Article
Oncology
Priyanka G. Bhosale, Robert A. Kennedy, Fiona M. Watt
Summary: Oral squamous cell carcinomas (OSCCs) are genetically diverse and have different microenvironments. Despite the presence of lymphocytes, the activation of CASP8 and CASP3 is low in tumors, while apoptosis is high in lymphocytes. Higher FasL expression in CASP8 mutated tumors may predict disease progression.
JOURNAL OF PATHOLOGY
(2023)
Article
Immunology
Soeren Schnellhardt, Johannes Hirneth, Maike Buettner-Herold, Christoph Daniel, Marlen Haderlein, Arndt Hartmann, Rainer Fietkau, Luitpold Distel
Summary: This study investigated the impact of CD8+ cytotoxic T cell density on the prognostic association of FoxP3+ T cell densities in rectal cancer (RC) and found that the association varies depending on the immune phenotype, suggesting functional heterogeneity within the group of FoxP3+ T cells. Additionally, CD8 immunohistochemistry may serve as a tool to identify tumors infiltrated by different subtypes of FoxP3+ T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Juan P. Rodrigo, Mario Sanchez-Canteli, Fernando Lopez, Gregory T. Wolf, Juan C. Hernandez-Prera, Michelle D. Williams, Stefan M. Willems, Alessandro Franchi, Andres Coca-Pelaz, Alfio Ferlito
Summary: Tumor-infiltrating lymphocytes (TIL) have been shown to be prognostically significant in Laryngeal Squamous Cell Carcinoma (LSCC), with high stromal TIL, CD8+ TIL, and CD3+/CD4+ TIL associated with better clinical outcomes. Evaluation of TIL in HE sections and assessment of CD3+, CD4+, and/or CD8+ TIL levels may serve as predictive markers for patient prognosis in LSCC.
Review
Oncology
Koen Brummel, Anneke L. Eerkens, Marco de Bruyn, Hans W. Nijman
Summary: Tumour-infiltrating lymphocytes (TILs) are crucial in anti-tumour immunity and have prognostic and predictive value. This review discusses the changing understanding of TILs' prognostic value over the past decade, as well as new insights on novel TIL subsets. It also explores the predictive significance of TILs in the era of immune therapy and the incorporation of these predictive capacities into clinical trials through new techniques like machine learning.
BRITISH JOURNAL OF CANCER
(2023)
Article
Immunology
Jin Wu, Tianyi Zhang, Haofeng Xiong, Liujun Zeng, Zijia Wang, Ying Peng, Weijun Chen, Xin Hu, Tong Su
Summary: This study aimed to screen immune cells and genes related to the prognosis of oral squamous cell carcinoma (OSCC). Through the analysis of data from the TCGA database, CD4(+) central memory T cells were identified as the only independent immune cell associated with the prognosis of OSCC. A prognostic prediction model based on the abundance of CD4(+) T cells was established. In addition, 34 prognostic genes related to the infiltration of CD4(+) central memory T cells were screened, and DEFB1 was found to potentially regulate the abundance of these cells and improve the prognosis of OSCC.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Immunology
Youwei Yue, Xinyi Cai, Changhao Lu, Leonardo Antonio Sechi, Paolo Solla, Shensuo Li
Summary: In this study, we found a significant association between clear cell renal cell carcinoma (ccRCC) and tumor-infiltrating B lymphocytes (TIL-Bs). Several key gene modules related to TIL-Bs were identified, and a 10-gene prognostic signature was proposed. These findings contribute to further understanding the potential role of TIL-Bs in ccRCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Lennert Eismann, Severin Rodler, Alexander Buchner, Gerald Bastian Schulz, Yannic Volz, Robert Bischoff, Benedikt Ebner, Thilo Westhofen, Jozefina Casuscelli, Raphaela Waidelich, Christian Stief, Boris Schlenker, Stephan Ledderose
Summary: This study investigated the impact of tumor-infiltrating lymphocytes (TILs) in squamous cell carcinoma (SCC) of the bladder on patient prognosis. The findings suggest that subsets of TILs can predict overall survival (OS) and progression-free survival (PFS), and may be used to stratify patients with bladder SCC for immunotherapy.
Review
Oncology
Celine M. Laumont, Allyson C. Banville, Mara Gilardi, Daniel P. Hollern, Brad H. Nelson
Summary: Tumour-infiltrating B cells and plasma cells have a crucial role in tumour control, promoting antitumour immunity through unique antigen presentation, assembling and perpetuating immunologically 'hot' tumour microenvironments, combating immune editing and tumour heterogeneity.
