Article
Oncology
Eran Nizri, Yaniv Berger, Eraan Green, Matan Kyzer, Asaf Aizic, Nadav Nevo, Fabian Gerstenhaber, Joseph M. Klausner, Mordechai Gutman, Guy Lahat, Aviad Hoffman, Ravit Geva
Summary: This study found that patients with visceral peritoneal colorectal metastases (VPCMs) who also had lymph node metastases (LNMs) may be more prone to systemic recurrence, indicating a potential need for adjuvant treatment.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Katherine Jackson, Luis Ruffolo, Lauren Kozakiewicz, Shuyang S. Qin, Alexander C. Chacon, Rachel Jewell, Brian Belt, Glynis A. Scott, David C. Linehan, Eva Galka, Peter A. Prieto
Summary: Lymph node involvement is a significant prognostic factor for melanoma, but the significance of few tumor cells within a single node remains unclear. This study investigated the implications of minimal nodal disease on clinical outcomes. Results showed that patients with picomets had better outcomes compared to historical stage matched cohorts, but a small subset still experienced disease recurrence. Further research with a larger population is needed to draw more conclusive results.
Article
Chemistry, Multidisciplinary
Liwei Jiang, Sungwook Jung, Jing Zhao, Vivek Kasinath, Takaharu Ichimura, John Joseph, Paolo Fiorina, Andrew S. Liss, Khalid Shah, Nasim Annabi, Nitin Joshi, Tomoya O. Akama, Jonathan S. Bromberg, Motohiro Kobayashi, Kenji Uchimura, Reza Abdi
Summary: The newly developed MHA112-Taxol drug delivery platform can simultaneously target tumors, TDLNs, and metastatic lesions, effectively reducing the size of primary tumors and the number of metastatic lesions.
Article
Oncology
Tine Henrichsen Schnack, Ligita Paskeviciute Froeding, Elisabeth Kristensen, Isa Niemann, Gitte Ortoft, Estrid Hogdall, Claus Hogdall
Summary: This study aims to examine the impact of tumor size, differentiation grade, and location on the risk of inguinal lymph node metastasis in vulvar squamous cell cancer (VSCC) patients. The results suggest that VSCC patients with grade 1 tumors, sizes less than 2cm, and no clitoral involvement have a very low risk of lymph node metastasis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Medicine, General & Internal
Aura Jurescu, Adrian Vaduva, Octavia Vita, Adelina Gheju, Remus Cornea, Codruta Lazureanu, Anca Muresan, Marioara Cornianu, Sorina Taban, Alis Dema
Summary: This study aimed to evaluate the prognostic significance of classic and less-studied histopathological parameters in colorectal cancer (CRC). The findings showed that a high degree of malignancy, deep invasion of the intestinal wall, advanced stage of the disease, and other factors were positively correlated with lymph node metastases. The study highlighted the value of classic prognostic factors along with easily assessable parameters.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Hong Pan, Hui Wang, Mengjia Qian, Xinrui Mao, Guojian Shi, Ge Ma, Muxin Yu, Hui Xie, Lijun Ling, Qiang Ding, Kai Zhang, Shui Wang, Wenbin Zhou
Summary: This cohort study examined the survival of breast cancer patients with distant lymph node metastases compared to ipsilateral supraclavicular lymph node metastases and other stage IV breast cancer. The results suggest that DLNM may be a regional disease with similar survival outcomes to N3c disease, indicating the need for reassessment of the role of lymph node metastases in breast cancer and consideration of aggressive locoregional therapies for DLNM patients.
Article
Oncology
Alberto Puccini, Andreas Seeber, Joanne Xiu, Richard M. Goldberg, Davide Soldato, Axel Grothey, Anthony F. Shields, Mohamed E. Salem, Francesca Battaglin, Martin D. Berger, Wafik S. El-Deiry, Ryuma Tokunaga, Madiha Naseem, Wu Zhang, Sukeshi Patel Arora, Moh'd M. Khushman, Michael J. Hall, Philip A. Philip, John L. Marshall, W. Michael Korn, Heinz-Josef Lenz
Summary: The study identified different genetic mutations, tumor mutational burden, and MSI-H classification frequencies in lymph nodes and distant metastases, highlighting the distinct molecular profiles between these two types of metastases.
