Article
Radiology, Nuclear Medicine & Medical Imaging
Zengjie Wu, Qing Lin, Haibo Wang, Guanqun Wang, Guangming Fu, Tiantian Bian
Summary: The study developed a radiomics nomogram based on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to accurately differentiate between ductal carcinoma in situ with microinvasion (DCISM) and pure ductal carcinoma in situ (DCIS) breast cancer. The radiomics signature and nomogram model showed better performance in calibration and validation compared to the clinical factor model, indicating good potential for clinical utility.
ACADEMIC RADIOLOGY
(2023)
Article
Biology
Satoi Nagasawa, Yuta Kuze, Ichiro Maeda, Yasuyuki Kojima, Ai Motoyoshi, Tatsuya Onishi, Tsuguo Iwatani, Takamichi Yokoe, Junki Koike, Motohiro Chosokabe, Manabu Kubota, Hibiki Seino, Ayako Suzuki, Masahide Seki, Katsuya Tsuchihara, Eisuke Inoue, Koichiro Tsugawa, Tomohiko Ohta, Yutaka Suzuki
Summary: The study conducted a multi-omic analysis of ductal carcinoma in situ (DCIS) and identified age, gene amplification, and gene mutation as possible indicators of relapse. The results revealed heterogeneous cell populations in DCIS, providing predictive markers for classifying and optimizing treatment.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Leslie R. Lamb, Sarah Mercaldo, Tawakalitu O. Oseni, Manisha Bahl
Summary: In a study of nearly 550 women with DCIS undergoing BCS, 31.6% required at least one reexcision. Factors associated with reexcision included younger age, African-American race, ultrasound biopsy modality, and earlier year of surgery. Pathological features of DCIS were not found to be associated with the risk of reexcision.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Yufei Zeng, Weiqi Gao, Xiaosong Chen, Kunwei Shen
Summary: Patients with invasive ductal carcinoma (IDC) accompanied by ductal carcinoma in situ (DCIS) have a lower 21-gene recurrence score (RS) possibly due to lower expression of proliferation and invasion genes. The proportion and grade of DCIS independently influence the 21-gene RS in IDC/DCIS patients. Further evaluation is needed to determine the impact of the DCIS component in IDC on prognosis due to the relatively short follow-up period and low recurrence rate.
BRITISH JOURNAL OF CANCER
(2021)
Review
Endocrinology & Metabolism
Shelby Lynn Hophan, Olena Odnokoz, Huiping Liu, Yuan Luo, Seema Khan, William Gradishar, Zhuan Zhou, Sunil Badve, Mylin A. Torres, Yong Wan
Summary: Ductal carcinoma in situ (DCIS) is a noninvasive breast cancer, but the molecular mechanisms behind its progression to invasive ductal carcinoma (IDC) and the complexity of each lesion are still unclear. Understanding the molecular features that lead to DCIS progression and finding new strategies to identify molecular mechanisms are crucial for more targeted therapy.
Article
Nutrition & Dietetics
Silvia D. Stan, Minna Abtahi
Summary: This study demonstrates that DATS inhibits cell proliferation and induces apoptosis in breast DCIS and minimally invasive breast cancer cells.
Article
Genetics & Heredity
Esther H. Lips, Tapsi Kumar, Anargyros Megalios, Lindy L. Visser, Michael Sheinman, Angelo Fortunato, Vandna Shah, Marlous Hoogstraat, Emi Sei, Diego Mallo, Maria Roman-Escorza, Ahmed A. Ahmed, Mingchu Xu, Alexandra W. Van den Belt-Dusebout, Wim Brugman, Anna K. Casasent, Karen Clements, Helen R. Davies, Liping Fu, Anita Grigoriadis, Timothy M. Hardman, Lorraine M. King, Marielle Krete, Petra Kristel, Michiel de Maaker, Carlo C. Maley, Jeffrey R. Marks, Brian A. Menegaz, Lennart Mulder, Frank Nieboer, Salpie Nowinski, Sarah Pinder, Jelmar Quist, Carolina Salinas-Souza, Michael Schaapveld, Marjanka K. Schmidt, Abeer M. Shaaban, Rana Shami, Mathini Sridharan, John Zhang, Hilary Stobart, Deborah Collyar, Serena Nik-Zainal, Lodewyk F. A. Wessels, E. Shelley Hwang, Nicholas E. Navin, P. Andrew Futreal, Alastair M. Thompson, Jelle Wesseling, Elinor J. Sawyer
Summary: A genomic analysis of ductal carcinoma in situ (DCIS) samples reveals that a significant portion of invasive breast cancer recurrences are unrelated to the initial DCIS and have distinct clonal origins. This finding is crucial for accurately assessing the risk of DCIS, developing effective treatment strategies, and identifying predictive biomarkers.
