Article
Chemistry, Multidisciplinary
Xiaosheng Bai, Yan Lin, Lingyi Gong, Junfeng Duan, Xiaoduan Sun, Changguang Wang, Zerong Liu, Jun Jiang, Xiangyu Zhou, Meiling Zhou, Zhirong Zhang, Zhongbing Liu, Pei Jing, Zhirong Zhong
Summary: Researchers have developed a novel nanoparticle system that inactivates the mitochondria of tumor cells to provide adequate local oxygen concentrations for photodynamic therapy. The nanoparticles solubilize the photosensitizer, prolong its circulation, and enhance its antitumor effects.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Morena Petrini, Silvia Di Lodovico, Giovanna Iezzi, Luigina Cellini, Domenico Tripodi, Adriano Piattelli, Simonetta D'Ercole
Summary: The use of a new gel containing aminolevulinic acid and red light (ALAD-PDI) was tested to counteract bacterial biofilm growth on different titanium implant surfaces. The study evaluated the antibacterial efficacy of ALAD-PDI against biofilm growth on several titanium surfaces. Results showed that ALAD-PDI significantly reduced bacterial colony-forming units (CFUs) and biofilm biomass on titanium surfaces, and effectively killed bacteria.
Article
Oncology
Naoki Omura, Naosuke Nonoguchi, Takahiro Fujishiro, Yangtae Park, Naokado Ikeda, Yoshinaga Kajimoto, Ryota Hosomi, Ryokichi Yagi, Ryo Hiramatsu, Motomasa Furuse, Shinji Kawabata, Kenji Fukunaga, Toshihiko Kuroiwa, Ichiro Nakano, Masahiko Wanibuchi
Summary: This study investigated the efficacy of ALA-PDT in destructing GSCs, including the MES-GSCs which have the lowest sensitivity to radiotherapy and chemotherapy. The results showed that ALA-PDT was effective against all GSC lines, and MES-GSCs exhibited higher PpIX expression than DGCs. Surviving MES-GSCs had lower stem cell marker expression and tumor forming potential. Thus, ALA-PDT may be clinically effective against HGG by targeting GSCs, including MES-GSCs.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Review
Pharmacology & Pharmacy
Liang Lou, Shizhe Zhou, Sijia Tan, Menghua Xiang, Wei Wang, Chuang Yuan, Liqian Gao, Qicai Xiao
Summary: ALA is a clinically approved prodrug that can be used to synthesize the natural photosensitizer PpIX. However, its weak lipophilicity, low stability, and poor bioavailability limit its clinical performance. Nanotechnology offers a solution to improve the therapeutic outcomes of ALA-based prodrugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Joanna Bartosinska, Paulina Szczepanik-Kulak, Dorota Raczkiewicz, Marta Niewiedziol, Agnieszka Gerkowicz, Dorota Kowalczuk, Miroslaw Kwasny, Dorota Krasowska
Summary: The study evaluated the efficacy and cosmetic outcome of different photosensitizers in AK patients, indicating that ALA-P may have better effects and lower pain intensity compared to ALA-HCl and MAL-HCl.
Review
Polymer Science
Simonetta D'Ercole, Teocrito Carlesi, Tatiane Cristina Dotta, Tania Vanessa Pierfelice, Emira D'Amico, Domenico Tripodi, Giovanna Iezzi, Adriano Piattelli, Morena Petrini
Summary: The aim of this study was to discuss the use of 5-aminolevulinic acid with red LED light in endodontic treatment. It is reported that the persistence of microorganisms is the main cause of endodontic treatment failure. Photodynamic therapy has become a promising antimicrobial strategy for endodontic treatment, as it is easy to apply, quick, and does not allow microbial resistance. Recent studies have shown that the combination of 5-aminolevulinic acid and red LED light has good results against various types of bacteria, including Enterococuss faecalis. A case report showed a significant decrease in bacterial count after irrigation with a gel containing 5% of 5-aminolevulinic acid and subsequent irradiation with red LED light. The use of 5-aminolevulinic acid with red LED light is therefore concluded to be effective in endodontic treatment.
