Article
Pharmacology & Pharmacy
Yang Wang, Dan Sun, Yan Mei, Sanlan Wu, Xinlin Li, Sichan Li, Jun Wang, Liuliu Gao, Hua Xu, Yali Tuo
Summary: The present study aimed to establish population pharmacokinetic models of latamoxef and provide guidance for individualized administration in pediatric patients. The study found that body surface area (BSA) was the most significant covariate affecting pharmacokinetics and provided specific recommendations for dosage adjustment based on BSA for pediatric patients.
Article
Infectious Diseases
Hideo Kato, Suzanne L. Parker, Jason A. Roberts, Mao Hagihara, Nobuhiro Asai, Yuka Yamagishi, David L. Paterson, Hiroshige Mikamo
Summary: Limited data on amikacin pharmacokinetics exist in the elderly population. This study aimed to describe the population pharmacokinetics of amikacin in patients over 70 years old and establish optimized initial dosing regimens. The results suggest that dosing regimens of 1800 mg at intervals of 48-72 hours based on creatinine clearance are recommended for achieving both efficacy and safety in elderly patients.
Article
Multidisciplinary Sciences
Erika Wallender, Ali Mohamed Ali, Emma Hughes, Abel Kakuru, Prasanna Jagannathan, Mary Kakuru Muhindo, Bishop Opira, Meghan Whalen, Liusheng Huang, Marvin Duvalsaint, Jenny Legac, Moses R. Kamya, Grant Dorsey, Francesca Aweeka, Philip J. Rosenthal, Rada M. Savic
Summary: Intermittent preventive treatment with dihydroartemisinin-piperaquine (DP) is highly protective against malaria in children, with DP every 4 weeks associated with 95% protective efficacy. A PPQ level of 15.4 ng/mL reduces the malaria hazard by 95%, while malnutrition decreases PPQ exposure.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Zi-bin Jin, Zhuo Wu, Yi-fan Cui, Xue-peng Liu, Hong-bo Liang, Jia-yong You, Chen-yu Wang
Summary: This study aimed to analyze the pharmacokinetics of lithium and investigate the impact of patient characteristics on the drug's clearance. The results showed that weight, creatinine clearance, and total daily dose of lithium can affect the drug's clearance, suggesting the need for individualized dosing regimens for patients with bipolar disorder.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ming-Lu Wang, Yu-Ying Tao, Xiao-Yu Sun, Yang Guo, Zhan-You Wang, Yun-Feng Cao, Limei Zhao
Summary: During pregnancy, a refined population pharmacokinetic model of lamotrigine (LTG) in women with epilepsy was developed to identify factors influencing pharmacokinetics and establish individualized dosing regimens. Changes in estrogen profile were found to be a major contributor to variations in LTG clearance, with specific genetic variants also impacting drug clearance. The refined model incorporating estrogen profiles and pharmacogenetics outperformed a simplified model based on clinical variables alone.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chao-Yang Chen, Min Xie, Jun Gong, Ning Yu, Ran Wei, Li-Li Lei, Si-Miao Zhao, Ruo-Ming Li, Xiu Dong, Xiang-Lin Zhang, Ying Zhou, Shuang-Ling Li, Yi-Min Cui
Summary: This study aimed to investigate the population pharmacokinetics (PPK) characteristics of teicoplanin in adult sepsis patients and provide recommendations for optimal teicoplanin dosing regimens. The study found that current standard doses may result in undertherapeutic concentrations and area under the curve (AUC), and a single dose of at least 12 mg/kg may be needed. Model-based simulations revealed the optimal dosing regimens for different renal functions. The importance of monitoring teicoplanin trough concentrations and AUC was emphasized.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Warit Ruanglertboon, Michael J. Sorich, Ashley M. Hopkins, Andrew Rowland
Summary: This study aimed to evaluate the effectiveness of concentration-guided sorafenib dosing protocols in increasing the proportion of patients achieving a sorafenib maximal concentration within a specific range. A physiologically based pharmacokinetic model was built and validated, identifying key factors associated with steady-state sorafenib C-max. The study found that concentration-guided dosing with model-informed dose selection was the quickest and most effective approach to achieve a specific sorafenib C-max range.
