Article
Cell Biology
Tao Wang, Yi Yang, Ting Sun, Haizhou Qiu, Jian Wang, Cheng Ding, Ren Lan, Qiang He, Wentao Wang
Summary: This study reveals that the risk score of pyroptosis-related lncRNA is significantly associated with the overall survival and tumor characteristics of hepatocellular carcinoma patients, as well as the infiltration of tumor microenvironment cells. The risk score can serve as a potential prognostic biomarker and provide guidance for precision drug treatment and immunotherapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Laura Amicone, Alessandra Marchetti, Carla Cicchini
Summary: Epithelial-to-mesenchymal transition (EMT) is a cell differentiation process that gives epithelial cells the ability to move and invade, and its abnormal reactivation in cancer cells is crucial for metastasis. EMT is a dynamic program with various states, and the inverse transition, mesenchymal-to-epithelial transition (MET), is important for colonization of distant sites. Long non-coding RNAs (lncRNAs), specifically HOTAIR, play a critical role in regulating epithelial cell plasticity and EMT in tumors. This review focuses on the molecular mechanisms of HOTAIR expression and its functions in gene regulation and protein activities, as well as the challenges of targeting HOTAIR for therapeutic approaches against EMT.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Cell Biology
Xin Yang, Minhui Mei, Jingze Yang, Jinlu Guo, Fan Du, Shi Liu
Summary: This study established a prognostic risk model for hepatocellular carcinoma (HCC) based on 17 ferroptosis-related long non-coding RNAs (lncRNAs). The model showed significant prognostic value for HCC and may serve as therapeutic targets associated with ferroptosis in clinical practice.
Article
Surgery
Yuqi Xin, Jieyuan Zhang, Qingkun Jiang, Jiaxuan Qiu
Summary: This study aimed to evaluate the association between pyroptosis-related lncRNAs and prognosis in patients with OSCC. By analyzing RNA-seq data and clinicopathological data, a risk prognostic model for OSCC was constructed, and 8 pyroptosis-related lncRNAs were identified. These lncRNAs showed high accuracy in predicting the prognosis of OSCC patients and affected immune responses in the microenvironment of OSCC.
FRONTIERS IN SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Lin Chen, Zhimou Cai, Kexing Lyu, Zhiwei Cai, Wenbin Lei
Summary: The risk score model established based on DEirlncRNA pairs can accurately predict the overall survival of HNSCC patients, aiding in personalized treatment. Compared with other lncRNA signatures, this model performs better and is correlated with the immune microenvironment and chemosensitivity in HNSCC.
Article
Oncology
Zehang Zhuang, Jing Huang, Weiwang Wang, Cheng Wang, Pei Yu, Jing Hu, Haichao Liu, Hanqi Yin, Jinsong Hou, Xiqiang Liu
Summary: This study identified a differentiation-related lncRNA, TINCR, in oral squamous cell carcinoma (OSCC). TINCR was found to be downregulated in tumor tissues and correlated with pathological differentiation and lymph node metastasis. Function experiments showed that TINCR played a crucial role in cell differentiation and suppressed cell migration and invasion in OSCC.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jie Cao, Lili Wu, Xin Lei, Keqing Shi, Liang Shi, Yifen Shi
Summary: This study established a 19-lncRNA signature to predict the prognosis of hepatocellular carcinoma (HCC) patients. The signature, combined with clinicopathologic factors, showed high predictive performance and may play a crucial role in guiding the management of HCC.
Article
Medicine, General & Internal
Junchao Huang, Jingwei Zhang, Haijun Xiao
Summary: This study characterized histone modifications in osteosarcoma and identified epigenetically dysregulated long non-coding RNAs (epi-lncRNAs). By analyzing differentially expressed lncRNAs (DElncRNAs) and performing Cox regression analysis, a 4-epi-lncRNA signature was developed to predict the prognosis of osteosarcoma.