NPJ PRECISION ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yuma Wada, Mitsuo Shimada, Tatsuro Murano, Hiroyuki Takamaru, Yuji Morine, Tetsuya Ikemoto, Yu Saito, Francesc Balaguer, Luis Bujanda, Maria Pellise, Ken Kato, Yutaka Saito, Hiroaki Ikematsu, Ajay Goel
Summary: The study demonstrates that a blood-based liquid biopsy assay can accurately detect lymph node metastasis in high-risk T1 CRC patients, with the risk-stratification model proving to be more accurate than the transcriptomic panel, potentially avoiding unnecessary surgery for high-risk patients.
Article
Medicine, General & Internal
Lei Chen, Funing Yang, Zhaoyan Qi, Jiandong Tai
Summary: Tumor budding (TB), a powerful predictor of colorectal cancer (CRC), was studied to develop a prediction model for lymph node metastasis (LNM) and local recurrence in pT1 CRC patients. Independent predictors for LNM and recurrence were identified and used to construct predictive nomograms for treatment decision-making. The models showed potential clinical application value and postoperative chemotherapy was associated with better outcomes in high-risk patients.
FRONTIERS IN MEDICINE
(2022)
Review
Surgery
A. L. Ebbehoj, L. N. Jorgensen, P-M Krarup, H. G. Smith
Summary: This study reviewed the association between histopathological findings and lymph node metastases in T1 colorectal cancer, finding that factors such as lymphovascular invasion, tumor budding, and depth of submucosal invasion were associated with LNMs. These distinct histopathological factors can help in selecting patients for local excision or major excisional surgery.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Hai-bin Zhu, Da Xu, Xue-Feng Sun, Xiao-Ting Li, Xiao-Yan Zhang, Kun Wang, Bao-Cai Xing, Ying-Shi Sun
Summary: In this study, a model was developed using clinical and MRI parameters to predict the lymph node status in patients with colorectal liver metastases. The model showed high accuracy in both the training and validation groups and predicted worse survival rates in patients with lymph node metastases.
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Biochemistry & Molecular Biology
Nathan E. Reticker-Flynn, Weiruo Zhang, Julia A. Belk, Pamela A. Basto, Nichole K. Escalante, Genay O. W. Pilarowski, Alborz Bejnood, Maria M. Martins, Justin A. Kenkel, Ian L. Linde, Sreya Bagchi, Robert Yuan, Serena Chang, Matthew H. Spitzer, Yaron Carmi, Jiahan Cheng, Lorna L. Tolentino, Okmi Choi, Nancy Wu, Christina S. Kong, Andrew J. Gentles, John B. Sunwoo, Ansuman T. Satpathy, Sylvia K. Plevritis, Edgar G. Engleman
Summary: Lymph node metastasis plays an active role in shaping distant metastasis in solid malignancies, and this mechanism involves the evasion of immune cells, colonization in lymph nodes, and subsequent colonization in other tissues. This mechanism is conserved in human cancers and murine cancer models.
Article
Oncology
Jeong-ki Kim, Ye-Young Rhee, Jeong Mo Bae, Jung Ho Kim, Seong-Joon Koh, Hyun Jung Lee, Jong Pil Im, Min Jung Kim, Seung-Bum Ryoo, Seung-Yong Jeong, Kyu Joo Park, Ji Won Park, Gyeong Hoon Kang
Summary: The optimal tumor budding cut-off number for estimating LN metastasis in submucosal CRC was determined and a composite scoring system (CSS) was developed.
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Emergency Medicine
Joel L. Lavanchy, Luciane Delafontaine, Tobias Haltmeier, Piotr Bednarski, Beat Schnuriger
Summary: The study in Switzerland found that higher hospital treatment volume was associated with a higher rate of successful non-operative management and shorter length of hospital stay for patients with splenic injuries, but not with reduced in-hospital mortality.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Pathology
Eva Karamitopoulou, Irene Esposito, Inti Zlobec, Andrea Cacciato Insilla, Martin Wartenberg, David F. Schaeffer, Steve Kalloger, Stefano La Rosa, Christine Sempoux, Irene Ramos Centeno, Philipp Lohneis
Summary: Tumor budding has been identified as an independent prognostic factor in pancreatic ductal adenocarcinoma (PDAC) and its assessment methods showed moderate agreement levels between pathologists in a multicenter interobserver study. The pancytokeratin 10HPF method demonstrated acceptable levels of agreement and is recommended for tumor budding assessment in PDAC resection specimens. Implementing machine learning applications should be considered to improve interobserver agreement levels.