Article
Biochemistry & Molecular Biology
Joanna Szpor, Joanna Streb, Anna Glajcar, Anna Streb-Smolen, Agnieszka Lazarczyk, Paulina Korta, Karolina Brzuszkiewicz, Robert Jach, Diana Hodorowicz-Zaniewska
Summary: The density of dendritic cells (DCs) with different superficial antigens is associated with various histopathological characteristics of ductal carcinoma in situ (DCIS). CD123(+) and DC-LAMP(+) cells are correlated with tumor size, grading, and neoductgenesis, while CD1a(+) cells are negatively correlated with hormone receptor expression. Additionally, the number of DC-LAMP(+) cells is higher in DCIS with comedo necrosis, ductal spread, lobular cancerization, and comedo-type tumors, while CD1a(+) cells are abundant in cases with Paget disease. DC-LAMP seems particularly promising as a target for further research in this area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Mathilde M. M. Almekinders, Michael Schaapveld, Bram Thijssen, Lindy L. Visser, Tycho Bismeijer, Joyce Sanders, Edoardo Isnaldi, Ingrid Hofland, Marjolijn Mertz, Lodewyk F. A. Wessels, Annegien Broeks, Erik Hooijberg, Wilbert Zwart, Esther H. Lips, Christine Desmedt, Jelle Wesseling
Summary: The study suggests that the size of breast adipocytes and COX-2 protein expression in DCIS cells are associated with the risk of subsequent invasive breast cancer. Large breast adipocytes and high COX-2 expression in DCIS are linked to a higher risk of developing invasive breast cancer.
Article
Oncology
Gabriel Farante, Antonio Toesca, Francesca Magnoni, Germana Lissidini, Jose Vila, Mauro Mastropasqua, Giuseppe Viale, Silvia Penco, Enrico Cassano, Matteo Lazzeroni, Bernardo Bonanni, Maria Cristina Leonardi, Francisco Ripoll-Orts, Giuseppe Curigliano, Roberto Orecchia, Viviana Galimberti, Paolo Veronesi
Summary: Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer with heterogeneous pathological and biological traits. This article provides evidence-based guidelines for proper DCIS clinical management, emphasizing multidisciplinary team discussion and consideration of recent scientific studies. It also includes updated treatment protocols and techniques based on peer-reviewed medical literature and outlines future perspectives.
Article
Oncology
Jiao Zhang, Hui Lin, Lei Hou, Hui Xiao, Xilong Gong, Xuhui Guo, Xuchen Cao, Zhenzhen Liu
Summary: This study identified differentially expressed genes in DCIS and normal tissue and validated a six-core gene signature with potential for prognostic prediction in DCIS.
Article
Oncology
Vu Pham Thao Vy, Melissa Min-Szu Yao, Nguyen Quoc Khanh Le, Wing P. Chan
Summary: Breast cancer is the most common cancer among women, and it can be classified into non-invasive and invasive types based on whether it has spread. Early identification of breast cancer types allows for more options of less invasive therapies. In this study, a machine learning classification model was developed to differentiate between ductal carcinoma in situ (DCIS) and minimally invasive breast cancer (MIBC), using clinical characteristics, mammography findings, ultrasound findings, and histopathology features. Five most important features were identified in the model.
Article
Pharmacology & Pharmacy
Fatemeh Khatami, Aysan Baharian, Shiva Akbari-Birgani, Nasser Nikfarjam
Summary: Ductal carcinoma in situ (DCIS), a common condition in breast cancer patients, can be effectively studied and treated using a biodegradable tubular 3D scaffold made of core-shell nanofibers. The scaffold has been shown to support the attachment and growth of breast cancer cells and offers a potential drug delivery platform for targeted chemotherapy in tumor tissues.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Oncology
Ying Jiang, Li Chai, Dandan Dong, Aamer Rasheed Chughtai, Weifang Kong
Summary: Mucocele-like tumors of the breast are associated with DCIS and have characteristic imaging features, with MR features not well-documented. FNAC carries a risk of tumor underestimation, so excision is recommended as the best approach, but close follow-up is suggested for low-risk patients.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Ruwangi Udayasiri, Tongtong Luo, Kylie L. Gorringe, Stephen B. Fox
Summary: Ductal carcinoma in situ (DCIS) is a non-invasive breast tumor with the potential to progress to invasive ductal carcinoma (IDC). The current inability to accurately predict the invasive potential of DCIS leads to both over-treatment and under-treatment in patients. Better understanding of the molecular features of DCIS could improve treatment decision-making and avoid unnecessary side-effects. This review summarizes the current knowledge of DCIS and discusses future research directions.