FRONTIERS IN MEDICINE
(2022)
Article
Genetics & Heredity
Ze-Jun Zheng, Yan-Shang Li, Jun-De Zhu, Hai-Ying Zou, Wang-Kai Fang, Yi-Yao Cui, Jian-Jun Xie
Summary: This study identified a six-lncRNA signature that can serve as a valuable survival predictor for ESCC patients. When combined with TNM staging, the accuracy of subgrouping ESCC patients was significantly improved. Furthermore, one of the lncRNAs, LINC01273, was found to play an oncogenic role in ESCC.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Jianhua Wu, Xueting Ren, Nan Wang, Ruina Zhou, Mengsha Chen, Yifan Cai, Shuai Lin, Hao Zhang, Xin Xie, Chengxue Dang, Shuqun Zhang, Zhangjian Zhou
Summary: The GILncSig, a GI-related lncRNA signature, serves as a potential biomarker and independent predictor of HCC patient prognosis. This highlights the importance of further investigating GI and HCC molecular mechanisms. Additionally, an integrated nomogram can efficiently evaluate the prognosis of HCC patients.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Qingkun Jiang, Danfeng Xue, Fanzhe Shi, Jiaxuan Qiu
Summary: By analyzing gene sequencing and clinicopathological data, this study identified autophagy-related lncRNAs in patients with OSCC/OPSCC and established a signature that can serve as an independent prognostic indicator, promoting research on targeted diagnosis and treatment for these patients.
Article
Oncology
Gasper Grubelnik, Emanuela Bostjancic, Aleksandar Anicin, Tadej Dovsak, Nina Zidar
Summary: The study revealed that in the development of oral squamous cell carcinoma (OSCC), NANOG, miR-145, RoR, and SNHG1 are up-regulated, while TP53 and miR-34a are down-regulated, with AB209630 showing variable expression. NANOG protein is up-regulated early in cancerogenesis, correlating with miR-145 and RoR.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Dandan Guo, Mei Yang, Shiyun Li, Weiwei Zhu, Meixin Chen, Jiayu Pan, Dan Long, Zhaohui Liu, Chunlin Zhang
Summary: Head and neck squamous cell carcinoma (HNSCC) is closely related to persistent HPV infection, and the incidence of HPV-positive HNSCC has been increasing. The main viral oncoproteins E6 and E7 play important roles in malignant transformation, cell proliferation promotion, and tumor invasion. HPV-positive HNSCC shows specific clinical-pathological features, possibly related to HPV infection and specific regulatory mechanisms. Non-coding RNA (ncRNA) plays a critical regulatory role in HPV-induced tumorigenesis and progression. Understanding the expression profile and regulatory role of ncRNAs can provide insights into the carcinogenesis mechanism and valuable biomarkers for HPV-positive HNSCC.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Aryan Rezaee, Sara Ahmadpour, Ameneh Jafari, Sarehnaz Aghili, Seyed Saeed Tamehri Zadeh, Ali Rajabi, Arash Raisi, Michael R. Hamblin, Maryam Mahjoubin-Tehran, Marzieh Derakhshan
Summary: Gynecologic cancer is a significant cause of death in women worldwide. Recent research has shown that non-coding RNAs play a critical role in the metastasis and invasion of gynecologic cancer.
FRONTIERS IN ONCOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Sara Fadaei, Fatemeh Zarepour, Mehrnoosh Parvaresh, Alireza Motamedzadeh, Seyed Saeed Tamehri Zadeh, Amirhossein Sheida, Mohammad Shabani, Michael R. Hamblin, Mehdi Rezaee, Maryam Zarei, Hamed Mirzaei
Summary: Myocardial infarction (MI) is a leading cause of global deaths. Non-coding RNAs (ncRNAs), such as microRNAs (miRNAs), have been found to regulate pathological processes in MI, and exosomal ncRNAs have been shown to play important roles in cell communication and disease development. Therefore, understanding the role of ncRNAs and exosomal ncRNAs in MI is of great significance for diagnosis and prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Oncology
Yajing Zhang, Yao Wang, Yang Liu, Chuan Tong, Chunmeng Wang, Yelei Guo, Dongdong Ti, Qingming Yang, Shen Qiao, Zhiqiang Wu, Weidong Han
Summary: A clinical trial of CAR T cell therapy for recurrent/refractory non-Hodgkin lymphoma showed a high overall response rate and progression-free survival, with manageable side effects such as cytokine release syndrome and CAR T cell-related encephalopathy syndrome.