Article
Veterinary Sciences
Carl Ekstrand, Peter Michanek, Matilda Salomonsson, Cecilia Tegner, Lena Pelander
Summary: This study aimed to investigate the plasma concentration-time course and potential adverse effects of nitrofurantoin in dogs. The results showed that nitrofurantoin had high concentrations in the plasma and urine of dogs with a short half-life. No adverse effects were observed clinically or in laboratory tests. The study suggests that nitrofurantoin could be effective in treating bacterial cystitis in dogs, but further clinical studies are needed to confirm its effectiveness.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Oncology
Lydia Meziani, Marine Gerbe de Thore, Celine Clemenson, Winchygn Liu, Pierre-Antoine Laurent, Michele Mondini, Marie-Catherine Vozenin, Eric Deutsch
Summary: CD73 targeting can improve the antitumor effects of irradiation and immune checkpoint inhibitor treatment, and the dosing regimen and iCOS expression are important factors that affect the therapeutic efficacy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Veterinary Sciences
Jacob R. Cawley, Samuel D. Stewart, Jonathan Paul Mochel, Sridhar Veluvolu, Chand Khanna, Joelle M. Fenger
Summary: This study evaluated the pharmacokinetics of sorafenib in tumor-bearing dogs and found that a twice-daily oral dose of 3 mg/kg was well-tolerated without any adverse events.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Computer Science, Interdisciplinary Applications
Iordanis Kesisoglou, Brianna M. Eales, Paul R. Merlau, Vincent H. Tam, Michael Nikolaou
Summary: The study presents a method for predicting the bactericidal efficacy of antibiotics using mathematical modeling and longitudinal optical density measurements. Experimental results confirm the effectiveness of periodic injections of ceftazidime/amikacin combinations in suppressing bacterial populations, while periodic injections of ceftazidime alone showed limited efficacy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Article
Infectious Diseases
Noemie de Cacqueray, Deborah Hirt, Yi Zheng, Emmanuelle Bille, Pierre Louis Leger, Jerome Rambaud, Julie Toubiana, Anais Chosidow, Sophie Vimont, Delphine Callot, Laurent Chouchana, Agathe Beranger, Jean Marc Treluyer, Sihem Benaboud, Mehdi Oualha
Summary: The study aimed to build a population pharmacokinetic (PK) model for cefepime in critically ill children and optimize individual initial dosing regimens. The results showed that body weight and estimated glomerular filtration rate were associated with drug clearance. According to the simulations, continuous intravenous infusion of cefepime was more likely to achieve the PK target in patients with renal failure, while intermittent intravenous infusion was adequate for patients with normal or augmented renal clearance. Close therapeutic drug monitoring is necessary for cefepime treatment.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Hematology
Laura H. Bukkems, Kathelijn Fischer, Idske Kremer-Hovinga, Anouk A. M. Donners, Karin Fijnvandraat, Roger E. G. Schutgens, Marjon H. Cnossen, Ron A. A. Mathot
Summary: The study developed a cost-efficient alternative dosing regimen for emicizumab maintenance, which achieved similar plasma concentrations compared to the registered dosing regimen and saved costs for patients.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Yaxin Liu, Yun Kuang, Min Hai, Cheng Cui, Dongyang Liu, Guoping Yang
Summary: The exposure to ticagrelor is higher in East Asians, resulting in an increased risk of bleeding. A population pharmacokinetic model was developed and machine learning methods were used to construct bleeding risk models. The Random Forest model performed the best and a lower bleeding risk ticagrelor regimen can be obtained using this model.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Infectious Diseases
Silke Gastine, Georg Hempel, Michael N. Neely, Thomas J. Walsh, Andreas H. Groll
Summary: This study simulated the use of extended twice-weekly dosing with caspofungin for antifungal prophylaxis in children. The results showed that a regimen of 200 mg/m2 twice-weekly with a maximum total dose of 200 mg can achieve the desired exposure levels and pharmacokinetic/pharmacodynamic targets.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Hematology
Isabelle Mahe, Giancarlo Agnelli, Cihan Ay, Aristotelis Bamias, Cecilia Becattini, Marc Carrier, Celine Chapelle, Alexander T. Cohen, Philippe Girard, Menno Huisman, Frederikus A. Klok, Juan J. Lopez-Nunez, Anthony Maraveyas, Didier Mayeur, Olivier Mir, Manuel Monreal, Marc Righini, Charles M. Samama, Kostas Syrigos, Sebastian Szmit, Adam Torbicki, Peter Verhamme, Eric Vicaut, Tzu-Fei Wang, Guy Meyer, Silvy Laporte
Summary: The API-CAT study aims to evaluate whether a reduced-dose regimen of apixaban is noninferior to a full-dose regimen in preventing recurrent VTE in cancer patients. This international, randomized, double-blind trial will assess VTE events as the primary efficacy outcome and clinically relevant bleeding as the principal safety endpoint.