NATURE REVIEWS CANCER
(2022)
Article
Oncology
Shoichi Nakamura, Kenoki Ohuchida, Yoshiki Ohtsubo, Yutaka Yamada, Chikanori Tsutsumi, Sho Okuda, Kyoko Hisano, Yuki Mochida, Tomohiko Shinkawa, Chika Iwamoto, Nobuhiro Torata, Yusuke Mizuuchi, Koji Shindo, Kohei Nakata, Taiki Moriyama, Takehiro Torisu, Eishi Nagai, Takashi Morisaki, Takanari Kitazono, Yoshinao Oda, Masafumi Nakamura
Summary: Investigated the functional heterogeneity of tumour-infiltrating B lymphocytes (TIL-Bs) in oesophageal squamous cell carcinoma (ESCC) and found that the function of TIL-Bs is enhanced after chemotherapy. The expression of IGKC is associated with improved prognosis in ESCC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Hematology
Qiqi Zhu, Xueqin Deng, Wenqing Yao, Zihang Chen, Yunxia Ye, Limin Gao, Wenyan Zhang, Weiping Liu, Sha Zhao
Summary: The study analyzed TILs in de novo AITL patients and found that high TIL-Bs and high CD4:CD8 were favorable prognostic factors. A new risk stratification based on TIL-Bs and CD4:CD8 was established, showing its value in evaluating prognosis and guiding immunotherapy strategies for AITL.
ANNALS OF HEMATOLOGY
(2021)
Article
Cell Biology
Ke Wu, Xinyi Zheng, Zhixian Yao, Zhong Zheng, Wenjie Huang, Xingyu Mu, Feng Sun, Zhihong Liu, Junhua Zheng
Summary: Research indicates that CD45RO+CD8+ T cells play a critical role in inhibiting the progression of clear cell renal carcinoma (ccRCC) through multiple signaling pathways, demonstrating significant clinical importance as potential indicators in ccRCC patients.
Article
Immunology
Zainab Ali Bazzi, Sophie Sneddon, Peter G. Y. Zhang, Isabella T. Tai
Summary: Colorectal cancer (CRC) is a leading cause of cancer-related deaths, and the presence of tumour-infiltrating leukocytes has a significant impact on prognosis. Three computational methods were used to predict immune cell types in CRC tissue and their abundance for assessing prognosis. The results showed significant differences in immune cell composition between CRC and normal colon tissue, with dendritic cells and mast cells identified as positive prognostic markers. The analysis also revealed that immune cell composition has a more pronounced effect on prognosis in early-stage CRC compared to late-stage CRC. Overall, characterizing the immune landscape in CRC provides a valuable tool for evaluating prognosis and facilitating the use of immunotherapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Masahiro Matsuki, Yoshihiko Hirohashi, Munehide Nakatsugawa, Aiko Murai, Terufumi Kubo, Shinichi Hashimoto, Serina Tokita, Kenji Murata, Takayuki Kanaseki, Tomohide Tsukahara, Sachiyo Nishida, Toshiaki Tanaka, Hiroshi Kitamura, Naoya Masumori, Toshihiko Torigoe
Summary: ICIs are used in cancer immunotherapy to block certain pathways, but low response rates and tumor heterogeneity can lead to resistance. This study found that the specificity of TILs in RCC may be related to gene mutations and reactivity, suggesting heterogenous tumors may have diverse gene mutations and responses to TILs.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Cell Biology
Fengwei Gao, Kunlin Xie, Qiwen Xiang, Yan Qin, Panyu Chen, Haifeng Wan, Yang Deng, Jiwei Huang, Hong Wu
Summary: This study found a dose-response relationship between TILs concentration in tumors and overall survival as well as disease-free survival in HCC patients, validating the prognostic value of TILs. Additionally, hepatitis B or C virus infection patients had higher TILs intensity in the para-tumor tissue.
Article
Oncology
Wei Shi, Mackenzie Fijardo, Jeff P. Bruce, Jie Su, Wei Xu, Rachel Bell, Pierre-Antoine Bissey, Angela B. Y. Hui, John Waldron, Trevor J. Pugh, Kenneth W. Yip, Fei-Fei Liu
Summary: This study reveals the prognostic significance of CD8+ tumor-infiltrating lymphocytes (TILs) in naso-pharyngeal cancer (NPC) and suggests the potential of utilizing CD8+ lymphocytes for immunotherapy.
CLINICAL CANCER RESEARCH
(2022)
