Article
Chemistry, Multidisciplinary
Xupeng Bai, Jie Ni, Julia Beretov, Shanping Wang, Xingli Dong, Peter Graham, Yong Li
Summary: The study shows that THOC2 and THOC5 are upregulated in radioresistant TNBC cells, promoting stem-like properties and radioresistance. Silencing THOC2 or THOC5 expression decreases protein expression of SOX2 and NANOG, depletes stem-like properties, and causes radiosensitization in TNBC cells. Depletion of THOC2 or THOC5 blocks xenograft tumorigenesis and growth of radioresistant TNBC in vivo, suggesting potential therapeutic strategies against relapsed TNBC.
Article
Oncology
Xueran Chen, Wanxiang Niu, Xiaoqing Fan, Haoran Yang, Chenggang Zhao, Junqi Fan, Xuebiao Yao, Zhiyou Fang
Summary: In this study, it was found that Oct4A can impact the tumorigenic activity of glioblastoma and its stability is maintained through palmitoylation. Oct4A palmitoylation helps to integrate Sox4 and Oct4A in the SOX2 enhancement subregion, thereby maintaining the stem performance of glioma stem cells. The study also designed Oct4A palmitoylation competitive inhibitors that can inhibit the self-renewal ability and tumorigenicity of glioma stem cells.
Article
Medicine, Research & Experimental
Qi-Yue Chen, Xiao-Bo Huang, Ya-Jun Zhao, Hua-Gen Wang, Jia-Bin Wang, Li-Chao Liu, Ling-Qian Wang, Qing Zhong, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Ping Li, Chang-Ming Huang
Summary: This study identified a decrease in FABP4 expression as a potential marker for gastric cancer (GC) metastasis and poor prognosis. Mechanistically, FABP4 inhibited GC metastasis by binding with PPAR-gamma and suppressing CADM3 transcription. The antidiabetic drug rosiglitazone showed therapeutic potential in restoring PPAR-gamma/CADM3 activation in FABP4-deficient GC cells.
Article
Plant Sciences
Lanyang Xu, Hao Duan, Yuheng Zou, Jing Wang, Huaxi Liu, Wanyu Wang, Xiao Zhu, Jiali Chen, Chuanwu Zhu, Zhixin Yin, Xiaoshan Zhao, Qirui Wang
Summary: In this study, the potential molecular mechanism and effect of the Chinese medicine Xihuang pill (XHP) on glioma stem-like cells (GSCs) were evaluated. Through analysis of the constituent of XHP and network pharmacology, it was found that XHP can induce apoptosis and inhibit self-renewal ability of GSCs. In addition, XHP can also reduce the expression of GSC markers and impede glioma growth in vivo.
Article
Cell Biology
Mohammed Razeeth Shait Mohammed, Mazin Zamzami, Hani Choudhry, Firoz Ahmed, Bushra Ateeq, Mohammad Imran Khan
Summary: This study discovered that H3K27 histone demethylases, KDM6A/B, are highly expressed during ECM detachment. Inhibition of KDM6A/B activity reduces sphere formation capacity and increases apoptosis. KDM6B maintains stemness by transcriptionally regulating the expression of stemness genes and plays a regulatory role in maintaining hypoxia in detached cancer cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuanke Liang, Danielle Voshart, Judith T. M. L. Paridaen, Nynke Oosterhof, Dong Liang, Arun Thiruvalluvan, Inge S. Zuhorn, Wilfred F. A. den Dunnen, Guojun Zhang, Haoyu Lin, Lara Barazzuol, Frank A. E. Kruyt
Summary: This study reveals the important role of the cell adhesion molecule CD146 in regulating the aggressiveness of the brain tumor Glioblastoma (GBM). Elevated CD146 levels are correlated with higher tumor grades, poor response to treatment, and worse overall survival. CD146 overexpression enhances mesenchymal and invasive properties, stemness, and radiotherapy resistance in GBM. These findings suggest that CD146 could be a potential therapeutic target for GBM treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Ander Saenz-Antonanzas, Veronica Moncho-Amor, Jaione Auzmendi-Iriarte, Alejandro Elua-Pinin, Karine Rizzoti, Robin Lovell-Badge, Ander Matheu
Summary: Deletion of SRR2 halts malignant activity of SOX2 in cancer cells, highlighting the importance of SRR2 enhancer in regulating SOX2 expression.
Article
Cell Biology
Prakash P. Praharaj, Srimanta Patra, Soumya R. Mishra, Subhadip Mukhopadhyay, Daniel J. Klionsky, Shankargouda Patil, Sujit K. Bhutia
Summary: This study found that cisplatin treatment activated higher mitophagy in oral cancer stem cells by regulating CLU levels. CLU regulated mitochondrial fission by activating AKT kinase, leading to mitochondrial fission. Furthermore, CLU-mediated mitophagy positively regulated oral cancer stem cells by degrading MSX2 and preventing its nuclear translocation, which suppressed SOX2 activity and inhibited cancer stemness and self-renewal ability.