Review
Biochemistry & Molecular Biology
Cheng Zhu, Qian Huai, Xu Zhang, Hanren Dai, Xiaolei Li, Hua Wang
Summary: This review summarizes the multiple roles of ceramides in the onset of fatty liver disease and the pathogenic mechanisms underlying their effects, and also discusses recent advances and challenges in pharmacological interventions targeting ceramide metabolism for the treatment of NAFLD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Yajing Zhang, Yang Xu, Xiuyong Dang, Zeyu Zhu, Wenbin Qian, Aibin Liang, Weidong Han
Summary: The remarkable improvement of CAR-T cell therapy in the treatment of hematological malignancies relative to traditional approaches has led to the sequential approvals of eight commercial CAR-T products in the past five years. While the productization of CAR-T cells is rapidly expanding their clinical application in real-world patients, the limitations of their clinical efficacy and associated toxicities inspire the further optimization of CAR structure and substantial development of innovative trials. This article summarizes the current status and major progress of CAR-T therapy for hematological malignancies, discusses the factors that may compromise the clinical efficacy of CAR-T cells, such as CAR-T cell exhaustion and loss of antigen, and proposes potential optimization strategies to address the challenges in the field of CAR-T therapy.
CHINESE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Zongzhi Liu, Xiang Li, Yibo Gao, Jiejie Liu, Yating Feng, Yang Liu, Junyun Wang, Chunmeng Wang, Dongrui Wang, Jie He, Weidong Han, Qian Mei, Yingli Sun
Summary: The combination of low-dose decitabine and PD-1 antibody treatment improves the complete response rate of cHL patients, indicating the correlation between epigenetic regulation and the clinical response to immunotherapy.
Article
Oncology
Ping Li, Yang Liu, Yun Liang, Jian Bo, Sujun Gao, Yongxian Hu, Yu Hu, He Huang, Xiaojun Huang, Hongmei Jing, Xiaoyan Ke, Jianyong Li, Yuhua Li, Qifa Liu, Peihua Lu, Heng Mei, Ting Niu, Yongping Song, Yuqin Song, Liping Su, Sanfang Tu, Jianxiang Wang, Depei Wu, Zhao Wang, Kailin Xu, Zhitao Ying, Qingming Yang, Yajing Zhang, Fengxia Shi, Bin Zhang, Huilai Zhang, Xi Zhang, Mingfeng Zhao, Weili Zhao, Xiangyu Zhao, Liang Huang, Jun Zhu, Wenbin Qian, Weidong Han, Aibin Liang
Summary: Adoptive cellular immunotherapy with CAR T cells is a promising approach for treating relapsed and/or refractory B-NHL. However, CAR T-cell-associated toxicities can be severe, compromising the survival benefit. Clinical management of these toxicities is crucial, but previous guidelines provide limited recommendations.
CANCER BIOLOGY & MEDICINE
(2023)
Article
Biology
Xiao Su, Xiaolei Li, Shiqing Wang, Xiaotong Xue, Rui Liu, Xiaojing Bai, Pixia Gong, Chao Feng, Lijuan Cao, Tingting Wang, Yayun Ding, Junjie Jiang, Yongjing Chen, Yufang Shi, Changshun Shao
Summary: This study found that Nestin-positive mesenchymal stromal cells (T-MSCs) mainly distribute in the medulla and cortical-medulla junction of the thymus, and possess immunosuppressive ability. Additionally, T-MSCs exhibit remarkable therapeutic efficacy in acute liver injury and inflammatory bowel disease (IBD).
Article
Immunology
Yuzhuo Yang, Yajing Zhang, Xiaoyan Xing, Gang Xu, Xin Lin, Yao Wang, Meixia Chen, Chunmeng Wang, Bin Zhang, Weidong Han, Xiaoyu Hu
Summary: Metoprolol, an FDA-approved drug for cardiovascular conditions, may alleviate cytokine release syndrome (CRS) caused by CAR T-cell therapy. It was found that metoprolol blocks IL-6 protein translation rather than IL-6 mRNA expression. Clinical trials have shown that metoprolol has a favorable safety profile in CRS management and does not compromise the efficacy of CAR T-cell therapy.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Obstetrics & Gynecology
Cheng Zhu, Yishan Du, Qian Huai, Nana Fang, Wentao Xu, Jing Yang, Xingyu Li, Yanyan Zhang, Xu Zhang, Hanren Dai, Xiaolei Li, Hua Wang, Ying Dai
Summary: The study identifies gamma-glutamyl hydrolase (GGH) as a candidate gene that may influence the progression of uterine corpus endometrial carcinoma (UCEC) by regulating the glycolytic process and is closely associated with various immune cell infiltrations. GGH plays a significant role in the prognosis of UCEC.
