, Jong-ho Lee, Linyong Du, Jianxin Lyu
Summary: This study found that DDR1 is highly expressed in lung adenocarcinoma tissues and is inversely correlated with prognosis. DDR1 promotes the migration and invasion capability of LUAD cells through the AKT/Snail signaling axis. Therefore, DDR1 could be a potential target for treating LUAD.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
H. Oka, Y. Ishida, G. Hong, P. T. T. Nguyen
EUROPEAN JOURNAL OF DENTAL EDUCATION
(2018)
Review
Biochemistry & Molecular Biology
Yosuke Shikama, Yasusei Kudo, Naozumi Ishimaru, Makoto Funaki
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Aya Ushio, Rieko Arakaki, Hiroshi Eguchi, Fumika Hotta, Akiko Yamada, Yasusei Kudo, Naozumi Ishimaru
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Cell Biology
Valerio Donato, Massimo Bonora, Daniele Simoneschi, Davide Sartini, Yasusei Kudo, Anita Saraf, Laurence Florens, Michael P. Washburn, Matthias Stadtfeld, Paolo Pinton, Michele Pagano
NATURE CELL BIOLOGY
(2017)
Article
Oncology
Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru, Yasusei Kudo
Article
Multidisciplinary Sciences
Chanbora Chea, Mutsumi Miyauchi, Toshihiro Inubushi, Nurina Febriyanti Ayuningtyas, Ajiravudh Subarnbhesaj, Phuong Thao Nguyen, Madhu Shrestha, Sivmeng Haing, Kouji Ohta, Takashi Takata
Article
Multidisciplinary Sciences
Ajiravudh Subarnbhesaj, Mutsumi Miyauchi, Chea Chanbora, Aki Mikuriya, Phuong Thao Nguyen, Hisako Furusho, Nurina Febriyanti Ayuningtyas, Minoru Fujita, Shigeaki Toratani, Masaaki Takechi, Shumpei Niida, Takashi Takata
Article
Biochemistry & Molecular Biology
Chanbora Chea, Mutsumi Miyauchi, Toshihiro Inubushi, Kana Okamoto, Sivmeng Haing, Phuong Thao Nguyen, Hiromichi Imanaka, Takashi Takata
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Gastroenterology & Hepatology
Toshikazu Ohigashi, Keishi Kanno, Akiko Sugiyama, Phuong Thao Nguyen, Nobusuke Kishikawa, Yuichiro Otani, Tomoki Kobayashi, Hiroaki Matsuo, Susumu Tazuma
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2019)
Article
Gastroenterology & Hepatology
Tomoki Kobayashi, Keishi Kanno, Phuong Thao Nguyen, Akiko Sugiyama, Akihiro Kawahara, Yuichiro Otani, Nobusuke Kishikawa, Masanori Ito, Susumu Tazuma
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Oncology
Phuong Thao Nguyen, Keishi Kanno, Quoc Thang Pham, Yuka Kikuchi, Masaki Kakimoto, Tomoki Kobayashi, Yuichiro Otani, Nobusuke Kishikawa, Mutsumi Miyauchi, Koji Arihiro, Masanori Ito, Susumu Tazuma
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Naoya Kitamura, Shinya Sento, Yasumasa Yoshizawa, Eri Sasabe, Yasusei Kudo, Tetsuya Yamamoto
Summary: In recent years, drug therapy for head and neck squamous cell carcinoma (HNSCC) has made rapid progress, with a focus on molecular targeted therapy and immune checkpoint inhibitors in addition to traditional cytotoxic anti-cancer agents. While the importance of anti-cancer drug therapy continues to increase, current trends and future prospects of molecular targeted therapy in HNSCC are being explored in clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Wenhua Shao, Orgil Jargalsaikhan, Mayuko Ichimura-Shimizu, Qinyi Cai, Hirohisa Ogawa, Yuko Miyakami, Kengo Atsumi, Mitsuru Tomita, Mitsuko Sutoh, Shunji Toyohara, Ryoji Hokao, Yasusei Kudo, Takeshi Oya, Koichi Tsuneyama
Summary: The GS-negative tumors of TSOD mice exhibit characteristics similar to various subtypes of human hepatocellular adenoma (HCA), suggesting that TSOD mice may share similar mechanisms of HCA development as in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shengjian Jin, Yasusei Kudo, Taigo Horiguchi
Summary: Ubiquitination and deubiquitination are two common post-translational modifications of proteins, affecting their intracellular localization, stability, and function. Deubiquitination is involved in various cellular processes, including histone modification, cell cycle regulation, apoptosis, and cancer development. This review focuses on the understanding of the function of deubiquitinating enzymes in head and neck squamous cell carcinoma (HNSCC) and discusses potential therapeutic strategies for HNSCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hung Trong Hoang, Phuong Thao Nguyen, Nam Cong-Nhat Huynh, Tam Thi-Thanh Nguyen, Trang Thi Huyen Tu, Michael George Botelho, Lan Van Nguyen, Kaori Shima, Tomonori Sasahira
Summary: In the midst of the fourth wave of COVID-19 in Vietnam, dental schools were closed due to national lockdowns. This study analyzed the implementation of Doctor of Dental Surgery (DDS) graduation exams in 2021 compared to onsite exams in 2020 and 2022 at the Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City. The final online examination consisted of theory and practicum sessions, with similar results observed between online and onsite exams. The study identified the need for additional measures to standardize the final examination and adapt to the new normal trend in dental education.