Article
Oncology
Tomohiro Ihata, Naosuke Nonoguchi, Takahiro Fujishiro, Naoki Omura, Shinji Kawabata, Yoshinaga Kajimoto, Masahiko Wanibuchi
Summary: This study investigated the effect of a hypoxic environment on the sensitivity of glioma stem cells (GSCs) to photodynamic therapy with 5-aminolevulinic acid (ALA-PDT). The results showed that hypoxia-GSCs had lower intracellular PpIX accumulation and less reduction in sensitivity to ALA-PDT compared to normoxia-GSCs.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mariela A. Cespedes, Daniel A. Saenz, Gustavo H. Calvo, Marina Gonzalez, Alexander J. MacRobert, Sinan Battah, Adriana G. Casas, Gabriela M. Di Venosa
Summary: The study showed that ALA dendrimer exhibited selective PDT response for foam cells, resulting in minimal damage to endothelial cells, with apoptosis cell death involved and no necrosis present. This research provides hope for the application of ALA dendrimers in the treatment of obstructive cardiovascular diseases.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Magdalena Ewa Sulewska, Jagoda Tomaszuk, Eugeniusz Sajewicz, Jan Pietruski, Anna Starzynska, Malgorzata Pietruska
Summary: The study aimed to evaluate the efficacy of photodynamic therapy in treating the reticular form of oral lichen planus (OLP). Twenty patients received photodynamic therapy using 5% 5-aminolevulinic acid as a photosensitizer. After 10 weekly sessions, 37 lesions showed improvement, with 14 achieving complete remission. The mean size reduction was 56.2% at the end of therapy and increased to 67.88% after 12 months.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Infectious Diseases
Magdalena Krupka, Andrzej Bozek, Dorota Bartusik-Aebisher, Grzegorz Cieslar, Aleksandra Kawczyk-Krupka
Summary: The study demonstrated the efficacy of photodynamic therapy for infected chronic leg ulcers, with 40% of patients achieving complete remission, 40% experiencing partial response, and 20% showing no response. It also suggested that PDT can be used as a minimally invasive and effective method for treating leg ulcers.
Article
Infectious Diseases
Roberto Rossi, Lorena Rispoli, Michele Antonio Lopez, Andrea Netti, Morena Petrini, Adriano Piattelli
Summary: This paper reviews the results of using ALAD gel as a supportive therapy in the treatment of periodontal disease and peri-implantitis. The study found that the application of ALAD gel improved the condition of both teeth and implants, with no pain reported by the patients. Significant decreases in periodontal pocket depth were observed in periodontal disease patients after 3 and 6 months of treatment. For implant patients, the treatment was associated with decreases in periodontal pocket depth and bleeding on probing, but only the decrease in pocket depth was statistically significant.
Review
Biochemistry & Molecular Biology
Martin Kiening, Norbert Lange
Summary: Mitochondria play essential roles in energy production, iron metabolism, apoptosis, and heme synthesis. Specifically, the accumulation of protoporphyrin IX photosensitizer has been observed in neoplastic cells, suggesting a selective mechanism. This report aims to provide an overview of mitochondrial heme metabolism and potential explanations for the selectivity towards cancer cells, including the involvement of enzymes and transporters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Yujie Zheng, Wen Fan, Li Jiang, Yan Lu
Summary: Sonophoresis can enhance the penetration of 5-ALA into the skin, improve the efficacy of PDT, facilitate earlier and more distinct localization of 5-ALA-PpIX in sebaceous glands, and enhance clinical improvement.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Taokun Luo, Yingjie Fan, Jianming Mao, Xiaomin Jiang, Luciana Albano, Eric Yuan, Tomas Germanas, Wenbin Lin
Summary: A dual-organelle-targeted nanoparticle platform was developed for enhanced photodynamic therapy (PDT) of cancer. The platform grafted 5-aminolevulinic acid (ALA) to a Hf-12-based nanoscale metal-organic layer (Hf-MOL), which improved ALA delivery and protoporphyrin IX (PpIX) synthesis in mitochondria, and trapped 5,15-di-p-benzoatoporphyrin (DBP) photosensitizers in lysosomes. By simultaneously exciting PpIX and DBP with light irradiation at 630 nm, synergistic enhancement of PDT efficacy was achieved through the damage to both mitochondria and lysosomes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Marek Mazurek, Dariusz Szczepanek, Anna Orzylowska, Radoslaw Rola
Summary: This article summarizes the current knowledge on the differences in the level of emitted fluorescence in glial tumors. It discusses how the level of fluorescence may depend on the histological type and genetic profile of the tumor, as well as the activity and expression of enzymes involved in the intracellular metabolism of fluorescent dyes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Julia Steinmann, Marion Rapp, Hosai Sadat, Franziska Staub-Bartelt, Bernd Turowski, Hans-Jakob Steiger, Daniel Hanggi, Michael Sabel, Marcel A. Kamp
Summary: This study analyzed the potential relationship between MRI-based apparent diffusion coefficients (ADC) and local recurrence and outcome in patients with brain metastases. The results showed that ADC values did not have a significant impact on local in-brain progression and survival parameters.