THROMBOSIS AND HAEMOSTASIS
(2022)
Editorial Material
Oncology
E. Minvielle, M. di Palma, O. Mir, F. Scotte
ANNALS OF ONCOLOGY
(2022)
Editorial Material
Oncology
B. C. Ozdemir, S. Oertelt-prigione, A. A. Adjei, S. Borchmann, J. B. Haanen, A. Letsch, O. Mir, A. Quaas, R. H. A. Verhoeven, A. D. Wagner
ANNALS OF ONCOLOGY
(2022)
Article
Oncology
E. Palassini, O. Mir, G. Grignani, B. Vincenzi, H. Gelderblom, A. Sebio, C. Valverde, G. G. Baldi, A. Brunello, G. G. Cardellino, A. Marrari, G. Badalamenti, J. Martin-Broto, V Ferraresi, M. Libertini, S. Turano, I Gataa, P. Collini, A. P. Dei Tos, M. Gennaro, F. Bini, S. Provenzano, S. Lo Vullo, L. Mariani, A. Le Cesne, P. G. Casali
Summary: This study retrospectively reviewed the outcomes of systemic treatments in 56 female patients with advanced breast PT. The results showed that anthracyclines plus ifosfamide (AI) had a higher response rate, but the median progression-free survival was only 5.7 months.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Bruno Vincenzi, Andrea Napolitano, Marta Fiocco, Olivier Mir, Piotr Rutkowski, Jean-Yves Blay, Peter Reichardt, Heikki Joensuu, Elena Fumagalli, Spyridon Gennatas, Nadia Hindi, Margherita Nannini, Mariella Spalato Ceruso, Antoine Italiano, Giovanni Grignani, Antonella Brunello, Silvia Gasperoni, Tommaso De Pas, Giuseppe Badalamenti, Maria A. Pantaleo, Winan J. van Houdt, Nikki S. IJzerman, Neeltje Steeghs, Hans Gelderblom, Ingrid M. E. Desar, Johanna Falkenhorst, Marianna Silletta, Marta Sbaraglia, Giuseppe Tonini, Javier Martin-Broto, Peter Hohenberger, Axel Le Cesne, Robin L. Jones, Angelo P. Dei Tos, Alessandro Gronchi, Sebastian Bauer, Paolo G. Casali
Summary: This study evaluated the effect of high-dose imatinib on the survival of patients with KIT exon 9-mutated gastrointestinal stromal tumors. The results showed that increasing the dose from 400 mg/day to 800 mg/day did not lead to better survival outcomes.
CLINICAL CANCER RESEARCH
(2022)
Editorial Material
Immunology
Tarek Assi, Olivier Mir
Article
Oncology
Charlotte Le Roy, Cecile Le Pechoux, Claire Alapetite, Ratislav Bahleda, Carine Ngo, Charles Honore, Matthieu Faron, Axel Le Cesne, Olivier Mir, Christine Haie-Meder, Cyrus Chargari, Antonin Levy
Summary: Non-operable scalp cutaneous angiosarcoma patients face a scarcity of effective treatments. However, curative-intent definitive sequential IMRT and plesiobrachytherapy have shown promising results in two elderly patients, providing a non-invasive therapeutic option for locally advanced presentation.
Review
Orthopedics
Charles Court, Sylvain Briand, Olivier Mir, Cecile Le Pechoux, Thierry Lazure, Gilles Missenard, Charlie Bouthors
Summary: Chordoma is a rare and slow-growing malignant tumor mainly located in the sacrum and spine. Late clinical diagnosis and histologic diagnosis are necessary for treatment. Surgical resection is the most effective treatment, but patients should be prepared for potential neurologic sequelae.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Article
Oncology
Sarah Watson, Benjamin Verret, Stanislas Ropert, Julien Adam, Rastislav Bahleda, Sylvain Briand, Andrea Cavalcanti, Ali N. Chamseddine, Charles Court, Elie Fadel, Matthieu Faron, Leila Haddag-Miliani, Clemence Henon, Cecile Le Pechoux, Antonin Levy, Olaf Mercier, Carine Ngo, Charles Honore, Axel Le Cesne, Olivier Mir
Summary: The activity of single-agent gemcitabine in advanced angiosarcoma was evaluated in this study. The results showed that gemcitabine had clinically meaningful activity, especially in cardiac angiosarcoma and patients who had received prior treatments.