Letter
Immunology
Borame Sue Lee Dickens, Jue Tao Lim, Jere Wenn Low, Chun Kiat Lee, Yinxiaohe Sun, Haziq Bin Mohamad Nasir, Farheen Akram Bte Mohamed Akramullah, Gabriel Yan, Jolene Oon, Benedict Yan, Louisa Sun, Alex R. Cook, Paul Anantharajah Tambyah, Louis Yi Ann Chai
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Oncology
Sarocha Chootipongchaivat, Xin Yi Wong, Kevin Ten Haaf, Mikael Hartman, Kelvin B. Tan, Nicolien T. van Ravesteyn, Hwee-Lin Wee
Summary: The current breast cancer screening program in Singapore is cost-effective and near the efficiency frontier, with starting screening at age 40 or 45 being recommended for optimal cost-effectiveness. Increasing screening attendance rates can further enhance benefits while maintaining cost-effectiveness.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Article
Computer Science, Artificial Intelligence
Wai Hoh Tang, Adrian Rollin
Summary: By training convolutional neural networks on synthetic data with known ground truths, we found that in ARMA time series models, this approach significantly outperforms traditional likelihood-based methods in terms of accuracy and speed, particularly in statistical inference and time series forecasting. This study demonstrates the feasibility of using artificial neural networks for statistical inference in situations where classical likelihood-based methods are difficult or costly to implement.
DECISION SUPPORT SYSTEMS
(2021)
Article
Mathematics
Jason Fulman, Adrian Rollin
Summary: By combining Stein's method with heat kernel techniques, this study investigates the properties of the function Tr(AO), where A is a fixed matrix and O is sampled from the Haar measure of the orthogonal group. The research shows that the total variation distance between Tr(AO) and a standard normal random variable is bounded by a certain constant, slightly improving upon previous results obtained using different methods.
JOURNAL OF ALGEBRA
(2022)
Article
Engineering, Industrial
Adrian Rollin
Summary: In this study, we bound the error in the normal approximation of the number of triangles in the Erdos-Renyi random graph with respect to the Kolmogorov metric. Our bounds match the best available Wasserstein bounds obtained by Barbour et al., resolving a long-standing open problem. The proofs are based on a new variant of the Stein-Tikhomirov method, which combines Stein's method and characteristic functions introduced by Tikhomirov.
PROBABILITY IN THE ENGINEERING AND INFORMATIONAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jagadish Sankaran, Harikrushnan Balasubramanian, Wai Hoh Tang, Xue Wen Ng, Adrian Rollin, Thorsten Wohland
Summary: This study presents an experimental strategy that optimizes spatial and temporal resolution simultaneously by implementing a GPU-supported, camera-based measurement strategy. The results demonstrate the importance of pixel-wise cross-correlation of parameters obtained from different techniques on the same data set for robust physicochemical parameter estimation and providing unique biological knowledge.
NATURE COMMUNICATIONS
(2021)
Article
Biochemical Research Methods
Kiesha Prem, Kevin van Zandvoort, Petra Klepac, Rosalind M. Eggo, Nicholas G. Davies, Alex R. Cook, Mark Jit
Summary: Mathematical models have been crucial in understanding the spread of directly-transmissible infectious diseases like COVID-19 and evaluating public health responses. Contact matrices are used to characterize the spread of infectious pathogens, with synthetic matrices being constructed in lieu of representative empirical contact studies. These synthetic matrices have shown qualitative similarities to empirically-constructed contact patterns, allowing for modeling in settings without direct contact data.
PLOS COMPUTATIONAL BIOLOGY
(2021)
Article
Oncology
Ruiyang Zou, Sau Yeen Loke, Yew Chung Tang, Heng-Phon Too, Lihan Zhou, Ann S. G. Lee, Mikael Hartman
Summary: This study conducted the largest comprehensive multi-center research to date and identified 30 dysregulated miRNAs associated with breast cancer. An optimized eight-miRNA panel was successfully validated in diverse ethnic groups and showed consistent performance. The panel has the potential to be used for breast cancer screening in conjunction with mammography.