Article
Biochemistry & Molecular Biology
Peng Ye, Xiaoxia Chi, Xiuwen Yan, Fangqin Wu, Zhigang Liang, Wen-Hao Yang
Summary: This study reveals the crucial role of alanine-glyoxylate aminotransferase (AGXT) in supporting liver cancer stem cells (LCSCs) and maintaining their stemness. AGXT may sustain the self-renewal potential of LCSCs by upregulating the expression of SRY-box transcription factor 2 (SOX2) and octamer-binding transcription factor 4 (OCT4).
Article
Biochemistry & Molecular Biology
Jeong-Yub Kim, Hee-Jin Kim, Chan-Woong Jung, Byung-Il Choi, Dae-Hee Lee, Myung-Jin Park
Summary: The study demonstrates that PARK7 plays a crucial role in maintaining stemness and therapeutic resistance in GSCs. Knockdown of PARK7 inhibits self-renewal and invasion abilities of GSCs, increases sensitivity to ionizing radiation, and suppresses the expression of GSC signatures. Overexpression of PARK7 in non-GSCs enhances self-renewal activities, migration, and IR resistance.
Article
Integrative & Complementary Medicine
Zhi-Yu Chen, Huan-Huan Huang, Qiao-Chu Li, Fang-Biao Zhan, Ling-Bang Wang, Tao He, Chao-Hua Yang, Yang Wang, Yuan Zhang, Zheng-Xue Quan
Summary: Previous studies have shown that capsaicin can inhibit osteosarcoma proliferation and enhance its sensitivity to cisplatin. This study further explored the inhibitory effects of capsaicin at low concentrations on stemness and metastasis of osteosarcoma. The results demonstrated that capsaicin can significantly reduce the number of osteosarcoma cancer stem cells and inhibit their invasive and metastatic abilities. This has important implications for the prevention and treatment of osteosarcoma metastasis.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim
Summary: The research reveals that the E3 ubiquitin ligase TRIM26 promotes SOX2 stability in a unique manner, consequently enhancing the tumorigenicity and tumor-forming ability of GSCs.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Robert J. MacAulay, Arnold B. Etame
Summary: This study identifies BIRC3 as a key regulator of stemness reprogramming in GBM, and demonstrates its role in driving stemness reprogramming through the regulation of BMP4 signaling axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Matilde Cescon, Elena Rampazzo, Silvia Bresolin, Francesco Da Ros, Lorenzo Manfreda, Alice Cani, Alessandro Della Puppa, Paola Braghetta, Paolo Bonaldo, Luca Persano
Summary: Collagen VI has a distinct distribution within GBM tumors and is strongly correlated with aggressive and phenotypically immature cells. It sustains the stem-like properties of GBM cells and promotes cancer cell proliferation and survival. Collagen VI plays a pivotal role in GBM tumor biology, affecting phenotypic identity, gene transcription, and response to treatment.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Engineering, Biomedical
Shengwei Jiang, Weihan Liu, Dan Shi, Huan Cheng, Tingwei Deng, Guoyong Chen, Li Ma, Xianbin Zhang, Peng Gong
Summary: Black phosphorus (BP) has potential clinical applications, and this study investigates its potential as a targeting PPAR-? agonist to overcome chemoresistance in pancreatic adenocarcinoma (PAAD). The study uses different cell models and mouse models to explore the effects of BP on PPAR pathway and stem-like cancer cells. The research demonstrates that BP can inhibit cancer stem cell properties and enhance the treatment efficacy of PAAD when combined with gemcitabine.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Clinical Neurology
Ian K. White, Ecaterina Pestereva, Kashif A. Shaikh, Daniel H. Fulkerson
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2016)
Article
Multidisciplinary Sciences
Saravanan Kanakasabai, Ecaterina Pestereva, Wanida Chearwae, Sushil K. Gupta, Saif Ansari, John J. Bright
Letter
Clinical Neurology
Catherine Peterson, Richard J. Garling, Eishi Asano, William J. Kupsky, Kallol Set, Rajkumar Agarwal, Sandeep Sood
PEDIATRIC NEUROLOGY
(2019)
Article
Clinical Neurology
Catherine Peterson, Michael Lawless, Sandeep Sood
PEDIATRIC NEUROSURGERY
(2020)
Review
Clinical Neurology
Bradley Kolb, Catherine Peterson, Hassan Fadel, Emre Yilmaz, Kwame Waife, R. Shane Tubbs, Gary Rajah, Blake Walker, Vicki Diaz, Marc Moisi
Summary: The lateral lumbar interbody fusion technique is becoming increasingly popular for lumbar arthrodesis, and we identified the top 25 most cited articles through literature analysis. These articles, mainly case series, reported on a total of 2981 patients, with the most cited article published between 2006 and 2015.
NEUROSURGICAL REVIEW
(2021)
Article
Clinical Neurology
Catherine Peterson, Richard J. Garling, Emre Yilmaz, Abilash Haridas, R. Shane Tubbs, Marc Moisi
INTERDISCIPLINARY NEUROSURGERY-ADVANCED TECHNIQUES AND CASE MANAGEMENT
(2018)
Review
Medicine, General & Internal
Catherine Peterson, Clay Elswick, Vicki Diaz, R. Shane Tubbs, Marc Moisi
CUREUS JOURNAL OF MEDICAL SCIENCE
(2017)