BRITISH JOURNAL OF NEUROSURGERY
(2023)
Article
Oncology
Marion Rapp, Daniel Haenggi, Michael Sabel
Summary: Cerebral metastases are common intracranial tumors in adults. Resection surgery can extend the survival of patients, even for metastases located in eloquent areas.
Article
Oncology
Marion Rapp, Christiane von Sass, Clara Backhaus, Daniel Hanggi, Marcel Alexander Kamp, Michael Sabel
Summary: The last therapy decision for malignant brain tumor patients greatly affects the caregivers' perspective. Caregivers are more likely to support the same therapy decision if they had a positive evaluation of the last therapy and were satisfied with the informed consent. Good interpersonal contact is crucial for satisfaction with surgery and chemotherapy. Caregivers should play an important role in therapy discussions.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, Research & Experimental
Thomas Zeyen, Anna-Laura Potthoff, Robert Nemeth, Dieter H. Heiland, Michael C. Burger, Joachim P. Steinbach, Peter Hau, Ghazaleh Tabatabai, Martin Glas, Uwe Schlegel, Oliver Grauer, Dietmar Krex, Oliver Schnell, Roland Goldbrunner, Michael Sabel, Niklas Thon, Daniel Delev, Hans Clusmann, Clemens Seidel, Erdem Gueresir, Matthias Schmid, Patrick Schuss, Frank A. Giordano, Alexander Radbruch, Albert Becker, Johannes Weller, Christina Schaub, Hartmut Vatter, Judith Schilling, Frank Winkler, Ulrich Herrlinger, Matthias Schneider
Summary: This study aims to evaluate the safety and efficacy of combined MFA/TMZ therapy in patients with recurrent MGMT-methylated glioblastoma. If successful, MFA may become the first clinically feasible targeted drug against TMs.
Article
Oncology
Franziska Staub-Bartelt, Oliver Radtke, Daniel Haenggi, Michael Sabel, Marion Rapp
Summary: The study found that undergoing awake surgery for brain tumor patients does not lead to higher rates or scores of distress, anxiety, or depression. Additionally, whether the surgery is primary or recurrent did not have a significant impact on the prevalence or severity of these psychological factors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jurij Rosen, Garry Ceccon, Elena K. Bauer, Jan-Michael Werner, Caroline Tscherpel, Veronika Dunkl, Marion Rapp, Michael Sabel, Ulrich Herrlinger, Alexander Heinzel, Niklas Schaefer, Maximilian Ruge, Roland Goldbrunner, Gabriele Stoffels, Christoph Kabbasch, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Summary: This study compared the effectiveness and cost effectiveness of F-18-FET PET with conventional MRI for identifying early responders to adjuvant temozolomide chemotherapy. The results showed that F-18-FET PET had a higher rate of correctly identifying responders and was cost-effective compared to MRI.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Johannes Weller, Niklas Schaefer, Christina Schaub, Anna-Laura Potthoff, Joachim P. Steinbach, Uwe Schlegel, Michael Sabel, Peter Hau, Clemens Seidel, Dietmar Krex, Roland Goldbrunner, Torsten Pietsch, Theophilos Tzaridis, Thomas Zeyen, Valeri Borger, Erdem Guresir, Hartmut Vatter, Ulrich Herrlinger, Matthias Schneider
Summary: Obesity is associated with shorter survival in patients with MGMT methylated glioblastoma, but not in patients with MGMT unmethylated glioblastoma.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Sabine Schloemer, Joerg Felsberg, Milena Pertz, Bettina Hentschel, Markus Loeffler, Gabriele Schackert, Dietmar Krex, Tareq Juratli, Joerg Christian Tonn, Oliver Schnell, Hartmut Vatter, Matthias Simon, Manfred Westphal, Tobias Martens, Michael Sabel, Martin Bendszus, Nils Doerner, Klaus Fliessbach, Christian Hoppe, Guido Reifenberger, Michael Weller, Uwe Schlegel
Summary: This study evaluates the effects of standard treatment modalities on neurocognitive functions in glioma patients within two years after surgery. The results show that radiotherapy, chemotherapy or their combination as standard treatment did not have a detrimental effect on cognitive functions in WHO grade 1-4 glioma patients during this period.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Sebastian Jeising, Gerd Geerling, Rainer Guthoff, Daniel Haenggi, Michael Sabel, Marion Rapp, Ann-Christin Nickel
Summary: This study demonstrates that PDT with the second-generation photosensitizer VP causes cell death in GBM cells. It also validates the cellular uptake of VP in GBM cells and suggests its potential use as an optical imaging dye in surgery.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2022)
Article
Medicine, Research & Experimental
Andrew P. Carlson, Emma M. H. Slot, Tristan P. C. van Doormaal, E. H. J. Voormolen, J. W. Dankbaar, P. Depauw, B. Brouwers, M. R. Germans, E. Baert, J. Vandersteene, C. F. Freyschlag, J. Freyschlag, C. Thome, F. Zenga, F. Penner, A. Abdulazim, M. Sabel, M. Rapp, T. Beez, M. Zuccarello, E. Sauvageau, K. Abdullah, B. Welch, D. Langer, J. Ellis, A. Dehdashti, J. VanGompel, B. Bendok, K. Chaichana, J. Liu, A. Dogan, M. K. Lim, M. G. Hayden
Summary: This study aims to assess the safety and effectiveness of a novel dural sealant patch (LIQOSEAL) in reducing CSF leakage in patients undergoing neurosurgery. A randomized controlled trial will be conducted with a total of 228 patients. The primary endpoint includes intraoperative and postoperative CSF leakage, wound infection, and pseudomeningocele.