BRITISH JOURNAL OF CANCER
(2022)
Article
Ethics
Tamra Lysaght, Gerald Owen Schaefer, Teck Chuan Voo, Hwee Lin Wee, Roy Joseph
Summary: The COVID-19 pandemic has brought about high levels of uncertainty and limited effective treatment options. Providing drug products outside of research settings has been a controversial topic. This article proposes the use of the Professional Oversight of Emergency-Use Interventions and Monitoring System (POEIMS) as an alternative pathway, based on guidance developed in Singapore. The authors argue for the moral duty of physicians to record outcomes data and institutions to establish monitoring systems for reporting safety and effectiveness information.
JOURNAL OF BIOETHICAL INQUIRY
(2022)
Article
Health Care Sciences & Services
Rayner Kay Jin Tan, Wee Ling Koh, Daniel Le, Sumita Banerjee, Martin Tze-Wei Chio, Roy Kum Wah Chan, Christina Misa Wong, Bee Choo Tai, Mee Lian Wong, Alex R. Cook, Mark I-Cheng Chen, Chen Seong Wong
Summary: This study evaluates the effectiveness of a web drama video series in promoting HIV and other STI testing behaviors among GBMSM. The results show that the intervention has positively impacted participants' intention to test and their regular testing behaviors for HIV and chlamydia/gonorrhea. This intervention has the potential to reach GBMSM who may not have access to conventional prevention messaging.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Biochemical Research Methods
Haoyang Sun, Alex Perkins, Joel Koo, Borame L. Dickens, Hannah E. Clapham, Alex R. Cook
Summary: This study used an individual-based model to simulate the effectiveness of sustained vector control in different dengue transmission settings. The results identified critical factors influencing the time-varying effectiveness of vector control and can inform future studies and predictions of dengue vector control.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Cell Biology
Mario A. Mendieta-Serrano, Sunandan Dhar, Boon Heng Ng, Rachna Narayanan, Jorge J. Y. Lee, Hui Ting Ong, Pearlyn Jia Ying Toh, Adrian Rollin, Sudipto Roy, Timothy E. Saunders
Summary: The process of skeletal myogenesis involves dynamic changes in cell shape, fusion, and rearrangement, leading to the organized structure of striated fibers. Through live imaging and quantitative analysis in zebrafish, the fusion of fast-twitch myocytes within the myotome was studied. It was found that fusion timing had a strong medial-lateral bias, while at the cellular scale, there was heterogeneity in cell shape and the relationship between initial position and fusion partners. The study suggests that slow muscle rearrangement guides the fusion of fast myocytes, enhancing fusion probability and contributing to the emergence of a robust myotome structure.
DEVELOPMENTAL CELL
(2022)
Review
Health Care Sciences & Services
Diana Beatriz Bayani, Hwee Lin Wee
Summary: This review examines the motivations, barriers, and facilitators to implementing outcomes-based risk-sharing agreements (OBRSA) for hematological cancer therapies. The findings suggest that there is a disconnect between the theoretical basis and practical reasons for choosing OBRSAs. Administrative burden is identified as a notable barrier, while effective stakeholder engagement and mutual trust among key groups are identified as facilitators. The review highlights important considerations and implications for the future role of OBRSAs, particularly in the context of blood cancer drugs.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Oncology
Zi Lin Lim, Peh Joo Ho, Mikael Hartman, Ern Yu Tan, Nur Khaliesah Binte Mohamed Riza, Elaine Hsuen Lim, Phyu Nitar, Jingmei Joint Breast Cancer Registry (JBCR), Fuh Yong Wong, Jingmei Li
Summary: This two-part study found that non-Chinese ethnicity is associated with a higher incidence of febrile neutropenia (FN) in chemotherapy-treated breast cancer patients. Indian patients had a greater decrease in absolute neutrophil count during chemotherapy, while Malay patients were more likely to receive anthracycline treatment, both contributing to higher FN risk. Non-Chinese patients were also more likely to experience multiple FN episodes. Further research is needed to investigate pharmacogenetic differences across ethnicities.
Article
Public, Environmental & Occupational Health
Yilin Ning, Peh Joo Ho, Nathalie C. Stoer, Ka Keat Lim, Hwee-Lin Wee, Mikael Hartman, Marie Reilly, Chuen Seng Tan
Summary: Assessing the proxy assumption and estimating the exposure effect using the cumulative link model (CLM) offers a valid test for the presence of an association. The CLM had good performance in estimating the difference in means with simulated ordinal data and provided a method for assessing the proxy assumption, highlighting the importance of evaluating the proxy assumption to avoid reporting invalid estimates in terms of the difference in scores.
CLINICAL EPIDEMIOLOGY
(2021)