Article
Oncology
Ruth Gabriela Herrera-Gomez, Miruna Grecea, Claire Gallois, Valerie Boige, Patricia Pautier, Barbara Pistilli, David Planchard, David Malka, Michel Ducreux, Olivier Mir
Summary: This study retrospectively evaluated the safety and efficacy of combining bevacizumab and chemotherapy in adult cancer patients with inflammatory bowel disease. The results showed that the combination treatment was safe in patients with quiescent or moderately active inflammatory bowel disease.
Article
Oncology
Anne-Sophie Michallet, Stephanie Malartre, Elodie Vignaud, Alexiane Bocquet, Pascale Sontag, Christelle Galvez, Jean-Yves Blay, Pierre Heudel, Alexandre Vimont, Martin Blachier, Marie Ferrua, Etienne Minvielle, Olivier Mir
Summary: This study evaluates the cost-effectiveness of an Ambulatory Medical Assistance (AMA) programme in patients with haematological malignancies. The results show that the AMA programme is cost-effective compared to a simulated control arm with no intervention.
EUROPEAN JOURNAL OF CANCER CARE
(2022)
Review
Health Care Sciences & Services
E. Minvielle, A. Fierobe, A. Fourcade, M. Ferrua, M. di Palma, F. Scott, O. Mir
Summary: This study examines the use of patient-reported measures (PRMs) as quality indicators (QIs) for health policy purposes, focusing on the field of oncology. The research analyzed 61 articles and 19 websites/reports, identifying 29 patient-reported experience measures (PREMs) and 48 patient-reported outcome measures (PROMs) from multiple countries. The study found that there are still barriers to overcome before PRMs can be effectively used for health policy in oncology, and further research is needed to develop valid QIs on a national level.
Article
Oncology
Alice Boileve, Laurence Albiges, Michel Ducreux, Eric Baudin, Alexandra Leary, Benjamin Besse, Julien Hadoux, David Malka, Andre Rieutord, Florian Scotte, Amandine Maulard, Olivier Mir
Summary: This study retrospectively investigated the safety of concomitant use of DOAC and anti-VEGF agents in cancer patients. The results showed that the use of DOAC was safe in selected patients treated with KI, but the safety with bevacizumab was unclear. More data are needed to establish guidelines for this specific group of patients.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
P. Gougis, A. Geraud, M. Hilmi, A. Vozy, L. Campedel, B. Abbar, C. Allio, S. De Chatillon, A. Portalier, F. Lapray, S. Choquet, J. -P. Spano, F. Reyal, O. Mir, C. Funck-Brentano, A. -S. Hamy
Summary: This study aimed to assess the feasibility of self-assessment of herb, food, and dietary supplement interactions with cancer treatment in patients. The results showed that self-assessment using an application could detect possible interactions, and further prospective interventional studies are recommended to evaluate the clinical benefits of this approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mickael Tordjman, Charles Honore, Amandine Crombe, Amine Bouhamama, Antoine Feydy, Laurent Dercle, Leila Haddag, Pierre-Alban Bouche, Carine Ngo, Axel Le Cesne, Jean-Yves Blay, Olivier Mir, Mehdi Brahmi, Charlotte Martin, Marie Karanian, Samy Ammari, Michele Kind, Virginie Audard, Francois Le Loarer, Behnam Rabiee, Antoine Italiano, Pascaline Boudou-Rouquette, David Biau, Corinne Balleyguier, Frederique Larousserie, Jean-Luc Drape, Fadila Mihoubi
Summary: This study demonstrated that imaging biomarkers can be used to predict long-term outcome in patients with synovial sarcomas. Strikingly, the presence of calcifications on CT scan is associated with favorable outcome and provides an incremental value over existing prognostic factors such as age, grade, and size.
EUROPEAN RADIOLOGY
(2023)