Article
Pathology
Tariq Sami Haddad, Alessandro Lugli, Susan Aherne, Valeria Barresi, Benoit Terris, John-Melle Bokhorst, Scarlet Fiona Brockmoeller, Miriam Cuatrecasas, Femke Simmer, Hala El-Zimaity, Jean-Francois Flejou, David Gibbons, Gieri Cathomas, Richard Kirsch, Tine Plato Kuhlmann, Cord Langner, Maurice B. Loughrey, Robert Riddell, Ari Ristimaki, Sanjay Kakar, Kieran Sheahan, Darren Treanor, Jeroen van der Laak, Michael Vieth, Inti Zlobec, Iris D. Nagtegaal
Summary: An international group of experts reached consensus on a standardized method for tumor budding assessment and reporting, which has been validated and included in international colorectal cancer pathology and clinical guidelines.
Article
Pathology
Viktor Hendrik Koelzer, Rainer Grobholz, Inti Zlobec, Andrew Janowczyk
Summary: The survey suggests that the pandemic has accelerated the adoption of digital pathology, especially in centers with established workflows. However, institutions in the early stages of implementation face significant technical and organizational challenges.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Article
Surgery
Joel L. Lavanchy, Jean-Baptiste Dubuis, Alice Osterwalder, Sebastian Winterhalder, Tobias Haltmeier, Daniel Candinas, Beat Schnueriger
Summary: The impact of inter-hospital transfer on outcomes of emergency abdominal surgery (EAS) patients may vary based on the nature of the surgery.
WORLD JOURNAL OF SURGERY
(2021)
Article
Emergency Medicine
Christian T. J. Magyar, Piotr Bednarski, Dominik A. Jakob, Beat Schnuriger
Summary: This study found that severe penetrating trauma is very rare in Switzerland, with mortality rates ranging from 9% in stab wounds to 67% in self-inflicted gunshot wounds. Particularly in cases of torso injuries, reducing prehospital time may improve patient outcomes.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2022)
Article
Surgery
Claudine Di Pietro Martinelli, Tobias Haltmeier, Joel L. Lavanchy, Stephanie F. Perrodin, Daniel Candinas, Beat Schnuriger
Summary: This study investigated the daily work characteristics of ACS surgeons at a Swiss tertiary care hospital, finding that surgery, patient consultations, and administrative work were the main activities with approximately one third of working time each. There was a bimodal temporal distribution for both surgery and patient consultations, which may help improve hospital resources and on-call rosters of ACS services.
WORLD JOURNAL OF SURGERY
(2022)
Article
Oncology
Karlijn Hummelink, Vincent van der Noort, Mirte Muller, Robert D. Schouten, Ferry Lalezari, Dennis Peters, Willemijn S. M. E. Theelen, Viktor H. Koelzer, Kirsten D. Mertz, Alfred Zippelius, Michel M. van den Heuvel, Annegien Broeks, John B. A. G. Haanen, Ton N. Schumacher, Gerrit A. Meijer, Egbert F. Smit, Kim Monkhorst, Daniela S. Thommen
Summary: This study established PD-1T TILs as a predictive biomarker for clinical benefit to PD-1 blockade in patients with advanced NSCLC. The biomarker showed high sensitivity and specificity, and had a high negative predictive value in identifying patients without clinical benefit. Additionally, high levels of PD-1T TILs were associated with longer progression-free and overall survival.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Simone Benhamou, Evelyne Fournier, Giacomo Puppa, Thomas McKee, Frederic Ris, Laura Rubbia-Brandt, Valeria Viassolo, Thomas Zilli, Inti Zlobec, Pierre Olivier Chappuis, Elisabetta Rapiti
Summary: This study established a large cohort of colorectal cancer (CRC) patients and their relatives to investigate the impact of family history and tumor biomarkers on patient outcomes. The cohort includes 5499 patients and provides detailed clinical and molecular data. Future plans involve further research and correlation analysis with the latest follow-up data.