Article
Oncology
Alexander Heinzel, Daniela Dedic, Norbert Galldiks, Philipp Lohmann, Gabriele Stoffels, Christian P. Filss, Martin Kocher, Filippo Migliorini, Kim N. H. Dillen, Stefanie Geisler, Carina Stegmayr, Antje Willuweit, Michael Sabel, Marion Rapp, Michael J. Eble, Marc Piroth, Hans Clusmann, Daniel Delev, Elena K. Bauer, Garry Ceccon, Veronika Dunkl, Jurij Rosen, Caroline Tscherpel, Jan-Michael Werner, Maximilian I. Ruge, Roland Goldbrunner, Jurgen Hampl, Carolin Weiss Lucas, Ulrich Herrlinger, Gabriele D. Maurer, Joachim P. Steinbach, Joerg Mauler, Wieland A. Worthoff, Bernd N. Neumaier, Christoph Lerche, Gereon R. Fink, Nadim Jon Shah, Felix M. Mottaghy, Karl-Josef Langen
Summary: PET imaging using O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) as a tracer has become essential for diagnosing brain tumors, with increasing demand seen for differentiating tumor progress and treatment-related changes. Referring physicians rate FET PET highly for diagnosing recurrent gliomas and brain metastases.
Review
Oncology
Antonio Santacroce, Constantin Tuleasca, Roman Liscak, Enrico Motti, Christer Lindquist, Matthias Radatz, Brigitte Gatterbauer, Bodo E. Lippitz, Roberto Martinez Alvarez, Nuria Martinez Moreno, Marcel A. Kamp, Bente Sandvei Skeie, Stephanie Schipmann, Michele Longhi, Frank Unger, Ian Sabin, Thomas Mindermann, Otto Bundschuh, Gerhard A. Horstmann, A. T. C. J. van Eck, Maja Walier, Manfred Berres, Makoto Nakamura, Hans Jakob Steiger, Daniel Haenggi, Thomas Fortmann, Samer Zawy Alsofy, Jean Regis, Christian Ewelt
Summary: Meningiomas are common tumors of the central nervous system, and cavernous sinus meningiomas (CSMs) require special treatment due to their location. Stereotactic radiosurgery (SRS) has been found to be a safe and effective alternative for the treatment of CSMs. This multicenter study analyzed the outcomes of over 1000 patients with CSMs treated with SRS, and found that SRS achieved a high tumor control rate with few complications.
Article
Oncology
J. Weller, N. Schaefer, C. Schaub, T. Tzaridis, T. Zeyen, M. Schneider, A. L. Potthoff, F. A. Giordano, J. P. Steinbach, P. S. Zeiner, T. Kowalski, M. Sabel, P. Hau, D. Krex, O. Grauer, R. Goldbrunner, O. Schnell, G. Tabatabai, F. Ringel, F. Schmidt-Graf, S. Brehmer, J. C. Tonn, L. Bullinger, P. Vajkoczy, M. Glas, H. Vatter, U. Herrlinger, C. Seidel
Summary: In the CeTeG/NOA-09 randomized phase III trial, TMZ/CCNU combination therapy was found to be superior to TMZ in newly diagnosed MGMT methylated glioblastoma, with higher incidence of hematotoxicity. This study analyzed high-grade hematotoxicity and its prognostic relevance in the trial population.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Oncology
Franziska Staub-Bartelt, Julia Steinmann, Oliver Radtke, Daniel Haenggi, Michael Sabel, Marion Rapp
Summary: The COVID-19 pandemic does not significantly affect the prevalence of distress, anxiety, and depression in neuro-oncological patients. There is no significant difference in the rates of these psychological issues compared to before the pandemic.