REPRODUCTIVE SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qian Huai, Cheng Zhu, Xu Zhang, Hanren Dai, Xiaolei Li, Hua Wang
Summary: Liver disease is a major global cause of death and disability. Chronic liver inflammation and fibrosis can result from various insults, leading to irreversible dysfunction. Liver transplantation is currently the last resort for end-stage liver disease, but faces challenges. Mesenchymal stromal/stem cells (MSCs) offer a promising alternative with anti-inflammatory and immunomodulatory properties. This review discusses the characteristics of MSCs and their potential mechanism in liver disease treatment, as well as strategies to enhance their therapeutic properties. The clinical application of MSCs and their extracellular vesicles in liver diseases is also explored.
CELL AND BIOSCIENCE
(2023)
Letter
Oncology
Xu Zhang, Xuezhe Feng, Qian Huai, Cheng Zhu, Yingyin Sun, Xiaolei Li, Hanren Dai, Honglin Wang, Hua Wang
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yao Wang, Chuan Tong, Yuting Lu, Zhiqiang Wu, Yelei Guo, Yang Liu, Jianshu Wei, Chunmeng Wang, Qingming Yang, Weidong Han
Summary: CAR-T cell therapy has become an important treatment option for patients with relapsed/refractory B-cell malignancies, but a significant number of DLBCL patients fail to achieve durable response. This study analyzed the characteristics of pre-manufacture T cells and CAR-T cell products in DLBCL patients and identified the key role of CD8+ stem cell-like memory T cells in achieving durable clinical response. Heterogeneity in the cellular and molecular features of pre-manufacture T cells contributes to the variation in efficacy after CAR-T cell therapy, and loss of CCR7 gene expression and increased expression of activation- and inhibitor-related genes in CD8+ naive-T cell populations may explain the differences in anti-tumor efficacy among patients with different clinical outcomes.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Gastroenterology & Hepatology
Xiaolei Li, Qian Huai, Cheng Zhu, Xu Zhang, Wentao Xu, Hanren Dai, Hua Wang
Summary: GDF15 plays an immunomodulatory role in liver fibrosis and has therapeutic potential. It improves liver fibrosis by modulating liver macrophages and can acquire an anti-inflammatory function by reprogramming macrophage metabolic pathways.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xin Yan, Deyun Chen, Yao Wang, Yelei Guo, Chuan Tong, Jianshu Wei, Yajing Zhang, Zhiqiang Wu, Weidong Han
Summary: Loss of NOXA, a BCL2 family protein, was identified as a key regulator of resistance to CAR T-cell therapy. Low NOXA expression was associated with worse survival in patients with B-cell lymphoma. In vitro and in vivo experiments showed that enhancing NOXA expression using HDAC inhibitors dramatically increased sensitivity of cancer cells to CAR T-cell clearance.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Oncology
Dongdong Ti, Xin Yan, Jianshu Wei, Zhiqiang Wu, Yao Wang, Weidong Han
Summary: Immunogenic cell death is a regulated form of cell death that activates immune responses in the tumor microenvironment, improving the efficacy of cancer treatment. Inducers of immunogenic cell death enhance the immunogenicity of cancer cells and modulate the tumor microenvironment, amplifying antitumor immune responses.
CHINESE JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Baolin Liu, Xueda Hu, Kaichao Feng, Ranran Gao, Zhiqiang Xue, Sujie Zhang, Yuanyuan Zhang, Emily Corse, Yi Hu, Weidong Han, Zemin Zhang
Summary: In lung cancer patients treated with anti-PD-1, precursor exhausted T cells were found in responders, accumulating through local expansion and clonal revival from peripheral T cells.