Article
Pathology
Magdalena Skoworonska, Annika Blank, Irene Centeno, Caroline Hammer, Aurel Perren, Inti Zlobec, Tilman T. Rau
Summary: The standardized preanalytical code (SPREC) is a precise format for aggregating warm ischemia (WIT), cold ischemia (CIT), and fixation times (FIT). Through empirical research, the Tissue Bank Bern has developed a fully informative SPREC code and identified its dual role as a sample characteristic and a traceable process parameter. The study also reveals specific differences in WIT, CIT, and FIT values in various organs, as well as the potential to optimize the SPREC fixation and adapt its categories based on real-life data.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Oxana (Sachenkova) Lundstrom, Max Adriaan Verbiest, Feifei Xia, Helyaneh Ziaei Jam, Inti Zlobec, Maria Anisimova, Melissa Gymrek
Summary: Short tandem repeats (STRs), consisting of repeated one to six nucleotide motifs, have been shown to influence various traits in humans. However, the study of STRs has been limited due to technical challenges. Recent advancements in genome-wide analysis tools have enabled large-scale analysis of STR variations in populations.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Article
Pathology
Ana Leni Frei, Raphael Oberson, Elias Baumann, Aurel Perren, Rainer Grobholz, Alessandro Lugli, Heather Dawson, Christian Abbet, Ibai Lertxundi, Stefan Reinhard, Aart Mookhoek, Johann Feichtinger, Rossella Sarro, Gallus Gadient, Corina Dommann-Scherrer, Jessica Barizzi, Sabina Berezowska, Katharina Glatz, Susanne Dertinger, Yara Banz, Rene Schoenegg, Laura Rubbia-Brandt, Achim Fleischmann, Guenter Saile, Pierre Mainil-Varlet, Ruggero Biral, Luca Giudici, Alex Soltermann, Audrey Baur Chaubert, Sylvia Stadlmann, Joachim Diebold, Kristof Egervaril, Charles Beniere, Francesca Saro, Andrew Janowczyk, Inti Zlobec
Summary: Estimating tumor cell fraction (TCF) is a common clinical task with high variability among pathologists. This study evaluated the impact of using a tumor cell fraction computer-aided diagnostic (TCFCAD) tool to support pathologists' evaluation. The results showed that with the assistance of TCFCAD, interobserver variability decreased and estimates were closer to the ground truth. Pathologists also reported increased confidence in their assessments when aided by the TCFCAD tool.
Proceedings Paper
Computer Science, Artificial Intelligence
Ruby Wood, Korsuk Sirinukunwattana, Enric Domingo, Alexander Sauer, Maxime W. Lafarge, Viktor H. Koelzer, Timothy S. Maughan, Jens Rittscher
Summary: Using deep learning approaches, this study predicts the complete response to radiotherapy in rectal cancer patients by extracting morphological features from histology biopsies. The proposed adjustments to the Vision Transformer network improve the utilization of contextual information in whole slide images. The experiments show that the PREViT and ClusterViT models demonstrate improvements in prediction over baseline models.
ARTIFICIAL INTELLIGENCE OVER INFRARED IMAGES FOR MEDICAL APPLICATIONS AND MEDICAL IMAGE ASSISTED BIOMARKER DISCOVERY
(2022)
Review
Gastroenterology & Hepatology
Daniel Segna, Paul J. Jaklin, Beat Schnueriger, Benjamin Misselwitz
Summary: Most studies indicate that patients with diverticular disease experience improved quality of life after surgery, with high satisfaction rates. While functional disorders and abdominal pain may occur postoperatively, longitudinal studies do not show a significant increase in functional disorders following elective diverticular surgery.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Meeting Abstract
Surgery
T. Haltmeier, M. Falke, O. Quaile, D. Candinas, B. Schnuriger
BRITISH JOURNAL OF SURGERY
(2021)
